- Original Article
- Salmonellosis in children: Analysis of 72 Salmonella-positive culture cases during the last 10 years
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Sung Hoon Noh, Ka Young Yu, Jung Soo Kim, Pyoung Han Hwang, Dae Sun Jo
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Clin Exp Pediatr. 2009;52(7):791-797. Published online July 15, 2009
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Purpose : We aimed to investigate the clinical manifestations of and antibiotic resistance in culture-proven childhood salmonellosis.
Methods : Clinical manifestations and laboratory data of and antibiotic use in subjects with culture-proven childhood salmonellosis, who were treated at the Chonbuk National University Hospital between September 1998 and August 2008, were analyzed retrospectively. Patients with underlying diseases or concomitant illnesses were excluded.
Results... |
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- The societal cost of rotavirus infection in South Korea
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Bong Min Yang, Dae Sun Jo, Youn Hee Kim, Ji Min Hong, Jung Soo Kim
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Clin Exp Pediatr. 2008;51(9):977-986. Published online September 15, 2008
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Purpose : This study aims to estimate the financial cost of rotavirus infection in Korea in the year of 2005.
Methods : The incidence rates used were from the epidemiological profile at Jeoungeub District (5.8 cases/1,000 children <5 years old for inpatients, and 22.65 cases/1,000 children <5 years old for outpatients, per year). The health care cost per capita of rotavirus... |
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- Capsaicin induced apoptosis and the enhanced anticancer
effect of anticancer drugs in cancer cells
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Sun Young Kim, You Jin Lee, Eun Hye Park, Ho Keun Yi, Dae Sun Jo, Jung Soo Kim, Pyoung Han Hwang
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Clin Exp Pediatr. 2008;51(3):307-314. Published online March 15, 2008
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Purpose : Capsaicin, the major pungent ingredient in red pepper, has long been used in spices and food additives. It has been recently shown to induce apoptosis in several cell lines through a not well known mechanism. The aim of this study was to investigate the apoptosis-inducing effect of capsaicin on gastric cancer cells, and to provide valuable information concerning... |
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- Immunogenicity and safety of enhanced-inactivated poliovaccine(eIPV) in healthy Korean infants
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Jung Soo Kim, Young Jin Hong, Jong Duk Kim, Young Taek Jang, Jin Han Kang
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Clin Exp Pediatr. 2006;49(8):864-869. Published online August 15, 2006
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Purpose : We evaluated the immunogenicity and safety of eIPV(Imovax PolioⓇ) in a group of healthy Korean infants on a three-dose primary vaccination.
Methods : Eighty one healthy infants aged 8-10 weeks were enrolled, and 79(male 42, female 37) completed the study. Three doses of eIPV were injected intramuscularly at 2, 4 and 6 months of age as of primary... |
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- The effect of local rifampicin instillation on the treatment of suppurative BCG lymphadenitis
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Min Son Kim, Dae Sun Jo, Kang Mi Kyung, Sang Jae Kim, Jung Soo Kim
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Clin Exp Pediatr. 2006;49(1):40-45. Published online January 15, 2006
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Purpose : The purpose of this study was to evaluate the types of lymphadenitis after BCG vaccination and the effect of local rifampicin instillation on the treatment of suppurative BCG lymphadenitis.
Methods : A total of 32 otherwise healthy infants with suppurative BCG lymphadenitis, who visited the Department of Pediatrics of Chonbuk National University Hospital, from March 2002 through June 2004,... |
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- Alteration of Growth Factor Expression after Acute Ischemic Renal Injury
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Yang Sim Koe, Soo Yeon Lee, Won Kim, Soo Chul Cho, Pyoung Han Hwang, Jung Soo Kim, Dae-Yeol Lee
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Clin Exp Pediatr. 2003;46(7):687-694. Published online July 15, 2003
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Purpose : Regeneration and repair after ischemic renal injury appears to be modulated by circulating or locally produced growth factors. This study examined the changes of serum insulin like growth factor(IGF-I) and renal expression of IGF-I and II, vascular endothelial growth factor(VEGF), transforming growth factor-β(TGF-β), and connective tissue growth factor(CTGF) during the active regeneration period after acute ischemic injury.
