Most downloaded
- Page Path
-
- HOME
- BROWSE ARTICLES
- Most downloaded
"Most downloaded" Articles are from the articles published in 2024 during the last six months.
- Original Article
- Rheumatology
- Recurrent immunoglobulin A vasculitis in children and adolescents: prevalence and associated risk factors
(48 times)
-
Nootsara Atchariyaphuk, Maynart Sukharomana, Thanaporn Chaiyapak, Sirirat Charuvanij
-
Clin Exp Pediatr. 2026;69(1):46-55. Published online October 22, 2025
-
|
Question: What can predict immunoglobulin A vasculitis (IgAV) recurrence, and when does it occur? How do childhood- and adolescent-onset IgAV compare?
Finding: The IgAV recurrence rate was 35.6%. It usually occurred within 12 months and was associated with corticosteroids treatment.
Meaning: Childhood-onset IgAV more commonly featured gastrointestinal and musculoskeletal manifestations and required hospitalization. Adolescent-onset IgAV more commonly featured renal involvement. Vigilant monitoring for recurrence is necessary, particularly with corticosteroids treatment. |
-
-
- Review Article
- Critical Care Medicine
- Recent updates on systemic treatment of atopic dermatitis
(47 times)
-
Jiyoung Ahn
-
Clin Exp Pediatr. 2024;67(11):580-588. Published online November 1, 2024
-
|
|
Atopic dermatitis (AD) is a complex disease with multifactorial pathogenesis and variable clinical presentation. Up to one-fifth of patients with AD develop moderate to severe disease that is often refractory to classical therapies and can compromise quality of life. This review summarizes recent clinical evidence on biological agents and small-molecule immunotherapies for the treatment of AD. |
-
-
- Original Article
- Critical Care Medicine
- Effect of postoperative enteral protein supplementation on nitrogen balance in critically ill children
(47 times)
-
Irene Yuniar, Kadek Apik Lestari, Antonius Hocky Pudjiadi, Fatima Safira Alatas, Yoga Devaera
-
Clin Exp Pediatr. 2025;68(10):790-800. Published online May 30, 2025
-
|
Question: Does high-protein enteral nutrition better increase the average nitrogen balance (NB) and decrease the intestinal fatty acid-binding protein (I-FABP) level of critically ill postoperative children than standard-protein enteral nutrition?
Finding: The study demonstrated a significant increase in average NB but no significant decrease in I-FABP levels in the high- versus low-protein group.
Meaning: These findings suggest that high-protein enteral nutrition can improve NB in critically ill postoperative children, thereby supporting their recovery. |
-
-
- Review Article
- Allergy
- Eosinophil-derived neurotoxin levels can predict allergic disease development and atopic march in children
(46 times)
-
Zak Callaway, Chang-Keun Kim
-
Clin Exp Pediatr. 2025;68(6):398-405. Published online February 3, 2025
-
|
· Allergic march occurs in a subset of children, beginning with atopic dermatitis and progressing to food allergies, allergic rhinitis, and/or asthma. Its early diagnosis is important to slowing its progression.
· Eosinophil-derived neurotoxin (EDN), an excellent biomarker of eosinophil activity, is often elevated in allergic diseases.
· EDN levels have been used to predict allergic disease development and diagnose, treat, and monitor allergic diseases. |
-
-
- Editorial
- Other
- Beyond the eye: a multidisciplinary perspective on managing pediatric myopia
(46 times)
-
Eoi Jong Seo
-
Clin Exp Pediatr. 2025;68(8):566-568. Published online July 18, 2025
-
|
Myopia is a growing global public health concern because of its association with irreversible vision loss such as myopic traction maculopathy, rhegmatogenous retinal detachment, and glaucoma. The effective prevention of myopia in childhood requires a multidisciplinary approach that integrates ophthalmologic care with lifestyle, nutrition, and sleep interventions. Early detection through regular visual screening in schools and primary care settings and timely ophthalmology referrals are critical to preventing high myopia. |
-
-
- Neonatology (Perinatology)
- Intermittent sigh breaths during high-frequency oscillatory ventilation among newborn infants
(45 times)
-
Ga Won Jeon
-
Clin Exp Pediatr. 2025;68(7):486-488. Published online April 16, 2025
-
|
Intermittent sigh breaths during high-frequency oscillatory ventilation can improve ventilation and oxygenation by enhancing lung recruitment. Although research on this approach in newborn infants is limited, some published studies suggest that sigh breaths are generally applied at a rate of 2–3 breaths/min with an inspiratory time of 0.5–1 second and pressure of current mean airway pressure + 5 cmH2O (maximum, 30 cmH2O). |
-
-
- Original Article
- Hematology
- Peripheral blood cell counts of prematurely born, small for gestational age neonates
(45 times)
-
Mara O. Zuiderwijk, Sophie Groene, Enrico Lopriore, Vincent Bekker, Michiel H.D. Schoenaker
-
Clin Exp Pediatr. 2026;69(7):572-581. Published online May 12, 2026
-
|
Question: As small for gestational age (SGA) neonates are more susceptible to infections, we hypothesized that their complete blood count and leukocyte differentiation might be affected.
