- Original Article
- Developmental and Behavioral Medicine
- Neonatal risk factors associated with autism spectrum disorders: an umbrella review
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Amir Mohammad Salehi, Erfan Ayubi, Salman Khazaei, Ensiyeh Jenabi, Saeid Bashirian, Zohreh Salimi
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Clin Exp Pediatr. 2024;67(9):459-464. Published online July 19, 2024
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Question: What are the neonatal risk factors for autism spectrum disorder (ASD)?
Findings: Significant effect sizes were observed for congenital heart disease (odds ratio [OR], 1.35), macrosomia (OR, 1.11), low birth weight (OR, 1.63), very low birth weight (OR, 2.25), small for gestational age (OR, 1.17), jaundice (OR, 1.74), male sex (OR, 1.47), and Apgar score (OR, 1.40).
Meaning: These factors were identified as risk factors for ASD. |
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- Neurobehavior
- Association between previous abortion history and risk of autism spectrum disorders among offspring: a meta-analysis
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Ensiyeh Jenabi, Erfan Ayubi, Saeid Bashirian, Mahdieh Seyedi, Mohammad Rezaei
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Clin Exp Pediatr. 2023;66(2):70-75. Published online August 17, 2022
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Question: This study aimed to determine whether there is an association between previous abortion history and the risk of autism spectrum disorders (ASDs) among children.
Finding: We found that the risk of ASD associated with previous abortion history had an odds ratio of 1.64 (95% confidence interval, 1.28–2.0; I2=61.7%).
Meaning: These findings suggest a positive and significant association between history of previous abortion and risk of ASD in children. |
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- General Pediatrics
- Virtual reality for pain reduction during intravenous injection in pediatrics: a systematic review and meta-analysis of controlled clinical trials
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Ensiyeh Jenabi, Saeid Bashirian, Amir Mohammad Salehi, Masoud Rafiee, Mozhdeh Bashirian
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Clin Exp Pediatr. 2023;66(12):533-537. Published online June 14, 2023
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Question: This is the first meta-analysis to examine published evidence of the effectiveness of virtual reality at reducing pain during pediatric intravenous injections.
Finding: Our results suggest that virtual reality effectively reduces pain associated with intravenous injections in pediatric patients.
Meaning: These findings suggest the importance of virtual reality in decreasing the pain of intravenous injections among children. |
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- Developmental and Behavioral Medicine
- Neonatal risk factors associated with attention-deficit/hyperactivity disorder: an umbrella review
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Ensiyeh Jenabi, Erfan Ayubi, Sajjad Farashi, Saeid Bashirian, Fereshteh Mehri
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Clin Exp Pediatr. 2023;66(10):441-446. Published online July 14, 2023
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Question: The risk factors for attention deficit hyperactivity disorder (ADHD), such as breastfeeding, congenital heart disease, and low birth weight, in neonates are not well understood.
Finding: This umbrella review obtained significant effect sizes for ADHD for congenital heart disease (odds ratio [OR], 3.04), low birth weight (OR, 2.25), never breastfed (OR, 1.55), and Apgar score (OR, 1.30).
Meaning: Congenital heart disease, low birth weight, lack of breastfeeding, and Apgar scores were significant factors for ADHD. |
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- Nutrition
- Not breastfeeding and risk of autism spectrum disorders among children: a meta-analysis
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Ensiyeh Jenabi, Saeid Bashirian, Amir Mohammad Salehi, Salman Khazaei
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Clin Exp Pediatr. 2023;66(1):28-31. Published online July 19, 2022
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This study aimed to determine whether there is an association between not breastfeeding (versus breastfeeding) and the risk of autism spectrum disorders (ASD) among children. We found that the risk of ASD associated with not breastfeeding had an odds ratio of 1.81 (95% confidence interval, 1.35–2.27; I2=0 %). These findings suggest the importance of breastfeeding in decreasing the risk of ASD among children. |
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- Endocrinology
- Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis
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Azam Maleki, Saeid Bashirian, Ali Reza Soltanian, Ensiyeh Jenabi, Abdollah Farhadinasab
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Clin Exp Pediatr. 2022;65(2):85-89. Published online April 15, 2021
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Question: Have polycystic ovary syndrome (PCOS) increased risk of having an offspring with attention-deficit/hyperactivity disorder (ADHD)?
Finding: Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on odds ratio (OR) and relative ratio (RR) (OR, 1.42; 95% confidence interval [CI], 1.27–1.57) and (RR, 1.43; 95% CI, 1.35–1.51), respectively.
Meaning: Our study showed that maternal PCOS is a risk factor for ADHD. |
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- Neurobehavior
- Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?
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Ensiyeh Jenabi, Mahdieh Seyedi, Saeid Bashirian, Bita Fereidooni
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Clin Exp Pediatr. 2021;64(9):489-493. Published online February 5, 2021
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· This meta-analysis pooled all observational (case-control and cohort) studies to obtain the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children.
· The findings showed that labor induction is not associated with increased risk of ADHD among children. |
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- Developmental and Behavioral Medicine
- Is meconium exposure associated with autism spectrum disorders in children?
