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"Most viewed" Articles are from the articles published in 2020 during the last six month.

Editorial
Infection
Babies born to mothers positive for SARS-CoV-2 – Are they in danger?   (552 times)
Joon Kee Lee
Clin Exp Pediatr. 2021;64(6):280-281.   Published online May 4, 2021
Concerns have arisen in the coronavirus disease 2019 (COVID-19) pandemic upon pregnancy and postnatal care starting from reproductive decision-making. To the utmost knowledge, reproductive decisions should not be based primarily on health-related COVID-19 concerns, as the possibility of vertical transmission is negligible and the perinatal outcome is generally not poor compared to pregnancies without COVID-19, as long as infection control measures are well kept.
Allergy
Insights into pediatric pollen food allergy syndrome   (544 times)
Jeong Hee Kim
Clin Exp Pediatr. 2020;63(12):483-484.   Published online June 1, 2020
Neonatology (Perinatology)
Barriers to and enablers of kangaroo mother care   (543 times)
Soon Min Lee
Clin Exp Pediatr. 2020;63(11):431-432.   Published online October 10, 2019
Perspective
Infection
Addressing children’s health amid the coronavirus disease 2019 pandemic   (532 times)
Young June Choe, Bilal Aurang Zeb Durrani, Stefan Swartling Peterson
Clin Exp Pediatr. 2021;64(2):46-48.   Published online December 15, 2020
In the coronavirus disease 2019 (COVID-19) pandemic, children experience heightened barriers to health and protective services. Children may also be disproportionately affected due to their reliance on the education system for daily tasks and lack of access to remote learning options. Republic of Korea findings on how vaccination coverage could be sustained in children and schools could be reopened without aggravating COVID-19 underlie the need for coordinated efforts across sectors.
Editorial
Endocrinology
Pediatricians must consider familial environment when diagnosing and managing childhood obesity   (532 times)
Young Suk Shim
Clin Exp Pediatr. 2022;65(1):31-32.   Published online April 19, 2021
•The prevalence of childhood obesity is increasing worldwide, including in the Republic of Korea, creating a major public healthissue.
•Accumulated evidence indicates a strong relationship between parentalandchildobesity.
•A family-based approach is indicated to prevent and manage childhoodandadultobesity.
Ambient air pollution and pediatric diabetes   (531 times)
Jae Hyun Kim
Clin Exp Pediatr. 2021;64(10):523-534.   Published online March 12, 2021
· Epidemiological studies have shown that ambient air pollution is associated with diabetes mellitus in children and adults.
· The mechanism of ambient air pollution causing diabetes mellitus is unclear.
· A study of the association between diabetes and air pollution in Korean pediatric populations is required.
Original Article
Gastroenterology
Thyroid disturbances in children treated with combined pegylated interferon-alpha and ribavirin for chronic hepatitis C   (526 times)
Yasser K. Rashed, Fatma A. Khalaf, Sobhy E. Kotb
Clin Exp Pediatr. 2020;63(2):52-55.   Published online September 27, 2019
Background: Immunomodulatory properties of interferon (IFN) have been documented. It may induce autoimmune diseases such as autoimmune thyroiditis with hypo- or hyperthyroidism. In addition, it may impair thyroid hormone synthesis through affecting iodide organification in thyroid gland.
Purpose: The aim of this study was to describe thyroid function tests disturbances in children with chronic hepatitis C (CHC) receiving pegylated interferon-alpha (PEG...
Editorial
Neurology
Recent trends in autism spectrum disorder research using text mining of PubMed: importance of early detection   (526 times)
Seung Soo Kim
Clin Exp Pediatr. 2021;64(7):339-340.   Published online November 9, 2020
Behavioral therapy, the most widely proven intervention for the core symptoms of autism spectrum disorder (ASD), is required for life for individuals with ASD. Parent involvement, early detection, and early therapy play important roles. We must organize the risk factors for ASD and develop a screening tool that can be easily applied in the clinical, daycare, or school setting.
Original Article
Nephrology (Genitourinary)
Variation in clinical usefulness of biomarkers of acute kidney injury in young children undergoing cardiac surgery   (523 times)
Hee Sun Baek, Youngok Lee, Hea Min Jang, Joonyong Cho, Myung Chul Hyun, Yeo Hyang Kim, Su-Kyeong Hwang, Min Hyun Cho
Clin Exp Pediatr. 2020;63(4):151-156.   Published online February 5, 2020
Question: Can clinical usefulness of biomarkers of acute kidney injury vary on the clinical circumstances?
Finding: In young children undergoing cardiac surgery, urine KIM-1/Cr level peaked at 24 hours with significant difference from baseline level and was significantly higher at 6 hours in the AKI group. However, urine NGAL/Cr and IL-18/Cr levels showed no specific trend with time for 48 hours after cardiac surgery.
