- Original Article
- Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis
-
Ji Hyeon Baek, Hyun Kyong Seo, Hye Mi Jee, Youn Ho Shin, Man Yong Han, Eun Sang Oh, Hyun Ju Lee, Kyung Hyo Kim
-
Clin Exp Pediatr. 2013;56(7):286-290. Published online July 19, 2013
-
|
|
Purpose Although chronic and recurrent rhinosinusitis is prevalent in children, little is known about its causes. Here, we investigated the humoral immunity in children with chronic or recurrent rhinosinusitis. MethodsWe examined 16 children attending the outpatient clinic at the CHA Bundang Medical Center including 11 boys and 5 girls, aged 3.11 years (mean age, 5.6 years), who had rhinosinusitis for >3 months... |
-
-
- Review Article
- Recommendation for the use of newly introduced Tdap vaccine in Korea
-
Kyong Min Choi, Kyung Hyo Kim, Yae-Jean Kim, Jong-Hyun Kim, Su Eun Park, Hoan Jong Lee, Byung Wook Eun, Dae Sun Jo, Eun Hwa Choi, Young Jin Hong
-
Clin Exp Pediatr. 2011;54(4):141-145. Published online April 30, 2011
-
|
|
Pertussis is an acute respiratory infection characterized by paroxysmal cough and inspiratory whoop for over 2 weeks. The incidence of pertussis has decreased markedly after the introduction of DTwP/DTaP vaccine, but the incidence of pertussis has increased steadily among young infant and among adolescents and adults in many countries. Td vaccine was used in this age group but the increase... |
-
-
- Recommendation for use of the newly introduced pneumococcal protein conjugate vaccines in Korea
-
Eun Hwa Choi, Kyung Hyo Kim, Yae Jean Kim, Jong Hyun Kim, Su Eun Park, Hoan Jong Lee, Byung Wook Eun, Dae Sun Jo, Kyong Min Choi, Young Jin Hong
-
Clin Exp Pediatr. 2011;54(4):146-151. Published online April 30, 2011
-
|
|
Streptococcus pneumoniae remains a leading cause of invasive infections including bacteremia and meningitis, as well as mucosal infections such as otitis media and pneumonia among children and adults. The 7-valent pneumococcal conjugate vaccine (PCV7) was licensed for use among infants and young children in many countries including Korea. The routine use of PCV7 has resulted in a decreased incidence of... |
-
-
- Review Article
- Enterovirus 71 infection: An experience in Korea, 2009
-
Kyung Hyo Kim
-
Clin Exp Pediatr. 2010;53(5):616-622. Published online May 31, 2010
-
|
|
Enterovirus 71 (EV71) has been recognized as a frequent cause of epidemics of hand-foot-and-mouth disease (HFMD) associated with severe neurological symptoms. In the spring of 2009, HFMD was epidemic in Korea. Severe cases with complication, including death, have been reported and it has become a public health issue. Most symptomatic EV71 infections commonly result in HFMD or herpangina. These clinical... |
-
-
- Original Article
- Immunogenicity of 7-valent pneumococcal conjugate vaccine
related to booster immunization in Korean children
-
So Eun Park, Hyunju Lee, Soo Young Lim, Kyung Hyo Kim
-
Clin Exp Pediatr. 2008;51(6):622-628. Published online June 15, 2008
-
|
|
Purpose : The purpose of this study was to evaluate the immunogenicity of the booster immunization with pneumococcal conjugate vaccine in Korean children.
Methods : Thirty-nine children aged 12-23 months who visited Kangnam CHA Hospital between September 2006 and December 2006 were enrolled. The children were divided into primary and booster groups depending on their vaccination status for the 7-valent pneumococcal... |
-
-
- Erratum
- Provisional update on varicella vaccination in Korea, 2008
-
Eun Hwa Choi, Kyung Hyo Kim, Jong-Hyun Kim, Su Eun Park, Seon Hee Shin, Sung Hee Oh, Hoan Jong Lee, Dae Sun Jo, Jae Kyun Hur, Young Jin Hong
-
Clin Exp Pediatr. 2008;51(6):665-667. Published online June 15, 2008
-
-
-
- Original Article
- Bacterial meningitis in children experienced at a university hospital, 1993-2006
-
Sung Yoon Cho, Tae Yeon Kim, Hyunju Lee, Kyung Hyo Kim, Eun Sun Yoo, Hae Soon Kim, Eun Ae Park, Kyung Ha Ryu, Jeong Wan Seo, Sejung Sohn, Seung Joo Lee
-
Clin Exp Pediatr. 2008;51(10):1077-1084. Published online October 15, 2008
-
|
|
Purpose : Despite the seriousness of bacterial meningitis in children, there is little information on the incidence, causative organisms, mortality rate and age distribution. We studied the frequency by age group and causal pathogens, and clinical characteristics in children with bacterial meningitis in the private sector in Korea.
