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"Most viewed" Articles are from the articles published in 2023 during the last six month.
- Review Article
- Endocrinology
- Growth plate closure and therapeutic interventions
(10,661 times)
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Ja Hyang Cho, Hae Woon Jung, Kye Shik Shim
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Clin Exp Pediatr. 2024;67(11):553-559. Published online October 28, 2024
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Height gains result from longitudinal bone growth. Upon adequate growth, growth plate closure limits longitudinal bone growth. To date, gonadotropin-releasing hormone analogs, aromatase inhibitors, C-type natriuretic peptide analogs, and fibroblast growth factor receptor 3 inhibitors have been studied or used as therapeutic interventions to delay growth plate closure and increase human height. The development of more effective therapeutic modalities for short stature, precocious puberty, and skeletal dysplasia is anticipated. |
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- Other
- Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy
(9,645 times)
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Lisa Zhao, John P. Jones, Lauren G. Anderson, Zacharoula Konsoula, Cynthia D. Nevison, Kathryn J. Reissner, William Parker
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Clin Exp Pediatr. 2024;67(3):126-139. Published online June 14, 2023
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Despite worldwide acceptance of acetaminophen (paracetamol) in pediatric medicine, careful examination reveals no valid objections to the conclusion that early exposure to acetaminophen causes neurodevelopmental injury in susceptible babies and children. Nevertheless, debate that early exposure to acetaminophen causes neurodevelopmental injury has centered around the prenatal period, evidence of which is relatively limited compared to that in the postnatal period, which is the time of greatest absolute and relative risk. |
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- Infection
- Community-acquired pneumonia in children: updated perspectives on its etiology, diagnosis, and treatment
(9,465 times)
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Ki Wook Yun
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Clin Exp Pediatr. 2024;67(2):80-89. Published online June 14, 2023
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· Most commonly confirmed causes of community-acquired pneumonia (CAP) in children are Mycoplasma pneumoniae (8%–40%) and respiratory syncytial virus (15%–20%).
· Pyogenic bacteria, most commonly Streptococcus pneumoniae (40%–50%) and Streptococcus pyogenes (10%–25%), are detected in 2%–5% of children hospitalized with CAP.
· CAP should be diagnosed conservatively according to clinical and radiological criteria.
· The etiology should be identified via appropriate test result interpretation. |
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- Developmental and Behavioral Medicine
- Comprehensive evaluation of the child with global developmental delays or intellectual disability
(8,848 times)
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Abdullah Nasser Aldosari, T. Saeed Aldosari
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Clin Exp Pediatr. 2024;67(9):435-446. Published online May 29, 2024
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· A detailed history and comprehensive physical examination remain the cornerstones for establishing a diagnosis of global developmental delay/intellectual disability (GDD/ID).
· Comprehensive surveillance and screening programs play a significant role in the early detection of GDD.
· Whole-exome sequencing is highly recommended as first- or second-line testing for individuals with idiopathic GDD/ID.
· Early intervention by a well-versed multidisciplinary team can significantly improve the outcomes and prognosis of GDD/ID. |
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- Original Article
- Neonatology (Perinatology)
- Effect of vitamin E supplementation on bilirubin levels in infants with hyperbilirubinemia: a double-blind randomized clinical trial
(8,263 times)
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Mojtaba Cheraghi, Maziar Nikouei, Majid Mansouri, Siros Hemmatpour, Yousef Moradi
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Clin Exp Pediatr. 2024;67(5):249-256. Published online March 26, 2024
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Question: Is vitamin E a viable therapeutic option for managing neonatal hyperbilirubinemia?
Finding: This randomized clinical trial examined the effects of oral vitamin E supplementation on bilirubin reduction (primary outcome), phototherapy duration, and length of hospital stay (secondary outcome) in 138 infants.
Meaning: Infants administered vitamin E versus placebo demonstrated similar reductions in bilirubin levels and length of hospital stay. |
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- Review Article
- Infection
- Pathogenetic and etiologic considerations of febrile seizures
(7,530 times)
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Ji Yoon Han, Seung Beom Han
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Clin Exp Pediatr. 2023;66(2):46-53. Published online January 13, 2023
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· Inflammatory responses accompanying fever increase neuronal excitability in the central nervous system, which in turn provokes seizures.
