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Most-cited articles are from the articles published during the last two years (2020 ~ ).
- Epidemiology and clinical features of coronavirus disease 2019 in children
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Soo-Han Choi, Han Wool Kim, Ji-Man Kang, Dong Hyun Kim, Eun Young Cho
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Clin Exp Pediatr. 2020;63(4):125-132. Published online April 6, 2020
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Coronavirus disease-2019 (COVID-19), which started in Wuhan, China, in December 2019 and declared a worldwide pandemic on March 11, 2020, is a novel infectious disease that causes respiratory illness and death. Pediatric COVID-19 accounts for a small percentage of patients and is often milder than that in adults; however, it can progress to severe disease in some cases. Even neonates... |
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- Original Article
- Allergy
- Ten-year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017
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Jihyun Ha, Seung Won Lee, Dong Keon Yon
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Clin Exp Pediatr. 2020;63(7):278-283. Published online January 29, 2020
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Background: Major questions remain regarding the agestratified trends of allergic diseases and asthma in Korea.
Purpose: To identify the estimated recent prevalence and 10- year trends in asthma, allergic rhinitis, and atopic dermatitis among the Korean population from 2008 to 2017.
Methods: This nationwide cross-sectional survey (Korean National Health and Nutrition Examination Survey) over 10 years (2008–2017) examined representative samples of the... |
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- Review Article
- Immunology
- Immunopathogenesis of COVID-19 and early immunomodulators
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Kyung-Yil Lee, Jung-Woo Rhim, Jin-Han Kang
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Clin Exp Pediatr. 2020;63(7):239-250. Published online June 18, 2020
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The novel coronavirus disease 2019 (COVID-19) is spreading globally. Although its etiologic agent is discovered as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there are many unsolved issues in COVID-19 and other infectious diseases. The causes of different clinical phenotypes and incubation periods among individuals, species specificity, and cytokine storm with lymphopenia as well as the mechanism of damage to organ... |
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- Nutrition
- Components of human breast milk: from macronutrient to microbiome and microRNA
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Su Yeong Kim, Dae Yong Yi
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Clin Exp Pediatr. 2020;63(8):301-309. Published online March 23, 2020
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Human breast milk (HBM) is essential for the infant’s growth and development right after birth and is an irreplaceable source of nutrition for early human survival. Various infant formulas have many similarities to HBM in many components, but there is no perfect substitute for HBM. Recently, various breast milk components and their roles have been studied according to the development... |
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- Pulmonology
- High-flow nasal cannula oxygen therapy in children: a clinical review
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Ji-Won Kwon
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Clin Exp Pediatr. 2020;63(1):3-7. Published online October 28, 2019
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High-flow nasal cannula (HFNC) is a relatively safe and effective noninvasive ventilation method that was recently accepted as a treatment option for acute respiratory support before endotracheal intubation or invasive ventilation. The action mechanism of HFNC includes a decrease in nasopharyngeal resistance, washout of dead space, reduction in inflow of ambient air, and an increase in airway pressure. In preterm... |
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- Infection
- The COVID-19 pandemic: an unprecedented tragedy in the battle against childhood obesity
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Maximilian Andreas Storz
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Clin Exp Pediatr. 2020;63(12):477-482. Published online November 5, 2020
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Large-scale quarantine and home confinement during the coronavirus disease 2019 (COVID-19) pandemic will impose new and unfamiliar stressors on children, thereby worsening the childhood obesity epidemic. Physical, nutritional, and psychosocial factors that promote obesity in children during this special situation complementarily contribute to an unprecedented obesogenic environment. Involved stakeholders, including governments, schools, and families, must make all efforts to minimize the impact of the COVID-19 epidemic on childhood obesity. |
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- General Pediatrics
- Clinical features, diagnosis, and outcomes of multisystem inflammatory syndrome in children associated with coronavirus disease 2019
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Ji Hee Kwak, Soo-Young Lee, Jong-Woon Choi; the Korean Society of Kawasaki Disease
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Clin Exp Pediatr. 2021;64(2):68-75. Published online December 30, 2020
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Hundreds of cases of children and adolescents with hyperinflammatory responses such as Kawasaki disease have been reported amid the coronavirus disease 2019 (COVID-19) pandemic, leading to coining of the new term COVID-19–associated multisystem inflammatory syndrome in children. In this review article, we introduce the illness and describe its case definitions, epidemiology, pathogenesis, clinical features, treatments, and outcomes. |
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- Systematic review and meta-analysis
- Genetics and Metabolism
- Global prevalence of classic phenylketonuria based on Neonatal Screening Program Data: systematic review and meta-analysis
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Hamid Reza Shoraka, Ali Akbar Haghdoost, Mohammad Reza Baneshi, Zohre Bagherinezhad, Farzaneh Zolala
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Clin Exp Pediatr. 2020;63(2):34-43. Published online February 6, 2020
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Question: What is the global prevalence of classic phenylketonuria based on Neonatal Screening Program Data?
