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"Most viewed" Articles are from the articles published in 2020 during the last six month.

Letter to the Editor
Allergy
Environmental and dietary factors to be checked for treatment of atopic dermatitis in rural children   (651 times)
Sanghwa Youm, Eunjoo Lee, Jeongmin Lee
Clin Exp Pediatr. 2021;64(12):661-663.   Published online October 1, 2021
Question: What are the distinctive features of rural children with atopic dermatitis?
Finding: Birch and dog dander were the second most sensitized aeroallergens (32.6%), followed by house dust mites. Doctors and guardians reported food allergy comorbidities differently (19.9% and 43.5%, respectively). Dietary restrictions without medical evaluation were observed in 39.7% of patients.
Meaning: Effects of pollen distribution and indirect animal exposure should be evaluated. Evidence-based dietary restrictions must be implemented.
Editorial
Allergy
Hereditary angioedema in childhood   (643 times)
Young Min Ahn
Clin Exp Pediatr. 2020;63(1):18-19.   Published online January 15, 2020
Neonatology (Perinatology)
Risk factors for in-hospital mortality in premature infants with critical congenital heart disease   (643 times)
Jeonghee Shin
Clin Exp Pediatr. 2020;63(10):391-392.   Published online October 6, 2020
The incidence and mortality rates of critical congenital heart disease (CHD) are higher in preterm than in term infants. The risk factors for in-hospital mortality in premature infants with critical CHD are unclear. However, the mortality of preterm infants with critical CHD may be related to CHD complexity as well as gestational age, birth weight, the presence of prematurity-associated comorbidities, and the treatment itself.
Letter to the Editor
General Pediatrics
Effectiveness of comprehensive hand hygiene module on preschool children in Klang Valley, Malaysia   (642 times)
Mohd Dzulkhairi Mohd Rani, Nurul Azmawati Mohamed, Tengku Zetty Maztura Tengku Jamaluddin, Zarini Ismail, Shalinawati Ramli, Habibah Faroque, Farishah Nur Abd Samad, Abdul Rasyid Ariffien, Aisyah Ar Redha Che Amir Farid, Ilina Isahak
Clin Exp Pediatr. 2020;63(3):115-116.   Published online February 5, 2020
Original Article
Endocrinology
Effect of agricultural pesticide on precocious puberty in urban children: an exploratory study   (639 times)
Junghwan Suh, Han Saem Choi, Ahreum Kwon, Hyun Wook Chae, Ho-Seong Kim
Clin Exp Pediatr. 2020;63(4):146-150.   Published online December 6, 2019
Question: Does agricultural pesticide effect precocious puberty in girls?
Finding: Dinotefuran, an insecticide of neonicotinoid class, was detected in one of 30 patients with precocious puberty, and in 2 girls of the normal control group, which was not statistically significant.
Meaning: There was no close relationship between agricultural pesticides and development of precocious puberty.
Editorial
Neurology
Targeted temperature management and neuroprotective outcomes of pediatric patients after cardiac arrest   (636 times)
Yun-Jin Lee
Clin Exp Pediatr. 2020;63(5):180-181.   Published online April 14, 2020
Nephrology (Genitourinary)
Obesity and chronic kidney disease: what should pediatric nephrologists know?   (636 times)
Jung Won Lee
Clin Exp Pediatr. 2021;64(10):521-522.   Published online June 1, 2021
• Obesity is not only a comorbidity of hypertension, it may be a riskfactorfor chronickidneydisease.
• Renal impairment associated with obesity is believed to start early in childhood and continue into adulthood, implying a higher risk of adverse cardiovascular events.
• The identification of kidney injury, implementation of preventive strategies, and prompt treatment are essential to improving clinical outcomes in obese children with early kidney disease.
Gastroenterology
Does smartphone overuse affect functional gastrointestinal disorders?   (630 times)
Jee Hyun Lee
Clin Exp Pediatr. 2021;64(9):471-472.   Published online December 28, 2020
Functional gastrointestinal disorders are common disorders characterized by persistent and recurrent gastrointestinal symptoms. Pathophysiological mechanisms have been suggested, including intestinal microbiota, altered intestinal permeability and motility, dietary effects, sensory abnormalities, and brain-gut dysregulation. Lifestyle factors such as diet, sleep, affect, and physical activity might function as moderators.