· Fever in children with febrile seizures is usually caused by common respiratory viruses, the distributions of which match those of seasonal community-acquired respiratory tract infections.
· Several genetic variations in ion channels seem associated with neuronal hyperexcitability in children with febrile seizures. |
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- Original Article
- Neonatology (Perinatology)
- Effect of high-frequency oscillatory ventilation with intermittent sigh breaths on carbon dioxide levels in neonates
(7,104 times)
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Kulthida Baingam, Anucha Thatrimontrichai, Manapat Praditaukrit, Gunlawadee Maneenil, Supaporn Dissaneevate
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Clin Exp Pediatr. 2025;68(2):178-184. Published online November 13, 2024
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Question: Can sigh breaths (Sighs) application during high-frequency oscillatory ventilation (HFOV) decrease partial pressure of carbon dioxide (PaCO2) levels?
Finding: The mean PaCO2 level after Sighs during HFOV was significantly decreased compared to that after HFOV alone (mean difference, -3.6 mmHg).
Meaning: HFOV plus Sighs functionality can reduce PaCO2 levels. However, further studies are required to conclusively determine the effects of Sighs. |
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- Review Article
- General Pediatrics
- Prevalence of childhood overweight and obesity in Malaysia: a systematic review and meta-analysis
(5,548 times)
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Ker Yang Chua, Ker Yung Chua, Karuthan Chinna, Chooi Ling Lim, Maheeka Seneviwickrama
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Clin Exp Pediatr. 2025;68(2):115-126. Published online November 13, 2024
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The incidence of childhood obesity is increasing worldwide. National surveys in Malaysia have shown similar trends. This review aimed to increase our understanding of the prevalence and associated factors of childhood overweight, obesity, and excess weight in Malaysia. A systematic review and meta-analysis were conducted of studies reporting the prevalence of overweight and obesity in Malaysian children aged <18 years.... |
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- Other
- Hearing loss in neonates and infants
(5,256 times)
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Goun Choe, Su-Kyoung Park, Bong Jik Kim
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Clin Exp Pediatr. 2023;66(9):369-376. Published online January 9, 2023
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· Congenital hearing loss is common, with an approximate incidence of 1.5 per 1,000 newborns and affecting 1.2%–11% of preterm and 1.6%–13.7% of neonatal intensive care unit neonates.
· Etiologies vary, and up to 80% of cases are genetic.
· Newborn hearing screenings follow the 1-3-6 rule, and babies at high risk of hearing loss should be referred to otolaryngology for early detection and timely intervention. |
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- Neonatology (Perinatology)
- Demographic transition in South Korea: implications of falling birth rates
(5,168 times)
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Chae Young Kim, Sung-Hoon Chung
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Clin Exp Pediatr. 2024;67(10):498-509. Published online June 27, 2024
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· Since 1960, South Korea's TFR decreased from 6.33 to 0.78 in 2022, below the 2.1 replacement level since 1983, with women's average age at first marriage rising to 31.3 in 2022.
· Policies needed: financial incentives, longer parental leave, better childcare.
· The U.S. (15.3% immigrants) and Germany (18.8%) use immigration to maintain demographic stability, a strategy South Korea is considering. |
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- Other
- Microplastic and human health with focus on pediatric well-being: a comprehensive review and call for future studies
(4,923 times)
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Rogers Wainkwa Chia, Ntegang Venant Atem, Jin-Yong Lee, Jihye Cha
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Clin Exp Pediatr. 2025;68(1):1-15. Published online November 6, 2024
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· Milk and formula are common sources of microplastic in infants.
· Water and air are the most common sources of microplastic pollution from infancy to adolescence.
· Microplastic use by children of all ages can cause cell damage and affect their health.
