Most viewed
- Page Path
-
- HOME
- BROWSE ARTICLES
- Most viewed
"Most viewed" Articles are from the articles published in 2023 during the last six month.
- Original Article
- Gastroenterology
- Outcome of pediatric inflammatory bowel disease in Asian children: a multinational 1-year follow-up study
(4,953 times)
-
Pornthep Tanpowpong, Suporn Treepongkaruna, James Guoxian Huang, Kee Seang Chew, Karen Sophia Calixto Mercado, Almida Reodica, Shaman Rajindrajith, Wathsala Hathagoda, Yoko Kin Yoke Wong, Way Seah Lee, Marion Margaret Aw
-
Clin Exp Pediatr. 2025;68(3):247-256. Published online November 13, 2024
-
|
Question: Short-term (1-year) follow-up data in pediatric patients with inflammatory bowel disease (IBD), especially in Southeast Asian countries, are limited.
Finding/Meaning: Abdominal pain and pallor rates remained high at 1 year after IBD diagnosis. Three independent factors of 1-year clinical remission for Crohn disease were oral prednisolone, antibiotic, and immunomodulator use at 1-year follow-up. A history of weight loss at diagnosis was the only independent risk factor of IBD flare. |
-
-
- Review Article
- Neurology
- Cerebral organoid research for pediatric patients with neurological disorders
(4,926 times)
-
Jin Eun, Jung Eun Lee, Seung Ho Yang
-
Clin Exp Pediatr. 2025;68(4):269-277. Published online November 28, 2024
-
|
Cerebral organoids obtained from human induced pluripotent stem cells are transforming the study of pediatric neurological diseases by providing more accurate models of human brain development and pathology. These advancements have improved pathology modeling and the potential for novel therapeutic approaches despite existing challenges such as reproducibility and vascularization. |
-
-
- General Pediatrics
- Protecting our future: environmental hazards and children’s health in the face of environmental threats: a comprehensive overview
(4,907 times)
-
Jungha Lee, Hyo-Bin Kim, Hun-Jong Jung, Myunghee Chung, So Eun Park, Kon-Hee Lee, Won Seop Kim, Jin-Hwa Moon, Jung Won Lee, Jae Won Shim, Sang Soo Lee, Yunkoo Kang, Young Yoo; The Environmental Health Committee of the Korean Pediatric Society
-
Clin Exp Pediatr. 2024;67(11):589-598. Published online October 31, 2024
-
|
· Exposure to air pollutants cause allergic and respiratory diseases as well as chronic kidney disease.
· Adequate physical activity and proper nutrition are essential for children to maintain good health.
· We must educate people about the harmful effects of noise, blue light, heavy metals and smoke.
· Government and society must actively decrease environ-mental hazards. |
-
-
- Original Article
- Developmental and Behavioral Medicine
- Neonatal risk factors associated with attention-deficit/hyperactivity disorder: an umbrella review
(4,902 times)
-
Ensiyeh Jenabi, Erfan Ayubi, Sajjad Farashi, Saeid Bashirian, Fereshteh Mehri
-
Clin Exp Pediatr. 2023;66(10):441-446. Published online July 14, 2023
-
|
Question: The risk factors for attention deficit hyperactivity disorder (ADHD), such as breastfeeding, congenital heart disease, and low birth weight, in neonates are not well understood.
Finding: This umbrella review obtained significant effect sizes for ADHD for congenital heart disease (odds ratio [OR], 3.04), low birth weight (OR, 2.25), never breastfed (OR, 1.55), and Apgar score (OR, 1.30).
Meaning: Congenital heart disease, low birth weight, lack of breastfeeding, and Apgar scores were significant factors for ADHD. |
-
-
- Review Article
- Endocrinology
- Hidden link between endocrine-disrupting chemicals and pediatric obesity
(4,882 times)
-
Min Won Shin, Shin-Hye Kim
-
Clin Exp Pediatr. 2025;68(3):199-222. Published online November 28, 2024
-
|
Studies indicate potential connections between exposure to endocrine-disrupting chemicals (EDCs) and childhood obesity. Variations in the impact of EDCs in epidemiological studies may result from differences in exposure concentrations and timing, measurement methods, and interactive effects of multiple EDCs. Longitudinal studies on exposure to multiple EDCs are crucial to elucidating their contribution to pediatric obesity and minimize the adverse health consequences of EDC exposure. |
-
-
- Editorial
- Neonatology (Perinatology)
- The predetermined future: tackling South Korea’s total fertility rate crisis
(4,877 times)
-
Jin Kyu Kim
-
Clin Exp Pediatr. 2025;68(3):225-227. Published online November 6, 2024
-
|
· South Korea faces a severe demographic crisis with the lowest global fertility rate. Despite significant investments, the total fertility rate continues to decline.
