Clin Exp Pediatr > Accepted Articles
DOI: https://doi.org/10.3345/cep.2022.00108    [Accepted]
Published online August 17, 2022.
Association between previous abortion history and risk of autism spectrum disorders among offspring: A meta-analysis
Ensiyeh Jenabi1  , Erfan Ayubi2  , Saeid Bashirian2  , Mahdieh Seyedi1  , Mohammad Rezaei1
1Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Correspondence: 
Erfan Ayubi, Email: aubi65@gmail.com
Received: 17 January 2022   • Revised: 11 May 2022   • Accepted: 13 June 2022
Abstract
The present meta-analysis aimed to evaluate the association between previous abortion history and the risk of autism spectrum disorders (ASD). The PubMed, Scopus, and Web of Sciences databases were systematically searched for studies published through December 2021. The presence of statistical heterogeneity among the eligible studies was determined using the I2 value. According to heterogeneity, random- or fixed-effect models were applied to the meta-analysis of associations. Egger’s and Begg’s tests were used to assess publication bias. Thirteen studies involving 331,779 children were included in this meta-analysis. The overall odds ratio (95% confidence interval) for the association between previous abortion history and ASD through the random-effects model was 1.64 (1.28, 2.0; I2=61.7%). No publication bias was found (Begg’s: p=0.393; Egger’s: p=0.056). These results suggest a positive and significant association between a history of previous abortion and the risk of ASD in offspring.
Key Words: Autism spectrum disorders, Abortion, Children, Meta-analysis


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