Finding: The counts of multiple blood cells of extreme SGA neonates were affected as illustrated by multivariate analyses, which showed significant decreases in neutrophil, monocyte, lymphocyte, and thrombocyte counts.
Meaning: The mechanisms underlying this phenomenon and its clinical effects require further elucidation. |
-
-
- Guideline
- Infection
- Recommendation for use of 15- and 20-valent pneumococcal conjugate vaccines in Korean infants and children
(45 times)
-
Ki Wook Yun, Dong Hyun Kim, Jong Gyun Ahn, Byung-Wook Eun, Jin Lee, Jina Lee, Taek-Jin Lee, Hyunju Lee, Dae Sun Jo, Eun Young Cho, Hye-Kyung Cho, Soo-Han Choi, Young June Choe, Ui Yoon Choi, Yun-Kyung Kim; The Committee on Infectious Diseases of the Korean Pediatric Society
-
Clin Exp Pediatr. 2026;69(1):76-83. Published online December 30, 2025
-
|
|
Compared to PCV13, PCV15 includes 2 (22F and 33F), and PCV20 includes 7 (8, 10A, 11A, 12F, 15B, 22F, and 33F) additional serotypes. The vaccination schedule remains the same: primary doses at 2, 4, and 6 months, and a booster at 12–15 months. If PCV13 was administered in the primary series, PCV15 and PCV20 may be used to complete it or as a booster. |
-
-
- Original Article
- Pulmonology
- Telomere biology disorders associated with childhood interstitial lung disease
(44 times)
-
Maria Greiner-Mai, Christina Katharina Rapp, Katrin Knoflach, Daniel Gräfe, Franz Wolfgang Hirsch, Julia Ley-Zaporozhan, Simone Reu-Hofer, Julia Hentschel, Stefan Zielen, Monika Helena Tedy, Heymut Omran, Ernst Rietschel, Tuğba Sismanlar Eyuboglu, Ayse Tana-Aslan, Nagehan Emiralioglu, Nicola Ullmann, Samuele Naviglio, Massimo Maschio, Fabian Beier, Tuğba Ramaslı Gürsoy, Matthias Griese, Freerk Prenzel
-
Clin Exp Pediatr. 2026;69(7):593-603. Published online June 18, 2026
-
|
Question: What are the pulmonary manifestations and clinical characteristics of telomere biology disorders in children with interstitial lung disease?
Finding: Telomere biology disorders are an important but often underrecognized cause of childhood interstitial lung disease and are associated with variable pulmonary, radiologic, and histopathologic findings, frequent multisystem involvement, and often severe disease progression.
Meaning: Early genetic testing and multidisciplinary evaluation are essential for timely diagnosis, optimized management, and improved outcomes in affected children. |
-
-
- Neonatology (Perinatology)
- Thrombocytopenia in preterm infants born to mothers with systemic lupus erythematosus: a retrospective cohort study
(43 times)
-
Ru Xue, Guoqing Zhang, Xiafang Chen, Jun Bu, Lanlan Mi, Fei Bei
-
Clin Exp Pediatr. 2026;69(3):266-273. Published online December 22, 2025
-
|
Question: What are the characteristics and clinical implications of thrombocytopenia in preterm neonates born to mothers with systemic lupus erythematosus?
