Journal of the Korean Pediatric Society 2003;46(9):846-853.
Published online September 15, 2003.
Serotypes and Penicillin Susceptibility of Streptococcus pneumoniae Isolated from Clinical Specimens and Healthy Carriers of Korean Children
Jin-A Lee1, Nam-Hee Kim1, Dong-Ho Kim1, Ki-Won Park1, Yun-Kyung Kim1, Kyoung-Hyo Kim2, Jin-Young Park3, Eun-Hwa Choi1, Hoan-Jong Lee1
1Departments of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
2Departments of Pediatrics, Ewha Women's University College of Medicine, Seoul, Korea
3Departments of Pediatrics, Sungkyunkwan University College of Medicine, Kangbuk Samsung Hospital, Seoul, Korea
소아의 임상 검체 및 건강한 소아의 비인두에서 분리된폐구균의 혈청형 및 페니실린 감수성
이진아1, 김남희1, 김동호1, 박기원1, 김윤경1, 김경효2, 박진영3, 최은화1, 이환종1
1서울대학교 의과대학 소아과학교실
2이화여자대학교 의과대학 소아과학교실
3성균관대학교 의과대학 강북삼성병원 소아과
Correspondence: 
Hoan-Jong Lee, Email: hoanlee@plaza.snu.ac.kr
Abstract
Purpose
: Pneumoccocus is one of the most important causes of invasive infection through the childhood period and the prevelance of antibiotics resistance of pneumococcus is increasing worldwide. A 7-valent conjugate vaccine has been developed. It is important to know the prevalence of each serotype of pneumococci in the countries where the vaccine is used to estimate the coverage rate by the vaccine.
Methods
: One hundred and twenty seven strains of clinical isolates and 72 strains from healthy carriers recovered from Korean children during the period from 1997 to 2002 were subjected to determination of serotype by Quellung reaction and penicillin susceptibility with oxacillin disc diffusion test.
Results
: Forty-three per cent of clinical isolates were obtained from children under two years of age. Thirty strains(24%) were isolated from normally sterile body fluids. The frequent serotypes were 19F, 19A, 23F, 6A, 6B and 9V. Fifty-six per cent of the clinical isolates were represented in the current 7-valent protein conjugate pneumococccal vaccine, and 84% when the cross-reactive serotypes were included. Frequent serotypes of strains isolated from one to five year-old healthy children were 19F, 14, 11A, 23F, 18C, and 19A. Seventy-one per cent of the carrier strains were included in the 7- valent vaccine. Ninety-three per cent of the clinical isolates and 86% of carrier strains were not susceptible to penicilline.
Conclusion
: Fifty-six to 84% of pneumococci recovered from Korean children are covered by the current 7-valent protein conjugate pneumococcal vaccine and the prevalence of penicillin resistance was very high.
Key Words: Streptococcus pneumoniae, Quellung reaction, Conjugate vaccine


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