Finding: The overall worldwide prevalence of the disease is 6.002 per 100,000 neonates. The highest prevalence (38.13) was reported in Turkey, while the lowest (0.3) in Thailand.
Meaning: This difference in the prevalence may be due to differences in the number of consanguineous marriages among the different regions, phenylalanine cutoff points, and sample sizes. |
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- Review Article
- Neurology
- Genetic tests by next-generation sequencing in children with developmental delay and/or intellectual disability
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Ji Yoon Han, In Goo Lee
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Clin Exp Pediatr. 2020;63(6):195-202. Published online November 4, 2019
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Developments in next-generation sequencing (NGS) techogies have assisted in clarifying the diagnosis and treatment of developmental delay/intellectual disability (DD/ID) via molecular genetic testing. Advances in DNA sequencing technology have not only allowed the evolution of targeted panels but also, and more currently enabled genome-wide analyses to progress from research era to clinical practice. Broad acceptance of accuracy- guided targeted gene... |
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- Endocrinology
- Air pollution and childhood obesity
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Moon Young Seo, Shin-Hye Kim, Mi Jung Park
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Clin Exp Pediatr. 2020;63(10):382-388. Published online March 27, 2020
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Questions: What are the possible effects of air pollution on the occurrence of childhood obesity and what are the mechanisms?
Finding: Epidemiologic studies suggest that air pollutants might act as obesogens in the pediatric population, and their possible mechanisms include oxidative stress, physical inactivity, and epigenetic modulation.
Meaning: This paper reviews updated information on air pollution, one of the modifiable environmental factors in childhood obesity. |
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- Systematic review and meta-analysis
- Psychiatric/Psychology
- Association between neonatal jaundice and autism spectrum disorders among children: a meta-analysis
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Ensiyeh Jenabi, Saeid Bashirian, Salman Khazaei
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Clin Exp Pediatr. 2020;63(1):8-13. Published online November 7, 2019
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Autism spectrum disorder is a common neurodevelopmental disorder with an unknown etiology. The correlation between neonatal jaundice and the risk of developing autism spectrum disorder was investigated previously. Some studies showed significant associations, whereas others demonstrated no association. In this meta-analysis, we pooled the results of observational studies to examine the association between neonatal jaundice and the risk of autism... |
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- Original Article
- Neonatology (Perinatology)
- Long-term cognitive, executive, and behavioral outcomes of moderate and late preterm at school age
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Ju Hyun Jin, Shin Won Yoon, Jungeun Song, Seong Woo Kim, Hee Jung Chung
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Clin Exp Pediatr. 2020;63(6):219-225. Published online September 25, 2019
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Question: Infants born at moderate to late preterm gestations are known to have little problem later on, but is that really true?
Finding: At school age, cognitive problem was observed in about a quarter of the children. In addition, more than half of the children was suspected of having attention problems.
Meaning: Moderate to late preterm infants are at risk of developing abnormal intelligence and attention problems at early school age, therefore they should not be neglected on longterm follow-up evaluation. |
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- Allergy
- Cohort profile: National Investigation of Birth Cohort in Korea study 2008 (NICKs-2008)
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Ju Hee Kim, Jung Eun Lee, So Min Shim, Eun Kyo Ha, Dong Keon Yon, Ok Hyang Kim, Ji Hyeon Baek, Hyun Yong Koh, Kyu Young Chae, Seung Won Lee, Man Yong Han
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Clin Exp Pediatr. 2021;64(9):480-488. Published online January 5, 2021
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This national cohort study included all Korean children born in 2008 and 2009 observed over a period of more than 10 years. Our findings demonstrate that it is possible to analyze disease onset prior to hospitalization based on information such as lifestyle, eating habits, and risk factors by integrating National Health Insurance System data with national health screening data. |
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