Volume 65(3); March

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Clin Exp Pediatr > Volume 65(3); 2022
Jenabi: Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis
The authors reply: We appreciate your opinion and your suggestions, and I’d like to reply to the points that you mentioned. We in this meta-analysis assessed the association between polycystic ovary syndrome (PCOS) and risk of attention-deficit/hyperactivity disorder (ADHD) in offspring compared with women without PCOS [1]. Hergüner et al. [2] aimed to compare ADHD symptoms between women with PCOS and controls. However, Hergüner et al. [2] measured ADHD symptoms based on 18 items on Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for ADHD. DSM-IV is a diagnostic critera for ADHD [3,4]. Therefore, the symptoms of ADHD based on DSM-IV criteria indicate the diagnosis of ADHD. On the other, there was a significant association between PCOS and risk ADHD in 5 of 6 included articles. Therefore, it cannot introduce bias and a false conclusion.


Conflicts of interest

No potential conflict of interest relevant to this article was reported.


This letter received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.


1. Kosidou K, Dalman C, Widman L, Arver S, Lee BK, Magnusson C, et al. Maternal polycystic ovary syndrome and risk for attention-deficit/hyperactivity disorder in the offspring. Biol Psychiatry 2017;82:651–9.
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2. Hergüner S, Harmancı H, Toy H. Attention deficit-hyperactivity disorder symptoms in women with polycystic ovary syndrome. Int J Psychiatry Med 2015;50:317–25.
crossref pmid
3. Epstein J, Johnson DE, Conners CK. Conners' adult ADHD diagnostic interview for DSM-IV™ (CAADID™). North Tonawanda (NY): Multi-Health Systems Inc., 2001.

4. McBurnett K, Lahey BB, Pfiffner LJ. Diagnosis of attention deficit disorders in DSM-IV: Scientific basis and implications for education. Except Child 1993;60:108–17.
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