· It is necessary to fully mobilize national capabilities and execute comprehensive strategies that focus on both intangible and tangible values.
· Immediate and decisive action is essential to addressing these challenges effectively. |
-
-
- Developmental and Behavioral Medicine
- Neonatal risk factors associated with autism spectrum disorders: an umbrella review
(4,754 times)
-
Amir Mohammad Salehi, Erfan Ayubi, Salman Khazaei, Ensiyeh Jenabi, Saeid Bashirian, Zohreh Salimi
-
Clin Exp Pediatr. 2024;67(9):459-464. Published online July 19, 2024
-
|
Question: What are the neonatal risk factors for autism spectrum disorder (ASD)?
Findings: Significant effect sizes were observed for congenital heart disease (odds ratio [OR], 1.35), macrosomia (OR, 1.11), low birth weight (OR, 1.63), very low birth weight (OR, 2.25), small for gestational age (OR, 1.17), jaundice (OR, 1.74), male sex (OR, 1.47), and Apgar score (OR, 1.40).
Meaning: These factors were identified as risk factors for ASD. |
-
-
- Gastroenterology
- Relationship between nonalcoholic fatty liver disease and hyperandrogenemia in adolescents with polycystic ovary syndrome
(4,727 times)
-
Ozlem Kara, Hanife Aysegul Arsoy, Murat Keskin
-
Clin Exp Pediatr. 2023;66(9):395-402. Published online June 14, 2023
-
|
Question: Is polycystic ovary syndrome (PCOS) a risk factor for nonalcoholic fatty liver disease (NAFLD) in adolescents?
Finding: The frequency of NAFLD did not increase in adolescents with PCOS. However, hyperandrogenemia was a risk factor for NAFLD.
Meaning: Adolescents with PCOS and hyperandrogenemia should be closely monitored for hepatic steatosis. |
-
-
- Allergy
- Regional differences in diagnosis and management of cow's milk allergy
(4,706 times)
-
Fabian Hendricx, Emma Robert, Jaime A. Ramirez-Mayans, Karen Rubi Ignorosa Arellano, Erick M. Toro Monjaraz, Yvan Vandenplas
-
Clin Exp Pediatr. 2024;67(11):601-607. Published online October 28, 2024
-
|
· Although there is broad consensus on many aspects regarding the symptoms, diagnosis, and treatment of cow's milk allergy, the impact of geographical, cultural, and socioeconomic factors remains unestablished.
· Availability and cost of formula for the management of cow's milk allergy have a major impact on the therapeutic choice.
· Region-specific guidelines for the treatment of cow's milk allergy are required. |
-
-
- Pulmonology
- Nonlinear association between neutrophil-to-lymphocyte ratio and asthma in children and adolescents in the United States: a cross-sectional study
(4,703 times)
-
Chuhan Cheng, Liyan Zhang
-
Clin Exp Pediatr. 2025;68(7):489-496. Published online March 11, 2025
-
|
Question: Is there a nonlinear relationship between neutrophil-to-lymphocyte ratio (NLR) and asthma in children and adolescents?
Finding: NLR showed a nonlinear association with asthma, with an NLR threshold of 2.23 identifying individuals at higher risk.
Meaning: An NLR<2.23 may serve as a potential biomarker for asthma risk assessment and management in pediatric populations, thereby offering a simple tool for the early identification of at-risk individuals. |
-
-
- Review Article
- Gastroenterology
- High-resolution esophageal manometry in children
(4,701 times)
-
Yogesh Waikar
-
Clin Exp Pediatr. 2023;66(4):155-160. Published online October 17, 2022
-
|
High-resolution esophageal manometry can be safely performed in children where recurrent vomiting and persistent dysphagia is the working diagnosis after excluding nonluminal and structural obstructive pathologies using pediatric upper gastrointestinal endoscopy. Normal manometry values are available. Clinical picture, biochemical tests, radiological interpretation, and endoscopic findings with manometry completes the analysis of patients with recurrent vomiting and dysphagia. |
-
-
- Endocrinology
- Two- versus one-bag fluid delivery in pediatric and adolescent diabetic ketoacidosis: a systematic review and meta-analysis
(4,681 times)
-
Maya L. Nasser, Joseph Nasr, Reem B. Zalloum, Nathanael Q.E. Yap, Natalie E. Bourdakos, Shahid Miangul, Tara A. Betts, Hayato Nakanishi, Christian A. Than, Serge Jabbour
-
Clin Exp Pediatr. 2024;67(10):486-497. Published online June 27, 2024
-
|
· The safety and efficacy of the two-bag versus one-bag system for treating patients with diabetic ketoacidosis (DKA) < 21 years remains unestablished.
