| Study of Seroprevalence of Antimycoplasma Antibody in Healthy Children and its Diagnostic Value |
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Soo Kyung Choi, Ji Ah Jung, Kyung Hyo Kim, Gyoung Hee Kim |
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Department of Pediatrics, Ewha Womans University Medical College, Seoul, Korea |
| 건강한 소아에서 Mycoplasma 항체가의 분포 및 이의 진단적 유용성에 관한 연구 |
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최수경, 정지아, 김경효, 김경희 |
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이화여자대학교 의과대학 소아과학교실 |
Correspondence:
Soo Kyung Choi, Email: 1
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| Abstract |
Purpose
: To evaluate the diagnostic reliability of the single serum titers of the specific serum
antibody determiantion method, we compared antimycoplasma antibody titers of 177 healthy children
with 353 children who had respiratory symptoms indicative of Mycoplasma pneumoniae infection.
Methods
: We used Serodia-Myco II particle agglutination test and the titers of ≥1:40 were
regarded as positive.
Results
: Age distribution of 177 healthy children was between 4-17 years and among these
children there were 105 males and 75 females. Age distribution of 353 children with respiratory
symptoms was between 2-17 years and consisted of 187 males and 166 female children. The results
of antimycoplasma antibody titers of healthy 177 children were 95 cases(53.7%) of negative AMA,
30 cases(16.9%) of 1:40, 27 cases(15.3%) of 1:80, 19 cases(10.7%) of 1:160, 6 cases(3.4%) of 1:320
and there were no cases of ≥1:640. The results of antimycoplasma antibody titers of 353 children
with respiratory symptoms were 195 cases(55.2%) of negative antimycoplasma antibody 19
cases(5.4%) of 1:40, 28 cases(7.9%) of 1:80, 30 cases(8.5%) of 1:160, 33 cases(9.3%) of 1:320, and
there were a total of 48 cases(13.6%) that were ≥1:640. In healthy children the antimycoplasma
antibody titers above 1:40 were 14% at 4 years of age, 7% at 5 years, 40% at 6 years and leveled
out until 16 years of age.
Conclusion
: Antimycoplasma antibody titer distribution in healthy children ranged from negative to
1:320, therefore, if the single serum sample titer is ≤1:320, for a definitive diagnosis it is necessary
to compare antibody levels after 2-3 weeks. |
| Key Words:
Mycoplasma pneumoniae, Antimycoplasma antibody titer, Particle agglutination test |
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