· Microplastics present in children can be quantified using a stereomicroscope and characterized using micro- Fourier transform infrared spectroscopy. |
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- Cardiology
- Heart failure in children and adolescents: an update on diagnostic approaches and management
(4,766 times)
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Amit Agrawal, Dalwinder Janjua, Abdulrahman Ahmed Alsayed Ali Zeyada, Ahmed Taher Elsheikh
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Clin Exp Pediatr. 2024;67(4):178-190. Published online June 19, 2023
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· Pediatric heart failure (PHF) is a clinical syndrome featuring various symptoms (shortness of breath, ankle swelling, fatigue) and signs (pulmonary crackles, peripheral edema).
· Congenital heart diseases are the most common underlying etiology of PHF, whereas myocarditis and primary cardio-myopathies are common in children without structural ab-normalities.
· PHF pathophysiology is complex and multifactorial and varies by etiology and age.
· PHF management includes decongestive therapy, treatment of underlying causes, preventing progression, and managing pulmonary or systemic obstructions.
· Drugs should be chosen based on pharmacodynamics, clinical manifestations, hemodynamic state, and renal function. |
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- Gastroenterology
- Current diagnosis and image-guided reduction for intussusception in children
(4,666 times)
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Jisun Hwang, Hee Mang Yoon, Pyeong Hwa Kim, Ah Young Jung, Jin Seong Lee, Young Ah Cho
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Clin Exp Pediatr. 2023;66(1):12-21. Published online July 4, 2022
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· Intussusception, the most common cause of small bowel obstruction in young children, has an overall incidence in Korea of 28.3 cases per 100,000 person-years.
· Its cause is idiopathic inmost cases, although viral or bacterial gastroenteritis has beenpostulated as a cause. Approximately 4% of children have pathological lead points for intussusception, and Meckel’s diverticulum is the most common cause.
· Intussusception in preterm infants is extremely rare. Older children (>5 years of age) are at increased risk of pathological lead points. |
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- Neonatology (Perinatology)
- Prevalence of anxiety, depression, and stress among parents of neonates admitted to neonatal intensive care unit: a systematic review and meta-analysis
(4,497 times)
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Asha P. Shetty, Kurvatteppa Halemani, Alwin Issac, Latha Thimmappa, Sanjay Dhiraaj, Radha K, Prabhaker Mishra, Vijai Datta Upadhyaya
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Clin Exp Pediatr. 2024;67(2):104-115. Published online November 14, 2023
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Question: What emotions do parents experience when their newborns are admitted to the neonatal intensive care unit (NICU)?
Finding: Mothers experienced more anxiety (51%), depression (31%), and stress (41%) symptoms than fathers (26%, 12%, and 22%, respectively).
Meaning: Parents often experience anxiety, stress, and depression following NICU admission. Healthcare workers are responsible for providing regular parental counseling. |
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- Review Article
- Gastroenterology
- Prevalence, risk factors, and treatment of small intestinal bacterial overgrowth in children
(4,484 times)
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Yu Kyung Cho, Jin Lee, Chang Nyol Paik
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Clin Exp Pediatr. 2023;66(9):377-383. Published online August 21, 2023
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· Pediatric small intestinal bacterial overgrowth (SIBO) manifestations range from nonspecific abdominal symptoms to malabsorption or malnutrition.
· SIBO is prevalent in children and adolescents with functional abdominal pain disorders.
· Predisposing factors include disturbed intestinal motility, altered anatomy, and/or abnormal body defense systems against intestinal bacteria.
· Breath tests are safe and noninvasive.
· Treatment principles include managing predisposing conditions, nutritional support, symptom control, and antibiotics. |
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- Original Article
- Neurology
- Effectiveness of Helmet therapy for infants with moderate to severe positional plagiocephaly
(4,401 times)
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Jeongho Kim, Jina Kim, Kyu Young Chae
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Clin Exp Pediatr. 2024;67(1):46-53. Published online December 5, 2023
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Question: Is helmet therapy effective for positional plagiocephaly? What factors influence helmet therapy efficacy for positional plagiocephaly?
Finding: Helmet therapy is effective for infants with moderate to severe positional plagiocephaly, and its effectiveness is influenced by age at treatment initiation, severity of head asymmetry, and daily duration of helmet wear.
