Clinical and Experimental Pediatrics

Review Articles

Gastroenterology

The role of fecal calprotectin in pediatric disease

Su Jin Jeong

Clin Exp Pediatr. 2019;62(8):287-291. Published online March 28, 2019

Fecal calprotectin (FC) is a calcium- and zinc-binding protein of the S100 family, mainly expressed by neutrophils and released during inflammation. FC became an increasingly useful tool both for gastroenterologists and for general practitioners for distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome. Increasing evidences support the use of this biomarker for diagnosis, follow-up and evaluation of response to...

DOI: https://doi.org/10.3345/kjp.2019.00059

Original Articles

Neurology

Correlation of serum S100B levels with brain magnetic resonance imaging abnormalities in children with status epilepticus

Prastiya Indra Gunawan, Darto Saharso, Dian Purnama Sari

Clin Exp Pediatr. 2019;62(7):281-285. Published online May 8, 2019

Purpose: To evaluate the association between elevated S100B levels with brain tissue damage seen in abnormalities of head magnetic resonance imaging (MRI; diffusion tensor imaging [DTI] sequence) in patients with status epilepticus (SE). Methods: An analytical observational study was conducted in children hospitalized at Dr Soetomo Hospital, Surabaya, from July to December 2016. The patients were divided into 2 groups: SE...

DOI: https://doi.org/10.3345/kjp.2018.07017

Endocrinology

Comparison of effectiveness of growth hormone therapy according to disease-causing genes in children with Noonan syndrome

Kyo Jin Jo, Yoo Mi Kim, Ju Young Yoon, Yeoun Joo Lee, Young Mi Han, Han-Wook Yoo, Hyang-Sook Kim, Chong Kun Cheon

Clin Exp Pediatr. 2019;62(7):274-280. Published online December 3, 2018

Cited By 1

Purpose: To analyze the growth response to growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations. Methods: Twenty-three patients with prepubertal NS treated at Pusan National University Children’s Hospital between March 2009 and July 2017 were enrolled. According to the disease-causing genes identified, the patients with NS were divided into 4 groups. Three groups were...

DOI: https://doi.org/10.3345/kjp.2018.06842

Neurology

Efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy

Yuni Yun, Dongsub Kim, Yun-Jeong Lee, Soonhak Kwon, Su-Kyeong Hwang

Clin Exp Pediatr. 2019;62(7):269-273. Published online December 26, 2018

Cited By 2

Purpose: There is limited data on the use of perampanel in children under 12 years of age. We evaluated the efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy. Methods: This retrospective observational study was performed in Kyungpook National University Hospital from July 2016 to March 2018. A responder was defined as a...

DOI: https://doi.org/10.3345/kjp.2018.06863

Endocrinology

Secular change in waist circumference and waist-height ratio and optimal cutoff of waist-height ratio for abdominal obesity among Korean children and adolescents over 10 years

Min Sub Kim, Se Young Kim, Jae Hyun Kim

Clin Exp Pediatr. 2019;62(7):261-268. Published online December 3, 2018

Cited By 1

Purpose: This study aimed to evaluate the time trends of waist circumference (WC) and waist-height ratio (WHR), and to present WC and WHR distributions with optimal WHR cutoff for abdominal obesity in Korean children and adolescents. Methods: We performed a retrospective cross-sectional analysis of data from 13,257 children and adolescents (6,987 boys and 6,270 girls) aged 6–18 years who were included...

DOI: https://doi.org/10.3345/kjp.2018.07038

Editorials

Neurology

Perampanel is also a useful adjunctive treatment option in refractory epilepsy in children

Jon Soo Kim, Won Seop Kim

Clin Exp Pediatr. 2019;62(7):259-260. Published online March 5, 2019

DOI: https://doi.org/10.3345/kjp.2019.00108

Endocrinology

Simple universal cutoff point of waist-height ratio for metabolic risk in Korean children and adolescents

Hae Soon Kim

Clin Exp Pediatr. 2019;62(7):257-258. Published online March 28, 2019

DOI: https://doi.org/10.3345/kjp.2019.00045

Review Articles

Eun Hwa Choi, Su Eun Park, Yae-Jean Kim, Dae Sun Jo, Yun-Kyung Kim, Byung-Wook Eun, Taek-Jin Lee, Jina Lee, Hyunju Lee, Ki Hwan Kim, Hye-Kyung Cho, Eun Young Cho, Jong-Hyun Kim

Clin Exp Pediatr. 2019;62(7):252-256. Published online July 15, 2019

Cited By 1

The Committee on Infectious Diseases of the Korean Pediatric Society recommended immunization schedule for children and adolescents aged 18 years or younger in the 9th (2018) edition of Immunization guideline. This report provides the revised recommendations made by the committee and summarizes several changes from the 2015 guideline. National immunization program (NIP) launched a human papillomavirus (HPV) immunization for girls...

