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"Most downloaded" Articles are from the articles published in 2018 during the last six months.

Perspective
Other
The long journey toward improving children’s health: from ‘Korean Journal of Pediatrics’ to ‘Clinical and Experimental Pediatrics   (41 times)
Man Yong Han, Yeong Ho Rha, Chong-Woo Bae, Baik-Lin Eun
Clin Exp Pediatr. 2020;63(1):1-2.   Published online January 15, 2020
Review Article
Nephrology (Genitourinary)
Reconsideration of urine culture for the diagnosis of acute pyelonephritis in children: a new challenging method for diagnosing acute pyelonephritis   (102 times)
Jun Ho Lee, Seonkyeong Rhie
Clin Exp Pediatr. 2019;62(12):433-437.   Published online October 18, 2019
Acute pyelonephritis (APN) should be detected and treated as soon as possible to reduce the risk of the development of acquired renal scarring. However, in the medical field, urine culture results are not available or considered when the prompt discrimination of APN is necessary and empirical treatment is started. Furthermore, urine culture cannot discriminate APN among children with febrile urinary...
Review article
Pulmonology
High-flow nasal cannula oxygen therapy in children: a clinical review   (32 times)
Ji-Won Kwon
Clin Exp Pediatr. 2020;63(1):3-7.   Published online October 28, 2019
High-flow nasal cannula (HFNC) is a relatively safe and effective noninvasive ventilation method that was recently accepted as a treatment option for acute respiratory support before endotracheal intubation or invasive ventilation. The action mechanism of HFNC includes a decrease in nasopharyngeal resistance, washout of dead space, reduction in inflow of ambient air, and an increase in airway pressure. In preterm...
Original Articles
Neonatology (Perinatology)
Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia   (120 times)
Ga Won Jeon, R. Ann Sheldon, Donna M Ferriero
Clin Exp Pediatr. 2019;62(12):444-449.   Published online October 18, 2019
Background: Sixty percent of infants with severe neonatal hypoxic-ischemic encephalopathy die, while most survivors have permanent disabilities. Treatment for neonatal hypoxic-ischemic encephalopathy is limited to therapeutic hypothermia, but it does not offer complete protection. Here, we investigated whether hypoxia-inducible factor (HIF) promotes cell survival and suggested neuroprotective strategies. Purpose: HIF-1α-deficient mice have increased brain injury after neonatal hypoxia-ischemia (HI), and the...
Clinical note
Allergy
Complement 4 levels of a 4-year-old girl with angioedema   (29 times)
Soyoung Shin, Yoon Tae Lee, Kyung Yil Lee, Joonhong Park, Jae Ho Lee, Eun Ae Yang
Clin Exp Pediatr. 2020;63(1):30-31.   Published online November 8, 2019
Perspective
Food allergy and food-induced anaphylaxis in children: an increasing critical public health issue   (71 times)
Sooyoung Lee
Clin Exp Pediatr. 2019;62(12):431-432.   Published online November 12, 2019
Original articles
Neonatology (Perinatology)
Effectiveness of various nonpharmacological analgesic methods in newborns   (120 times)
Pancham Kumar, Rakesh Sharma, Sukhdev Rathour, Sunidhi Karol, Mohit Karol
Clin Exp Pediatr. 2020;63(1):25-29.   Published online August 16, 2019
Question: Can nonpharmacological methods be used for neonatal pain management.
Finding: Nonpharmacological methods like Sucrose, breastfeeding etc have shown to significantly reduce the pain caused by intramuscular hepatitis B vaccination.
Meaning: Nonpharmacological methods are the safe and cheap potential modalities of analgesia which can be used during mild to moderate pain in newborns.
Editorials
Prevention and management of pain in the neonatal intensive care unit   (21 times)
Sung Shin Kim
Clin Exp Pediatr. 2020;63(1):16-17.   Published online January 15, 2020
Systematic review and meta-analysis
Psychiatric/Psychology
Association between neonatal jaundice and autism spectrum disorders among children: a meta-analysis   (41 times)
Ensiyeh Jenabi, Saeid Bashirian, Salman Khazaei
Clin Exp Pediatr. 2020;63(1):8-13.   Published online November 7, 2019
Autism spectrum disorder is a common neurodevelopmental disorder with an unknown etiology. The correlation between neonatal jaundice and the risk of developing autism spectrum disorder was investigated previously. Some studies showed significant associations, whereas others demonstrated no association. In this meta-analysis, we pooled the results of observational studies to examine the association between neonatal jaundice and the risk of autism...
Original Articles
Neurology
Evaluation of hematologic profile may be needed for patients treated with oxcarbazepine   (103 times)
Gu Hyun Jung, Su Jeong You
Clin Exp Pediatr. 2019;62(8):312-316.   Published online April 11, 2019
Purpose: The major side effects of treatment with oxcarbazepine (OXC) are skin rash and hyponatremia. Hematologic side effects are reported rarely. The aim of this study was to investigate the rate and types of the hematologic side effects of OXC. Methods: The medical records of 184 patients diagnosed with epilepsy or movement disorder and on OXC monotherapy, at the Department of...