Meaning: Pediatricians should initiate helmet therapy for positional plagiocephaly sooner, ideally before 9 months of age, to maximize treatment efficacy. |
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- Review Article
- Gastroenterology
- Practical concepts and strategies for early diagnosis and management of eosinophilic gastrointestinal disorders in East-Asian children
(4,309 times)
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Byung-Ho Choe
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Clin Exp Pediatr. 2025;68(3):185-198. Published online November 13, 2024
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Eosinophilic gastrointestinal disorders (EGIDs) often coexist with functional gastrointestinal disorders (FGIDs) and other IgE or non-IgE mediated GI diseases. Diagnosing EGIDs requires a high index of suspicion and a comprehensive approach to differentiate them from conditions like inflammatory bowel disease. Tests such as fecal calprotectin and biopsies aid in severe cases. Maintaining a food diary helps identify triggers for long-term elimination. Awareness and education are key to effective management. |
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- Original Article
- General Pediatrics
- Nonpharmacological interventions for managing postoperative pain and anxiety in children: a randomized controlled trial
(4,168 times)
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Edlin Glane Mathias, Mamatha Shivananda Pai, Vijay Kumar, Dinesh Narayanakurup, Malavika Kulkarni, Vasudeva Guddattu, Ann-Cathrine Bramhagen, Baby S Nayak, Anice George
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Clin Exp Pediatr. 2024;67(12):677-685. Published online October 31, 2024
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Question: What is the effect of nonpharmacological interventions on postoperative pain and anxiety among children.
Finding: Nurse-provided distraction interventions reduce pain and anxiety among pediatric surgical patients.
Meaning: The findings suggest that nonpharmacological interventions provided postoperatively to children reduce their pain and anxiety levels. |
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- Review Article
- Developmental and Behavioral Medicine
- Clinical practice guidelines for attention-deficit/hyperactivity disorder: recent updates
(4,000 times)
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Tae Hoon Eom, Young-Hoon Kim
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Clin Exp Pediatr. 2024;67(1):26-34. Published online June 14, 2023
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· Primary pediatricians should play a key role in the diagnosis and treatment of attention-deficit/hyperactivity disorder (ADHD).
· The Diagnostic and Statistical Manual of Mental Disorders, fifth edition, has lowered the diagnostic threshold for older teens and adults and a comorbid diagnosis with autism is now allowed.
· The American Academy of Pediatrics had added recommendation-related comorbid conditions in its guideline and the Society of Developmental and Behavioral Pediatrics recently developed a complex ADHD guideline.
· The European ADHD Guideline Group recently developed a guideline for managing ADHD during the coronavirus disease 2019 pandemic. |
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- Cardiology
- Research trends on causes of Kawasaki disease in the COVID-19 era: focus on viral infections
(3,840 times)
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Young Hwan Lee
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Clin Exp Pediatr. 2023;66(1):1-11. Published online June 22, 2022
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· The etiology of Kawasaki disease (KD) is unclear, but its clinical, epidemiological, and pathophysiological characteristics are strongly associated with infectious diseases.
· In the coronavirus disease 2019 pandemic era, viruses are attracting the most attention. Sudden acute respiratory syndrome coronavirus 2 infection causes various hyperinflammation in children that require differentiation from KD.
· Immune responses in patients with KD may be induced by host cell damage. To effectively prevent and treat KD, the genetic background and immune responses of KD patients and triggering pathogens require identification. |
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- Allergy
- Comparison and review of international guidelines for treating asthma in children
(3,780 times)
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Eui Jeong Roh
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Clin Exp Pediatr. 2024;67(9):447-455. Published online August 20, 2024
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Asthma is the most common chronic disease among children. Although asthma in children may spontaneously improve, it continues into adulthood in many cases. Therefore, appropriate disease management and medication are essential. Consistent and objective guidelines are needed to manage pediatric asthma and related adverse reactions. |
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- Review Article
- Neonatology (Perinatology)
- Neurodevelopmental outcomes of preterm infants
(3,680 times)
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In Gyu Song
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Clin Exp Pediatr. 2023;66(7):281-287. Published online December 30, 2022
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· Among survivors, 60.9% of infants born at 22 weeks’ gestation had moderate to severe impairments, whereas 50.3% born at 23 weeks’ and 42.2% at 24 weeks’ gestation had moderate to severe impairments.
