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Review Article
Neonatology (Perinatology)
Bronchopulmonary dysplasia: how can we improve its outcomes?
Tae-Jung Sung
Clin Exp Pediatr. 2019;62(10):367-373.   Published online May 17, 2019
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants with multiple factors affected from prenatal to postnatal periods. Despite significant advances in neonatal care over almost 50 years, BPD rates have not decreased; in fact, they may have even increased. Since more preterm infants, even at periviable gestational age, survive today, different stages of lung development affect the...
Original Articles
Developmental and Behavioral Medicine
Effect of omega-3 plus methylphenidate as an alternative therapy to reduce attention deficit-hyperactivity disorder in children
Soleiman Mohammadzadeh, Narmin Baghi, Fayegh Yousefi, Bahar Yousefzamani
Clin Exp Pediatr. 2019;62(9):360-366.   Published online May 20, 2019
Background: Attention deficit-hyperactivity disorder (ADHD) is one of the most common chronic behavioral disorders in school-aged children. Purpose: This study aimed to evaluate the effect of omega-3 supplementation as an alternative therapy for ADHD, which can be caused by vitamin and mineral deficiencies. Methods: This was a double-blinded clinical trial study. Sixty-six children with ADHD (aged 6–12 years) referred to our child...
Allergy
Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis
Yeonu Choi, Haeun Jeon, Eun Ae Yang, Jong-Seo Yoon, Hyun Hee Kim
Clin Exp Pediatr. 2019;62(9):353-359.   Published online April 24, 2019
Background: Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. However, its use as a marker of eosinophilic inflammation in nasal secretions is limited because the diagnostic cutoff values of EPO for use as a one-time test for allergic diseases such as allergic rhinitis have not been established. Purpose: To identify the correlation...
Nutrition
The effect of high fat dietary modification and nutritional status on the outcome of critically ill ventilated children: single-center study
Nehal Mohamed El Koofy, Hanaa Ibrahim Rady, Shrouk Moataz Abdallah, Hafez Mahmoud Bazaraa, Walaa Ahmed Rabie, Ahmed Ali El-Ayadi
Clin Exp Pediatr. 2019;62(9):344-352.   Published online April 2, 2019
Background: Ventilator dependency constitutes a major problem in the intensive care setting. Malnutrition is considered a major determinant of extubation failure, however, attention has been attracted to modulating carbon dioxide production through decreasing carbohydrate loading and increasing the percent of fat in enteral feeds. The detected interrelation between substrate oxidation and ventilation outcome became the base of several research to...
Review Articles
Cardiology
Understanding the importance of cerebrovascular involvement in Kawasaki disease
Jung Sook Yeom, Jae Young Cho, Hyang-Ok Woo
Clin Exp Pediatr. 2019;62(9):334-339.   Published online May 16, 2019
Kawasaki disease (KD) is a systemic vasculitis in infants and young children. However, its natural history has not been fully elucidated because the first case was reported in the late 1960s and patients who have recovered are just now entering middle age. Nevertheless, much evidence has raised concerns regarding the subclinical vascular changes that occur in post-KD patients. KD research...
Allergy
Phenotypes of allergic diseases in children and their application in clinical situations
Eun Lee, Soo-Jong Hong
Clin Exp Pediatr. 2019;62(9):325-333.   Published online April 23, 2019
Allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, are common heterogeneous diseases that encompass diverse phenotypes and different pathogeneses. Phenotype studies of allergic diseases can facilitate the identification of risk factors and their underlying pathophysiology, resulting in the application of more effective treatment, selection of better treatment responses, and prediction of prognosis for each phenotype. In the early phase...
Original Articles
General Pediatrics
Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016–2017 Korea National Health and Nutrition Examination Survey
Jung Hyun Lee
Clin Exp Pediatr. 2019;62(8):317-323.   Published online June 24, 2019
Purpose: Investigating the prevalence of hyperuricemia and its association with metabolic syndrome (MetS) and cardiometabolic risk factors (CMRFs) in Korean children and adolescents. Methods: This cross-sectional survey used data from the 7th Korea National Health and Nutrition Examination Survey (2016–2017); 1,256 males and females aged 10–18 years were included. Hyperuricemia was defined as serum uric acid levels were >6.6 mg/dL at...
Neurology
Evaluation of hematologic profile may be needed for patients treated with oxcarbazepine
Gu Hyun Jung, Su Jeong You
Clin Exp Pediatr. 2019;62(8):312-316.   Published online April 11, 2019
Purpose: The major side effects of treatment with oxcarbazepine (OXC) are skin rash and hyponatremia. Hematologic side effects are reported rarely. The aim of this study was to investigate the rate and types of the hematologic side effects of OXC. Methods: The medical records of 184 patients diagnosed with epilepsy or movement disorder and on OXC monotherapy, at the Department of...
Neonatology (Perinatology)
The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates
Heba Mostafa Ahmed, Nsreen Mostafa Kamel
Clin Exp Pediatr. 2019;62(8):307-311.   Published online March 15, 2019
Purpose: Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport. The aim of this study was to assess the role of epidermal growth factor in the...
Cardiology
Iron deficiency anemia as a predictor of coronary artery abnormalities in Kawasaki disease
Sohyun Kim, Lucy Youngmin Eun
Clin Exp Pediatr. 2019;62(8):301-306.   Published online February 8, 2019
Purpose: Coronary artery abnormalities (CAA) are the most important complications of Kawasaki disease (KD). Iron deficiency anemia (IDA) is a prevalent micronutrient deficiency and its association with KD remains unknown. We hypothesized that presence of IDA could be a predictor of CAA. Methods: This retrospective study included 173 KD patients, divided into 2 groups according to absence (group 1) and presence...
Editorials
Allergy
Why should we monitor for hematologic adverse drug reactions to oxcarbazepine?
Gwang Cheon Jang
Clin Exp Pediatr. 2019;62(8):299-300.   Published online June 24, 2019
Cardiology
Can iron be a risk factor for coronary lesions in Kawasaki disease?
Kyung Lim Yoon
Clin Exp Pediatr. 2019;62(8):297-298.   Published online June 7, 2019
Review Articles
Reality of Kawasaki disease epidemiology
Gi Beom Kim
Clin Exp Pediatr. 2019;62(8):292-296.   Published online July 9, 2019
Epidemiologic studies of Kawasaki disease (KD) have shown a new pattern or change of its occurrence suggestive of its pathophysiology or risk factors from the first patient with KD reported in 1961. The incidence of KD in Northeast Asian countries including Japan, South Korea, China, and Taiwan is 10–30 times higher than that in the United States and Europe. Knowing...

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