Methods : The medical records containing the data on bacterial meningitis patients... |
-
-
- Erratum
- Rotavirus Vaccine
-
Su Eun Park, Kyung Hyo Kim, Jong-Hyun Kim, Seon Hee Shin, Sung Hee Oh, Hoan Jong Lee, Dae Sun Jo, Eun Hwa Choi, Jae Kyun Hur, Young Jin Hong
-
Clin Exp Pediatr. 2007;50(8):803-810. Published online August 15, 2007
-
-
-
- Human Papillomavirus Vaccine
-
Kyung Hyo Kim, Jong-Hyun Kim, Su Eun Park, Seon Hee Shin, Sung Hee Oh, Hoan Jong Lee, Dae Sun Jo, Eun Hwa Choi, Jae Kyun Hur, Young Jin Hong
-
Clin Exp Pediatr. 2007;50(8):811-819. Published online August 15, 2007
-
-
-
- Original Article
- Antibody prsistence after Haemophilus influenzae type b (Hib)
primary vaccination and response to boosters in Korean children
-
Hyunju Lee, So Eun Park, Soo Young Lim, Kyong Min Choi, Hoan Jong Lee, Kyung Hyo Kim
-
Clin Exp Pediatr. 2007;50(5):449-456. Published online May 15, 2007
-
|
|
Purpose : Antibody persistence after primary series of Haemophilus influenzae type b (Hib) vaccine and responses to boosters are seldom studied in Korean children. We performed this study to evaluate the antibody titer in relation to booster immunization of Hib vaccine in Korean children.
Method : One hundred forty four children aged 12-23 months were enrolled in three university hospitals. The... |
-
-
- A study of serotyping of Streptococcus pneumoniae by multibead assay
-
Ky Young Cho, Jung Ah Lee, Sung Eun Cho, Nam Hee Kim, Jin A Lee, Ki Sook Hong, Hoan Jong Lee, Kyung Hyo Kim
-
Clin Exp Pediatr. 2007;50(2):151-156. Published online February 15, 2007
-
|
|
Purpose : Streptococcus pneumoniae is a major etiologic agent for pneumonia, meningitis, otitis media, and sepsis among young children. Multi-drug resistant strains have raised great concern worldwide, thus the importance of prevention with vaccines has been emphasized. However, vaccines may force the appearance of pneumococcal infections by nonvaccine serotypes. Thus, distribution of pneumococcal serotypes should be monitored to estimate vaccine... |
-
-
- Review Article
- Present status and prospects of Haemophilus influenzae type b(Hib) immunization
-
Kyung Hyo Kim
-
Clin Exp Pediatr. 2006;49(3):242-250. Published online March 15, 2006
-
|
|
Haemophilus influenzae type b(Hib) conjugate vaccines prevent Hib disease in individuals and reduce the carriage and transmission of the organism in the community. The incidence of Hib disease has been decreased dramatically in a diverse range of countries through the use of a variety of conjugate vaccines and vaccine schedules. In some countries, the vaccine has caused a near-disappearance of... |
-
-
- Original Article
- Functional Immunity to Cross-Reactive Serotype 6A Induced by Serotype 6B in Pneumococcal Polysaccharide Vaccine
-
Kyung Hyo Kim
-
Clin Exp Pediatr. 2005;48(5):506-511. Published online May 15, 2005
-
|
|
Purpose : Streptococcus pneumoniae serotype 6B and 6A are important pathogens in pneumococcal infections. It is commonly assumed that the 6B vaccines elicit antibodies cross-reacting with the 6A serotype and the cross-reactive antibodies protect against infections of 6A. To examine this assumption, we measured the opsonophagocytic capacity to serotype 6A and 6B in adults.
