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MicroRNAs as novel biomarkers for the diagnosis and treatment of pediatric diseases

Clin Exp Pediatr > Accepted Articles
DOI: https://doi.org/10.3345/cep.2023.00171    [Accepted]
Published online May 24, 2023.
MicroRNAs as novel biomarkers for the diagnosis and treatment of pediatric diseases
Hwal Rim Jeong1  , Il Tae Hwang2 
1Department of pediatrics, College of Medicine, Soonchunhyang University, Cheonan, Korea
2Department of Pediatrics, Kangdong sacred heart hospital, College of Medicine, Hallym University, , Seoul, Korea
Il Tae Hwang, Email: ithwang83@kdh.or.kr
Received: 26 January 2023   • Revised: 22 April 2023   • Accepted: 24 April 2023
MicroRNAs (miRNAs) are highly conserved noncoding RNAs that regulate gene expression by silencing or degrading messenger RNAs. Many of the approximately 2,500 miRNAs discovered in humans are known to regulate vital biological processes, including cell differentiation, proliferation, apoptosis, and embryonic tissue development. Aberrant miRNA expression may have pathological and malignant consequences. Therefore, miRNAs have emerged as novel diagnostic markers and potential therapeutic targets for various diseases. Children undergo various stages of growth, development, and maturation between birth and adulthood. It is important to study the role of miRNA expression in normal growth and disease development during these developmental stages. In this mini-review, we discuss the role of miRNAs as diagnostic and prognostic biomarkers in various pediatric diseases.
Key Words: microRNA, children, biomarkers

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