Clinical and Experimental Pediatrics

Original Article

Intramuscular and subcutaneous gonadotropin-releasing hormone agonist tests for central precocious puberty in girls: a randomized controlled trial

Worapimon Lerdrassameethad, Suttipong Wacharasindhu, Vichit Supornsilchai, Khomsak Srilanchakon

Background: Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal axis. Although the standard intravenous gonadotropin-releasing hormone (GnRH) stimulation test is often inaccessible, a subcutaneous (SC) GnRH analogue (GnRHa) test is used. However, the conventional SC route presents logistical challenges including prolonged observation times and the need for multiple blood draws. Thus, identifying a more efficient administration route...

DOI: https://doi.org/10.3345/cep.2026.00052 [Accepted]

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Serum metabolomic profile in children with sepsis-associated acute kidney injury

Nisha Chaudhary, Praveen Singh, Abhijeet Saha, Shantanu Sengupta

Background: Sepsis-associated acute kidney injury (SA-AKI) contributes to high morbidity and mortality rates in children; however, current diagnostic tools (serum creatinine and urine output) lack sensitivity for early detection. Metabolomics can be used to discover novel metabolic markers to enable early diagnosis and prognosis and provide therapeutic targets for SA-AKI.
Purpose: This study was aimed to identify the differentially expressed serum...

DOI: https://doi.org/10.3345/cep.2025.02439 [Accepted]

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Anthropometric trajectories of Korean children and adolescents with severe obesity

Jeongho Han, Hakyung Lee, Dong Jun Ha, Jieun Lee, Yong Hee Hong, Hwa Young Kim, Jaehyun Kim

Background: The burden of severe pediatric obesity is increasing globally, including in South Korea, and associated with metabolic and cardiovascular complications. However, longitudinal data of Korean children with severe obesity are limited.
Purpose: This study evaluated the changes in body mass index (BMI) and associated metabolic syndrome components in children and adolescents with severe obesity managed without pharmacological or surgical treatment. Methods:...

DOI: https://doi.org/10.3345/cep.2025.02999 [Accepted]

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The High-Risk CCL14 Lineage Drives Severe Mycoplasma pneumoniae Pneumonia in Children: A Study in Central China

Chunbo Hao, Zijie Li, Yanjuan Yu, Song Wang, Genhao Wang, Gaijing Jia, Tiantian Sun, Shouhang Chen, Yang Wu, Yu Tang, Fang Wang, Guangcai Duan, Yuefei Jin

Background: The post-pandemic resurgence of Mycoplasma pneumoniae (MP) infections, particularly in China, underscores the need to understand the drivers of disease severity. However, the genotypic landscape of the prevalent strains in central China and its link to clinical outcomes remain poorly characterized.
Purpose: This study aimed to evaluate the associations between predominant circulating strains of MP and disease severity. Method: We integrated...

DOI: https://doi.org/10.3345/cep.2025.02796 [Accepted]

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Thyroid peroxidase gene variants and susceptibility to congenital hypothyroidism and autoimmune thyroid disease among Egyptian pediatric cohort

Hala M. Sakhr, Mohammed H. Hassan, Esraa Abbass Abdallah, Amira Mahmoud Ewis, Mohamed Hesham Mohamed, Shymaa Gaber Rizk

Background: Pediatric thyroid disorders arise from complex interactions among genetic susceptibility, immune dysregulation, and metabolic factors that influence their onset and severity.
Purpose: This study aimed to evaluate the clinical, biochemical, micronutrient, and genetic determinants of thyroid dysfunction in children with particular emphasis on the thyroid peroxidase (TPO) Arg386His and Thr725Pro polymorphisms. Methods: This case-control study enrolled 150 Egyptian children aged 2–15...

DOI: https://doi.org/10.3345/cep.2025.02957 [Accepted]

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Cited By 49	Prevalence of anxiety, depression, and stress among parents of neonates admitted to neonatal intensive care unit: a systematic review and meta-analysis
Cited By 32	Microplastic and human health with focus on pediatric well-being: a comprehensive review and call for future studies
Cited By 32	Community-acquired pneumonia in children: updated perspectives on its etiology, diagnosis, and treatment
Cited By 30	Metabolic complications of obesity in children and adolescents
Cited By 23	Development of orphan drugs for rare diseases

Accepted articles