Methods : Twenty-four adults were immunized... |
-
-
- Chest X-ray Findings and Serum Tumor Necrosis Factor-α Levels in Patients with Kawasaki Disease
-
Ji Young Kim, Jung Hyun Kwon, Kyung Hyo Kim, Jung Hyun Yu, Young Mi Hong
-
Clin Exp Pediatr. 2005;48(5):534-538. Published online May 15, 2005
-
|
|
Purpose : Kawasaki disease(KD) is a multisystemic inflammatory vasculitis of unknown etiology. Many complications other than cardiovascular involvement have been recognized in KD. However, there have been few reports published concerning involvement of the lungs in this disease. The purpose of this study was to examine the relationship between serum TNF-α, the degree of coronary artery dilatation and chest X-ray(CXR)... |
-
-
- Pneumococcal Surface Protein A of Streptococcus pneumoniae Isolates from Koreans
-
Kyung Hyo Kim
-
Clin Exp Pediatr. 2005;48(11):1206-1211. Published online November 15, 2005
-
|
|
Purpose : Pneumococcal protein vaccine based on pneumococcal surface protein A (PspA) is in development with the potential to offer a broad range of protection against different strains. PspA elicits protection in mice against fatal sepsis as well as carriage and lung infection. This study was performed to investigate the frequency of PspA families among Streptococcus pneumoniae recovered from Korean... |
-
-
- A Study for Adiponectin in Obese Adolescents with Hypertension
-
Jee Yoon Park, Su Jin Cho, Kyung Hyo Kim, Young Mi Hong, Keun Lee
-
Clin Exp Pediatr. 2004;47(7):719-725. Published online July 15, 2004
-
|
|
Purpose : The adipocyte has traditionally been known as a reservoir for energy, but currently there is growing evidence that the adipocyte plays an important role in the pathogenesis of energy metabolism and homeostasis. Adipocytokine released from the adipocyte has been known to play a role in diabetes mellitus, coronary artery disease and other diseases related with obesity. The purpose... |
-
-
- Aseptic Meningitis Secondary to High-Dose Intravenous
Immunoglobulin Therapy in Kawasaki Disease
-
Ae Ra Cho, Jee Yoon Park, Kyung Hyo Kim, Young Mi Hong
-
Clin Exp Pediatr. 2004;47(5):561-566. Published online May 15, 2004
-
|
|
Purpose : Kawasaki disease is a multisystemic inflammatory vasculitis and associated with neurologic features such as aseptic meningitis. High-dose intravenous immunoglobulin(IVIG) is used to treat Kawasaki disease and generally considered to be safe, but rare cases of aseptic meningitis with unknown etiology have been reported. The aseptic meningitis associated with Kawasaki disease was compared with meningitis as the adverse reaction... |
-
-
- Functional Antibody Responses to Seven Serotypes in Pneumococcal Polysaccharide Vaccine in Children
-
Ji Hye Park, Hee Jung Kim, Young Mi Hong, Kyung Hyo Kim
-
Clin Exp Pediatr. 2004;47(11):1173-1180. Published online November 15, 2004
-
|
|
Purpose : Streptococcus pneumoniae is an important pathogen in children as well as in elderly people. The aim of this study was to assess the opsonization activity of pneumococal capsular antibody to seven serotypes in 23-valent pneumococcal polysaccharide vaccine before and after immunization in Korean children.
Methods : Nine children from 24 to 49 months of age were immunized with 23-valent... |
-
-
- Original Article
- A Study of Receptor Expression in Leukocytes by
Quantitative Fluorescence Measurement
-
Kyung Hyo Kim, Ju Young Seoh
-
Clin Exp Pediatr. 2002;45(5):637-645. Published online May 15, 2002
-
|
|
Purpose : It is well known that the receptors for Fcγ moiety of IgG(FcγR) are instrumental in antibody-mediated clearance of microorganisms by granulocytes and monocytes, and immune regulation in lymphocytes. Furthermore, complement receptor-3(CR3) is also important in neutrophilic adhesion, diapedesis, and phagocytic functions. In an attempt to examine their roles in neonates, we compared the expressions of FcγRs and CR3... |
-
-
- Serogroup and Antimicrobial Resistance of
Streptococcus pneumoniae Isolated from Oropharynx in
Children Attending Day Care Center
-
Kyung Hyo Kim, Jong Eun Lee, Il Tae Whang, Kyung Ha Ryu, Young Mi Hong, Gyoung Hee Kim, Keun Lee, Eun-Suk Kang, Ki-Sook Hong
-
Clin Exp Pediatr. 2002;45(3):346-353. Published online March 15, 2002
-
|
|
Purpose : Penicillin- and multidrug-resistant S. pneumoniae poses a serious threat to clinicians because the rate of resistance of S. pneumoniae to penicillin in Korea has surged up to the world's highest level. This study was performed to assess the carriage rate, serogroups and antimicrobial susceptibility of S. pneumoniae isolated from oropharynx in children.