Original Article
Endocrinology
Correlation between total air pollutant emissions and incidence of type 1 diabetes in the Russian Federation   (624 times)
Hoon Sung Choi, Jin Taek Kim, Ji-Young Seo, Faina Linkov, Evgeniy Shubnikov, Hong Kyu Lee
Clin Exp Pediatr. 2021;64(10):525-530.   Published online January 18, 2021
Question: Is there a quantitative relationship between air pollutant emissions and the incidence of type 1 diabetes (T1D)?
Finding: The incidence of T1D in each region of the Russian Federation correlated with the total air pollutants emitted each year.
Meaning: These findings suggest that air pollution contributes to the development of T1D.
Neonatology (Perinatology)
The protective effect of CXC chemokine receptor 2 antagonist on experimental bronchopulmonary dysplasia induced by postnatal systemic inflammation   (619 times)
Seung Hyun Lee, Chang Won Choi
Clin Exp Pediatr. 2021;64(1):37-43.   Published online July 15, 2020
Question: Can CXC chemokine receptor 2 (CXCR2) antagonist preserve alveolarization by attenuating the inflammation induced by systemic lipopolysaccharide (LPS) administration in a rat model of bronchopulmonary dysplasia (BPD)?
Finding: CXCR2 antagonist significantly decreased neutrophil counts in bronchoalveolar lavage fluid and peripheral blood induced by systemic LPS administration and restored alveolarization in newborn rats.
Meaning: CXCR2 antagonist protected the lungs from the inflammation in a rat model of BPD.
Clinical note
Immunology
Salivary and lacrimal gland enlargement with serum immunoglobulin G4 elevation   (616 times)
Jinseok Lee, Da-Eun Kim, Jeong-Hwan Yang, Misun Lim, Hye Yung Yum, JoongGon Kim
Clin Exp Pediatr. 2021;64(2):93-95.   Published online December 8, 2020
Question: What diseases should be considered in a 15-year-old girl presenting enlarged lacrimal and salivary glands?
Finding: Laboratory tests revealed elevated IgG4 levels. A submandibular gland biopsy showed lymphoplasmacytic infiltration and more than 40 immunoglobulin G4 (IgG4)-positive cells per high-power field. The patient was diagnosed with IgG4-related disease.
Meaning: Although rare in children, IgG4-related disease should be considered a differential diagnosis in children with enlarged salivary and lacrimal glands.
Editorial
Infection
Pneumococcal conjugate vaccines: choice of schedule and product development   (612 times)
Jin Lee
Clin Exp Pediatr. 2020;63(7):259-260.   Published online April 27, 2020
Neurology
Increasing our understanding of rotavirus-induced central nervous system manifestations   (609 times)
Jon Soo Kim
Clin Exp Pediatr. 2022;65(11):536-537.   Published online May 6, 2022
· Diverse clinicoradiological features of central nervous system (CNS) complications in rotavirus infection can be identified with the rapid and wide use of various brain magnetic resonance imaging protocols.
· An increased understanding of the various pathophysiological mechanisms of rotavirus-induced CNS manifestations will enable precise management in the future.
Letter to the Editor
Other
Evaluation of simulation-based ultrasound course for pediatricians: a starting point for future training curriculum   (604 times)
Chon In Kuok, Avis Siu Ha Leung, Jonan Chun Yin Lee, Winnie Kwai Yu Chan
Clin Exp Pediatr. 2022;65(1):53-55.   Published online July 28, 2021
Question: Simulation-based ultrasound training is becoming more popular. Is there a role for pediatricians in such training programs?
Finding: Our program received promising feedback from its participants. Self-rated confidence in image interpretation and ultrasound-guided catheter insertion improved after the simulation. Participants reported a higher preference for performing ultrasound scans before radiologist assessment.
Meaning: Ultrasound training can be considered as part of the pediatric training curriculum in the future.
Perspective
Neurology
How can pediatricians treat neurodevelopmental disorders   (602 times)
Young-Hoon Kim
Clin Exp Pediatr. 2021;64(1):1-2.   Published online July 27, 2020
∙ Recently neurodevelopmental therapy for preschool-aged children with neurodevelopmental disorders is paid for by health insurance in Korea.
