| The Expression of Fcγ Receptors in Cord and Adult Blood Granulocytes |
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Kyung Hyo Kim1, Gyoung Hee Kim1, Ju Young Seoh2, Hae-Kyung Park2 |
1Department of Pediatrics, College of Medicine, Ewha Woman`s University, Seoul, Korea
2Department of Microbiology, College of Medicine, Ewha Woman`s University, Seoul, Korea |
| 성인과 비교한 제대혈 과립구의 Fcγ 수용체 표현에 관한 연구 |
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김경효1, 김경희1, 서주영2, 박혜경2 |
1이화여자대학교 의과대학 소아과학교실
2이화여자대학교 의과대학 미생물학교실 |
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| Abstract |
Purpose
: The immature neonatal immune system is thought to result in increased risk of infection.
Receptors for the Fc moiety of IgG(FcγR) are important in antibody-mediated clearance of
microbes by granulocytes and monocytes/macrophages. As an approach to understand their role in
neonatal life, we compared the constitutive expression of the three Fc receptors-FcγRI(CD64), Fcγ
RII(CD32) and FcγRIII(CD16)-of neonatal granulocytes with those of adult granulocytes.
Methods
: Using quantitative immunofluorescence by flow cytometry, we have compared the
constitutive expression of the three Fc receptors-FcγRI(CD64), FcγRII(CD32) and FcγRIII(CD16)-
by neonatal and adult blood granulocytes.
Results
: The proportion of FcγRI＋ granulocytes is significanly high in cord blood compared to
that of adult. However, the proportions of FcγRII＋ or FcγRIII＋ cells are significanly low in cord
blood compared to those of adlut.
Conclusion
: There were differences in the expression of FcγR on granulocytes between cord
blood and adult peripheral blood. This results suggest that the differences in FcγR expression
may be contributed to the differences in functional activity. |
| Key Words:
Cord blood, Granulocytes, FcγR |
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