Methods : From March to July 1998,... |
-
-
- Risk Factors for Fatty Liver in Obese Children
-
Ki Won Park, Jong Eun Lee, Kyung Ha Ryu, Kyung Hyo Kim, Young Mi Hong, Gyung Hee Kim, Keun Lee, Jeong Hyun Yoo
-
Clin Exp Pediatr. 2001;44(6):669-676. Published online June 15, 2001
-
|
|
Purpose : The incidence of obese patients has increased recently in Korea. Obesity is associated with hypertension, hyperlipidemia, insulin resistance, and fatty liver. Since recent investigators have revealed that not only fat accumulation but also fibrosis and nonspecific hepatitis can be found in the livers of obese children, fatty liver is currently considered as an important complication. The purpose of... |
-
-
- Original Article
- Carriage and Antimicrobial Susceptibility of
Haemophilus influenzae Isolated from Oropharynges of Children
-
Kyung Hyo Kim, Kyoung Ah Lim, Il Tae Whang, Young Mi Hong, Eun Sook Kang, Ki Sook Hong
-
Clin Exp Pediatr. 2001;44(5):509-516. Published online May 15, 2001
-
|
|
Purpose : Haemophilus influenzae, one of the normal flora of the upper respiratory tract, can cause such infections as otitis, sinusitis, pneumonia, and meningitis in children. The oropharyngeal flora has therefore mainly been analyzed as a reservoir for pathogens. This study was performed to reveal the colonization rate of H. influenzae in the upper respiratory tract, their biotypes, their antimicrobial... |
-
-
- The Effect of rhG-CSF and rhGM-CSF on Expression of Fcγ Receptors and β2 Integrin and Respiratory Burst Function in Human Granulocytes
-
Kyung Hyo Kim, Kyung Ha Ryu, Moon Kook Park
-
Clin Exp Pediatr. 2001;44(4):397-404. Published online April 15, 2001
-
|
|
Purpose : Receptors for the Fc of IgG(FcγR) and a β2 integrin molecule, CD11c/CD18 are important in clearance of microbes by granulocytes. We performed an in vitro study on the effect of recombinant human granulocyte colony-stimulating factor(rhG-CSF), or granulocyte-macrophage colony-stimulating factor(rhGM-CSF) on the expression of FcγR II, FcγR III, CD11c and CD18 and respiratory burst function of granulocytes.
Methods : Peripheral... |
-
-
- Antibody Levels and Opsonophagocytic Function to S. pneumoniae 19F Capsular Polysaccharide
-
Kyung Hyo Kim, Ju Young Seoh, Moon Kook Park
-
Clin Exp Pediatr. 2001;44(4):405-412. Published online April 15, 2001
-
|
|
Purpose : The increasing prominence of pneumococcal infections and of antimicrobial resistance has emphasized the need for a effective vaccine to reduce the risk of pneumococcal disease in childhood. To study the antibody response of pneumococcal vaccine, we compared the concentration and opsonophagocytic capacity of antibodies to the capsular polysaccharide of S. pneumoniae serotype 19F in sera from healthy adults... |
-
-
- Case Report
- A Case Of Common Variable Immunodeficiency with Fatal Measles
-
Su Jin Cho, So Hyun Kim, Soo Jung Lee, Kyung Ha Yoo, Kyung Hyo Kim
-
Clin Exp Pediatr. 2001;44(12):1463-1468. Published online December 15, 2001
-
|
|
Common variable immunodeficiency(CVID) is a heterogeneous immunodeficiency syndrome characterized by hypogammaglobulinemia, recurrent bacterial infections, and a variety of immunological abnormalities. We report a 10-year-old boy diagnosed with CVID and a fatal case of measles. He was admitted for fever, cough, conjunctival injection with purulent discharge and maculopapular rash with some scattered pinpoint sized petechial lesions on the whole body for... |
-
-
- Original Article
- The Changes of Apoptosis and Viability in Stem Cells after Thawing with Lapse of the Time
-
Seun Joo Park, Sang Young Bae, Kyung Ha Ryu, Il Tae Whang, Kyung Hyo Kim, Young Mi Hong, Kyung Hee Kim, Keun Lee, Joo Young Seoh
-
Clin Exp Pediatr. 2000;43(12):1576-1582. Published online December 15, 2000
-
|
|
Purpose : Thawed stem cells should be infused as early as possible because delay of infusion leads to decrease of cell viability and formation of DNA clumping. The procedure of 10% Dimethyl sulfoxide(DMSO) removal and a long distance from the thawing location to the patient are the main causes of delay of infusion that results in the loss of cell... |
-
-
- Inhibitory Effects of Dexamethasone on Production IL-1α and TNF-α in Peripheral Blood Mononuclear Cells
-
Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
-
Clin Exp Pediatr. 1999;42(7):921-927. Published online July 15, 1999
-
|
|
Purpose : IL-1α and TNF-α have a seminal role in the intial events of inflammation. An area of intense interest is the assessment of new therapeutic modalities that regulate inflammatory response in acute bacterial infection. We conducted this study to compare the inhibitory effects of dexamethasone on the secretion of proinflammatory cytokines, such as IL-lα and TNF-α from cord... |
-
-
- Fcr Receptor and Mac-1 Expression and Functional Differentiation of HL-60 Cells by All-trans Retinoic Acid
-
Hae Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh,
-
Clin Exp Pediatr. 1999;42(4):462-471. Published online April 15, 1999
-
|
|
Purpose : During differentiation of HL-60 cells by all-trans retinoic acid(ATRA), we analyzed the expression of Fcr receptors and Mac-1 by molecules of equivalent soluble fluorochromes(MESF) and functional studies.
Methods : HL-60 cells were induced to differentiate by adding 1μM ATRA. On the 4th and 7th day after stimulation as well as before stimulation, the cells were analyzed for phenotypic and... |
-
-
- Functional Differentiation of HL-60 Cells by Dimethylsulfoxide and Phorbol 12-myristate 13-acetate
-
Hae Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh
-
Clin Exp Pediatr. 1999;42(3):355-363. Published online March 15, 1999
-
|
|
Purpose : During hematopoietic differentiation of HL-60 cells by DMSO and PMA, we demonstrated functional changes of HL-60 cells-phagocytic activity, respiratory burst, antibody-dependent cell-mediated cytotoxicity(ADCC) and opsonophagocytic activity.
