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"Most viewed" Articles are from the articles published in 2021 during the last six month.

Editorial
Cardiology
When should mechanical circulatory support be considered in pediatric patients with acute fulminant myocarditis?   (595 times)
Hye Won Kwon
Clin Exp Pediatr. 2021;64(5):227-228.   Published online September 22, 2020
Acute fulminant myocarditis is an uncommon syndrome characterized by sudden and severe cardiac inflammation, which leads to cardiogenic shock, ventricular arrhythmia, heart blocks, or multiorgan failure. Despite aggressive clinical course, patients with acute fulminant myocarditis have better outcomes than those with the nonfulminant type when appropriately supported during the acute phase of the disease. Therefore, early recognition of deteriorating myocarditis and timely mechanical circulatory support are crucial to improve outcomes.
Letter to the Editor
Oncology
Retrospective review of severe acute respiratory syndrome coronavirus-2 infection in children with acute leukemia from a tertiary care hospital in Northern India   (585 times)
Suhail Chhabra, Aditya Dabas, Richa Mittal, Neha Goel, Ritabrata Roy Chowdhary, Satyendra Batra, Amitabh Singh, Rani Gera
Clin Exp Pediatr. 2022;65(3):150-151.   Published online November 26, 2021
Editorial
Endocrinology
Pediatricians must consider familial environment when diagnosing and managing childhood obesity   (583 times)
Young Suk Shim
Clin Exp Pediatr. 2022;65(1):31-32.   Published online April 19, 2021
•The prevalence of childhood obesity is increasing worldwide, including in the Republic of Korea, creating a major public healthissue.
•Accumulated evidence indicates a strong relationship between parentalandchildobesity.
•A family-based approach is indicated to prevent and manage childhoodandadultobesity.
Other
Is correcting exposure misclassification bias an additional option in meta-analyses?   (579 times)
Ki Eun Kim
Clin Exp Pediatr. 2021;64(3):117-118.   Published online January 14, 2021
Systematic reviews and meta-analyses examine various existing research results. Such studies are conducted according to a technically determined algorithm to minimize errors. It is particularly important to understand basic analytical methods such as the fixed-effect and random-effects models and apply appropriate statistical techniques to verify interstudy heterogeneity. A design that eliminates possible bias from the early stages of the research in a step-by-step manner is required whenever possible.
Letter to the Editor
General Pediatrics
Skipping breakfast is associated with lifestyle habits among Japanese pupils   (578 times)
Jun Kohyama
Clin Exp Pediatr. 2021;64(8):433-435.   Published online November 4, 2020
Question: Breakfast is important; however, adolescents are increasingly skipping it.
Finding: Skipping breakfast is independently associated with sleepiness, physical inactivity, dinner irregularity, screen time on school days, poor academic performance, after-school activity, and decreased sleep duration before school day.
Meaning: Reducing screen time on school days, after-school activity, and irregular dinner habits might decrease breakfast skipping, resulting in decreased sleepiness and improved academic performance.
Editorial
Immunology
Importance of neonatal screening for primary immunodeficiencies   (569 times)
Jung Woo Rhim
Clin Exp Pediatr. 2021;64(10):519-520.   Published online May 4, 2021
· Early detection of asymptomatic infants with primary immunodeficiencies before the onset of infections enables effective treatment and intervention to prevent serious sequelae.
· T-cell receptor excision circles and kappa-deleting recombination excision circles have recently been used to detect T- or B-cell lymphopenia in neonates.
Perspective
Infection
Addressing children’s health amid the coronavirus disease 2019 pandemic   (567 times)
Young June Choe, Bilal Aurang Zeb Durrani, Stefan Swartling Peterson
Clin Exp Pediatr. 2021;64(2):46-48.   Published online December 15, 2020
In the coronavirus disease 2019 (COVID-19) pandemic, children experience heightened barriers to health and protective services. Children may also be disproportionately affected due to their reliance on the education system for daily tasks and lack of access to remote learning options. Republic of Korea findings on how vaccination coverage could be sustained in children and schools could be reopened without aggravating COVID-19 underlie the need for coordinated efforts across sectors.
Editorial
Nephrology (Genitourinary)
Inhibition of the renin-angiotensin system during fetal kidney development   (556 times)
Eujin Park
Clin Exp Pediatr. 2021;64(3):121-122.   Published online September 22, 2020
· Fetal exposure to renin-angiotensin system (RAS) inhibitors leads to short- and long-term kidney complications.
· Women of reproductive age who are absolutely indicated for RAS inhibitors should be adequately informed of the risks for the duration of treatment.