Editorials
Nephrology (Genitourinary)
Is there a simple and less invasive way to accurately diagnose acute pyelonephritis?   (67 times)
Seong Heon Kim
Clin Exp Pediatr. 2019;62(12):442-443.   Published online November 19, 2019
Review Articles
Neonatology (Perinatology)
Practice for preterm patent ductus arteriosus; focusing on the hemodynamic significance and the impact on the neonatal outcomes   (306 times)
Jin A Lee
Clin Exp Pediatr. 2019;62(7):245-251.   Published online April 8, 2019
Hemodynamically significant preterm patent ductus arteriosus (PDA) affects mortality; comorbidities such as necrotizing enterocolitis, intraventricular hemorrhage, and bronchopulmonary dysplasia; and adverse long-term neurodevelopmental outcomes in preterm infants, particularly in very low birth weight infants. However, recent studies have indicated that there is no consensus on the causal relationship between PDA and neonatal outcomes, the benefit of PDA treatment, the factors...
Editorials
Genetics and Metabolism
Considerations for evaluating the effectiveness and long-term outcome of enzyme replacement therapy in Pompe disease   (107 times)
Chong Kun Cheon
Clin Exp Pediatr. 2020;63(1):14-15.   Published online August 7, 2019
Allergy
Hereditary angioedema in childhood   (14 times)
Young Min Ahn
Clin Exp Pediatr. 2020;63(1):18-19.   Published online January 15, 2020
Original Articles
Endocrinology
Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity   (48 times)
Bahar Özcabı, Salih Demirhan, Mesut Akyol, Hatice Öztürkmen Akay, Ayla Güven
Clin Exp Pediatr. 2019;62(12):450-455.   Published online October 28, 2019
Background: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults. Purpose: Here we evaluated the ability of LAP to predict NAFLD in obese children. Methods: Eighty obese children (38 girls; age 6–18 years) were included. Anthropometric measurements and biochemical values were obtained from the patients’ medical records. LAP was calculated as [waist...
Critical Care Medicine
Comparative validity of microalbuminuria versus clinical mortality scores to predict pediatric intensive care unit outcomes   (42 times)
Shifa Nismath, Suchetha S. Rao, B.S. Baliga, Vaman Kulkarni, Gayatri M. Rao
Clin Exp Pediatr. 2020;63(1):20-24.   Published online August 12, 2019
Question: Does microalbuminuria predict mortality in pediatric intensive care unit?
Finding: Positive correlation was found between albumin-creatinine ratio and pediatric intensive care unit stay, organ dysfunction and need of inotropes. Area under the receiver operating characteristic curve for albumin-creatinine ratio was comparable to mortality scores.
Meaning: Microalbuminuria is a good predictor of outcome in pediatric intensive care unit and is comparable with mortality scores.
Editorials
Neonatology (Perinatology)
Practical considerations when administering surfactants to preterm infants with respiratory distress syndrome   (52 times)
Heui Seung Jo
Clin Exp Pediatr. 2019;62(12):440-441.   Published online August 16, 2019
Review Article
General Pediatrics
The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects   (262 times)
Jae Hyun Kim, Sungha Yun, Seung-sik Hwang, Jung Ok Shim, Hyun Wook Chae, Yeoun Joo Lee, Ji Hyuk Lee, Soon Chul Kim, Dohee Lim, Sei Won Yang, Kyungwon Oh, Jin Soo Moon
Clin Exp Pediatr. 2018;61(5):135-149.   Published online May 28, 2018
Growth charts are curves or tables that facilitate the visualization of anthropometric parameters, and are widely used as an important indicator when evaluating the growth status of children and adolescents. The latest version of the Korean National Growth Charts released in 2007 has raised concerns regarding the inclusion of data from both breastfed and formula-fed infants, higher body mass index...
Allergy
Phenotypes of allergic diseases in children and their application in clinical situations   (213 times)
Eun Lee, Soo-Jong Hong
Clin Exp Pediatr. 2019;62(9):325-333.   Published online April 23, 2019
Allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, are common heterogeneous diseases that encompass diverse phenotypes and different pathogeneses. Phenotype studies of allergic diseases can facilitate the identification of risk factors and their underlying pathophysiology, resulting in the application of more effective treatment, selection of better treatment responses, and prediction of prognosis for each phenotype. In the early phase...
Cardiology
Reality of Kawasaki disease epidemiology   (143 times)
Gi Beom Kim
Clin Exp Pediatr. 2019;62(8):292-296.   Published online July 9, 2019
Epidemiologic studies of Kawasaki disease (KD) have shown a new pattern or change of its occurrence suggestive of its pathophysiology or risk factors from the first patient with KD reported in 1961. The incidence of KD in Northeast Asian countries including Japan, South Korea, China, and Taiwan is 10–30 times higher than that in the United States and Europe. Knowing...


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