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"Most downloaded" Articles are from the articles published in 2021 during the last six months.
- Original Article
- Nutrition
- Survey of Korean pediatrician’s perceptions of barriers to and improvements in breastfeeding (49 times)
- Seong Phil Bae, Woo Ryoung Lee, Won-Ho Hahn, Hye-Jung Shin, Young Min Ahn, Son Moon Shin, Yong Joo Kim, Ellen Ai-Rhan Kim, Youn Jeong Shin, Dae Yong Yi, Soon Min Lee, Juyoung Lee, Jin A Lee, Sung-Hoon Chung, Euiseok Jung, Eui Kyung Choi, Ju Sun Heo
- Clin Exp Pediatr. 2022;65(11):540-546. Published online July 29, 2022
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Question: What barriers to breastfeeding do Korean pediatricians perceive?
Finding: Regardless of medical institution, breastfeeding counseling for parents is currently limited, and breastfeeding is commonly discontinued due to various maternal and neonatal factors.
Meaning: To promote breastfeeding, increasing pediatrician participation in breastfeeding counseling with the establishment of appropriate breastfeeding counseling fees and the expansion of practical and high-quality breastfeeding education for medical staff should be considered.
- Letter to the Editor
- Critical Care Medicine
- Role of serum bilirubin-to-albumin ratio as a prognostic index in critically ill children (49 times)
- You Min Kang, Ga Eun Kim, Mireu Park, Jong Deok Kim, Min Jung Kim, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Son, Soo Yeon Kim
- Clin Exp Pediatr. 2023;66(2):85-87. Published online December 5, 2022
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- Review Article
- General Pediatrics
- Clinical features, diagnosis, and outcomes of multisystem inflammatory syndrome in children associated with coronavirus disease 2019 (48 times)
- Ji Hee Kwak, Soo-Young Lee, Jong-Woon Choi; the Korean Society of Kawasaki Disease
- Clin Exp Pediatr. 2021;64(2):68-75. Published online December 30, 2020
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Hundreds of cases of children and adolescents with hyperinflammatory responses such as Kawasaki disease have been reported amid the coronavirus disease 2019 (COVID-19) pandemic, leading to coining of the new term COVID-19–associated multisystem inflammatory syndrome in children. In this review article, we introduce the illness and describe its case definitions, epidemiology, pathogenesis, clinical features, treatments, and outcomes.
- Neurobehavior
- Psychological aspects in children and parents of children with chronic kidney disease and their families (48 times)
- Alemsungla Aier, Priya Pais, Vijaya Raman
- Clin Exp Pediatr. 2022;65(5):222-229. Published online November 10, 2021
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· Childhood chronic kidney disease (CKD) is complex and requires lifetime medical treatment.
· Children with CKD are at risk for emotional, behavioral, social, and academic difficulties that significantly affect their quality of life.
· Caring for children with CKD is stressful for families.
· These unique challenges are crucial and can negatively impact treatment outcomes.
· Awareness of and addressing these evolving psychosocial issues can foster their developing needs.
- Gastroenterology
- Changing prevalence of Helicobacter pylori infection in children and adolescents (47 times)
- Ji Sook Park, Jin Su Jun, Ji-Hyun Seo, Hee-Shang Youn, Kwang-Ho Rhee
- Clin Exp Pediatr. 2021;64(1):21-25. Published online July 15, 2020
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Although Helicobacter pylori infection rate in children is unclear due to diversity and limitation of diagnostic tests unlike in adults, investigation the childhood prevalence is important for predicting H. pylori-related diseases in the future.
H. pylori infection occurred in early childhood, and declined during 30 years in our study.
Change in risk factors of H. pylori transmission and consensus for eradication therapy in children might further reduce the infection rate.
- Original Article
- Neonatology (Perinatology)
- Mediation effect of cord blood cortisol levels between maternal prepregnancy body mass index and birth weight: a hospital-based cross-sectional study (47 times)
- Nisanth Selvam, Jayashree K, Prasanna Mithra
- Clin Exp Pediatr. 2022;65(10):500-506. Published online July 29, 2022
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Question: What is the association between cord blood cortisol and maternal weight, birth weight, and cord blood lipid profile?