Finding: Nearly one-third of preterm infants developed thrombocytopenia. Key modulators of this risk included gestational age, maternal hypertensive disorders of pregnancy, and hydroxychloroquine use. Thrombocytopenia may be associated with neonatal morbidity.
Meaning: Platelet count should be monitored during the first week of life, and infants should be assessed for potential complications. |
-
-
- Context-dependent features of transcriptomic landscapes in pregnant mother-neonate dyads of preeclampsia
(43 times)
-
Yu-Chun Cheng, Yun-Ju Lai, Wei-Shiung Lian, Ching-Chang Tsai, Hsin-Hsin Cheng, Hong-Ren Yu, Mao-Meng Tiao, Jiunn-Ming Sheen, Ying-Lun Hsu, Feng-Sheng Wang, I-Chun Lin
-
Clin Exp Pediatr. 2026;69(5):394-406. Published online February 19, 2026
-
|
Question: What genes are commonly altered in mother-neonate dyads immediately after shared exposure to preeclampsia?
Finding: Perinatal/peripartum gene expression in preeclampsia is context-dependent, involves diverse signaling pathways, and is associated with some perinatal features.
Meaning: Our results may help build the fundamentals for managing future cardiometabolic risks in these populations. Further investigation of the long-term influence of these candidate genes on cardiometabolic phenotypes is required. |
-
-
- Association between impaired renal function based on decline in serum creatinine level and brain injury in neonates with hypoxic-ischemic encephalopathy
(43 times)
-
Mélaine Boget, William Rozalen, Jeanne Fayard, Mohamed Boucekine, Diane Gillot, Isabelle Grandvuillemin, Farid Boubred
-
Clin Exp Pediatr. 2026;69(5):437-442. Published online April 27, 2026
-
|
Question: The clinical relevance of impaired renal function (IRF), based on the rate of serum creatinine level decline during the week after birth, in neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy need further investigation.
Finding: In this study, neonates with IRF had 2-fold higher risk of early death or severe brain injury.
Meaning: IRF can be used as a marker of adverse neonatal outcomes. |
-
-
- Association between base excess levels and clinical outcomes among very low birth weight infants: a multicenter birth cohort study in South Korea
(43 times)
-
Ji Yoo Kim, Hyeon Jin Kim, Heeyoon Choi, Minji Kim, Jinseok Lee, Yong Sung Choi, Dong Keon Yon
-
Clin Exp Pediatr. 2026;69(7):555-562. Published online May 21, 2026
-
|
Question: Is metabolic acidosis at birth in very low birth weight infants (VLBWIs) associated with long-term clinical outcomes?
Finding: Metabolic acidosis at birth was associated with increased mortality, adverse respiratory outcomes, neurological morbidities, and infection-related and gastrointestinal outcomes.
Meaning: VLBWIs with metabolic acidosis are at high risk of systemic complications. This finding emphasizes the need for close monitoring and comprehensive care. |
-
-
- Review Article
- Nephrology (Genitourinary)
- Effects of diethylene glycol contamination of pharmaceutical products on unexplained acute kidney injury in children: a systematic review
(42 times)
-
Sani Rachman Soleman, Muhammad Luthfi Adnan, Hilmi Ardian Sudiarto, Satria Bintang Mahathma, Alya Ayu Tazkia, Hana Afifah Firdaus, Alfreda Amelia Khotijah, Miranti Dewi Pramaningtyas, Emi Azmi Choironi
-
Clin Exp Pediatr. 2024;67(8):395-402. Published online January 4, 2024
-
|
A recent unexplained acute kidney injury (AKI) outbreak due to pharmaceutical product contamination with diethylene glycol (DEG) raises public attention. Our study revealed that DEG-contaminated paracetamol causes unexplained AKI in children. However, paracetamol is not the only contaminated drug. Other drugs, such as cough expectorants, antihistamines, and sedatives, can also be affected. Other chemicals, such as ethylene glycol and propylene glycol, can also contribute to poisonings. |
-
-
- Allergy
- Skin and oral intervention for food allergy prevention based on dual allergen exposure hypothesis
(42 times)
-
Kiwako Yamamoto-Hanada, Yukihiro Ohya
-
Clin Exp Pediatr. 2024;67(10):477-485. Published online June 14, 2023
-
|
To prevent food allergy in infants, based on the dual allergen exposure hypothesis, we recommend a personalized approach consisting of both skin intervention (eczema treatment to achieve early remission and well-controlled skin without eczema to prevent percutaneous immunoglobulin E sensitization) and oral intervention (early allergenic food introduction). |
-
-
- Original Article
- Hematology
- Treatment and clinical outcomes of pediatric autoimmune hemolytic anemia: real-world single-center data from Korea
(42 times)
-
Young Dai Kwon, Eun Sun Jung, Yeon Jung Lim
-
Clin Exp Pediatr. 2025;68(7):522-529. Published online April 16, 2025
-
|
Question: Can pediatric autoimmune hemolytic anemia (AIHA) be effectively managed using first-line steroids?
