- Review Article
- Other
- Myopia: a review of current concepts, association with nonophthalmological conditions, and treatment strategy in children and adolescents
- Yeon Woong Chung
- Clin Exp Pediatr. 2025;68(8):554-565. Published online April 1, 2025
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Myopia is a major ophthalmological disorder with increasing prevalence worldwide, particularly in East Asia. Evidence indicates that its development involves complex interactions between genetic and environmental factors. Body stature, sleep patterns, and nutritional status significantly influence the progression of myopia during childhood and adolescence. Its treatment and prevention strategies include optical correction, atropine therapy, increased outdoor activity, decreased near work, and regular retinal monitoring.
- Editorial
- Other
- Beyond the eye: a multidisciplinary perspective on managing pediatric myopia
- Eoi Jong Seo
- Clin Exp Pediatr. 2025;68(8):566-568. Published online July 18, 2025
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Myopia is a growing global public health concern because of its association with irreversible vision loss such as myopic traction maculopathy, rhegmatogenous retinal detachment, and glaucoma. The effective prevention of myopia in childhood requires a multidisciplinary approach that integrates ophthalmologic care with lifestyle, nutrition, and sleep interventions. Early detection through regular visual screening in schools and primary care settings and timely ophthalmology referrals are critical to preventing high myopia.
- Original Article
- Neurology
- Establishing an induced pluripotent stem cell bank using urine cells from pediatric patients with neurogenetic diseases
- Hien Bao Dieu Thai, WonWoo Jung, Sol Choi, Woo Joong Kim, JangSup Moon, ByungChan Lim
- Clin Exp Pediatr. 2025;68(8):569-577. Published online April 1, 2025
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Question: What can be used to create a reliable supply of somatic cells for induced pluripotent stem cells (iPSCs) generation and standardize procedures for building an iPSC bank for researching pediatric neurogenetic disorders?
Findings: Noninvasively acquired urine cells are a desirable cell source for iPSC reprogramming.
Meaning: An iPSC bank can be created from diverse patient cell sources and offer a useful resource for translating research results into clinical therapy for pediatric neurogenetic disorders.
- Critical Care Medicine
- Serum amyloid A and proadrenomedullin as early markers in critically ill children with sepsis
- Nagwan Y. Saleh, Wafaa M. Abo El Fotoh, Mona S. Habib, Salem E. Deraz
- Clin Exp Pediatr. 2025;68(8):578-586. Published online February 26, 2025
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Question: Are serum amyloid A (SAA) and proadrenomedullin (proADM) levels early markers in critically ill children with sepsis?
Finding: This prospective case-control study included 65 critically ill children with sepsis admitted to the pediatric intensive care unit and 31 controls. SAA and proADM levels were significantly higher in patients versus controls.
Meaning: SAA and proADM are promising biomarkers for diagnosing and predicting outcomes in pediatric sepsis.
- Gastroenterology
- Somatic symptom severity during acute illnesses among children with functional gastrointestinal disorders
- Rattanachart Sirinil, Anundorn Wongteerasut
- Clin Exp Pediatr. 2025;68(8):587-593. Published online March 11, 2025
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Functional gastrointestinal disorders (FGIDs) are associated with various somatic symptoms measured using a visual analogue scale and the Children’s Somatic Symptoms Inventory-24 questionnaire. Children with FGIDs exhibited more significant somatic symptoms than controls during acute illnesses. Gastrointestinal (GI) and non-GI manifestations are significantly more common in children with FGIDs.
- Efficacy and safety of carbon dioxide versus room-air insufflation in pediatric colonoscopy: a randomized controlled trial
- Ajay Aravind, Ujjal Poddar, Anshu Srivastava, Moinak Sen Sarma
- Clin Exp Pediatr. 2025;68(8):594-600. Published online March 11, 2025
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CO2 insufflation has been used instead of air insufflation to reduce postprocedure pain and discomfort in adults; however, adequately powered studies in children are scarce. This randomized controlled trial of 200 children showed that CO2 insufflation reduces postprocedure pain and discomfort during pediatric colonoscopy with no signs of CO2 retention. CO2 insufflation is safe and causes less pain in children.
- Hematology
- Hematopoietic stem cell transplantation in pediatric patients with type VI mucopolysaccharidosis
- Vedat Uygun, Koray Yalçın, Hayriye Daloğlu, Seda Öztürkmen, Suna Çelen, Suleimen Zhumatayev, Gülsün Karasu, Akif Yeşilipek
- Clin Exp Pediatr. 2025;68(8):601-607. Published online March 11, 2025
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Question: Could hematopoietic stem cell transplantation (HSCT) be an alternative to enzyme replacement therapy (ERT) for type VI mucopolysaccharidosis (MPS VI)?
Finding: HSCT is generally not offered due to reports of high toxicity and mortality. However, we detected fewer complications and graft-versus-host disease cases and no deaths with HSCT.
Meaning: HSCT is both less expensive than ERT and permanent; thus, it should be considered an alternative treatment for MPS VI.
- General Pediatrics
- Liposomal SunActive versus conventional iron for treatment of iron-deficiency anemia in children aged 2–12 years: a prospective randomized controlled trial
- Wael A. Bahbah, Yasmin A.H.S. Younis, Hanan Salama Elbelouny, Asmaa A. Mahmoud
- Clin Exp Pediatr. 2025;68(8):608-615. Published online July 18, 2025
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Background: Liposomal iron, a novel oral formulation of ferric pyrophosphate that demonstrates improved gastrointestinal absorption and bioavailability with fewer side effects than conventional iron, represents a significant advancement in the treatment of iron-deficiency anemia (IDA).
Purpose: To conduct an in-depth comparative study of liposomal SunActive and conventional iron supplements (iron polymaltose complex) for treating IDA in children aged 2–12 years Methods: This...
- Clinical Note
- Genetics and Metabolism
- Expanding genotype-phenotype correlation of Kenny-Caffey syndrome type 1
- Manuela Lo Bianco, Federica Sipala, Xena Giada Pappalardo, Gaia Fusto, Roberta Rizzo, Federico Favata, Carla Cimino, Silvia Marino, Martino Ruggieri, Agnese Suppiej, Simone Ronsisvalle, Raffaele Falsaperla
- Clin Exp Pediatr. 2025;68(8):616-619. Published online May 12, 2025
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- Perspective
- General Pediatrics
- Navigating the complex behavioral landscape of children in foster care and adopted families
- Anisha Choi, Sandhya J. Kadam
- Clin Exp Pediatr. 2025;68(8):620-623. Published online May 12, 2025
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- Correspondence
- Infection
- A commentary on "COVID-19 vaccine hesitancy among parents of children with systemic lupus erythematosus"
- Hinpetch Daungsupawong, Viroj Wiwanitkit
- Clin Exp Pediatr. 2025;68(8):624-625. Published online April 16, 2025
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- Nephrology (Genitourinary)
- Authors' reply: a commentary on “COVID-19 vaccine hesitancy among parents of children with systemic lupus erythematosus”
- Karnchanit Sausukpaiboon, Nuanpan Penboon, Pornpimol Rianthavorn
- Clin Exp Pediatr. 2025;68(8):626-627. Published online July 18, 2025
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