Journal of the Korean Pediatric Society 1989;32(2):165-179.
Published online February 28, 1989.
Changes of Antimicrobial Susceptibilities of Bacteria Isolated from Clinical Specimens During Recent Four Years.
Byung Rai Cho, Young Jin Hong, Don Hee Ahn, Keun Chan Sohn
Department of Pediatrics, National Medical Center, Seoul, Korea
최근 4년간에 있어서 각종 항생제에 대한 균 감수성의 변천
조병래, 홍영진, 안돈희, 손근찬
국립의료원 소아과
Received: 4 August 1988   • Accepted: 23 September 1988
Abstract
From Jan,M 1983 to Dec., 1986, we studied total 2386 microorganisms which were isolated from various clinical specimens of admitted patients and out-patients in the department of pediatrics, NMC, and their antimicrobial susceptibilities were compared. The results were as follows; 1) The most frequently isolated stains from various specimens were S. aureus from throat, E. coli from urine, Shigella from stool, S. aureus from blood, Streptococcus from CSF and S. aureus from others. 2) S. aureus was highly susceptible to cephalothin as 94% susceptibility. Its susceptibility to cefotaxim was 85%, to amikacin 80%, to methicillin 51 % and to penicillin 2%. Its susceptibility to methicillin was decreased to half during recent 15 years. 3) S. epidermidis was highly susceptible to cephalothin as 92% susceptibility. Its susceptibliity to amikacin 88%, to cefotaxim 64%, to methicillin 24% and to penicillin 3%. Its susceptiblity to methicillin was decreased during recent 5 to 6 years from 50% susceptility to 25%. 4) Enterococcus was highly suceptible to ampicillin as 96% susceptibility, and its susceptibility to ampicillin was not changed during recent 15 years. 5) Streptococcus was less susceptible to penicillin as 42% susceptibility, and moderately susceptible to cephalothin as 57% susceptibility. 6) E. coli was less susceptible to ampiciUin and cephalothin as 20% and 19% susceptibility respectively, and was highly susceptible to amikacin and cefotaxim as 95% susceptibility. Its susce. ptiblities to gentamicin and tobramycin were gradually decreased during recent 4 years. 7) Klebsiella was highly susceptible to amikacin and cefotaxim as 96% and 94% susceptibility respectively. Its susceptibility to gentamicin was decreased from 90% susceptibility to 60% during recent 10 years. 8) Proteus was highly susceptible to amikacin and cefotaxim as 95% susceptibility and its sus. ceptibilities to gentamin and tobramycin were 80% and 83% respectively. 9) Pseudomonas was highly susceptible to amikacin as 75% susceptibility. However, its suscepti. bilities to gentamicin and tobramycin were gradually decreased to 45% in 1986. Its susceptibilities to cefotaxim and carbenicillin were 42%. 10) Enterobacter was highly susceptible to amikacin and cefotaxim as 87% and 83% susceptibility respectively. Its susceptibilities to gentamicin and tobramycin were average 61 % and 55% respective. ly during recent 4 years. 11) Acinetobacter was moderately susceptible to aminoglycosides as 45-65% susceptibility, and less susceptible to other antibiotics. 12) Salmonella was highly susceptible to amikacin, gentamicin, tobramycin, and cefotaxim as 100 % susceptibility. Its susceptibilities to ampicillin and chloramphenicol were average 76% and 88% respectively during recent 4 years. It is noticeable that high resistance to ampicillin and chloram. phenicol appeared recently. 13) Shigella was highly susceptible to amikacin, gentamicin, tobarmycin and cefotaxim as 86-100 % susceptibility. However, its susceptibilities to ampicillin and chloramphenicol were 10% and 0% respectively. 14) Serratia was moderately susceptible to amikacin as 58% susceptibilty, and to cefotaxim as 60 % susceptibility. 15). H. influenza was highly susceptible to ampicillin as 91 % susceptibility, and to chloramphenicol as 100% susceptibility. However, its accuracy is doubtful due to small number of strains.
Key Words: Antimicrobial susceptibilities infection in childhood


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