· Our meta-analysis demonstrated similar safety outcomes but sooner DKA resolution and shorter mean response time for intravenous fluid changes for the two-bag system.
· This preliminary evidence suggests that the two-bag system has some advantages in efficacy, but further studies are needed to evaluate their extent. |
-
-
- Editorial
- Nutrition
- Zinc as a treatment modality for acute infectious diarrhea in children
(4,675 times)
-
Ji Sook Park
-
Clin Exp Pediatr. 2025;68(3):223-224. Published online October 31, 2024
-
|
|
· Prevention and management of dehydration is the major goal of treatment in acute infectious diarrhea in children.
· Zinc could be effective as an adjuvant therapy in reducing the duration of acute infectious diarrhea in malnourished children. |
-
-
- Original Article
- Pulmonology
- Polysomnographic features of children with obesity: body mass index predict severe obstructive sleep apnea in obese children?
(4,674 times)
-
Rungrat Sukharom, Prakarn Tovichien, Kanokporn Udomittipong, Pinyapach Tiamduangtawan, Wattanachai Chotinaiwattarakul
-
Clin Exp Pediatr. 2025;68(1):80-90. Published online November 6, 2024
-
|
Question: How Common is obstructive sleep apnea (OSA) in obese children? OSA is common in obese children, even without habitual snoring.
Finding: Among the subjects, 60.6% had positional OSA, 40.2% had rapid eye movement-related OSA, 59.8% had desaturation, 20.5% had sleep-related hypoventilation, and 5.0% had obesity hypoventilation syndrome. Body mass index (BMI) and neck and waist circumferences were significantly associated with severe OSA.
Meaning: We recommend screening obese children (BMI > 29.2 kg/m2) for OSA. |
-
-
- Review Article
- Allergy
- Trends of vitamin D in asthma in the pediatric population for two decades: a systematic review
(4,663 times)
-
Myongsoon Sung
-
Clin Exp Pediatr. 2023;66(8):339-347. Published online June 14, 2023
-
|
· Vitamin D may affect asthma via multiple mechanisms, including lung and optimal immune system functions.
· Many clinical trials have demonstrated the beneficial effects of vitamin D on asthma onset and aggravation. However, definitive clinical trials are lacking, and reports have detailed contradictory effects of vitamin D in children with asthma.
· Some exciting reports stated that obesity and vitamin D deficiency are associated with increased asthma symptoms in the pediatric population. |
-
-
- Gastroenterology
- High-resolution anorectal manometry in children
(4,497 times)
-
Yogesh Waikar
-
Clin Exp Pediatr. 2024;67(2):57-63. Published online June 14, 2023
-
|
· Anorectal manometry is safe in children.
· Defecation Dyssynergia is one of the commonest cause of chronic constipation.
· Positive Rectoanal inhibiory reflex rules out Hirschsprung's Disease |
-
-
- Original Article
- Infection
- Carbapenem resistance in gram-negative pathogens in an Iranian hospital: high prevalence of OXA-type carbapenemase genes
(4,495 times)
-
Setareh Mamishi, Reihaneh Hosseinpour Sadeghi, Sadaf Sajedi Moghaddam, Babak Pourakbari, Shiva Poormohammadi, Maryam Sotoudeh Anvari, Shima Mahmoudi
-
Clin Exp Pediatr. 2025;68(1):65-72. Published online October 31, 2024
-
|
Question: What is the prevalence of carbapenem resistance in gram-negative bacteria and associated carbapenemase genes?
Findings: This study identified a notable prevalence of carbapenem-resistant gram-negative isolates, with Escherichia coli being the predominant contributor, follow ed by Klebsiella pneumoniae, Acinetobacter baumannii, while bla OXA48 was the most prevalent carbapenemase gene.
Meaning: These findings highlight the urgent need for proactive measures including the rapid detection of carbapenemase- producing isolates and effective infection control. |
-
-
- Neurology
- Instability of revised Korean Developmental Screening Test classification in first year of life
(4,465 times)
-
Ji Eun Jeong, You Min Kim, Na Won Lee, Gyeong Nam Kim, Jisuk Bae, Jin Kyung Kim
-
Clin Exp Pediatr. 2025;68(1):97-103. Published online November 11, 2024
-
|
Question: How stable are the revised Korean Developmental Screening Test score classifications in early infancy?