Methods :... |
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- Pediatrician Perspectives on the Evaluation and Treatment of
Acute Gastrointestinal Infections, Jeonbuk, South Korea, 2002
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So Hee Lim, Yang Sim Koe, Dae Sun Jo, Sin Jae Lee, Pyoung Han Hwang, P. Kilgore, B. Nyhambat, Jung Soo Kim
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Clin Exp Pediatr. 2003;46(12):1217-1223. Published online December 15, 2003
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Purpose : This study was conducted to assess clinical practices related to the evaluation and treatment of patients with acute gastrointestinal infection(AGI) in infants and children. This survey also evaluated the current opinion regarding the use of rotavirus vaccine.
Methods : This survey was conducted using a self-administered questionnaire provided to 82 pediatricians in private clinics of Jeonbuk province. From April... |
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- The Findings and Significances of Brain SPECT in
Acute Mealses Encephalitis
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Jung Chul Kim, Ju Mi Choung, So Hee Eun, Dae-Yeol Lee, Jung Soo Kim
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Clin Exp Pediatr. 2002;45(11):1373-1380. Published online November 15, 2002
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Purpose : Acute measles encephalitis(ME) is characterized by an abrupt onset of fever and obtundation,
frequently accompanied by seizures and multifocal neurological signs. The aim of this
study was to clarify the clinical manifestation, progression and the brain SPECT patterns in patients
with acute ME.
Methods : This study included 11 children with acute ME admitted to Chonbuk National University
Hospital. Ten patients received a... |
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- Study on Vaccination State in Children : Jeonbuk Province, 2000
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Ju Mi Choung, Jung Chul Kim, So Hee Eun, Pyoung Han Hwang, B. Nyhambat, P. Kilgore, Jung Soo Kim
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Clin Exp Pediatr. 2002;45(10):1234-1240. Published online October 15, 2002
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Purpose : This study was carried out to obtain the vaccination rate and age appropriateness of
vaccination in children under five years of age in Jeonbuk province.
Methods : Eight hundred and fifty infants and children were enrolled in this study. Vaccination
rate(Number of vaccinees/Number of subjects), places of vaccination, age appropriateness of vacination
were examined by either vaccine record review or interview with... |
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- Anti-angiogenesis and Anti-metastasis Characteristics of the
Novel Tumor Suppressor Gene PTEN
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Pyoung Han Hwang, Ho Keun Yi, Myoung Hee Han, Dae Yeol Lee, Dae Yeol Lee, Jung Soo Kim
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Clin Exp Pediatr. 2001;44(6):654-663. Published online June 15, 2001
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Purpose : The tumor suppressor gene PTEN/MMAC1 is mutated in a variety of advanced and metastatic cancers, strongly suggesting that PTEN/MMAC1 alterations may be involved in tumor progression and the formation of metastases. However, the roles of PTEN in tumor growth and metastasis and its functional mechanisms are not fully understood. We evaluated the tumor suppressor function of PTEN/MMAC1 gene... |
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- Studies on Functional Differentiation of Small Intestinal Epithelial Cells
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Ho Keun Yi, Su Mi Oh, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
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Clin Exp Pediatr. 2001;44(5):523-532. Published online May 15, 2001
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Purpose : We investigated compounds from food sources given to children that may induce the differentiation of small intestinal epithelial cells in order to signal pathways that induce the proliferation and differentiation of small intestinal epithelial cells.
Methods : We analyzed small intestinal epithelial cell differentiation using in vitro IEC-6 cells model. The growth curve of IEC-6 cells was obtained... |
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- Effectiveness of Preoperative Transcatheter Arterial Chemoembolization in Hepatoblastoma
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Pyoung Han Hwang, Dae Sun Jo, Dae Yeol Lee, Jung Soo Kim
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Clin Exp Pediatr. 2000;43(8):1098-1105. Published online August 15, 2000
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Purpose : To evaluate the effectiveness of transcatheter arterial chemoembolization(TACE) as a preoperative treatment for initially unresectable hepatoblastomas.
