| A Study for Adiponectin in Obese Adolescents with Hypertension |
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Jee Yoon Park, Su Jin Cho, Kyung Hyo Kim, Young Mi Hong, Keun Lee |
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Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea |
| 고혈압이 동반된 비만 청소년에서 Adiponectin에 대한 연구 |
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박지윤, 조수진, 김경효, 홍영미, 이근 |
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이화대학교 의과대학 동대문병원 소아과 |
Correspondence:
Young Mi Hong, Email: hongym@chollian.net
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| Abstract |
Purpose
: The adipocyte has traditionally been known as a reservoir for energy, but currently there is growing evidence that the adipocyte plays an important role in the pathogenesis of energy metabolism and homeostasis. Adipocytokine released from the adipocyte has been known to play a role in diabetes mellitus, coronary artery disease and other diseases related with obesity. The purpose of this study was to investigate the relationship between adipocytokines and hypertension and to find out whether it is useful to evaluate adipocytokines as a risk factor for the development of hypertension in obese adolescents.
Methods
: Forty five obese adolescents(16-17-years-old, obesity index >130) with hypertension and 27 normal controls with normotensive blood pressure were included in this sudy. Obesity index and body mass index were calculated and blood pressure was measured at the resting state. Lipid profile, insulin, adiponectin, leptin, TNF-α and IL-6 levels were tested after 10 hours of fasting.
Results
: Adiponectin was significantly lower in the obese group, compared to the control group (3,241.3±2,055.9 g/mL vs 5,088.4±1,347.1 g/mL). Leptin(10.6±5.4 ng/mL), TNF-α(7.2±0.8 pg/mL) and IL-6(7.2±0.8 pg/mL) were significantly higher in the obese group. Insulin was significantly higher in the obese group than the control group(14.7±7.5 IU/mL vs 7.9±2.9 IU/mL). Adiponectin had negative correlations with TNF-α, body mass index, LDL cholesterol, obesity index, diastolic, and systolic blood pressure.
Conclusion
: Adiponectin might be a predictor of hypertension and a guideline for clinical intervention. Further clinical research will be necessary to ascertain the relation of adiponectin in hypertensive patients without obesity. |
| Key Words:
Adipocytokines, Adiponectin, Hypertension, Obesity |
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