Finding: Cord blood cortisol levels did not influence the relationship between maternal weight changes or birth weight. Maternal weight changes, birth weight, and cortisol levels altered the cord blood lipid profile.
Meaning: Our findings may aid United Nations Sustainable Development Goal 3 (Good Health and Well-Being) achievement by 2030.
- Review Article
- Critical Care Medicine
- Ferritin in pediatric critical illness: a scoping review (47 times)
- Ivy Cerelia Valerie, Anak Agung Sagung Mirah Prabandari, Dyah Kanya Wati
- Clin Exp Pediatr. 2023;66(3):98-109. Published online September 16, 2022
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The number of studies on ferritin predictive ability in pediatric critical illness has grown exponentially over the past 2 decades. However, among the 66 of 1,580 studies analyzed here, summary statistics for overall and condition-specific studies were only reported in 45.4% and 71.2%, respectively. In contrast, ferritin as a categorical variable with a preset threshold was a significant predictor in 84.6% of studies.
- Letter to the Editor
- Endocrinology
- Accuracy of predicted adult height using the Greulich-Pyle method and artificial intelligence medical device (47 times)
- Dongho Cho, Yun Sun Choi, Hayun Oh, Young min Ahn, Ji-Young Seo
- Clin Exp Pediatr. 2023;66(3):145-147. Published online January 25, 2023
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- Original Article
- General Pediatrics
- Global relationship between parent and child obesity: a systematic review and meta-analysis (44 times)
- Ju Suk Lee, Mi Hyeon Jin, Hae Jeong Lee
- Clin Exp Pediatr. 2022;65(1):35-46. Published online March 29, 2021
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Question: Are parent and child obesity correlated worldwide?
Finding: Overweight and obese status of parents and children were significantly associated worldwide. The association between parent and child obesity was stronger in Asia than in Europe and the Middle East, and in high-income than in middle- and low-income countries.
Meaning: Childhood obesity is highly influenced by parental weight status, indicating that parents could play an important role in its prevention.
- Review Article
- Infection
- Updates on the coronavirus disease 2019 vaccine and consideration in children (44 times)
- Hyun Mi Kang, Eun Hwa Choi, Yae-Jean Kim
- Clin Exp Pediatr. 2021;64(7):328-338. Published online June 21, 2021
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· The number of coronavirus disease 2019 cases has exponentially increased worldwide, and children ≤19 years old account for 11.0% of all confirmed cases.
· mRNA vaccines, BNT162b2 and mRNA-1273, and adenoviral vector vaccines, AZD1222 and Ad26.COV2.S, authorized for emergency use in the Emergency Use Listing of the World Health Organization are reviewed.
· Clinical trials of these vaccines have shown that they are safe and serious adverse reactions are rarely observed.
- Editorial
- Emergency Medicine
- Current diagnosis and image-guided reduction for intussusception in children: teamwork approach (44 times)
- Ji-Hyun Seo
- Clin Exp Pediatr. 2023;66(2):66-67. Published online September 1, 2022
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· The successful and safe enema reduction of intussusception depends primarily on the experience and preference of the radiologists and the availability of resources.
· The establishment of a standardized manual or protocol for reduction and pre-reduction treatment of intussusception, along with the collaboration of pediatricians, radiologists, and surgeons, is expected to improve the treatment success rate.
- Review Article
- Endocrinology
- Endocrine comorbidities of pediatric obesity (43 times)
- Jieun Lee, Jae Hyun Kim
- Clin Exp Pediatr. 2021;64(12):619-627. Published online August 26, 2021
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∙ Pediatric obesity can involve endocrine comorbidities such as prediabetes, type 2 diabetes, dyslipidemia, metabolic syndrome, polycystic ovary syndrome, and central precocious puberty.
∙ Prediabetes and type 2 diabetes in youth aged 10–19 years had a prevalence of 25.9% and 0.6% in 2013–2014, respectively.
