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"Most viewed" Articles are from the articles published in 2022 during the last six month.
- Review Article
- Allergy
- Comparison and review of international guidelines for treating asthma in children (96,714 times)
- Eui Jeong Roh
- Clin Exp Pediatr. 2024;67(9):447-455. Published online August 20, 2024
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Asthma is the most common chronic disease among children. Although asthma in children may spontaneously improve, it continues into adulthood in many cases. Therefore, appropriate disease management and medication are essential. Consistent and objective guidelines are needed to manage pediatric asthma and related adverse reactions.
- Original Article
- Pulmonology
- Oligohydramnios affects pulmonary functional/structural abnormalities in school-aged children with bronchopulmonary dysplasia (59,335 times)
- Jeong Eun Shin, Soon Min Lee, Mi-Jung Lee, Jungho Han, Joohee Lim, Haerin Jang, Ho Seon Eun, Min Soo Park, Soo Yeon Kim, Myung Hyun Sohn, Ji Ye Jung, Kyung Won Kim
- Clin Exp Pediatr. 2024;67(5):257-266. Published online April 16, 2024
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Question: Is bronchopulmonary dysplasia (BPD) associated with functional/structural abnormalities later in life?
Finding: School-aged children with severe BPD had abnormalities on pulmonary function tests and lung computed tomography despite no subjective respiratory symptoms; however, only prenatal oligohydramnios and prolonged ventilator use were associated with abnormal lung function.
Meaning: Long-term monitoring of preterm infants’ lung health is essential, especially for those with prenatal oligohydramnios or prolonged ventilator use.
- Review Article
- Allergy
- Action-plan and as-needed therapy in allergic rhinitis (53,250 times)
- Hyeon-Jong Yang
- Clin Exp Pediatr. 2024;67(6):267-273. Published online May 21, 2024
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· The guidelines may not work in the real world.
· An action-plan reflecting patient’s severity and variable of symptoms, values and preferences as well as the benefits and harms of treatment, may be a useful alternative.
· The action plan and as-needed therapy must include the following elements: when, what, how, and why.
· Action plan and as-needed therapy can help patients manage their symptoms more effectively.
- Original Article
- Nutrition
- Parental support and exclusive breastfeeding at 3 months in West Java, Indonesia: a mixed-methods approach (48,967 times)
- Ratu Ayu Dewi Sartika, Fadila Wirawan, Wawan Gunawan, Primasti Nuryandari Putri, Nurul Husna Mohd Shukri
- Clin Exp Pediatr. 2024;67(7):358-367. Published online June 21, 2024
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Question: Does paternal support affect exclusive breastfeeding failure?
Finding: Exclusive breastfeeding failure by 3 months was affected by paternal support.
Meaning: Fathers should be included in breastfeeding education and antenatal care.
- Infection
- Construction and validation of predictive models for intravenous immunoglobulin–resistant Kawasaki disease using an interpretable machine learning approach (39,061 times)
- Linfan Deng, Jian Zhao, Ting Wang, Bin Liu, Jun Jiang, Peng Jia, Dong Liu, Gang Li
- Clin Exp Pediatr. 2024;67(8):405-414. Published online July 23, 2024
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Question: Is there a reliable model to predict intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD)?
Finding: We constructed 5 machine learning models to predict IVIG-resistant KD. Extreme gradient boosting (XGBoost) model was superior to logistic, support vector machine, light gradient boosting machine and multiple layers perception models. The SHAP (SHapley Additive exPlanations) value interpreted the contribution of each feature in XGBoost model.
Meaning: XGBoost model showed the excellent performance to predict IVIG-resistant KD with explainable and visualizable machine learning algorithm.
- Review Article
- Infection
- Pathogenetic and etiologic considerations of febrile seizures (5,786 times)
- Ji Yoon Han, Seung Beom Han
- Clin Exp Pediatr. 2023;66(2):46-53. Published online January 13, 2023
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· Inflammatory responses accompanying fever increase neuronal excitability in the central nervous system, which in turn provokes seizures.
· Fever in children with febrile seizures is usually caused by common respiratory viruses, the distributions of which match those of seasonal community-acquired respiratory tract infections.
· Several genetic variations in ion channels seem associated with neuronal hyperexcitability in children with febrile seizures.
