Journal of the Korean Pediatric Society 1995;38(7):970-975.
Published online July 15, 1995.
Study on Anti-neutrophil Cytoplasmic Antibodies in Children with Henoch-Schölein Purpura
Shin Jong Lee1, Woo Yeong Chung1, Chul Ho Kim1, Jeong Nyeo Lee2
1Department of Pediatrics, Pusan Paik Hospital, College of Medicine, Inje University, Pusan, Korea
2Department of Clinical Parthology, Pusan Paik Hospital, College of Medicine, Inje University, Pusan, Korea
Henoch-Schölein자반증 환아에서 항호중구 세포질 자가항체에 관한 연구
이신종1, 정우영1, 김철호1, 이정녀2
1인제대학 의과대학 부산 백병원 소아과학교실
2인제대학 의과대학 부산 백병원 임상병리학교실
Abstract
The presence of IgG, IgA and IgM antineutrophil cytoplasmic antibodies(ANCA) were inves-tigated in 32 children with Henoch-Schölein Purpura(HS purpura), in 14 children with HS pur-pura nephritis who were confirrned by renal biopsy and in 12 control children using flow cytom-etry(FASCan, Beckton-Dickinson, Co, USA) and indirect immunofluorescence technique(Sigma Diagnostics, USA). There were no evidence of IgG, IgA or IgM cytoplasmic ANCA(p-ANCA), and perinuclear ANCA(c-ANCA) in the sera of 32 children. These results suggest that ANCA are not involved in the pathogenesis of vasculitis in HS purpura & HS purpura nephritis.
Key Words: Henoch-Schö, lein purpura, Anti-neutrphil cytoplasmic antibodies


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