Journal of the Korean Pediatric Society 2002;45(3):346-353.
Published online March 15, 2002.
Serogroup and Antimicrobial Resistance of Streptococcus pneumoniae Isolated from Oropharynx in Children Attending Day Care Center
Kyung Hyo Kim1, Jong Eun Lee1, Il Tae Whang1, Kyung Ha Ryu1, Young Mi Hong1, Gyoung Hee Kim1, Keun Lee1, Eun-Suk Kang2, Ki-Sook Hong2
1Department of Pediatrics, College of Medicine, Ewha Woman's University, Seoul, Korea
2Department of Clinical Pathology, College of Medicine, Ewha Woman's University, Seoul, Korea
유아원 소아의 구인강에서 분리된 폐구균의 혈청군과 항균제 내성에 관한 연구
김경효1, 이종은1, 황일태1, 유경하1, 홍영미1, 김경희1, 이근1, 강은숙2, 홍기숙2
1이화여자대학교 의과대학 소아과학교실
2이화여자대학교 의과대학 임상병리학교실
Correspondence: 
Kyung Hyo Kim, Email: kaykim@mm.ewha.ac.kr
Abstract
Purpose
: Penicillin- and multidrug-resistant S. pneumoniae poses a serious threat to clinicians because the rate of resistance of S. pneumoniae to penicillin in Korea has surged up to the world's highest level. This study was performed to assess the carriage rate, serogroups and antimicrobial susceptibility of S. pneumoniae isolated from oropharynx in children.
Methods
: From March to July 1998, 209 children under 5 years of age were recruited from five day care centers. The carriage rate for pneumococci was obtained. Antimicrobial susceptibilities were determined with the E-test and agar dilution methods. Serogrouping was performed on 48 of the pneumococcal isolates by the Quellung reaction.
Results
: The carriage rate of S. pneumoniae was 30.1%. Antimicrobial susceptibility profiles were available for 59 of the isolates. Sixty-six percent of isolates were not susceptible to penicillin, and multidrug-resistance was observed in 76.3% of the isolates. A high proportion of the penicillin-resistant strains showed associated resistance to trimethoprim-sulfamethoxazole, tetracycline, erythromycin, and oxacillin. The most prevalent oropharyngeal serogroups were 19, 6, 3, 23, and 29. Resistance of the pneumococcal isolates to penicillin was different according to the serogroups. All of the strains of serogroup 19, 23, and 29 was resistant to penicillin but 87.5% of serogroup 3 strains were susceptible to penicillin.
Conclusion
: The resistance rate of S. pneumoniae isolated from oropharynx in children was very high to penicillin and other antimicrobial agents. For the reduction of the drug-resistant rate of S. pneumoniae, clinicians should be required to be more judicious in their use of antimicrobial agents.
Key Words: S. pneumoniae, Colonization rate, Serogroup, Antimicrobial resistance


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