- Global varicella vaccination programs (5,432 times)
- Young Hwa Lee, Young June Choe, Jia Lee, Eunseong Kim, Jae Young Lee, Kwan Hong, Yoonsun Yoon, Yun-Kyung Kim
- Clin Exp Pediatr. 2022;65(12):555-562. Published online November 2, 2022
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It is important to evaluate its effectiveness at the national level and to determine the varicella vaccine schedule based on the evidence generated through the studies.
- Other
- Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy (5,095 times)
- Lisa Zhao, John P. Jones, Lauren G. Anderson, Zacharoula Konsoula, Cynthia D. Nevison, Kathryn J. Reissner, William Parker
- Clin Exp Pediatr. 2024;67(3):126-139. Published online June 14, 2023
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Despite worldwide acceptance of acetaminophen (paracetamol) in pediatric medicine, careful examination reveals no valid objections to the conclusion that early exposure to acetaminophen causes neurodevelopmental injury in susceptible babies and children. Nevertheless, debate that early exposure to acetaminophen causes neurodevelopmental injury has centered around the prenatal period, evidence of which is relatively limited compared to that in the postnatal period, which is the time of greatest absolute and relative risk.
- Neonatology (Perinatology)
- Retinopathy of prematurity: a review of epidemiology and current treatment strategies (4,865 times)
- Eun Hee Hong, Yong Un Shin, Heeyoon Cho
- Clin Exp Pediatr. 2022;65(3):115-126. Published online October 12, 2021
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There have been global tri-phasic epidemic periods of retinopathy of prematurity (ROP). In recent years, its incidence has reportedly been 10%–40% depending on country and study population. Current treatment strategies for ROP include laser photocoagulation, surgical treatment, and anti-vascular endothelial growth factor treatment, the role of which has drawn attention in recent years.
- Endocrinology
- Genetic factors in precocious puberty (4,775 times)
- Young Suk Shim, Hae Sang Lee, Jin Soon Hwang
- Clin Exp Pediatr. 2022;65(4):172-181. Published online October 18, 2021
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· Mutations in the kisspeptin (KISS1), kisspeptin receptor (KISS1R), makorin ring finger protein 3 (MKRN3), and delta-like homolog 1 (DLK1) genes are associated with idiopathic central precocious puberty (ICPP).
· A few genes related to pubertal onset have been implicated in ICPP.
· Epigenetic factors such as DNA methylation, histone posttranslational modifications, and noncoding ribonucleic acids may be related to ICPP
- Original Article
- Genetics and Metabolism
- Interleukin (IL)-1B and IL-1 receptor antagonist gene polymorphisms in children with primary immune thrombocytopenia (4,248 times)
- Seham Mohamed Ragab, Wafaa Moustafa Abo ElFotoh, Mahmoud Ahmed El-Hawy, Eman Abdelfatah Badr, Saara Khairat Ali Mostafa, Mai El-Sayad Abd El-Hamid
- Clin Exp Pediatr. 2024;67(9):465-473. Published online July 24, 2024
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· Polymorphisms in interleukin (IL)-1B and IL-1 receptor (IL-1R) antagonists may significantly affect the pathogenesis of immune thrombocytopenia (ITP).
· IL-1B and IL-1R antagonist gene polymorphisms are correlated with severity and susceptibility to primary ITP in children.
- Review Article
- Infection
- Community-acquired pneumonia in children: updated perspectives on its etiology, diagnosis, and treatment (4,210 times)
- Ki Wook Yun
- Clin Exp Pediatr. 2024;67(2):80-89. Published online June 14, 2023
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· Most commonly confirmed causes of community-acquired pneumonia (CAP) in children are Mycoplasma pneumoniae (8%–40%) and respiratory syncytial virus (15%–20%).
· Pyogenic bacteria, most commonly Streptococcus pneumoniae (40%–50%) and Streptococcus pyogenes (10%–25%), are detected in 2%–5% of children hospitalized with CAP.
· CAP should be diagnosed conservatively according to clinical and radiological criteria.
· The etiology should be identified via appropriate test result interpretation.
- Original Article
- General Pediatrics
- Global relationship between parent and child obesity: a systematic review and meta-analysis (4,204 times)
- Ju Suk Lee, Mi Hyeon Jin, Hae Jeong Lee
- Clin Exp Pediatr. 2022;65(1):35-46. Published online March 29, 2021
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Question: Are parent and child obesity correlated worldwide?
