Clinical and Experimental Pediatrics

Original Articles

Endocrinology

Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity

Bahar Özcabı, Salih Demirhan, Mesut Akyol, Hatice Öztürkmen Akay, Ayla Güven

Clin Exp Pediatr. 2019;62(12):450-455. Published online October 28, 2019

Background: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults. Purpose: Here we evaluated the ability of LAP to predict NAFLD in obese children. Methods: Eighty obese children (38 girls; age 6–18 years) were included. Anthropometric measurements and biochemical values were obtained from the patients’ medical records. LAP was calculated as [waist...

DOI: https://doi.org/10.3345/kjp.2019.00248

Editorials

Correlation between genetic heterogeneity and variability for response to growth hormone in Noonan syndrome

Young-Lim Shin

Clin Exp Pediatr. 2019;62(11):412-413. Published online July 9, 2019

DOI: https://doi.org/10.3345/kjp.2019.00220

Original Articles

Comparison of effectiveness of growth hormone therapy according to disease-causing genes in children with Noonan syndrome

Kyo Jin Jo, Yoo Mi Kim, Ju Young Yoon, Yeoun Joo Lee, Young Mi Han, Han-Wook Yoo, Hyang-Sook Kim, Chong Kun Cheon

Clin Exp Pediatr. 2019;62(7):274-280. Published online December 3, 2018

Cited By 1

Purpose: To analyze the growth response to growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations. Methods: Twenty-three patients with prepubertal NS treated at Pusan National University Children’s Hospital between March 2009 and July 2017 were enrolled. According to the disease-causing genes identified, the patients with NS were divided into 4 groups. Three groups were...

DOI: https://doi.org/10.3345/kjp.2018.06842

Secular change in waist circumference and waist-height ratio and optimal cutoff of waist-height ratio for abdominal obesity among Korean children and adolescents over 10 years

Min Sub Kim, Se Young Kim, Jae Hyun Kim

Clin Exp Pediatr. 2019;62(7):261-268. Published online December 3, 2018

Cited By 1

Purpose: This study aimed to evaluate the time trends of waist circumference (WC) and waist-height ratio (WHR), and to present WC and WHR distributions with optimal WHR cutoff for abdominal obesity in Korean children and adolescents. Methods: We performed a retrospective cross-sectional analysis of data from 13,257 children and adolescents (6,987 boys and 6,270 girls) aged 6–18 years who were included...

DOI: https://doi.org/10.3345/kjp.2018.07038

Editorials

Simple universal cutoff point of waist-height ratio for metabolic risk in Korean children and adolescents

Hae Soon Kim

Clin Exp Pediatr. 2019;62(7):257-258. Published online March 28, 2019

DOI: https://doi.org/10.3345/kjp.2019.00045

Review Articles

Prevalence of obesity and overweight in Iranian children aged less than 5 years: a systematic review and meta-analysis

kamyar mansori, Sorour Khateri, Yousef Moradi, Zaher Khazaei, Hossein Mirzaei, Shiva Mansouri Hanis, Mehran Asadi Aliabadi, Mehdi Ranjbaran, Fatemeh Varse, Serveh Parang

Clin Exp Pediatr. 2019;62(6):206-212. Published online April 23, 2019

Purpose: The present study aimed to determine the prevalence of childhood obesity and overweight in Iranian children under 5 years of age using a systematic review and meta-analysis. Methods: We searched MEDLINE (PubMed), Web of Science, Google Scholar, Scopus, CINHAL, and the Iranian databases, including Scientific Information Database (www.sid.ir), Iranian Research Institute for Information Science and Technology (Irandoc.ac.ir), Iranmedex (www.iranmedex.com), and...

DOI: https://doi.org/10.3345/kjp.2018.07255

Original Articles

Prevalence and associates of obesity and overweight among school-age children in a rural community of Thailand

Teechaya Nonboonyawat, Wuttipat Pusanasuwannasri, Nattanon Chanrat, Natta Wongthanavimok, Danutanut Tubngern, Piengkwan Panutrakul, Mathirut Mungthin, Thirapa Nivesvivat, Panadda Hatthachote, Ram Rangsin, Phunlerd Piyaraj

Clin Exp Pediatr. 2019;62(5):179-186. Published online February 8, 2019

Purpose: Information about overweight and obesity among students in rural areas of Thailand is limited. Therefore, we aimed to determine overweight and obesity prevalences and associated factors among school-aged children in a rural community of Thailand. Methods: We selected 9 public schools through cluster sampling in 2 provinces located in central Thailand in 2016. Anthropometric measurements were measured using standard techniques,...

DOI: https://doi.org/10.3345/kjp.2018.06499

Review Article

The adiposity rebound in the 21st century children: meaning for what?

Min Jae Kang

Clin Exp Pediatr. 2018;61(12):375-380. Published online December 6, 2018

With the increase in the prevalence of overweight and obesity worldwide, early adiposity rebound, which is known to have a strong association with obesity, has recently been a focus of research. Early adiposity rebound is conventionally known to have a close relationship with non-communicable diseases. However, novel insights into early adiposity rebound have implied an acceleration of growth and puberty,...