Finding: A significant number of infants improved into the peer and high-level group (≥-1 standard deviations), especially in the gross motor area.
Meaning: The early detection of developmental delay requires a comprehensive medical history, physical and neurological examinations, and repeated developmental screenings. |
-
-
- Review Article
- Neurology
- Role of nonpharmacological concussion management in children: systematic review of randomized controlled trials
(4,431 times)
-
Andre Marolop Pangihutan Siahaan, Alvin Ivander, Rr. Suzy Indharty, Steven Tandean, Anastasia Grace Milenia Ginting, Masrini Ginting, Felix Khosasi, Elbert
-
Clin Exp Pediatr. 2024;67(11):569-579. Published online October 28, 2024
-
|
The long-term effects of concussion for pediatric patient remains unclear. Children and teenagers do not experience or recover from concussion in the same manner as adults do. Concussions can cause a variety of anatomical and functional alterations. Nonpharmacological approach in pediatric concussion management is an understudied field of research with significant ability to affect prognosis and quality of life. Active rehabilitation and occupational therapy were especially promising. |
-
-
- Cardiology
- Research trends on causes of Kawasaki disease in the COVID-19 era: focus on viral infections
(4,401 times)
-
Young Hwan Lee
-
Clin Exp Pediatr. 2023;66(1):1-11. Published online June 22, 2022
-
|
· The etiology of Kawasaki disease (KD) is unclear, but its clinical, epidemiological, and pathophysiological characteristics are strongly associated with infectious diseases.
· In the coronavirus disease 2019 pandemic era, viruses are attracting the most attention. Sudden acute respiratory syndrome coronavirus 2 infection causes various hyperinflammation in children that require differentiation from KD.
· Immune responses in patients with KD may be induced by host cell damage. To effectively prevent and treat KD, the genetic background and immune responses of KD patients and triggering pathogens require identification. |
-
-
- Neonatology (Perinatology)
- Recent advances in understanding pathophysiology of non-nutritional stunting in very preterm infants
(4,392 times)
-
Eduardo Cuestas, Alina Rizzotti
-
Clin Exp Pediatr. 2025;68(4):287-297. Published online December 23, 2024
-
|
· Previous reviews of extrauterine growth restriction focused mainly on weight growth restriction caused by nutritional factors or pathological conditions.
· This review summarizes recent developments in the pathophysiology of nonnutritional length growth restriction in very preterm infants with focus on the impact of sustained neonatal inflammation on their short- and long-term outcomes.
· Further research is needed to investigate optimal strategies to improve length growth restriction in very preterm infants. |
-
-
- Original Article
- Endocrinology
- Efficacy of leuprolide acetate versus triptorelin pamoate administered every 3 months for treatment of central precocious puberty
(4,385 times)
-
Thanaporn Thaneetrakool, Suphab Aroonparkmongkol, Nattakarn Numsriskulrat, Vichit Supornsilchai, Suttipong Wacharasindhu, Khomsak Srilanchakon
-
Clin Exp Pediatr. 2025;68(1):91-96. Published online November 6, 2024
-
|
Question: What are the differences in efficacy between leuprolide acetate and triptorelin pamoate administered every 3 months for the treatment of central precocious puberty (CPP)?
Finding: There were no significant intergroup differences in luteinizing hormone suppression or predicted adult height at the end of treatment in girls with CPP.
Meaning: Leuprolide acetate and triptorelin pamoate have comparable efficacy for treating CPP. |
-
-
- Review Article
- Infection
- COVID-19 among infants: key clinical features and remaining controversies
(4,348 times)
-
Nevio Cimolai
-
Clin Exp Pediatr. 2024;67(1):1-16. Published online November 27, 2023
-
|
· Clinical studies of coronavirus disease 2019 (COVID-19) in infants should be supported by rigorous laboratory diagnostic criteria.
· Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads to infants similarly to other viral respiratory infections.
· Among infants ≤1 year of age beyond the immediate postpartum period, COVID-19 is relatively mild, but even the low risk of severe disease requires prevention.
· Comorbidities increase infection vulnerability and complications in infants.
· Clinical and laboratory data do not sufficiently distinguish COVID-19 from other respiratory viral infections.
· Coinfection with SARS-CoV-2 is uncommon among infants.
· Unique infection sequelae, including multi-inflammatory syndrome in children and neonates and long COVID require further study and refinement of diagnostic criteria.