Finding: Overweight and obese status of parents and children were significantly associated worldwide. The association between parent and child obesity was stronger in Asia than in Europe and the Middle East, and in high-income than in middle- and low-income countries.
Meaning: Childhood obesity is highly influenced by parental weight status, indicating that parents could play an important role in its prevention.
- Review Article
- Nephrology (Genitourinary)
- Blood pressure measurements and hypertension in infants, children, and adolescents: from the postmercury to mobile devices (4,193 times)
- Seon Hee Lim, Seong Heon Kim
- Clin Exp Pediatr. 2022;65(2):73-80. Published online September 15, 2021
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· Hypertension is defined as a blood pressure (BP) >90th (elevated) or 95th (hypertension) percentile in children by height, age, and sex and >95th percentile in neonates by age, birth weight, and sex.
· Although the oscillometric method can be used for screenings, the auscultatory method remains the gold standard. The hybrid method employs the auscultatory and electronic methods and can reduce bias.
· BP measurement mobile device applications have a potential for development.
- Neurology
- Neonatal seizures: diagnostic updates based on new definition and classification (4,154 times)
- Eun-Hee Kim, Jeongmin Shin, Byoung Kook Lee
- Clin Exp Pediatr. 2022;65(8):387-397. Published online April 4, 2022
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· Neonatal seizures are often electrographic-only seizures without clinical signs; therefore, the identification of electrical seizure activity on electroencephalography is the gold standard for diagnosis.
· Clinical signs of neonatal seizures are divided into motor or nonmotor seizures, and motor seizures are mostly focal or multifocal.
· Most neonatal seizures are caused by acute symptomatic etiologies, but in cases of intractable seizures, structural, genetic, or metabolic etiologies should be investigated.
- Original Article
- Neurology
- Changes in frequency of benign convulsions with mild gastroenteritis and their viral causes before and during the COVID-19 pandemic: a single-center study (3,962 times)
- Hyejin Na, Sanghoon Lee, Seo Hee Kim, Young Ok Kim
- Clin Exp Pediatr. 2024;67(4):213-220. Published online March 19, 2024
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Question: Did coronavirus disease 2019 (COVID-19) affect the frequency, seasonal variation, or virus type of benign convulsions with mild gastroenteritis (CwG)?
Findings: We compared 41 cases of CwG before and during the COVID-19 pandemic. After March 2020, frequency did not change significantly (18 patients vs. 23 patients), seasonal variation was lost, and number of cases of enteric adenovirus-associated CwG increased (1 cases vs. 7 cases).
Meaning: The COVID-19 pandemic affected CwG.
- Review Article
- Nephrology (Genitourinary)
- Neonatal hypertension: concerns within and beyond the neonatal intensive care unit (3,533 times)
- Kathleen Altemose, Janis M. Dionne
- Clin Exp Pediatr. 2022;65(8):367-376. Published online May 30, 2022
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Some neonates, especially those who are premature, may experience hypertension while in the neonatal intensive care unit (NICU). The most common causes are prematurity-related and the hypertension usually resolves over the first 1–2 years of life. Unfortunately, the increasing population of NICU graduates is at risk for later cardiovascular and kidney disease in childhood and adulthood. This population requires careful attention to blood pressure and weight throughout their life course.
- Original Article
- General Pediatrics
- Gross motor dysfunction and balance impairments in children and adolescents with Down syndrome: a systematic review (3,441 times)
- Preyal D. Jain, Akshatha Nayak, Shreekanth D. Karnad, Kaiorisa N. Doctor
- Clin Exp Pediatr. 2022;65(3):142-149. Published online June 11, 2021
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Question: What are the primary motor and balance dysfunctions in children with Down syndrome?
Finding: These individuals have gross delays, altered balance, and inefficient compensatory mechanisms.
Meaning: Neuromuscular and musculoskeletal impairments due to the chromosomal abnormality lead to developmental delay. These children also exhibit poor balance with greater instability and inefficient compensatory mechanisms including altered center of pressure displacement and trunk stiffening that predisposes them to falls.