Meaning: Urine KIM-1/Cr concentration could be considered a good biomarker for early AKI prediction after open cardiac surgery in young children.
Editorial
Neurology
Commentary on "Autoimmune encephalitis and epilepsy: evolving definition and clinical spectrum"   (517 times)
Jieun Choi
Clin Exp Pediatr. 2020;63(8):310-311.   Published online August 15, 2020
Allergy
Trends in prevalence of allergic diseases in Korean children: how and why?   (514 times)
Kyung Suk Lee
Clin Exp Pediatr. 2020;63(7):263-264.   Published online April 13, 2020
Other
Is correcting exposure misclassification bias an additional option in meta-analyses?   (506 times)
Ki Eun Kim
Clin Exp Pediatr. 2021;64(3):117-118.   Published online January 14, 2021
Systematic reviews and meta-analyses examine various existing research results. Such studies are conducted according to a technically determined algorithm to minimize errors. It is particularly important to understand basic analytical methods such as the fixed-effect and random-effects models and apply appropriate statistical techniques to verify interstudy heterogeneity. A design that eliminates possible bias from the early stages of the research in a step-by-step manner is required whenever possible.
Nephrology (Genitourinary)
Dapsone: a steroid-sparing drug for refractory immunoglobulin A vasculitis?   (500 times)
Jin-Soon Suh
Clin Exp Pediatr. 2020;63(5):178-179.   Published online April 14, 2020
Cardiology
When should mechanical circulatory support be considered in pediatric patients with acute fulminant myocarditis?   (500 times)
Hye Won Kwon
Clin Exp Pediatr. 2021;64(5):227-228.   Published online September 22, 2020
Acute fulminant myocarditis is an uncommon syndrome characterized by sudden and severe cardiac inflammation, which leads to cardiogenic shock, ventricular arrhythmia, heart blocks, or multiorgan failure. Despite aggressive clinical course, patients with acute fulminant myocarditis have better outcomes than those with the nonfulminant type when appropriately supported during the acute phase of the disease. Therefore, early recognition of deteriorating myocarditis and timely mechanical circulatory support are crucial to improve outcomes.
Perspective
Other
Role of the Korea National Institute of Health in the children’s health effect study of particulate matter   (500 times)
Young Youl Kim
Clin Exp Pediatr. 2021;64(4):139-140.   Published online November 17, 2020
Particulate matter (PM) adversely affects children’s lungs and cognitive development, and an early exposure to it can lead to chronic metabolic diseases. The Korea National Institute of Health convened a Task Force on the Health Impact of PM to produce scientific evidence and promote technological developments to prevent PM-induced health effects.
Infection
Can we get a clue for the etiology of Kawasaki disease in the COVID-19 pandemic?   (499 times)
Jong-Woon Choi
Clin Exp Pediatr. 2020;63(9):335-336.   Published online July 13, 2020
A new coronavirus disease 2019 (COVID-19) has been spreading globally since December 2019. Children with a Kawasaki disease (KD)-like illness related with COVID-19 have been reported in Europe and the United States. They presented with symptoms of KD with or without cardiac abnormalities or shock, showing manifestations of hyperactive proinflammatory cytokine reactions like KD. Such cases may provide the opportunity for us to learn more about the etiology and pathogenesis of KD.
Editorial
Cardiology
Can the accurate epidemiological study help to search the etiology of Kawasaki disease?   (497 times)
Ji Whan Han
Clin Exp Pediatr. 2020;63(3):96-97.   Published online August 7, 2019
Original Article
Other
Evaluation of goodness of fit of semiparametric and parametric models in analysis of factors associated with length of stay in neonatal intensive care unit   (488 times)
Fatemeh Kheiry, Sadegh Kargarian-Marvasti, Sima Afrashteh, Abolfazl Mohammadbeigi, Nima Daneshi, Salma Naderi, Seyed Hossein Saadat
Clin Exp Pediatr. 2020;63(9):361-367.   Published online June 10, 2020
Question: Hospitalization in neonatal intensive care unit (NICU) is associated with life-threatening hazards. What factors associated with neonatal length of stay (LOS) in the NICU?
Finding: Breastfeeding, phototherapy, acute renal failure (ARF), mechanical ventilation, and central venous catheter (CVC) access were identified as factors associated with NICU length of stay.
Meaning: Protective effects of breastfeeding and CVC access, whereas increase effects of phototherapy, ARF, and mechanical ventilation in LOS can be supporting evidence to establish effective interventions to reduce length of NICU stay.