Methods : HL-60 cells(ATCC CCL-240), cultured in RPMI 1640 and supplemented with 10% FBS, were induced to differentiate by adding 1.0% DMSO or 16nM PMA. On the 4th and 7th day after... |
-
-
- Microdeletion of Chromosome 7 in Williams Syndrome and Supravalvular Aortic Stenosis
-
Ho Sung Kim, Yoon Sung Kang, Kyung Hyo Kim, Young Mi Hong, Yong Soo Yun, Kwang Ho Lee
-
Clin Exp Pediatr. 1999;42(1):47-59. Published online January 15, 1999
-
|
|
Purpose : Williams syndrome is characterized by supravalvular aortic stenosis, mental retardation and peculiar facial appearance. Its genetic etiology is considered to be a hemizygotic deletion in Chromosome 7q11.23, which includes the elastin gene. We examined the hemizygotic deletion of Chromosome 7q11.23 in 12 Korean Williams syndrome patients and 8 patients with isolated supravalvular aortic stenosis and performed deletion mapping... |
-
-
- The Relationship between IL-1β, TNFα, IL-6 and Factors Associated with Febrile Reactions to Transfused Blood
-
Hae Shin Kyung, Kyung Ha Ryu, Kyung Hyo Kim, Young Mi Hong, Kyung Hi Kim, Keun Lee
-
Clin Exp Pediatr. 1999;42(1):108-114. Published online January 15, 1999
-
|
|
Purpose : Aggressive chemotherapy and bone marrow transplantation have a large demand for platelet concentrate and packed RBC transfusion. Febrile nonhemolytic transfusion reactions are an immunologically mediated reaction involving plasma in the recipient and the white blood cells in the donor. This study was performed to understand the role of cytokines and factors associated with febrile nonhemolytic transfusion reaction to... |
-
-
- Phenotypic and Functional Differentiation of Promyelocytic Cell Line HL-60 by N-N-dimethylformamide
-
Kyung Hyo Kim, Ju Young Seoh
-
Clin Exp Pediatr. 1998;41(4):481-488. Published online April 15, 1998
-
|
|
Purpose : HL-60 is a promyelocytic cell line. Fcγ receptors and complement receptor 3(CR3) play
important role in the protective response of granulocytes and monocytes against microbial infection.
We quantified the expression of FcγI, FcγII, FcγIII, and CD11b/CD18 during differentiation using
HL-60 cells by N-N-dimethylformamide(DMF). Functional studies, such as phagocytic activity,
respiratory burst and ADCC, were also performed.
Methods : HL-60 cells were induced to... |
-
-
- Study of Seroprevalence of Antimycoplasma Antibody in Healthy Children and its Diagnostic Value
-
Soo Kyung Choi, Ji Ah Jung, Kyung Hyo Kim, Gyoung Hee Kim
-
Clin Exp Pediatr. 1998;41(4):489-497. Published online April 15, 1998
-
|
|
Purpose : To evaluate the diagnostic reliability of the single serum titers of the specific serum
antibody determiantion method, we compared antimycoplasma antibody titers of 177 healthy children
with 353 children who had respiratory symptoms indicative of Mycoplasma pneumoniae infection.
Methods : We used Serodia-Myco II particle agglutination test and the titers of ≥1:40 were
regarded as positive.
Results : Age distribution of 177 healthy... |
-
-
- Normal Predicted Values of Pulmonary Function Test in Healthy Korean Children
-
Seung Yeon Nam, Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
-
Clin Exp Pediatr. 1998;41(3):338-345. Published online March 15, 1998
-
|
|
Purpose : We performed a pulmonary function test with simple, computerized spirometry composed
of pneumotachometry and evaluated the predicted normal values of air flow rates and lung volumes
in healthy Korean children. We calculated each of the simple and complex linear and logarithmic
regression equations setting the predicted values.