- Nutrition
- Effect of probiotics plus zinc supplementation on clinical outcomes of infants and children with acute infectious diarrhea: a randomized controlled trial (3,388 times)
- Deldar Morad Abdulah, Saad Jbraeil Sulaiman, Zaid Waad Ahmed
- Clin Exp Pediatr. 2024;67(4):203-212. Published online February 19, 2024
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Question: Does zinc supplementation along with probiotics affect disease severity or clinical outcomes of children with acute diarrhea?
Findings: This study indicated that zinc supplementation and probiotics had no effect on clinical improvement or disease severity among pediatric patients with acute diarrhea.
Meaning: Children who received probiotics plus zinc recovered faster than those who received probiotics only.
- Review Article
- Neurology
- Update on benign convulsions with mild gastroenteritis (3,360 times)
- Yeong Seok Lee, Ga Hee Lee, Young Se Kwon
- Clin Exp Pediatr. 2022;65(10):469-475. Published online December 27, 2021
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∙ The main pathogen for benign convulsions with mild gastroenteritis (CwG) was previously rotavirus; however, cases associated with norovirus are increasing.
∙ CwG is characterized by clustered generalized seizures. Electroencephalography and magnetic resonance imaging show transiently abnormal findings in the acute phase that eventually normalize with progression. Its prognosis is good, and long-term treatment is unnecessary.
∙ There are many reports on the pathophysiological mechanism of CwG, which remains unclear.
- Cardiology
- Diagnosis of coronary artery abnormalities in Kawasaki disease: recent guidelines and z score systems (3,351 times)
- Sung Hye Kim
- Clin Exp Pediatr. 2022;65(9):430-438. Published online December 17, 2021
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∙ Kawasaki disease is the leading cause of acquired heart disease among children in the developed countries, and Korea has the second-highest incidence in the world.
∙ Early diagnosis and proper treatment are imperative to prevent coronary complication, and evaluation of coronary artery abnormalities is fundamental.
∙ Recent guidelines have adapted z score system for the diagnosis of coronary artery abnormalities in Kawasaki disease.
∙ Applying z score in diagnosis of coronary abnormalities has better correlation with clinical outcomes than absolute cutoff values.
∙ Calculated z scores could be different according to the z score formula, which might influence the treatment plan.
- Neonatology (Perinatology)
- Treatment of congenital cytomegalovirus infection (3,306 times)
- Gyu Hong Shim
- Clin Exp Pediatr. 2023;66(9):384-394. Published online December 28, 2022
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· Congenital cytomegalovirus (CMV) infection is among the most common causes of nongenetic sensorineural hearing loss.
· Congenital CMV is initially treated with intravenous ganciclovir for 2–6 weeks and switched to oral valganciclovir, or with oral valganciclovir for the entire 6-month period.
· Infants with congenital CMV require periodic monitoring of absolute neutrophil count, platelet count, and blood urea nitrogen, creatinine, liver function tests, audiological, ophthalmological, and developmental tests during antiviral medication.
- Original Article
- Neonatology (Perinatology)
- Effect of vitamin E supplementation on bilirubin levels in infants with hyperbilirubinemia: a double-blind randomized clinical trial (3,280 times)
- Mojtaba Cheraghi, Maziar Nikouei, Majid Mansouri, Siros Hemmatpour, Yousef Moradi
- Clin Exp Pediatr. 2024;67(5):249-256. Published online March 26, 2024
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Question: Is vitamin E a viable therapeutic option for managing neonatal hyperbilirubinemia?
Finding: This randomized clinical trial examined the effects of oral vitamin E supplementation on bilirubin reduction (primary outcome), phototherapy duration, and length of hospital stay (secondary outcome) in 138 infants.
Meaning: Infants administered vitamin E versus placebo demonstrated similar reductions in bilirubin levels and length of hospital stay.
- Review Article
- Other
- Hearing loss in neonates and infants (3,166 times)
- Goun Choe, Su-Kyoung Park, Bong Jik Kim
- Clin Exp Pediatr. 2023;66(9):369-376. Published online January 9, 2023
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· Congenital hearing loss is common, with an approximate incidence of 1.5 per 1,000 newborns and affecting 1.2%–11% of preterm and 1.6%–13.7% of neonatal intensive care unit neonates.
· Etiologies vary, and up to 80% of cases are genetic.
· Newborn hearing screenings follow the 1-3-6 rule, and babies at high risk of hearing loss should be referred to otolaryngology for early detection and timely intervention.
