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Clinical note
Allergy
Complement 4 levels of a 4-year-old girl with angioedema
Soyoung Shin, Yoon Tae Lee, Kyung Yil Lee, Joonhong Park, Jae Ho Lee, Eun Ae Yang
Clin Exp Pediatr. 2020;63(1):30-31.   Published online November 8, 2019
Original articles
Neonatology (Perinatology)
Effectiveness of various nonpharmacological analgesic methods in newborns
Pancham Kumar, Rakesh Sharma, Sukhdev Rathour, Sunidhi Karol, Mohit Karol
Clin Exp Pediatr. 2020;63(1):25-29.   Published online August 16, 2019
Question: Can nonpharmacological methods be used for neonatal pain management.
Finding: Nonpharmacological methods like Sucrose, breastfeeding etc have shown to significantly reduce the pain caused by intramuscular hepatitis B vaccination.
Meaning: Nonpharmacological methods are the safe and cheap potential modalities of analgesia which can be used during mild to moderate pain in newborns.
Original Articles
Critical Care Medicine
Comparative validity of microalbuminuria versus clinical mortality scores to predict pediatric intensive care unit outcomes
Shifa Nismath, Suchetha S. Rao, B.S. Baliga, Vaman Kulkarni, Gayatri M. Rao
Clin Exp Pediatr. 2020;63(1):20-24.   Published online August 12, 2019
Question: Does microalbuminuria predict mortality in pediatric intensive care unit?
Finding: Positive correlation was found between albumin-creatinine ratio and pediatric intensive care unit stay, organ dysfunction and need of inotropes. Area under the receiver operating characteristic curve for albumin-creatinine ratio was comparable to mortality scores.
Meaning: Microalbuminuria is a good predictor of outcome in pediatric intensive care unit and is comparable with mortality scores.
Editorials
Allergy
Hereditary angioedema in childhood
Young Min Ahn
Clin Exp Pediatr. 2020;63(1):18-19.   Published online January 15, 2020
Neonatology (Perinatology)
Prevention and management of pain in the neonatal intensive care unit
Sung Shin Kim
Clin Exp Pediatr. 2020;63(1):16-17.   Published online January 15, 2020
Systematic review and meta-analysis
Psychiatric/Psychology
Association between neonatal jaundice and autism spectrum disorders among children: a meta-analysis
Ensiyeh Jenabi, Saeid Bashirian, Salman Khazaei
Clin Exp Pediatr. 2020;63(1):8-13.   Published online November 7, 2019
Autism spectrum disorder is a common neurodevelopmental disorder with an unknown etiology. The correlation between neonatal jaundice and the risk of developing autism spectrum disorder was investigated previously. Some studies showed significant associations, whereas others demonstrated no association. In this meta-analysis, we pooled the results of observational studies to examine the association between neonatal jaundice and the risk of autism...
Review article
Pulmonology
High-flow nasal cannula oxygen therapy in children: a clinical review
Ji-Won Kwon
Clin Exp Pediatr. 2020;63(1):3-7.   Published online October 28, 2019
High-flow nasal cannula (HFNC) is a relatively safe and effective noninvasive ventilation method that was recently accepted as a treatment option for acute respiratory support before endotracheal intubation or invasive ventilation. The action mechanism of HFNC includes a decrease in nasopharyngeal resistance, washout of dead space, reduction in inflow of ambient air, and an increase in airway pressure. In preterm...
Perspective
Other
The long journey toward improving children’s health: from ‘Korean Journal of Pediatrics’ to ‘Clinical and Experimental Pediatrics
Man Yong Han, Yeong Ho Rha, Chong-Woo Bae, Baik-Lin Eun
Clin Exp Pediatr. 2020;63(1):1-2.   Published online January 15, 2020
Original Articles
Endocrinology
Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity
Bahar Özcabı, Salih Demirhan, Mesut Akyol, Hatice Öztürkmen Akay, Ayla Güven
Clin Exp Pediatr. 2019;62(12):450-455.   Published online October 28, 2019
Background: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults. Purpose: Here we evaluated the ability of LAP to predict NAFLD in obese children. Methods: Eighty obese children (38 girls; age 6–18 years) were included. Anthropometric measurements and biochemical values were obtained from the patients’ medical records. LAP was calculated as [waist...
Neonatology (Perinatology)
Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia
Ga Won Jeon, R. Ann Sheldon, Donna M Ferriero
Clin Exp Pediatr. 2019;62(12):444-449.   Published online October 18, 2019
Background: Sixty percent of infants with severe neonatal hypoxic-ischemic encephalopathy die, while most survivors have permanent disabilities. Treatment for neonatal hypoxic-ischemic encephalopathy is limited to therapeutic hypothermia, but it does not offer complete protection. Here, we investigated whether hypoxia-inducible factor (HIF) promotes cell survival and suggested neuroprotective strategies. Purpose: HIF-1α-deficient mice have increased brain injury after neonatal hypoxia-ischemia (HI), and the...
Editorials
Nephrology (Genitourinary)
Is there a simple and less invasive way to accurately diagnose acute pyelonephritis?
Seong Heon Kim
Clin Exp Pediatr. 2019;62(12):442-443.   Published online November 19, 2019
Neonatology (Perinatology)
Practical considerations when administering surfactants to preterm infants with respiratory distress syndrome
Heui Seung Jo
Clin Exp Pediatr. 2019;62(12):440-441.   Published online August 16, 2019
Review Article
Nephrology (Genitourinary)
Reconsideration of urine culture for the diagnosis of acute pyelonephritis in children: a new challenging method for diagnosing acute pyelonephritis
Jun Ho Lee, Seonkyeong Rhie
Clin Exp Pediatr. 2019;62(12):433-437.   Published online October 18, 2019
Acute pyelonephritis (APN) should be detected and treated as soon as possible to reduce the risk of the development of acquired renal scarring. However, in the medical field, urine culture results are not available or considered when the prompt discrimination of APN is necessary and empirical treatment is started. Furthermore, urine culture cannot discriminate APN among children with febrile urinary...

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