Methods : Four hundred and fifty-two healthy children were enrolled from December, 1994 to
August, 1995.... |
-
-
- Immunologic Changes of HL-60 Cells by Differentiation Inducing Agents I : Phenotypic Differentiation of FcγR and Mac-1
-
Hye Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh
-
Clin Exp Pediatr. 1998;41(10):1342-1350. Published online October 15, 1998
-
|
|
Purpose : Fc receptors and Mac-1 play an important role in the protective response of granulocytes and monocytes against microbial infection. FcγRⅠ, FcγRⅡ, FcγRⅢ as well as CD11b/ CD18 have never been measured in a quantitative way during hemopoiesis. Thus we quantified the expression of FcγRⅠ, FcγRⅡ, FcγRⅢ, and CD11b/CD18 during hematopoietic differentiation using HL-60 cells, which was induced to... |
-
-
- Serum G-CSF Level Changes in Neonatal Sepsis
-
Kyung Ha Ryu, Eun Ae Park, Kyung Hyo Kim, Gyung Hee Kim
-
Clin Exp Pediatr. 1998;41(1):12-18. Published online January 15, 1998
-
|
|
Purpose : The neonate is susceptible to severe and overwhelming bacterial infections. One of the most important deficiency in the neonatal host defense system seems to be quantitative and qualitative deficiency of the myeloid and the phagocytic system. Granulocyte colony-stimulating factor(G-CSF) has been shown to induce neutrophilia and enhance mature effector neutrophil function. We examined serum levels of G-CSF in... |
-
-
- Urinary Interleukin-1β Levels in Children with Urinary Tract Infection
-
Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
-
Clin Exp Pediatr. 1997;40(7):981-990. Published online July 15, 1997
-
|
|
Purpose : IL-1β and TNF-α are important mediators of the inflammatory response in serious
bacterial infections. The mucosal and systemic IL-1β and TNF-α responses to urinary tract
infection are analyzed in children with acute urinary tract infection.
Methods : We studied the levels of these two cytokines in the urine and sera of 21 children at
diagnosis and after treatment with sandwich ELISA method.
Results... |
-
-
- The Expression of Fcγ Receptors in Cord and Adult Blood Granulocytes
-
Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh, Hae-Kyung Park
-
Clin Exp Pediatr. 1997;40(6):794-800. Published online June 15, 1997
-
|
|
Purpose : The immature neonatal immune system is thought to result in increased risk of infection.
Receptors for the Fc moiety of IgG(FcγR) are important in antibody-mediated clearance of
microbes by granulocytes and monocytes/macrophages. As an approach to understand their role in
neonatal life, we compared the constitutive expression of the three Fc receptors-FcγRI(CD64), Fcγ
RII(CD32) and FcγRIII(CD16)-of neonatal granulocytes with those of adult... |
-
-
- Production of Interleukin-1α and Tumor Necrosis Factor-α by Human Cord and Adult Blood Mononuclear Cells Stimulated by TSST-1 and LPS
-
Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
-
Clin Exp Pediatr. 1997;40(5):690-700. Published online May 15, 1997
-
|
|
Purpose : Immature immunological defens mechanism in the neonate may contribute to the high susceptibility to overwhelming sepsis. S. aureus TSST-1 and E. coli LPS known as one of the important pathogens of septic shock or toxic shock induce massive release of various cytokines, such as tumor necrosis factor-alpha(TNF-α) and interleukin-1α(IL-1α) produced from peripheral blood mononuclear cells(PBMC). In contrast, limited... |
-
-
- Dermatophagoides Pteronyssinus Specific IgG-subclass Antibodies in Allergic Children
-
Soo Ja Hwang, Kyung Hyo Kim, Young Mi Hong
-
Clin Exp Pediatr. 1997;40(5):701-707. Published online May 15, 1997
-
|
|
Purpose : Although immunoglobulin E play a major role in immediate hypersensitivity reactions, some reaginic activity is associated with IgG. Part of the reaginic activity is associated with IgG1, IgG4.
In contrast with this reaginic activity of IgG4, allergen-specific IgG4 antibody is allergen neutralizing antibody and contribute to the benificial effect of immunotherapy. The role of specific IgG antibody in allergic... |
-
-
- Plasma Fibronectin Concentration in the Premature,Fullterm Neonates and Infants
-
Hyun Joo Lee, Kyung Hyo Kim, Gyoung Hee Kim
-
Clin Exp Pediatr. 1997;40(4):473-479. Published online April 15, 1997
-
|
|
Purpose : Plasma fibronectin has important role in the inflammatory response as non-specific opsonin and host defense. Plasma fibronectin concentration is different according to age and presence of infection. We performed this study to evalulate plasma fibronectin concentration in the healthy preterm, term neonates and infants and how that correlate with gestational age and birth weight and increased CRP concentration.... |
-
-
- Enzyme Amplification, A Method Applied to Provide An ELISA
for Studying Anti-Hib-Ps Antibodies in Children
-
Kyung Hyo Kim, Moon H. Nahm
-
Clin Exp Pediatr. 1997;40(2):173-180. Published online February 15, 1997
-
|
|
Purpose : Enzyme immunoassay (EIA) is now a widely used technique. We have
described the application of enzyme amplification (sensitive ELISA) in the field of
immunoassays of pediatric population. There are two issues with the sensitive ELISA.