∙ Dyslipidemia in Korean adolescents aged 10–18 years had a prevalence of 7.64% (total cholesterol ≥200 mg/dL), 6.09% (low-density lipoprotein cholesterol ≥130 mg/dL), 8.69% (triglyceride ≥150 mg/dL), and 12.52% (high-density lipoprotein cholesterol ≤40 mg/dL) in 2007–2018.
∙ Metabolic syndrome in Korean youth has a prevalence of 1.9%–14.7% in males and 1.7%–12.6% in females with wide variation in definitions.
∙ Appropriate comorbidity screening and management and/or specialist referral are necessary for obese children and adolescents.
- Original Article
- General Pediatrics
- Early initiation of breastfeeding and factors associated with its delay among mothers at discharge from a single hospital (43 times)
- J. Jenifer Florence Mary, R. Sindhuri, A. Arul Kumaran, Amol R. Dongre
- Clin Exp Pediatr. 2022;65(4):201-208. Published online October 18, 2021
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Background: According to the National Family Health Survey– 4, in India, 78.9% of deliveries occur in institutions, although only 42.6% of new mothers initiate breastfeeding within 1 hour of delivery.
Purpose: To estimate the proportion of early initiation of breastfeeding (EIBF) among new mothers at discharge from a tertiary care hospital and identify the determinants of delayed initiation of breastfeeding among...
- Other
- Risk factors and screening timing for developmental dysplasia of the hip in preterm infants (43 times)
- Ga Won Jeon, Hye Jung Choo, Yong Uk Kwon
- Clin Exp Pediatr. 2022;65(5):262-268. Published online November 5, 2021
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Question: When is the best screening timing and what is the risk factor for developmental dysplasia of the hip (DDH) in preterm infants?
Finding: Ultrasonography performed earlier than 38 weeks of postmenstrual age caused unnecessary subsequent ultrasonography. DDH did not occur predominantly on the left side or in breech infants.
Meaning: The screening timing, etiology, and risk factors for DDH in preterm infants are somewhat different from those in term infants.
- Review Article
- Cardiology
- Diagnosis of coronary artery abnormalities in Kawasaki disease: recent guidelines and z score systems (43 times)
- Sung Hye Kim
- Clin Exp Pediatr. 2022;65(9):430-438. Published online December 17, 2021
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∙ Kawasaki disease is the leading cause of acquired heart disease among children in the developed countries, and Korea has the second-highest incidence in the world.
∙ Early diagnosis and proper treatment are imperative to prevent coronary complication, and evaluation of coronary artery abnormalities is fundamental.
∙ Recent guidelines have adapted z score system for the diagnosis of coronary artery abnormalities in Kawasaki disease.
∙ Applying z score in diagnosis of coronary abnormalities has better correlation with clinical outcomes than absolute cutoff values.
∙ Calculated z scores could be different according to the z score formula, which might influence the treatment plan.
- Neurology
- Big data analysis and artificial intelligence in epilepsy – common data model analysis and machine learning-based seizure detection and forecasting (42 times)
- Yoon Gi Chung, Yonghoon Jeon, Sooyoung Yoo, Hunmin Kim, Hee Hwang
- Clin Exp Pediatr. 2022;65(6):272-282. Published online November 26, 2021
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· Big data analysis, such as common data model and artificial intelligence, can solve relevant questions and improve clinical care.
· Recent deep learning studies achieved 0.887–0.996 areas under the receiver operating characteristic curve for automated interictal epileptiform discharge detection.
· Recent deep learning studies achieved 62.3%–99.0% accuracy for interictal-ictal classification in seizure detection and 75.0%– 87.8% sensitivity with a 0.06–0.21/hr false positive rate in seizure forecasting.
- Editorial
- Pulmonology
- Now lung ultrasound has been established as a fundamental examination in pediatric respiratory diseases (42 times)
- Kyunghoon Kim
- Clin Exp Pediatr. 2022;65(8):401-402. Published online July 13, 2022
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· Several studies demonstrated the usefulness of lung ultrasound in pediatric respiratory diseases including coronavirus disease 2019.
· Knowledge of lung ultrasound is increasing, and lung ultrasound has been established as a fundamental diagnostic examination for pediatric respiratory diseases.