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Ensiyeh Jenabi, Erfan Ayubi, Salman Khazaei, Saeid Bashirian, Mojtaba Khazaei
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Clin Exp Pediatr. 2021;64(7):341-346. Published online October 4, 2020
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• Meconium exposure is weakly associated with an increased risk of autism spectrum disorder (ASD) development in children.
• More evidence based on large prospective cohort studies is required to conclude whether meconium exposure is associated with an increased risk of ASD. |
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- Other
- Association between pesticide and polychlorinated biphenyl exposure during pregnancy and autism spectrum disorder among children: a meta-analysis
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Fereshteh Mehri, Saeid Bashirian, Salman khazaei, Ensiyeh Jenabi
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Clin Exp Pediatr. 2021;64(6):286-292. Published online July 27, 2020
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· This meta-analysis analyzed the association between pesticide and polychlorinated biphenyl (PCB) exposure during pregnancy and autism spectrum disorders (ASD) risk among children.
· A significant association was noted between PCB and pesticide exposure during pregnancy and ASD risk among children (odds ratio [OR], 1.80; 95% confidence interval [CI], 1.26–2.34 and OR, 1.20; 95% CI, 1.02–1.39), respectively.
· Pesticide and PCB exposure during pregnancy may affect ASD risk among children. |
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- Clinical Note
- Infection
- A neonate infected with coronavirus disease 2019 with severe symptoms suggestive of multisystem inflammatory syndrome in childhood
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Fatemeh Eghbalian, Ghazal Sami, Saeid Bashirian, Ensiyeh Jenabi
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Clin Exp Pediatr. 2021;64(11):596-598. Published online September 10, 2021
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Question: Can multisystem inflammatory syndrome in childhood (MIS-C) occur in the neonate associated with coronavirus disease 2019 (COVID-19)?
Finding: A 9-day-old neonate infected with COVID-19 had fever, respiratory distress, and gastrointestinal symptoms suggestive of MIS-C. This neonate recovered after treatment with intravenous immunoglobulin (IVIG).
Meaning: IVIG successfully treated a rare case of a 9-day-old neonate with COVID-19 and severe symptoms suggestive of MIS-C. |
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- Original Article
- Neurobehavior
- Association between small for gestational age and risk of autism spectrum disorders: a meta-analysis
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Ensiyeh Jenabi, Saeid Bashirian, Zahra Asali, Mahdieh Seyedi
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Clin Exp Pediatr. 2021;64(10):538-542. Published online January 28, 2021
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• The relationship between small for gestational age (SGA) and autism spectrum disorders (ASDs) and remains conflicting.
• We showed based on odds ratio reports in epidemiological studies that SGA can increase the risk of ASD and SGA is a risk factor for ASD.
• The association between SGA and the risk of ASD has further momentum to the current public health emphasis on appropriate prepregnancy weight and weight gain during pregnancy |
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- Association between assisted reproductive technology and autism spectrum disorders in Iran: a case-control study
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Ensiyeh Jenabi, Mahdieh Seyedi, Ronak Hamzehei, Saeid Bashirian, Mohammad Rezaei, Katayoon Razjouyan, Salman Khazaei
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Clin Exp Pediatr. 2020;63(9):368-372. Published online March 27, 2020
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Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by impairments in social interaction and verbal and nonverbal communication.
Purpose: Determine the association between use of assisted reproduction technology (ART) and the risk of ASD among children.
Methods: This case-control study included 300 participants (100 cases, 200 controls). The control group included women with a child aged 2–10 years without ASD,... |
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- Systematic review and meta-analysis
- Neurobehavior
- Association between neonatal jaundice and autism spectrum disorders among children: a meta-analysis
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Ensiyeh Jenabi, Saeid Bashirian, Salman Khazaei
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Clin Exp Pediatr. 2020;63(1):8-13. Published online November 7, 2019
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Autism spectrum disorder is a common neurodevelopmental disorder with an unknown etiology. The correlation between neonatal jaundice and the risk of developing autism spectrum disorder was investigated previously. Some studies showed significant associations, whereas others demonstrated no association. In this meta-analysis, we pooled the results of observational studies to examine the association between neonatal jaundice and the risk of autism... |
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- Original Article
- The association between preeclampsia and autism spectrum disorders among children: a meta-analysis
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Ensiyeh Jenabi, Manoochehr Karami, Salman Khazaei, Saeid Bashirian
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Clin Exp Pediatr. 2019;62(4):126-130. Published online December 24, 2018
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Purpose: In this meta-analysis, relevant case-control and cohort studies were pooled to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children.
Methods: A search for relevant studies in major databases, including Web of Science, PubMed, and Scopus, was performed up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals... |
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- Systematic review and meta-analysis
- Neurobehavior
- Evaluation of drug interventions for the treatment of sleep disorders in children with autism spectrum disorders: a systematic review
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Ensiyeh Jenabi, Sara Ataei, Saeid Bashirian
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Clin Exp Pediatr. 2019;62(11):405-409. Published online October 2, 2019
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A structured review study of drug interventions on sleep disorders in patients with autism spectrum disorders (ASD) has not been published to date. This systematic review aimed to investigate drug interventions for the treatment of sleep disorders in children with ASD. The Web of Science, PubMed, and Scopus databases were searched until March 2019. Study quality was assessed using the... |
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