Korean Journal of Pediatrics 2008;51(6):622-628.
Published online June 15, 2008.
Immunogenicity of 7-valent pneumococcal conjugate vaccine related to booster immunization in Korean children
So Eun Park1, Hyunju Lee2, Soo Young Lim3, Kyung Hyo Kim2
1Department of Pediatrics, College of Medicine, Pochon CHA University, Center for Vaccine Evaluation and Study, Ewha Medical Research Institute, Seoul, Korea
2Department of Pediatrics, School of Medicine, Ewha Womans University, Center for Vaccine Evaluation and Study, Ewha Medical Research Institute, Seoul, Korea
3Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea
한국 소아에서 7가 폐렴사슬알균 단백결합 백신의 추가접종 면역원성에 관한 연구
박소은1, 이현주2, 임수영3, 김경효2
1포천중문의과대학 소아과학교실, 이화여자대학교 의과대학 의과학연구소 백신효능 연구센터
2이화여자대학교 의과대학 소아과학교실, 이화여자대학교 의과대학 의과학연구소 백신효능 연구센터
3이화여자대학교 의과대학 의과학연구소 백신효능 연구센터
Correspondence: 
Kyung Hyo Kim, Email: kaykim@ewha.ac.kr
Abstract
Purpose
: The purpose of this study was to evaluate the immunogenicity of the booster immunization with pneumococcal conjugate vaccine in Korean children.
Methods
: Thirty-nine children aged 12-23 months who visited Kangnam CHA Hospital between September 2006 and December 2006 were enrolled. The children were divided into primary and booster groups depending on their vaccination status for the 7-valent pneumococcal conjugate vaccine. The anti-pneumococcal antibody levels of each serotype included in the vaccine (4, 6B, 9V, 14, 18C, 19F, 23F) were determined by third-generation ELISA.
Results
: The geometric mean titer (GMT) of antibodies to each pneumococcal serotype in the booster group was higher than in the primary group (P<.05). The percentage of subjects with pneumococcal antibodies ≥0.35 g/mL was 90.5-100% for all serotypes in both the primary and booster groups. The percentage of subjects with pneumococcal antibodies ≥1.0 g/mL in the booster group was 94.4-100%, which was higher than the primary group except for serotypes 6B and 14 (P<.05). The percentage of subjects with pneumococcal antibodies ≥5.0 g/mL in the booster group was 50.0-94.4% which was higher than the primary group for all serotypes (P<0.05).
Conclusion
: The immunogenicity of a booster dose of the pneumococcal conjugate vaccine in Korean children was high and the immunogenicity of a primary series was also relatively high. To determine the feasibility of the introduction of the pneumococcal conjugate vaccine and the appropriate schedule for Korean children, further prospective investigation of the immunogenicity of the booster immunization is needed.
Key Words: Pneumococcal vaccine, Immunization, Secondary


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