· Infection control standards applied to mother-infant dyads should be tempered by standard preventive strategies, maternal input, accommodation potential, and overall safety.
· Maternal vaccination prevents disease in early infancy. |
-
-
- Original Article
- Gastroenterology
- Association between maternal weight gain during pregnancy and child’s body mass index at preschool age
(4,346 times)
-
Jeewon Shin, Yoowon Kwon, Ju Hee Kim, Su Jin Jeong
-
Clin Exp Pediatr. 2023;66(2):76-81. Published online November 30, 2022
-
|
Question: What are the risk factors of newborn birth weight? Does gestational weight gain and prepregnancy body mass index affect childhood weight?
Finding: Excess maternal weight gain increases the risk of overweight/obesity, newborn birth weight, and child body mass index at 4–6 years.
Meaning: Maternal weight control before and during pregnancy should be well controlled. |
-
-
- Editorial
- Hematology
- Absolute versus functional iron deficiency
(4,332 times)
-
Hye Lim Jung
-
Clin Exp Pediatr. 2025;68(2):138-140. Published online November 13, 2024
-
|
|
· Iron deficiency (ID), the most common cause of anemia, can be classified into absolute and functional types. Absolute ID is a state of low total body iron, while functional ID is a state of imbalance between iron demand and iron availability due to inflammation and/or infection.
· ID is diagnosed by serum ferritin and transferrin saturation levels. |
-
-
- Review Article
- Rheumatology
- Double-negative T cells in pediatric rheumatic diseases
(4,262 times)
-
Dimitri Poddighe, Tilektes Maulenkul, Kuanysh Dossybayeva, Gulsamal Zhubanova, Zaure Mukusheva, Lyudmila Akhmaltdinova
-
Clin Exp Pediatr. 2024;67(12):632-640. Published online September 12, 2024
-
|
Double-negative T (DNT) cells appear to be increased in several pediatric rheumatic diseases and this finding may be correlated with disease activity to some extent. However, due to significant heterogeneity in several methodological aspects, further investigations in rheumatic children are needed to assess the potential relevance of DNT cells as biomarkers and clarify their immunopathological role. |
-
-
- Nephrology (Genitourinary)
- Kidney complications associated with COVID-19 infection and vaccination in children and adolescents: a brief review
(4,250 times)
-
Hee Sun Baek, Min Hyun Cho
-
Clin Exp Pediatr. 2023;66(10):424-431. Published online June 28, 2023
-
|
Several observational studies have shown that acute kidney injury affects up to 46% of children and adolescents who develop severe postinflammatory responses, such as multisystem inflammatory syndrome in childhood, due to coronavirus disease 2019 (COVID-19). Although causality has not been established, some cases of glomerulopathy or nephrotic syndrome occurring after COVID-19 infection or vaccination have been reported. Therefore, kidney complications associated with these conditions in children and adolescents warrant attention. |
-
-
- Infection
- COVID-19 in immunocompromised children and adolescents
(4,215 times)
-
Byung Ok Kwak, Byung Wook Eun
-
Clin Exp Pediatr. 2023;66(5):182-189. Published online April 18, 2023
-
|
Most immunocompromised children and adolescents are not at increased risk of developing severe coronavirus disease 2019 (COVID-19). COVID-19 outcomes for low- or medium-risk immunocompromised children are favorable, while more serious illness reportedly occurs in high-risk immunocompromised children by underlying disease, its treatments, and other factors. Therefore, the early detection and timely management of severe COVID-19 and treatment of underlying disease are important. Hospitalization and COVID-19 vaccination should be carefully considered. |
-
-
- Original Article
- Hematology
- Impact of Xmn1 polymorphism on hydroxyurea therapy in children with HbE-β non-transfusion dependent thalassemia: a cohort study
(4,212 times)
-
Saheli Roy, Paramita Bhattacharya, Atanu Kumar Dutta, Mrinal Kanti Das
-
Clin Exp Pediatr. 2025;68(6):437-444. Published online February 3, 2025
-
|
Question: Does the T allele of Xmn1 polymorphism favorably influence hydroxyurea efficacy in children of Eastern descent with fetal hemoglobin (HbE)-β nontransfusion dependent thalassemia (NTDT)?
Finding: Decrease in transfusion requirement and increase in height following hydroxyurea therapy was noted in both groups, however, change in CT was more critical than that in CC genotype.
Meaning: T allele of Xmn1 polymorphism favorably influences hydroxyurea efficacy in children with HbE-β NTDT. |
-
-