∙ There are good evidences that parenting programs and neurodevelopmental therapy can work in attention deficit hyperactivity disorder and autism spectrum disorder.
∙ Pediatricians must be able to pass away important information to parents.
Editorial
General Pediatrics
Is it time to add point-of-care ultrasound education to pediatric residency curriculum?   (601 times)
Shin Ae Yoon
Clin Exp Pediatr. 2022;65(1):33-34.   Published online October 12, 2021
Growing point-of-care ultrasound (POCUS) use in pediatric patients has led to the need for POCUS education for pediatric residents. Recent experimental studies have suggested that POCUS education improves self-rated POCUS confidence and comfort in pediatric resident training. Considering the effective and sustainable POCUS education curriculum in pediatric resident training, simulation-based education would be a solution.
Clinical note
Nephrology (Genitourinary)
Extracorporeal membrane oxygenation with systemic heparinization as a rescue therapy for acute life-threatening pulmonary thromboembolism complicating nephrotic syndrome   (600 times)
Kyusang You, So Mi Kim, Dongmin Kim, Kyoungmin Ryu, Mee Jeong Lee
Clin Exp Pediatr. 2021;64(8):430-432.   Published online November 16, 2020
Question: How would you treat acute life-threatening pulmonary thromboembolism occurring in nephrotic patients?
Finding: A 16-year-old woman with minimal change-associated nephrotic syndrome presented with cardiac arrest caused by an acute bilateral pulmonary thromboembolism. Her hemodynamics stabilized with resolution of thrombi while on venoarterial extracorporeal membrane oxygenation (ECMO) and systemic heparinization.
Meaning: In selected cases, ECMO with systemic heparinization may rescue patients from acute life-threatening pulmonary thromboembolism even without reperfusion therapy.
Editorial
Allergy
Targeting eosinophils: another strategy for asthma treatment   (586 times)
Hye Mi Jee
Clin Exp Pediatr. 2021;64(5):223-224.   Published online March 5, 2021
Identifying phenotypes and endotypes of asthma patients is challenging, and eosinophilic phenotypes are generally characterized by severe or refractory asthma.
Biologicals targeting eosinophils are promising for the control of severe or refractory asthma symptoms.
To ensure proper treatment, increased understanding of the diverse phenotypes of high Th2 inflammation in pediatric asthma is needed.
Neonatology (Perinatology)
Utility of neonatal early-onset sepsis calculator in risk-based group B Streptococcus screening approach   (585 times)
Myo-Jing Kim
Clin Exp Pediatr. 2020;63(10):393-394.   Published online May 22, 2020
· Evaluation of the risk factors for early-onset sepsis (EOS) is important to optimal prevention and treatment.
· The EOS calculator is still valid as part of the risk-based group B Streptococcus (GBS) screening approach.
· The risk factor assessment using the EOS calculator is worth use before the introduction of universal GBS screening.
Hematology
When to suspect inherited platelet disorders and how to diagnose them   (584 times)
Eun Sil Park
Clin Exp Pediatr. 2020;63(3):98-99.   Published online February 5, 2020
Original Article
Nephrology (Genitourinary)
Expression profiling of cultured podocytes exposed to nephrotic plasma reveals intrinsic molecular signatures of nephrotic syndrome   (581 times)
Stuti Panigrahi, Varsha Chhotusing Pardeshi, Karthikeyan Chandrasekaran, Karthik Neelakandan, Hari PS, Anil Vasudevan
Clin Exp Pediatr. 2021;64(7):355-363.   Published online November 1, 2020
Question: Is it possible to classify nephrotic syndrome (NS) through gene expression profiling of podocytes exposed to NS plasma?
Finding: Our data showed different expression profiles in podocytes exposed to nephrotic plasma from different clinical groups, suggesting the molecular stratification of patients into intrinsic subtypes.
Meaning: Transcriptome profiling of podocytes treated with NS plasma can stratify patients into intrinsic subtypes and provide insight into the molecular mechanisms of podocyte injury.
Neonatology (Perinatology)
Placental histopathology in late preterm infants: clinical implications   (580 times)
Kristina Ericksen, Joshua Fogel, Rita P. Verma
Clin Exp Pediatr. 2020;63(2):48-51.   Published online August 19, 2019
Question: Placental histopathology and its clinical implications in late preterm infants.