- Cardiology
- Heart failure in children and adolescents: an update on diagnostic approaches and management (3,136 times)
- Amit Agrawal, Dalwinder Janjua, Abdulrahman Ahmed Alsayed Ali Zeyada, Ahmed Taher Elsheikh
- Clin Exp Pediatr. 2024;67(4):178-190. Published online June 19, 2023
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· Pediatric heart failure (PHF) is a clinical syndrome featuring various symptoms (shortness of breath, ankle swelling, fatigue) and signs (pulmonary crackles, peripheral edema).
· Congenital heart diseases are the most common underlying etiology of PHF, whereas myocarditis and primary cardio-myopathies are common in children without structural ab-normalities.
· PHF pathophysiology is complex and multifactorial and varies by etiology and age.
· PHF management includes decongestive therapy, treatment of underlying causes, preventing progression, and managing pulmonary or systemic obstructions.
· Drugs should be chosen based on pharmacodynamics, clinical manifestations, hemodynamic state, and renal function.
- Pulmonology
- Epidemiology and surveillance implications of community-acquired pneumonia in children (3,090 times)
- Eui Jeong Roh, Jung Yeon Shim, Eun Hee Chung
- Clin Exp Pediatr. 2022;65(12):563-573. Published online October 17, 2022
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The identification of the causative pathogens of community-acquired pneumonia and appropriate treatment and prevention can reduce mortality and the socioeconomic burden by reducing the medical expenses. The world has been in the coronavirus disease 2019 pandemic since 2020, and there is always a risk of continuous emergence and epidemic of new respiratory infectious diseases. Therefore, it is important to sustain a monitoring system for respiratory infectious diseases including pneumonia.
- Neurology
- Recent trends of healthcare information and communication technologies in pediatrics: a systematic review (3,024 times)
- Se young Jung, Keehyuck Lee, Hee Hwang
- Clin Exp Pediatr. 2022;65(6):291-299. Published online December 15, 2021
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· The innovation of healthcare information communication technology (ICT) was accelerated with the adoption of electronic health records (EHRs).
· Telemedicine currently has no technical barriers.
· EHRs and personal health records are being connected, and mobile/wearable technologies are being integrated into them.
· Conventional rule-based clinical decision support systems have already been implemented and used in EHRs and PHRs. Artificial intelligence/machine learning improves precision and accuracy.
- Gut microbiota affects brain development and behavior (3,004 times)
- Gun-Ha Kim, Jung-Ok Shim
- Clin Exp Pediatr. 2023;66(7):274-280. Published online November 8, 2022
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· The gut microbiota can alter a host’s brain development and behavior.
· Gut bacteria communicate with the brain via the microbiota-gut-brain axis.
· Fecal microbial transplantation is a promising treatment strategy for autism spectrum disorder.
- Neurobehavior
- Psychological aspects in children and parents of children with chronic kidney disease and their families (2,982 times)
- Alemsungla Aier, Priya Pais, Vijaya Raman
- Clin Exp Pediatr. 2022;65(5):222-229. Published online November 10, 2021
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· Childhood chronic kidney disease (CKD) is complex and requires lifetime medical treatment.
· Children with CKD are at risk for emotional, behavioral, social, and academic difficulties that significantly affect their quality of life.
· Caring for children with CKD is stressful for families.
· These unique challenges are crucial and can negatively impact treatment outcomes.
· Awareness of and addressing these evolving psychosocial issues can foster their developing needs.
- Original Article
- General Pediatrics
- Early initiation of breastfeeding and factors associated with its delay among mothers at discharge from a single hospital (2,974 times)
- J. Jenifer Florence Mary, R. Sindhuri, A. Arul Kumaran, Amol R. Dongre
- Clin Exp Pediatr. 2022;65(4):201-208. Published online October 18, 2021
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Background: According to the National Family Health Survey– 4, in India, 78.9% of deliveries occur in institutions, although only 42.6% of new mothers initiate breastfeeding within 1 hour of delivery.
Purpose: To estimate the proportion of early initiation of breastfeeding (EIBF) among new mothers at discharge from a tertiary care hospital and identify the determinants of delayed initiation of breastfeeding among...
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Impact Factor3.2
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8.02023CiteScore94nd percentilePowered by