First is that one can minimize the serum volume, an important concern for pediatricians. The second is the problem of background signal. We demonstrate that it... |
-
-
- Serum Secretory CD4 and CD8 Levelsin Kawasaki Disease
-
Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
-
Clin Exp Pediatr. 1996;39(4):543-551. Published online April 15, 1996
-
|
|
Purpose : Kawasaki disease (KD) is an acute febrile illness of infancy and early childhood characterized by diffuse vasculitis. Although the disease is generally self-limited, up to 25% of untreated patients with KD may develop coronary artery abnormalities. The acute phase of KD is characterized by marked activation of the immune system leading to increased cytokine production by immune effector... |
-
-
- Study of Epstein Barr Virus Antibodies in Patients with Kawasaki Disease
-
Dong Hee Shin, Kyung Hyo Kim, Young Mi Hong, Gyung Hee Kim
-
Clin Exp Pediatr. 1996;39(11):1603-1610. Published online November 15, 1996
-
|
|
Purpose : The etiology of the Kawasaki disease remains unclear, many strong clinical and
epidemiologic characteristics suggest an infectious etiology. However, conventional bacterial and
viral cultures and extensive serologic studies have not revealed a consistent causative agent. Thus
we studied the Epstein Barr virus(EBV), one of the most important pathogens, to access the
association between the EBV and Kawasaki disease.
Methods : Seventy-two patients with... |
-
-
- Pulmonary Function Test in Korean Neonates by Expiratory Flow-Volume Curve
-
So Young Park, Kyung Hyo Kim, Gyoung Hee Kim
-
Clin Exp Pediatr. 1996;39(1):53-62. Published online January 15, 1996
-
|
|
Purpose : Neonatal pulmonary function test(PFT) adds a new dimension to the understanding and care of the infant at risk for lung dysfunction. PFT can be identified the risk for pulmonary problems and safely and effectively diagnosed, quantified, and qualified the dysfunction. So it is possible to early institution of prophylatic respiratory therapy in such neonates and it can improved... |
-
-
- Structure and Expression of Human Antibody Clones Specific for
H. influenzae type b Capsular Polysaccharides
-
Kyung Hyo Kim, Gook Hyun Chung, Mitchell G. Scott, Moon H. Nahm
-
Clin Exp Pediatr. 1995;38(5):649-659. Published online May 15, 1995
-
|
|
Purpose : Haemophilas influenzae type b is a significant pathogen in children and several v accines with different immunologic properties are clinically used. An individual produces oligoc-lonal anti-Hib-PS antibodies and the repertoire of human anti-HihPS Antibody (Ah) can be div- ided into two types by the structure of the light chain V region. Ah using A2-VK II gene product, which... |
-
-
- Production, Characterization, and Clinical Application of Perchloric Acid Soluble M. tuberculosis Antigen (TB-I)
-
Kyung Hyo Kim, John Linton, Yunsop Chong, Dong Soo Kim
-
Clin Exp Pediatr. 1993;36(8):1107-1115. Published online August 15, 1993
-
|
|
The immune response to M. tuberculosis engages T-cell medicated reactions which determine the degree of resistance and also the clinical pattern of disease. Although antibodies produced by the infected host have yet no proven protection, they are appilicable for alternative diagnostic tests in tuberculosis. Preparation of purified antigens from Mycobacteria with specific antigenic determinants would improve serological diagnosis in tuberculosis.
The... |
-
-
- Production and Characterization of Monoclonal Antibodies to Perchloric Acid Soluble Antigen of M. tuberculosis(TB-II)
-
Kyung Hyo Kim, Dong Soo Kim
-
Clin Exp Pediatr. 1993;36(8):1116-1123. Published online August 15, 1993
-
|
|
Mycobacteria cause diseases which occur the world over and whoich carry a considerable burden in morbidity, mortality and social problems. A battery of monoclonal antibodies specific for mycobacterial antigens would provide a useful tool for rapid diagnosis of mycobacterial diseases. Fourtenn monoclonal antibodies to perchloric acid soluble antigne of M. tuberculosis were produced. Immunoglobulin isotypes of monoclonal antibodies were ten... |
-
-
- A Study on Serum Immunoglobulins and Complements in Newborn Infants by Gestational Weeks
-
Ji Eun Lee, Kyung Hyo Kim, Kyung Hee Kim
-
Clin Exp Pediatr. 1993;36(11):1555-1561. Published online November 15, 1993
-
|
|
The author investigated serum immunoglobulin (IgG, IgA, and IgM) and complements (C3) of cord blood in 74 cases of normal fulterm infants and 50 cases of premature infants. Serum immunolglobulin and complement levels were measured by the single radial immunodiffusion method.