DOI: https://doi.org/10.3345/kjp.2019.00227

Neonatology (Perinatology)

Practice for preterm patent ductus arteriosus; focusing on the hemodynamic significance and the impact on the neonatal outcomes

Jin A Lee

Clin Exp Pediatr. 2019;62(7):245-251. Published online April 8, 2019

Cited By 1

Hemodynamically significant preterm patent ductus arteriosus (PDA) affects mortality; comorbidities such as necrotizing enterocolitis, intraventricular hemorrhage, and bronchopulmonary dysplasia; and adverse long-term neurodevelopmental outcomes in preterm infants, particularly in very low birth weight infants. However, recent studies have indicated that there is no consensus on the causal relationship between PDA and neonatal outcomes, the benefit of PDA treatment, the factors...

DOI: https://doi.org/10.3345/kjp.2018.07213

Corrigendum: Correction of the fourth author’s name and institution

Corrigendum: Cardiac function associated with home ventilator care in Duchenne muscular dystrophy

Sangheun Lee, Heeyoung Lee, Lucy Youngmin Eun, Seung-Woong Gang

Clin Exp Pediatr. 2019;62(6):244-244. Published online June 14, 2019

DOI: https://doi.org/10.3345/kjp.2018.61.2.59.e1
Corrects: Clin Exp Pediatr 2018;61(2):59

Original Articles

Cardiology

Change of coronary artery indices according to coronary dominance pattern in early childhood

Yoon jin Lee, Kyoung Soo Park, Hong Ryang Kil

Clin Exp Pediatr. 2019;62(6):240-243. Published online November 22, 2018

Cited By 1

Purpose: Coronary arterial lesion assessment in children can be difficult, depending on the coronary dominance pattern. Although it is easier to determine coronary dominance with echocardiography in children than in adults, it is still difficult. This study aimed to examine the coronary dominance pattern according to the objective coronary artery (CA) indices. Methods: The CA diameter, aortic valve annulus, and abdominal...

DOI: https://doi.org/10.3345/kjp.2018.07129

High antistreptolysin O titer is associated with coronary artery lesions in patients with Kawasaki disease

Dong Eun Min, Do Hee Kim, Mi Young Han, Sung Ho Cha, Kyung Lim Yoon

Clin Exp Pediatr. 2019;62(6):235-239. Published online November 7, 2018

Cited By 1

Purpose: In Kawasaki disease (KD) patients, coronary artery complications, incomplete and refractory types occur more frequently in patients with streptococcal or other bacterial/viral infections. Recently, we observed a higher incidence of coronary lesions in KD patients with high anti-streptolysin O (ASO) titer. Therefore, we hypothesized that KD patients diagnosed with concurrent streptococcal infection have poor prognosis, with respect to treatment...

DOI: https://doi.org/10.3345/kjp.2018.06989

Genetics and Metabolism

Clinical and molecular characterization of Korean children with infantile and late-onset Pompe disease: 10 years of experience with enzyme replacement therapy at a single center

Min-Sun Kim, Ari Song, Minji Im, June Huh, I-Seok Kang, Jinyoung Song, Aram Yang, Jinsup Kim, Eun-Kyung Kwon, Eu-Jin Choi, Sun-Ju Han, Hyung-Doo Park, Sung Yoon Cho, Dong-Kyu Jin

Clin Exp Pediatr. 2019;62(6):224-234. Published online October 4, 2018

Cited By 1

Purpose: Pompe disease (PD) is an autosomal recessive disorder caused by a deficiency of acid alphaglucosidase resulting from pathogenic GAA variants. This study describes the clinical features, genotypes, changes before and after enzyme replacement therapy (ERT), and long-term outcomes in patients with infantile-onset PD (IOPD) and late-onset PD (LOPD) at a tertiary medical center. Methods: The medical records of 5 Korean...

DOI: https://doi.org/10.3345/kjp.2018.06968

Neonatology (Perinatology)

Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis

Rocky Wilar

Clin Exp Pediatr. 2019;62(6):217-223. Published online October 8, 2018

Cited By 4

Purpose: To determine the diagnostic value of eosinopenia and the neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of early onset neonatal sepsis (EONS). Methods: This cross-sectional study was conducted in the Neonatology Ward of R.D. Kandou General Hospital Manado between July and October 2017. Samples were obtained from all neonates meeting the inclusion criteria for EONS. Data were encoded using logistic regression...

DOI: https://doi.org/10.3345/kjp.2018.06723

Editorials

Cardiology

Importance of coronary artery dominance in children to determine coronary artery dilatation

Hee Joung Choi

Clin Exp Pediatr. 2019;62(6):215-216. Published online May 3, 2019

DOI: https://doi.org/10.3345/kjp.2019.00066

Cited By 32	The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects
Cited By 7	Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment
Cited By 4	A long-term subacute sclerosing panencephalitis survivor treated with intraventricular interferon-alpha for 13 years
Cited By 4	Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis
Cited By 3	Epilepsy syndromes during the first year of life and the usefulness of an epilepsy gene panel

Topics