Methods : From January 1995 to July 1999, we identified two boys and three girls(age range : 5- 27 months; mean age : 12 months) with pathologically-confirmed hepatoblastoma. To assess response to treatment, we utilized an identical TACE procedure for all the patients.... |
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- Induction of Apoptosis of Ewing`s Sarcoma Cells by Regulating Fusion Protein Expression
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Ho Keun Yi, Ran Ju Kim, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
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Clin Exp Pediatr. 2000;43(7):942-951. Published online July 15, 2000
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Purpose : Fusion genes(EWS-Fli-1 and EWS-erg ) function as transcription activators and are essential for maintaining tumorigenic properties in Ewing`s sarcoma cells. Several reports have noted that Ets family transcription factors bind with CBP(CREB binding protein) in vitro. To understand the interaction of fusion proteins and CBP, we studied the CBP protein in TC135 cells expressing the EWS-Fli-1 gene. We... |
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- Comparative Reactivity of 2 TU and 5 TU PPD Skin Tests
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Dae Sun Jo, Kyeong Mee Lee, Dae-Yeol Lee, Jung Soo Kim
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Clin Exp Pediatr. 2000;43(5):638-643. Published online May 15, 2000
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Purpose : These days 5 TU purified protein derivative(PPD) is substituted with 2 TU PPD for the tuberculin skin test, a test essential in the diagnosis of tuberculosis in pediatric population. However, there had been no adequate criteria for the positivity of 2 TU PPD skin test. This study was performed to clarify the criteria of positive reactivity of 2... |
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- Type I Vitamin D Dependent Rickets
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Soo Ja Hwang, Jung Soo Kim, Hae Il Cheong, Yong Choi
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Clin Exp Pediatr. 1998;41(7):877-882. Published online July 15, 1998
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Purpose : Vitamin D dependent rickets(VDDR) is a rare, autosomal recessively transmitted disorder characterized by hypocalcemia, hypophosphatemia, increased alkaline phosphatase, secondary hyperparathyroidism and many other clinical features. Type Ⅰ VDDR arises from primary deficiency in the renal 1α-hydroxylase that produces 1,25(OH)2D3. So patients with type I VDDR require life long administration of vitamin D.
Methods : There had been 6 children(4... |
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- The Study of Transplacental Transfer of Immunoglobulin G in Premature Infants
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Sung Soo Moon, Yoon Ki Kang, Soo Chul Cho, Jung Soo Kim
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Clin Exp Pediatr. 1998;41(6):747-753. Published online June 15, 1998
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Purpose : Premature infants have low serum immunoglobulin G(IgG) levels because IgG is transplacentally
acquired, primarily after 32-34 weeks of gestational age. We studied the transplacental
transfer of serum IgG in preterm infants.
Methods : The IgG levels in the sera were measured by radial immunodiffusion method(Behring
nephelometer, Germany).
Results : There was a significant difference between IgG concentration and gestational age; the
IgG concentration increased... |
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- Effects of Cefodizime on Phagocytosis of COS-1 Ccells
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Pyoung Han Hwang, Sang Yun Nam, Ho Keun Yi, Min Ho Kim, Kong Soo Kim, Jung Soo Kim
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Clin Exp Pediatr. 1998;41(12):1632-1638. Published online December 15, 1998
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Purpose : Cefodizime is a new third-generation cephalosporin which has a structure and immunomodutation properties similar to cefotaxime. Various studies on cefodizime have demonstrated the direct eradication of bacteria in cooperation with the host defense mechanism, particularly with phagocytosis. We evaluated the effects of cefodizime on the phagocytosis of COS-1 cells transfected with FcγRI/γγ or FcγRIIA cDNA.
Methods : Phagocytosis was... |
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- Changes of Anti-H.influenzae Type b IgG in the Sera of Korean Infants and Children after Birt
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Jong Man Park, Keoung Hie Moon, Kyung Mee Lee, Sun Jun Kim, Soo Chul Cho, Jung Soo Kim
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Clin Exp Pediatr. 1997;40(2):181-188. Published online February 15, 1997
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Purpose : Most of invasive Haemophilus influenzae diseases occur in children under 5
years of age, and are due almost exclusively to type b strain. Although antibodies to
several surface antigens of H.influenzae play a role in conferring immunity, antibody to the type b capsular polysaccharide appeared to have the most important protective functions. However, the antibody response to vaccines or natural... |
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- Effects of Cyclosporine on the Renal Sympathetic Nerve Activity and Baroreflex Function in Rabbits
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Chan Uhng Joo, Tae Hee Park, Moon Hwan Lee, Jung Soo Kim
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Clin Exp Pediatr. 1995;38(7):955-962. Published online July 15, 1995
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Purpose : The immunosuppresive drug cyclosporine(CS) is a novel agent that has greatly enhanced long-term survival after organ transplantation and has proved beneficial in the treat-ment of many autoimmune diseases. However, CS has emerged as a new cause of hypertens-ion. Although the causes of the hypertension are undoubtedly multifactorial, there are evidenc-es to suggest that sympathetic overactivity is involved. We... |
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- Placental Transfer of Anti-H. influenzae Type b Specific IgG and IgG Subclasses
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Soo Hee Chang, Moon Hwan Lee, Pyoung Han Hwang, Soo Chul Cho, Jung Soo Kim
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Clin Exp Pediatr. 1995;38(12):1638-1644. Published online December 15, 1995
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Purpose : Haemophilus injluenzae type b (Hib) is one of the most important causes of invasive bacterial diseases in infants and children. In Korea, however, the proportion occupied by Hib as a cause of pediatric pathogen seems to be less compared to those of western countries.
