Volume 65(3); March

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Clin Exp Pediatr > Volume 65(3); 2022
Rastad and Seifi Alan: Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis
To the editor: We read with great interest a meta-analysis by Maleki et al. [1] on the association between prenatal excess of androgen exposure in the offspring of mothers with polycystic ovary syndrome (PCOS) and risk of attention-deficit/hyperactivity disorder (ADHD) in them. They found that maternal PCOS increases the offspring risk of ADHD. However, we have to point out a deficiency of this study, we noted that 1 of 6 articles that were included in this study did not meet the eligibility criteria as it’s object was different [2]. Hergüner et al. [2] aimed to compare ADHD symptoms between women with PCOS and controls. This deficiency may introduce bias and lead to a false conclusion.

Footnotes

Conflicts of interest

No potential conflict of interest relevant to this article was reported.

Funding

This letter received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

References

1. Maleki A, Bashirian S, Soltanian AZ, Jenabi E, Farhadinasab A. Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis. Clin Exper Pediatr 2021;37:716–20.
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2. Hergüner S, Harmancı H, Toy H. Attention deficit-hyperactivity disorder symptoms in women with polycystic ovary syndrome. Int J Psychiatry Med 2015;50:317–25.
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