Neurology
Cerebrospinal fluid biomarkers in various pediatric neurologic diseases   (552 times)
Jeongho Lee
Clin Exp Pediatr. 2022;65(2):81-82.   Published online January 6, 2022
Cerebrospinal fluid (CSF) has many important biomarkers that are commonly analyzed in pediatric neurologic diseases, including central nervous system infection and inflammation. Neurologic disease in pediatrics is difficult to diagnosis, there are challenges in developing CSF profiles. Some biomarkers are expected to help differential diagnosis.
Cardiology
Where should we start to improve pediatric heart transplantation outcomes?   (546 times)
Jinyoung Song
Clin Exp Pediatr. 2021;64(2):76-77.   Published online November 25, 2020
· Pediatric heart transplantation is achieving better outcomes.
· The waitlist mortality is still high, especially in Korea, and should be reduced.
· The use of ventricular assist device is promising and might offer improved waitlist mortality rates.
Perspective
Other
Role of the Korea National Institute of Health in the children’s health effect study of particulate matter   (532 times)
Young Youl Kim
Clin Exp Pediatr. 2021;64(4):139-140.   Published online November 17, 2020
Particulate matter (PM) adversely affects children’s lungs and cognitive development, and an early exposure to it can lead to chronic metabolic diseases. The Korea National Institute of Health convened a Task Force on the Health Impact of PM to produce scientific evidence and promote technological developments to prevent PM-induced health effects.
Editorial
Nutrition
Advantages and limitations of using national survey datasets in child and adolescent research   (528 times)
Yoon Lee
Clin Exp Pediatr. 2021;64(9):468-470.   Published online January 26, 2021
The Korean National Health and Nutrition Examination Survey and the Korea Youth Risk Behavior Web-based Survey are major nationwide health and nutrition surveys in Korea. Although these surveys have some limitations of cross-sectional sample surveys, the accumulated data are valuable and provide new prospects for understanding public health depending on the interpretation method.
Letter to the Editor
General Pediatrics
Hyperinflammatory syndrome in children during the coronavirus disease 2019 pandemic in sub-Himalayan region   (527 times)
Seema Sharma, Shikha Verma, Isha Bhatia, Ravinder Singh, Mohit Bajaj, Milap Sharma
Clin Exp Pediatr. 2021;64(7):370-372.   Published online May 11, 2021
Question: Is there an increase in patients with hyperinflammatory syndrome during the coronavirus disease 2019 pandemic?
Finding: We found 10 patients with hyperinflammatory syndrome with poor outcome during a period of 2 months in a single tertiary care centre.
Meaning: Pediatricians who come across patients with muco cutaneous manifestations and multiorgan involvement should consider hyperinflammatory syndrome. Early recognition and prompt treatment of such patients may result in promising outcome.
Editorial
Neurology
Recent trends in autism spectrum disorder research using text mining of PubMed: importance of early detection   (503 times)
Seung Soo Kim
Clin Exp Pediatr. 2021;64(7):339-340.   Published online November 9, 2020
Behavioral therapy, the most widely proven intervention for the core symptoms of autism spectrum disorder (ASD), is required for life for individuals with ASD. Parent involvement, early detection, and early therapy play important roles. We must organize the risk factors for ASD and develop a screening tool that can be easily applied in the clinical, daycare, or school setting.
Correspondence and Reply
Neurobehavior
Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis   (475 times)
Hadith Rastad, Mahnaz Seifi Alan
Clin Exp Pediatr. 2022;65(3):152-152.   Published online February 17, 2022
Editorial
Neonatology (Perinatology)
Neutrophil CD11b as a promising marker for early detection of neonatal sepsis   (465 times)
Ju Sun Heo
Clin Exp Pediatr. 2021;64(1):28-30.   Published online September 1, 2020
· Neonatal sepsis is a global problem and significant cause of neonatal mortality and adverse short- and long-term outcomes.
· Due to severe limitations diagnosing neonatal sepsis, there is a critical need to identify reliable specific biomarkers for early detection.
· nCD11b might be an accurate and rapid biomarker for the early detection of neonatal sepsis.
Correspondence and Reply
Neurobehavior
Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis   (434 times)
Ensiyeh Jenabi
Clin Exp Pediatr. 2022;65(3):152-152.   Published online February 17, 2022
Editorial
Hematology
Time to pay attention to anemia in female adolescents   (419 times)
Jae Min Lee
Clin Exp Pediatr. 2021;64(2):78-79.   Published online February 1, 2021
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