This study was performed to provide the epidemiologic and immunologic basis of H influenzae type... |
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- The Effect of Milk on the Bioavailability of 6-mercaptopurine
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Sun Kyu Park, Ran Ju Kim, Pyoung Ha Hwang, Soo Chul Cho, Jung Soo Kim
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Clin Exp Pediatr. 1994;37(12):1732-1737. Published online December 15, 1994
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The purine antimetabolite 6-Mercaptopurine (6-MP) has been in clinical use for over 30 years and is still a widely used agent in the treatment of childhood acute lymphoglastic leukemia. The bioavailibility, clinical effecacy and toxicity of 6-MP administered orally for maintenance therapy of children with acute lymphoblastic leukemia are highly variable in many studies, as well as at different times... |
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- Analysis of Platelet Membrane Glycoprotein Ⅱb-Ⅲa complex in Whole Blood of Glanzmann's Thrombasthenia by Flow Cytometry
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Byoung Geun Lee, Man Choon Kang, Jong Man Park, Pyung Han Hwang, Jung Soo Kim
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Clin Exp Pediatr. 1994;37(11):1540-1547. Published online November 15, 1994
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Glanzmann's thrompasthenia is a rare autosomal recessive hemorrhagic disorder characterized by prolonged bleeding time, and deficient or absent clot retraction in the presence of normal platelet count. The major underlying abnormality in this disease is grossly defective first-phase aggregation of platelet, which are unresponsive to ADP or other platelet agonists such as epinephrine, collagen, thrombin in any concentration. This disability... |
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- Case Report
- A Case of Wiskott-Aldrich Syndrome
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Byoung Geun Lee, Soo Hee Chang, Soo Young Cho, Pyoung Han Hwang, Jung Soo Kim
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Clin Exp Pediatr. 1994;37(11):1615-1619. Published online November 15, 1994
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Wiskott-Aldrich Syndrome is an X-linked disorder characterized by recurrent infection, thrombocytopenia and eczema. Various defects in cell-mediated immunity and deficient antibody response to carbohydrate antigens have been described. We experienced a case of Wiskott-Aldrich Syndrome of 28 months old male patient. He has been suffered from multiple petechiae with bleeding, recurrent pyogenic infections and generalized eczema since 3 months of... |
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- Original Article
- Changes of IgG Subclasses in the Sera of the Children with Kawasaki Disease
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Seog Beom Cho, Sun Kyu Park, Pyoung Han Hwang, Jung Soo Kim, Sa Hyoung Choi
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Clin Exp Pediatr. 1993;36(9):1197-1202. Published online September 15, 1993
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Kawasaki disease is an acute vasculitis of infancy and early childhood characterized by high fever, rash, mucositis, lymphadenopathy and coronary artery damage. The failure to indentify a causative organism using convetional culture and serological techniques, and the lack of response to antibiotics indicate that the disorder is probably not due to any known bacterial or viral pathogens. During... |
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- Case Report
- Changes of Serum IgG4 in Allergic Patients
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Soo Young Cho, Sun Kyu Park, Pyoung Han Hwang, Jung Soo Kim
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Clin Exp Pediatr. 1993;36(3):403-408. Published online March 15, 1993
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This study ws performed to evaluate the changes of serum IgG4 level in children with allergic diseases. Serum IgE, IgG and IgG4 level were measured using enyzme immunoassay(IgE) and radial immunodiffusion method (IgG and IgG4) in 21 children with bronchial asthma, allergic rhinitis or urticaria.
Eosinophil counts in peripheral blood and the values fo serum IgE were significantly increased in allergic... |
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- Original Article
- Systolic Pressure Amplification of the Aortic Pressure in Children with Congenital Heart Disease
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Chan Uhng Joo, Byoung Geun Lee, Sun Jun Kim, Jung Soo Kim
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Clin Exp Pediatr. 1993;36(2):232-238. Published online February 15, 1993
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Direct intraarterial measurement of blood pressure is an important diagnostic procedure in critical patients and premature baby care. Direct measurement was more accepted and confident method in physician than the indirect methods. But the presence of a significant amplification of systolic pressure in peripheral artery may lead to important error. So we have investigated the degree of the systolic pressure... |
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- Comparison of Anticancer Drug Efficacy Using the Short-Term Microplate Culture and MTT Dye Reduction Assa
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Nam Ki Kim, Kwang Rae Lee, Pyoung Han Hwang, Jung Soo Kim
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Clin Exp Pediatr. 1993;36(10):1426-1433. Published online October 15, 1993
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Individual tumors, even those of the same histologic type, show varying sensitivity to specific cytotoxic agent. Therefore, sensitivity testing assume an increasingly important as an orientational aid in planning chemotherapy.