DOI: https://doi.org/10.3345/kjp.2018.07227

Understanding of type 1 diabetes mellitus: what we know and where we go

Chong Kun Cheon

Clin Exp Pediatr. 2018;61(10):307-314. Published online October 4, 2018

Cited By 1

The incidence of type 1 diabetes mellitus (T1DM) in children and adolescents is increasing worldwide. Combined effects of genetic and environmental factors cause T1DM, which make it difficult to predict whether an individual will inherit the disease. Due to the level of self-care necessary in T1DM maintenance, it is crucial for pediatric settings to support achieving optimal glucose control, especially...

DOI: https://doi.org/10.3345/kjp.2018.06870

Original Articles

Changes of the growth plate in children: 3-dimensional magnetic resonance imaging analysis

Hyung Ho Yun, Hyun-Jung Kim, Min-Sun Jeong, Yun-Sun Choi, Ji-Young Seo

Clin Exp Pediatr. 2018;61(7):226-230. Published online July 15, 2018

Cited By 3

Purpose: This pilot study assessed changes in the growth plate and growth rates in children during a 6-month period. Methods: The study included 31 healthy children (17 boys, 14 girls) under evaluation for growth retardation. Height, weight, bone age, insulin like growth factor-1 (IGF-1), and insulin like growth factor binding protein 3 (IGF-BP3) were measured at baseline and after 6 months....

DOI: https://doi.org/10.3345/kjp.2018.61.7.226

Final height of Korean patients with early treated congenital hypothyroidism

Jiyun Lee, Jeongho Lee, Dong Hwan Lee

Clin Exp Pediatr. 2018;61(7):221-225. Published online July 15, 2018

Purpose: Congenital hypothyroidism (CH) is the most common endocrine disorder in children. Thyroid hormone deprivation results not only in mental retardation but also growth retardation. This study investigates the final height (FH) in Korean patients with CH detected by newborn screening and examines factors that may affect the FH. Methods: The medical records of Korean CH patients (n=45) were reviewed. The...

DOI: https://doi.org/10.3345/kjp.2018.61.7.221

Autoimmunity and intestinal colonization by Candida albicans in patients with type 1 diabetes at the time of the diagnosis

Semra Gürsoy, Tuba Koçkar, Sezen Ugan Atik, Zerrin Önal, Hasan Önal, Erdal Adal

Clin Exp Pediatr. 2018;61(7):217-220. Published online July 15, 2018

Cited By 3

Purpose: Type 1 diabetes mellitus (T1DM) is a chronic and immune-mediated disease, which is characterized by the progressive destruction of pancreatic beta cells. T1DM precipitates in genetically susceptible individuals through environmental factors. In this study, we aimed to evaluate the impact of autoimmunity and intestinal colonization of Candida albicans on the development of T1DM. Methods: Forty-two patients newly diagnosed with T1DM...

DOI: https://doi.org/10.3345/kjp.2018.61.7.217

The association of total blood mercury levels and overweight among Korean adolescents: analysis of the Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2013

Yi-Yeon Shin, In-Kyung Ryu, Mi-Jung Park, Shin-Hye Kim

Clin Exp Pediatr. 2018;61(4):121-128. Published online April 23, 2018

Cited By 3

DOI: https://doi.org/10.3345/kjp.2018.61.4.121

The effect of low-dose intravenous bisphosphonate treatment on osteoporosis in children with quadriplegic cerebral palsy

Soon Jeong Moon, Young Min An, Soon Ki Kim, Young Se Kwon, Ji Eun Lee

Clin Exp Pediatr. 2017;60(12):403-407. Published online December 22, 2017

Cited By 1

PurposeQuadriplegic children with cerebral palsy are more susceptible to osteoporosis because of various risk factors that interfere with bone metabolism. Pamidronate is effective for pediatric osteoporosis, but there are no guidelines for optimal dosage or duration of treatment in quadriplegic children with osteoporosis. We aimed to evaluate the efficacy of low-dose pamidronate treatment in these patients.MethodsTen quadriplegic patients on antiepileptic...

DOI: https://doi.org/10.3345/kjp.2017.60.12.403

The influence of gonadotropin-releasing hormone agonists on anthropometric change in girls with central precocious puberty

Jong Wan Yoon, Hyun A Park, Jieun Lee, Jae Hyun Kim

Clin Exp Pediatr. 2017;60(12):395-402. Published online December 22, 2017

Cited By 3

PurposeThe potential effect of gonadotropin-releasing hormone agonist (GnRHa) treatment on the weight of girls with central precocious puberty (CPP) remains a controversy. We investigated anthropometric changes during and after GnRHa treatment among girls with CPP.MethodsThis retrospective study evaluated data from 127 girls with CPP who received GnRHa treatment for ≥2 years. Height, weight, and body mass index (BMI) values were...

DOI: https://doi.org/10.3345/kjp.2017.60.12.395

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