· Moderate and late preterm infants reportedly have less severe disease than very preterm infants, but they still experience adverse neurodevelopmental outcomes.
· The careful follow-up and early detection of developmental problems in these patients are required. |
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- General Pediatrics
- Korean Developmental Screening Test for Infants and Children (K-DST): development, applications, and implications for future early childhood development interventions
(3,563 times)
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Dooyoung Kim, Young June Choe, Bilal Aurang Zeb Durrani, EunYoung Kim, Junghye Byeon, Baik-Lin Eun
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Clin Exp Pediatr. 2023;66(7):288-293. Published online December 22, 2022
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· This review discusses the development and application of the Korean Developmental Screening Test for Infants and Children (K-DST) for ensuring early childhood development.
· Various studies have demonstrated the integral role of the K-DST in facilitating the detection of developmental delays and delivery of timely interventions.
· The tailoring of the K-DST to Korean infants and children suggests that other countries may further translate and adapt it. |
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- Genetics and Metabolism
- Development of orphan drugs for rare diseases
(3,357 times)
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Han-Wook Yoo
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Clin Exp Pediatr. 2024;67(7):315-327. Published online June 28, 2023
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· Orphan disease is a rare disease, primarily affecting newborn and children. Vast majority of orphan diseases has genetic background.
· Orphan disease is individually rare. But as a whole, it is not rare, becoming a great socioeconomic burden.
· The diagnosis of rare genetic disease has been problematic, but recent progress of genome analysis technologies makes it faster and more precise.
· There are many unmet needs as to the curative treatment. However, the number of treatable rare diseases is growingly increasing owing to the development of biotechnology.
· Most orphan drugs are extremely expensive because of numer ous hurdles during the process of drug development as well as small number of patients. |
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- Developmental and Behavioral Medicine
- Screen time among preschoolers: exploring individual, familial, and environmental factors
(3,357 times)
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Sangha Lee, Donghee Kim, Yunmi Shin
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Clin Exp Pediatr. 2024;67(12):641-650. Published online September 12, 2024
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This systematic review examined the correlation between screen time and various factors in preschoolers. Findings suggest that media parenting, including setting appropriate media limits, is crucial in protecting against excessive screen exposure. However, limited research has been done on the impact of family and personal factors, particularly with the increasing use of portable devices among young children. |
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- Neonatology (Perinatology)
- Treatment of congenital cytomegalovirus infection
(3,337 times)
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Gyu Hong Shim
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Clin Exp Pediatr. 2023;66(9):384-394. Published online December 28, 2022
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· Congenital cytomegalovirus (CMV) infection is among the most common causes of nongenetic sensorineural hearing loss.
· Congenital CMV is initially treated with intravenous ganciclovir for 2–6 weeks and switched to oral valganciclovir, or with oral valganciclovir for the entire 6-month period.
· Infants with congenital CMV require periodic monitoring of absolute neutrophil count, platelet count, and blood urea nitrogen, creatinine, liver function tests, audiological, ophthalmological, and developmental tests during antiviral medication. |
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- Neurology
- Gut microbiota affects brain development and behavior
(3,274 times)
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Gun-Ha Kim, Jung-Ok Shim
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Clin Exp Pediatr. 2023;66(7):274-280. Published online November 8, 2022
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· The gut microbiota can alter a host’s brain development and behavior.
· Gut bacteria communicate with the brain via the microbiota-gut-brain axis.
· Fecal microbial transplantation is a promising treatment strategy for autism spectrum disorder. |
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- Pediatric syncope: pearls and pitfalls in history taking
(3,253 times)
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Jung Sook Yeom, Hyang-Ok Woo
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Clin Exp Pediatr. 2023;66(3):88-97. Published online February 15, 2023
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An accurate diagnosis depends on correct history taking and its interpretation. An in-depth understanding of the symptoms of syncope in connection with its pathophysiology can lead to avoiding critical pitfalls in the diagnostic process of history taking. |
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