- Review Article
- Gastroenterology
- Causes of acute gastroenteritis in Korean children between 2004 and 2019 (41 times)
- Eell Ryoo
- Clin Exp Pediatr. 2021;64(6):260-268. Published online September 18, 2020
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· Norovirus is the most common virus in Korean children with acute gastroenteritis.
· Escherichia coli and Salmonella spp. are the most common cause of bacterial gastroenteritis in Korean children, with a detection rate of 3%–20%.
· Uncommon bacterial and parasitic gastroenteritis require attention because of increasing international exchange and overseas travel.
- Neurology
- Myths and truths about pediatric psychogenic nonepileptic seizures (41 times)
- Jung Sook Yeom, Heather Bernard, Sookyong Koh
- Clin Exp Pediatr. 2021;64(6):251-259. Published online October 17, 2020
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• Psychogenic non-epileptic seizures (PNES) are events that look like epileptic seizures but are not caused by abnormal electrical discharges.
• PNES are a manifestation of psychological and emotional distress.
• Treatment for PNES does not begin with the psychological intervention but starts with the diagnosis and how the diagnosis is delivered.
• A multifactorial biopsychosocial process and a neurobiological review are both essential components when treating PNES
- Cardiology
- Application of CRISPR-Cas9 gene editing for congenital heart disease (41 times)
- Heeyoung Seok, Rui Deng, Douglas B. Cowan, Da-Zhi Wang
- Clin Exp Pediatr. 2021;64(6):269-279. Published online March 2, 2021
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Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR-Cas9) system has made a big step in the genome editing which still requires technical developments for the efficient applications in the many fields including congenital heart diseases (CHDs), closely related to the genomic abnormality. In this review, we tried to cover the most updated researches of CRISPR-Cas9 in the CHDs to understand the current technologies, eventually becoming therapeutic bases for the CHD patients.
- Letter to the Editor
- Developmental and Behavioral Medicine
- The influence of parental eating behaviors, child-feeding practices, and infants’ temperaments upon infants’ eating behaviors (41 times)
- Goh Woon Lim, Kyoung Min Shin
- Clin Exp Pediatr. 2022;65(9):466-468. Published online June 27, 2022
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- Review Article
- Other
- Behavioral insomnia in infants and young children (40 times)
- Eun Kyeong Kang, Seung Soo Kim
- Clin Exp Pediatr. 2021;64(3):111-116. Published online July 15, 2020
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• Behavioral insomnia is common and affects a child’s daytime functioning and emotions.
• Diagnosing insomnia using the child’s sleep history, a sleep diary/log, and sleep questionnaires is important.
• Behavioral intervention, the main treatment, involves creating positive associations with sleep, establishing a consistent sleep schedule and bedtime routines, and the development of selfsoothing skills.
- Original Article
- Neonatology (Perinatology)
- Predictive factors of death in neonates with hypoxic-ischemic encephalopathy receiving selective head cooling (40 times)
- Behnaz Basiri, Mohammadkazem Sabzehei, Mohammadmahdi sabahi
- Clin Exp Pediatr. 2021;64(4):180-187. Published online August 27, 2020
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Question: What is the most important factor that increases mortality in infants with hypoxic-ischemic encephalopathy (HIE) who receive selective head cooling?
Finding: All cases of neonatal mortality were severe HIE (stage 3), and a severely abnormal amplitude-integrated electroencephalography and mortality were increased with the need for advanced neonatal resuscitation upon delivery.
Meaning: Advanced neonatal resuscitation affects HIE outcomes, and medical personnel should be prepared to provide the best intervention.
- Infection
- Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis (40 times)
- Farhad Sarrafzadeh, Seyed Mojtaba Sohrevardi, Hamid Abousaidi, Hossein Mirzaei
- Clin Exp Pediatr. 2021;64(8):415-421. Published online November 20, 2020
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The pooled prevalence of methicillin-resistant Staphylococcus aureus (MRSA) was 42% among culture-positive cases of S. aureus, 51% in hospitalized children, and 14% in healthy children. The high prevalence of MRSA in Iranian children may be due to insufficient infection control measures in hospitals, inappropriate use of methicillin, inadequate staff training, and over-prescription of antibiotics in Iran.