Finding: In this single-center study, pediatric patients with AIHA achieved normal hemoglobin levels within 16.5 days (range, 9.0–22.0 days) of first-line steroid treatment and maintained effective responses for 2 months.
Meaning: These outcomes highlight the efficacy of steroid treatment in pediatric versus adult AIHA and underscore the need for multicenter trials to establish standardized treatment guidelines. |
-
-
- Review Article
- Endocrinology
- A review of vitamin D deficiency and vitamin D receptor polymorphisms in endocrine-related disorders
(41 times)
-
Nur Faten Hafizah Rosli, Noor Shafina Mohd Nor, Rose Adzrianee Adnan, Siti Hamimah Sheikh Abdul Kadir
-
Clin Exp Pediatr. 2025;68(1):30-52. Published online November 6, 2024
-
|
· The prevalence of vitamin D deficiency is high among children and adolescents and mainly attributed to changes in environmental factors.
· Vitamin D hormone-like properties are associated with many endocrine-related disorders.
· The effect of vitamin D is modulated by the vitamin D receptor, polymorphisms of which are reportedly associated with an increased risk of disease development in children and adolescents. |
-
-
- Other
- Cost-effectiveness of newborn screening for severe combined immunodeficiency: a systematic review
(41 times)
-
Rezwanul Rana, Syed Afroz Keramat, Moin Ahmed
-
Clin Exp Pediatr. 2025;68(9):628-640. Published online April 16, 2025
-
|
Universal newborn screening for severe combined immunodeficiency (SCID) demonstrates robust cost-effectiveness across diverse high-income healthcare systems, both from healthcare and societal standpoints. Early detection yields substantial savings. While uncertainties persist, impacting precise cost-effectiveness, the overall finding is positive. Future research must prioritize enhanced data collection and statistical rigor to refine our understanding of SCID's economic impact within the Australian context. |
-
-
- Editorial
- Other
- Further research on impact of microplastics on children's health is essential to protecting future generations
(40 times)
-
Jongin Lee, Dong-Wook Lee
-
Clin Exp Pediatr. 2025;68(5):359-361. Published online November 13, 2024
-
|
|
· The ecological impacts of microplastics have been documented. It was recently recognized that they can directly or indirectly cause diseases in humans.
· There are few established methods for assessing human exposure to microplastics.
· Standardization of exposure assessments and large-scale epidemiological studies are required to explore the human effects of microplastics. |
-
-
- Pulmonology
- Clinical course of children with postinfectious bronchiolitis obliterans with versus without comorbid bronchopulmonary dysplasia
(40 times)
-
Lamia Medghoul, Julien Grosjean, Christophe Marguet, Hortense Petat
-
Clin Exp Pediatr. 2025;68(7):497-502. Published online April 1, 2025
-
|
Question: Postinfectious bronchiolitis obliterans (PIBO) is a chronic respiratory disease that typically develops in children after a severe respiratory infection. Bronchopulmonary dysplasia (BPD) is often comorbid in patients with PIBO.
Finding: Corticosteroid pulse therapy effectively manages PIBO with or without comorbid BPD, significantly reducing exacerbations and decreasing the daily requirement for inhaled corticosteroids.