The following results were obtained ;
1) The mean serum IgG levels of cord blood in 74 cases of the normal... |
-
-
- Dermatophagoides Farinae Specific IgG-Subclass Antibody in Allergic Children
-
Young Mi Hong, Kyung Hyo Kim, Eun Ae Park, Gyoung Hee Kim
-
Clin Exp Pediatr. 1993;36(10):1651-1358. Published online October 15, 1993
-
|
|
For determining the distribution of specific IgE and IgG-subclass antibodies and their role in allergic disorders, we measured the serum levels of specific IgG-subclass and IgE antibodies to Dermatophagoides farinae(Df) on 60 atopic children, aged between 8 to 12. All of them had positive skin test to Df, and was grouped into three: children with asthma only (group 1), with... |
-
-
- Production and Characterization of Monoclonal Antibodies to Perchloric Acid Extract Antigen of M. bovis BCG(BCG Ⅱ)
-
Kyung Hyo Kim, Dong Soo Kim, Jeon Soo Shin
-
Clin Exp Pediatr. 1992;35(9):1183-1192. Published online September 15, 1992
-
|
|
Mycobacteria causes disease which occur over the world. The development of reliable serological teset for the diagnosis of tuberculosis in humans has been complicated by the large degree of cross reactivitiy between antigens of Mycobacteria species can be used as a tool for serodiagnosis of tuberculosis. Fourteen monoclonal antibodies to perchloric acid extract antigen of M. bovis BCG were produced.... |
-
-
- Production, Characterization, and Clinical Application of Perchloric Acid Extract of M. bovis BCG (BCG I)
-
Kyung Hyo Kim, Dong Soo Kim
-
Clin Exp Pediatr. 1992;35(8):1059-1065. Published online August 15, 1992
-
|
|
Tuberculosis has been an important world-wide infectious disease. The prevalence of radiologically active tuberculosis was 1.8% of population in Korea. Probably the most important aspect of the pathogenesis of tuberculosis is the nature and specificity of the response of the immune system to the antigens of tubercle bacilli. Preparation of purified antigens from Mycobacteria with specific antigenic deterninants would improve... |
-
-
- PPD Conversion Rate and Complications According to the Different Time of BCG Vaccination.
-
Kyung Hyo Kim, Seung Joo Lee, Keun Lee
-
Clin Exp Pediatr. 1987;30(5):487-490. Published online May 31, 1987
-
|
|
BCG vaccination shortly after birth has shown to protect against tuberculosis in some studies.
PPD conversion rate and complications were compared between 174 neonates who received BCG
vaccine within 1 week after birth and 330 infants who received BCG vaccine at the 1 month of age.
The results were as follows:
1) The PPD conversion rate was 20.11% in the neonates who received vaccine within... |
-
-
- A Prospective Study ot Neonatal Acute Renal Failure: The Significance of Various Diagnostic Indices.
-
Kyung Hyo Kim, Seung Joo Lee, Keun Lee
-
Clin Exp Pediatr. 1987;30(4):378-384. Published online April 30, 1987
-
|
|
Acute renal failure is defined as a sudden decrease in renal function resulting in progressive
retention of nitrogenous waste products. Acute renal failure should be suspected in any infant who has
a sustained decrease in urine output to less than 1 ml per kg per hour, a blood urea nitrogen level
above 20 mg per dl, a serum creatinine level greater than 1.0... |
-
-
- Case Report
- A Case of Iatrogenic Femoral Arteriovenous Fistula.
-
Kyung Hyo Kim, Moon Ja Kim, Kyung Hee Kim, Keun Lee
-
Clin Exp Pediatr. 1986;29(9):999-1001. Published online September 30, 1986
-
|
|
Arteriovenous fistula is an abnormal vascular structure that establishes a communication
between an artery and a vein without the interposition of the capillary bed. We experienced a case of
iatrogenic femoral arteriovenous fistula in a six month-old girl. She was admitted with the chief complaint of different size of both lower leg which was first noted about l?/2 months PT A.... |
-
-
- 2 Cases of Herpes Simplex Virus Infection in the neonates.
-
Kyung Hyo Kim, Jeong Wan Seo, Kyung Hee Kim, Keun Lee, Ki Sook Hong, Mi Ae Lee, Woon Sup Han, Ok Kyung Kim, Yung Oh Shin, Sung Bok Paik
-
Clin Exp Pediatr. 1986;29(1):101-107. Published online January 31, 1986
-
|
|
Herpes simplex virus infection in the newborn is generally thought to be associated with a grave prognosis
in terms of mortality and severe neurologic sequelae among survivors. Most neonatal herpes infection are
due to type 2 herpes virus hominis, acquired either by ascending infection from the mother’s genital area to the intrauterine infant after premature rupture of membrame, or by... |
-
-
- A Case of Acardius Twin.
-
Kyung Hyo Kim, Jung Soo Park, Mina Lee, Hye Kyung Lee, Sung Sik Shin, Je G Chi
-
Clin Exp Pediatr. 1984;27(1):84-88. Published online January 31, 1984
-
|
|
A case of acardiac twins to a 30 year-old primiparous mother is presented. This case was diagnosed to have this anomaly by ultrasonography at 28 weeks and 33 weeks of gestation. The acardiac monster was delivered as the second twin without any signs of Life. It weighed 2,175 gms and was connected to the placenta by an umbilical cord having... |
-
-
|