Editorial
Genetics and Metabolism
Considerations for evaluating the effectiveness and long-term outcome of enzyme replacement therapy in Pompe disease   (476 times)
Chong Kun Cheon
Clin Exp Pediatr. 2020;63(1):14-15.   Published online August 7, 2019
Original Article
Critical Care Medicine
Comparative validity of microalbuminuria versus clinical mortality scores to predict pediatric intensive care unit outcomes   (476 times)
Shifa Nismath, Suchetha S. Rao, B.S. Baliga, Vaman Kulkarni, Gayatri M. Rao
Clin Exp Pediatr. 2020;63(1):20-24.   Published online August 12, 2019
Question: Does microalbuminuria predict mortality in pediatric intensive care unit?
Finding: Positive correlation was found between albumin-creatinine ratio and pediatric intensive care unit stay, organ dysfunction and need of inotropes. Area under the receiver operating characteristic curve for albumin-creatinine ratio was comparable to mortality scores.
Meaning: Microalbuminuria is a good predictor of outcome in pediatric intensive care unit and is comparable with mortality scores.
Editorial
Neonatology (Perinatology)
Should we regularly evaluate the neurodevelopmental status of moderate and late preterm infants?   (475 times)
Son Moon Shin
Clin Exp Pediatr. 2020;63(6):217-218.   Published online June 11, 2020
Correspondence and Reply
Psychiatric/Psychology
Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis   (468 times)
Hadith Rastad, Mahnaz Seifi Alan
Clin Exp Pediatr. 2022;65(3):152-152.   Published online February 17, 2022
Editorial
Emergency Medicine
Pediatric transport medicine: a yet unknown territory in Korea   (467 times)
Jeong-Min Ryu
Clin Exp Pediatr. 2020;63(5):182-183.   Published online May 15, 2020
Neonatology (Perinatology)
Neutrophil CD11b as a promising marker for early detection of neonatal sepsis   (460 times)
Ju Sun Heo
Clin Exp Pediatr. 2021;64(1):28-30.   Published online September 1, 2020
· Neonatal sepsis is a global problem and significant cause of neonatal mortality and adverse short- and long-term outcomes.
· Due to severe limitations diagnosing neonatal sepsis, there is a critical need to identify reliable specific biomarkers for early detection.
· nCD11b might be an accurate and rapid biomarker for the early detection of neonatal sepsis.
Letter to the Editor
Neonatology (Perinatology)
Risk factors for BiPAP failure as an initial management approach in moderate to late preterm infants with respiratory distress   (459 times)
Heekwon Son, Eui Kyung Choi, Kyu Hee Park, Jeong Hee Shin, Byung Min Choi
Clin Exp Pediatr. 2020;63(2):63-65.   Published online February 15, 2020
Question: Which factors can predict BiPAP failure as the initial management approach for moderate to late preterm infants with respiratory distress?
Finding: RDS aggravation and increased oxygen and frequency requirements during BiPAP support were associated with BiPAP failure.
Meaning: Early changes to invasive ventilator care should be considered for moderate to late preterm infants showing RDS aggravation and increased oxygen and frequency requirements during BiPAP support.
Correspondence and Reply
Psychiatric/Psychology
Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis   (445 times)
Ensiyeh Jenabi
Clin Exp Pediatr. 2022;65(3):152-152.   Published online February 17, 2022
Editorial
Cardiology
Where should we start to improve pediatric heart transplantation outcomes?   (437 times)
Jinyoung Song
Clin Exp Pediatr. 2021;64(2):76-77.   Published online November 25, 2020
· Pediatric heart transplantation is achieving better outcomes.
· The waitlist mortality is still high, especially in Korea, and should be reduced.
· The use of ventricular assist device is promising and might offer improved waitlist mortality rates.
Letter to the Editor
Cardiology
Differences over 10 years in epidemiologic and clinical features of Kawasaki disease at a single tertiary center   (434 times)
Hyun Su Kim, Suk Won Shin, Bo Geum Choi, Hee Joung Choi
Clin Exp Pediatr. 2020;63(4):157-158.   Published online February 5, 2020
General Pediatrics
Hyperinflammatory syndrome in children during the coronavirus disease 2019 pandemic in sub-Himalayan region   (434 times)
Seema Sharma, Shikha Verma, Isha Bhatia, Ravinder Singh, Mohit Bajaj, Milap Sharma
Clin Exp Pediatr. 2021;64(7):370-372.   Published online May 11, 2021
Question: Is there an increase in patients with hyperinflammatory syndrome during the coronavirus disease 2019 pandemic?
Finding: We found 10 patients with hyperinflammatory syndrome with poor outcome during a period of 2 months in a single tertiary care centre.
Meaning: Pediatricians who come across patients with muco cutaneous manifestations and multiorgan involvement should consider hyperinflammatory syndrome. Early recognition and prompt treatment of such patients may result in promising outcome.
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