Meaning: Therapeutic effects of corticosteroid pulses are rapid and sustained over time, in both groups. |
-
-
- Neonatology (Perinatology)
- Less invasive surfactant administration versus intubation-surfactant-extubation: a single-center retrospective study
(40 times)
-
C.S. Jithin, A. Nalina, A. Shashidhar, P.N. Suman Rao
-
Clin Exp Pediatr. 2025;68(12):991-997. Published online October 2, 2025
-
|
Question: Does less invasive surfactant administration (LISA) (vs. intubation-surfactant-extubation) improve clinical outcomes in preterm infants with respiratory distress syndrome?
Finding: LISA significantly reduced intubation and invasive mechanical ventilation needs within the first 72 hours and shortened the overall invasive respiratory support duration without increasing other morbidities.
Meaning: LISA is a less invasive and safer surfactant delivery alternative. Larger multicenter trials are needed to confirm its long-term safety and efficacy, especially in low- and middle-income countries. |
-
-
- Nephrology (Genitourinary)
- Assessing kidney outcomes in childhood-onset lupus nephritis: role of National Institutes of Health-modified histological indices
(40 times)
-
Nuanpan Penboon, Pornpimol Rianthavorn
-
Clin Exp Pediatr. 2026;69(2):130-139. Published online October 23, 2025
-
|
Question: In children with proliferative lupus nephritis, do National Institutes of Health-modified indices and treatment choices predict long-term kidney function?
Finding: Higher chronicity index scores, especially tubular atrophy and interstitial fibrosis, predicted kidney impairment. Additionally, the use of mycophenolate mofetil (MMF) for maintenance therapy was associated with a lower risk of kidney function decline.
Meaning: The early recognition of chronic lesions and MMF-based maintenance therapy may improve kidney outcomes in childhood-onset lupus nephritis. |
-
-
- Review Article
- Hematology
- Iron deficiency in children with a focus on inflammatory conditions
(39 times)
-
Na Hee Lee
-
Clin Exp Pediatr. 2024;67(6):283-293. Published online May 21, 2024
-
|
· Iron deficiency has important effects on neurodevelopment and the immune system in children.
· Hepcidine plays an important role in iron homeostasis.
· Diagnosis and treatment of iron deficiency in chronic inflammatory disease are important for patients' quality of life and disease course. |
-
-
- Perspective
- General Pediatrics
- Parenting principles to combat attention-deficit/hyperactivity disorder and form resilient young minds
(37 times)
-
Jandy Le, Sandhya J. Kadam
-
Clin Exp Pediatr. 2025;68(10):838-841. Published online September 22, 2025
-
|
The prevalence of attention-deficit/hyperactivity disorder, conduct disorder, and other related behavioral problems is increasing among children, likely due to less interaction with their parents and the real world and more time spent on screens, on social media, and in the virtual world. This article highlights several simple, basic parenting principles to facilitate the growth of healthy, resilient minds and combat the symptoms of opposition, hyperactivity, and distractibility. |
-
-
- Review Article
- Endocrinology
- Association between pre- and postnatal exposure to endocrine-disrupting chemicals and birth and
neurodevelopmental outcomes: an extensive review
(36 times)
-
Ozge Yesildemir, Mensure Nur Celik
-
Clin Exp Pediatr. 2024;67(7):328-346. Published online November 16, 2023
-
|
· Sensitivity to endocrine-disrupting chemical (EDC) exposure increases during critical developmental periods (in embryos, fetuses, and neonates).
· Pre- and postnatal exposure to EDCs is associated with fetal growth restriction, preterm birth, and low birth weight.
· Exposure to EDCs during fetal and early postnatal life can have lasting and lifelong neurodevelopmental outcomes, including autism spectrum, attention deficit hyperactivity, and other cognitive and behavioral disorders. |
-
-
- Adolescence Medicine
- Diet-related behaviors affecting health and substance use among children and adolescents
(36 times)
-
Ji-Hyun Seo, Sochung Chung
-
Clin Exp Pediatr. 2024;67(12):664-671. Published online October 31, 2024
-
|
· Diet behaviors in children and adolescents are influenced by environmental and sociocultural factors.
· Unhealthy diet behaviors and poor diet quality are the main contributing factors to noncommunicable diseases and mental health problems during childhood and adolescence.
· Smoking and alcohol drinking in children and adolescents may be associated with unhealthy diet behavior or poor diet quality. |
-
-