In the past decade there have been many attempts to develop a chemosensitivity test that would predict the clinical effectiveness of various chemosherapeutic agents against human neoplasms. In the United States... |
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- A Clinical Study on Cardiovascular Disease of Children Taken Cardiac Catheterization and Cineangiography
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Gi Yeon Song, Seog Beom Cho, Pyoung Han Hwang, Chan Uhng Joo, Jung Soo Kim
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Clin Exp Pediatr. 1992;35(7):949-956. Published online July 15, 1992
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A clinical study was made on 533 patients with cardiovascular disease who were admitted to pediatric department of Chonbuk National University Hospital and performed cardiac catheterization and cineangiography from February 1984 to August 1991.
The results were as follows;
1) The ratio of male to female was about 0.81:1; among 533 cases, male 283cases, male 283cases, female 295cases.
2)The age distribution of the... |
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- Case Report
- Hutchinson-Gilford Progeria Syndrome
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Moon Whan Lee, Byoung Geun Lee, Pyung Han Hwang, Dae Yeol Lee, Jung Soo Kim
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Clin Exp Pediatr. 1992;35(7):971-977. Published online July 15, 1992
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Hutchinson-Gilford Progeria Syndrome is an extremely rare condition that was initially reported by Jonathan Hutchinson in 1886 and further described by Hastings Gilford in 1904.
Clinical manifestations are evident by the first or second year of life with the physical characteris-tics of the elderly. Progeric patients ordinarily develop atherosclerosis and die of cardiac or cerebral vascular disease between 7 and 27... |
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- Original Article
- A Clinicopathological Study on Renal Biopsies in Children
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Hun Choi, Dae Yeol Lee, Jung Soo Kim
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Clin Exp Pediatr. 1992;35(6):744-752. Published online June 15, 1992
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A clinical and histopathologic study was made oin 50 cases of renal biopies in children who admitted to chon buk national university hospital from December 1987 to July 1990.
The result were as follows :
1) Among 50 cases, 35 cases were male and 15 cases female. The sex ratio of male to female was 2.3 : 1. The age distribution was... |
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- Case Report
- A case of Trisomy 8 mosaicism
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Hong-Ro Lee, Byung-Geun Lee, Soo-Chul Cho, Dae Yeol Lee, Jung Soo Kim, So Ja Jin
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Clin Exp Pediatr. 1992;35(6):845-850. Published online June 15, 1992
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This paper presents clinical manifestations and result of cytogenetic examination of a patient with trisomy 8 mosaicism syndrome.
Characteristic features include hypertelolism, deep set eyes, anteverted nose, narrow pelves, hypospadia, camptodactyly and deep skin crease and furrows.
Karyotyping and chromosomal analysis revealed 47 XY, + 8 mosaicism. A brief review of literature was presented. |
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- Original Article
- A case of tuberous sclerosis developing with subependymal giant-cell astrocytoma.
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Young Chul Ahn, Yong Suk Choi, Pyoung Han Hwang, Jung Soo Kim
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Clin Exp Pediatr. 1991;34(7):1027-1033. Published online July 31, 1991
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Subependymal giant-cell astrocytoma is a rare cerebral glioma that characteristically arises in the
wall of the lateral ventricle and presents as an intraventricular mass, causing hydrocephalus by
obstruction of the foramen of Monro. The tumor mainly occurs in patients with tuberous sclerosis and
is slow growing and well circumscribed, so that long survival after total surgical resection is often
achieved.
We experienced a cas^ of... |
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- The effects of adriamycin on twitch force and membrane potential in an isolated Guinea-pig papillary muscle.
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Chan Uhng Joo, Pyung Han Hwang, Jung Soo Kim, Hee Cheol Yu, Soo Wan Chae
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Clin Exp Pediatr. 1991;34(5):677-681. Published online May 31, 1991
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The antiumor antibiotic adriamycin is presently considered to be a very effctive and useful
chemotherapeutic agent in the treatment of many human tumors. Cardiotoxicity of adriamycin limits
its clinical use. A number of hypotheses have been proposed to explain the mechanism of cardiotox-
icity with adriamycin, but none has yet been demonstrated.