Finding: Placental vascular anomalies are more, and placental inflammation less common in late preterm infants compared to term. Higher maternal age, magnesium sulfate therapy and hypertension are clinical risk factors associated with late preterm delivery.
Meaning: Prevention and aggressive management of hypertension, and conception before 30 years of age might be effective in preventing late preterm births.
Editorial
Nutrition
Advantages and limitations of using national survey datasets in child and adolescent research   (577 times)
Yoon Lee
Clin Exp Pediatr. 2021;64(9):468-470.   Published online January 26, 2021
The Korean National Health and Nutrition Examination Survey and the Korea Youth Risk Behavior Web-based Survey are major nationwide health and nutrition surveys in Korea. Although these surveys have some limitations of cross-sectional sample surveys, the accumulated data are valuable and provide new prospects for understanding public health depending on the interpretation method.
Nephrology (Genitourinary)
Pulmonary thromboembolism: a rare but life-threatening complication of nephrotic syndrome   (576 times)
Heeyeon Cho
Clin Exp Pediatr. 2021;64(8):406-407.   Published online February 4, 2021
Pulmonary thromboembolism (PTE) is often diagnosed in children with nephrotic syndrome. Massive PTE can cause hemodynamic instability, right ventricular failure, and circulatory collapse. Extracorporeal membrane oxygenation can be used for massive PTE as a method of hemodynamic support and adjunct to surgical embolectomy.
Letter to the Editor
Neonatology (Perinatology)
Role of neutrophil CD11b expression in diagnosis of earlyonset neonatal sepsis in full-term infant   (572 times)
Safaa ELMeneza, Walaa Mohamed, Iman Elbagoury, Karima Bahagat
Clin Exp Pediatr. 2021;64(1):44-45.   Published online April 14, 2020
Question: Can CD11b detect sepsis in full-term infants with suspected sepsis?
Finding: The percentage of neutrophils expressing CD11b was significantly upregulated in the sepsis and suspected sepsis groups versus the control group.
Meaning: CD11b is a sensitive marker for sepsis and suspected sepsis in full-term neonates and it may be added to sepsis markers. This information would allow the neonatologist to confidently discontinue antibiotic use as long as the neonate is clinically stable.
General Pediatrics
Skipping breakfast is associated with lifestyle habits among Japanese pupils   (568 times)
Jun Kohyama
Clin Exp Pediatr. 2021;64(8):433-435.   Published online November 4, 2020
Question: Breakfast is important; however, adolescents are increasingly skipping it.
Finding: Skipping breakfast is independently associated with sleepiness, physical inactivity, dinner irregularity, screen time on school days, poor academic performance, after-school activity, and decreased sleep duration before school day.
Meaning: Reducing screen time on school days, after-school activity, and irregular dinner habits might decrease breakfast skipping, resulting in decreased sleepiness and improved academic performance.
Editorial
Pulmonology
Are alternative antibiotics needed for antibiotic-nonresponsive Mycoplasma pneumoniae pneumonia?   (563 times)
Eun-Ae Yang, Kyung-Yil Lee
Clin Exp Pediatr. 2020;63(2):44-45.   Published online February 15, 2020
Infection
What are considerations for neonates at risk for COVID-19?   (560 times)
Soo-Han Choi
Clin Exp Pediatr. 2020;63(9):359-360.   Published online July 17, 2020
Nephrology (Genitourinary)
Inhibition of the renin-angiotensin system during fetal kidney development   (560 times)
Eujin Park
Clin Exp Pediatr. 2021;64(3):121-122.   Published online September 22, 2020
· Fetal exposure to renin-angiotensin system (RAS) inhibitors leads to short- and long-term kidney complications.
· Women of reproductive age who are absolutely indicated for RAS inhibitors should be adequately informed of the risks for the duration of treatment.
Neurology
Cerebrospinal fluid biomarkers in various pediatric neurologic diseases   (555 times)
Jeongho Lee
Clin Exp Pediatr. 2022;65(2):81-82.   Published online January 6, 2022
Cerebrospinal fluid (CSF) has many important biomarkers that are commonly analyzed in pediatric neurologic diseases, including central nervous system infection and inflammation. Neurologic disease in pediatrics is difficult to diagnosis, there are challenges in developing CSF profiles. Some biomarkers are expected to help differential diagnosis.
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