- Original article
- Infection
- The global prevalence of Toxocara spp. in pediatrics: a systematic review and meta-analysis (40 times)
- Behnam Abedi, Mehran Akbari, Sahar KhodaShenas, Alireza Tabibzadeh, Ali Abedi, Reza Ghasemikhah, Marzieh Soheili, Shnoo Bayazidi, Yousef Moradi
- Clin Exp Pediatr. 2021;64(11):575-581. Published online February 5, 2021
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Is the global prevalence of toxocariasis high among children? The prevalence of toxocariasis is high in pediatric patients. Asian children are more susceptible to the disease than other children. Its virulence varies among different socioeconomic classes in various countries. Hand washing after soil contact, routine pet deworming, and appropriate disposal of pet feces in households with Asian pediatrics are needed to prevent toxocariasis.
- Review Article
- Infection
- Therapeutics for the treatment of coronavirus disease 2019 in children and adolescents (40 times)
- Soo-Han Choi, Jae Hong Choi, Ki Wook Yun
- Clin Exp Pediatr. 2022;65(8):377-386. Published online June 27, 2022
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· Children and adolescents with high risks for severe coronavirus disease 2019 (COVID-19) should be identified and proper treatment should be provided promptly according to the patient’s condition.
· Remdesivir can be considered for pediatric patients of all ages with COVID-19 who have an emergent or increase in supplemental oxygen.
· The use of corticosteroids is not recommended for patients with nonsevere COVID-19. Corticosteroids are recommended in children and adolescents with severe and critical COVID-19.
- Original Article
- Gastroenterology
- Ability of polymicrobial probiotic and mono-strain probiotic to reduce functional abdominal pain in children: a randomized clinical trial (40 times)
- Seyed Sajad Jafari, Seyed Mojtaba Hashemi, Bahman Sadeghi, Amir Almasi-Hashiani
- Clin Exp Pediatr. 2022;65(12):589-594. Published online October 31, 2022
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· This study compared the ability of 2 probiotics to reduce and improve functional abdominal pain (FAP) in children.
· In the polymicrobial probiotic (PMP) group, 10.34% of children reported no pain; in the mono-strain probiotic (MSP) group, all patients reported low-degree pain. The mean pain score decreased significantly over time in both groups.
· The use of both PMP and MSP is recommended to reduce pain in patients with FAP.
- Letter to the Editor
- Cardiology
- Early prophylaxis of cardiomyopathy with beta-blockers and angiotensin receptor blockers in patients with Duchenne muscular dystrophy (39 times)
- Heirim Lee, Jinyoung Song, I-Seok Kang, June Huh, Jin A Yoon, Yong Beom Shin
- Clin Exp Pediatr. 2022;65(10):507-509. Published online August 22, 2022
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- Review Article
- Neurology
- Is it really a seizure? The challenge of paroxysmal nonepileptic events in young infants (38 times)
- Seung Yeon Jung, Joon Won Kang
- Clin Exp Pediatr. 2021;64(8):384-392. Published online September 18, 2020
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Paroxysmal nonepileptic events (PNE) comprise of a variety of nonepileptic behaviors and are divided into various types. A more accurate diagnosis is possible by examining the video clip provided by the caregiver. In infants, physiologic PNE accounts for the majority of the PNE. It is important to exclude epilepsy, for which blood tests, electroencephalography, and imaging tests can facilitate differential...
- Editorial
- Neurology
- Increasing our understanding of rotavirus-induced central nervous system manifestations (38 times)
- Jon Soo Kim
- Clin Exp Pediatr. 2022;65(11):536-537. Published online May 6, 2022
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· Diverse clinicoradiological features of central nervous system (CNS) complications in rotavirus infection can be identified with the rapid and wide use of various brain magnetic resonance imaging protocols.
· An increased understanding of the various pathophysiological mechanisms of rotavirus-induced CNS manifestations will enable precise management in the future.
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