The effects of adriamycin on twitch force and membrane potential in an... |
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- A case of xanthogranulomatous pyelonephritis.
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Jin Oh Kim, Soo Young Cho, Joo Hyung Kim, Dae Yeol Lee, Jung Soo Kim
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Clin Exp Pediatr. 1991;34(3):413-418. Published online March 31, 1991
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Xanthogranulomatous pyelonephritis is an atypical form of severe chronic renal parenchymal
infection, which can be mistaken for tumor or other inflammatory renal disease due to similar clinical
manifestations.
This disease was classified into three stages based on the extent of involvement of renal and
adjacent tissue by the xanthogranulomatous process. In stage I (nephric), the characteristic xantho-
granulomatous inflammatory process is confined to the kidney.
The... |
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- Prevalence of asymptomatic hematuria, proteinemia and glucosuria in primary school children in Chonju area.
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Jin Oh Kim, Joseph Choi, Soo Cheol Cho, Dae Yeol Lee, Jung Soo Kim
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Clin Exp Pediatr. 1991;34(2):223-229. Published online February 28, 1991
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The present study was performed to define the prevalene of asymptomatic hematuria, proteinuria,and
glucosuria. A total of 5011 primary school children in Chonju city were examined with test strip urinalysis
during the period of one month from June to July 1989.
Test strip (Hema-Combistix) was used in this examination.
The results were as. follows:
1) Prevalence of hematuria, proteinuria and glucosuria were 0.8% (40 children), 0.78%... |
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- A study on the immune reaction to the milk protein antigens in the postpartum mother, newborn baby, and children.
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Soo chul Cho, Ju Hyung Kim, Hong Ro Lee, Jong San Lee, Pyoung Han Hwang, Jung Soo Kim
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Clin Exp Pediatr. 1991;34(11):1547-1558. Published online November 30, 1991
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There is continuing interest in the isotype response of human serum antibodies reactive with
dietary proteins. This study was performed to clarify the humoral immune responses against cow’s
milk proteins, 分-lactoglobulin and a-lactalbumin. Milk protein specific IgG, IgA, IgM, and IgG
subclasses were measured using ELISA in the blood of various groups of age.
The results were as follows:
1) Milk protein specific immunoglobulins were higher... |
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- A case of hemiazygos continuation of a left inferior vena cava.
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Soo Young Cho, Joseph Choi, Chan Uhng Joo, Jung Soo Kim
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Clin Exp Pediatr. 1991;34(10):1428-1432. Published online October 31, 1991
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Anomalies of the inferior vena cava (IVC) are often discovered incidentally during imaging studies
performed for other reasons, since patients with these abnormalities are usually asymptomatic.
Infrahepatic interruption of the IVC with azygos or hemiazygos continuation is an unusual anomaly
of the IVC.
We report a case of single left-sided IVC with hemiazygos continuation in associated with patent
ductus arteriosus and left superior vena cava.... |
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- Osteogenic Sarcoma as Second Malignant Neoplasm After Treatment of Retinoblastoma.
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Ja Young Kim, Moon Whan Lee, Ju Hyung Kim, Pyoung Han Hwang, Jung Soo Kim
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Clin Exp Pediatr. 1990;33(12):1735-1740. Published online December 31, 1990
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The improvement in survival for childhood cancer has been achieved through the use of multiple-
agent chemotherapy and radiotherapy. However, one of the limitations to quality and length of
survival has been the development of second malignant neoplasm.
We exprienced a case of second malignant neoplasm in 13-year-old boy who developed osteogenic
sarcoma after successful treatment of retinoblastoma. At 3 years of his age,... |
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- Changes of PPD-Specific Immunoglobulin in Pulmonary Tuberculosis After Treatment.
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Ja Young Kim, Mun Hwan Lee, Pyoung Han Hwang, Chan Uhng Joo, Jung Soo Kim
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Clin Exp Pediatr. 1990;33(12):1647-1655. Published online December 31, 1990
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The definite diagnosis and precise assessment of response to therapy is still a problem in childhood
tuberculosis because these patients rarely produce sputum and if obtained it may be negative. For this
reason, diagnosis rely largely on the clinical and X-ray examination, which have a low specificity and
high proportion of false positive results.
Recently immunologic diagnosis of tuberculosis using enzyme-linked immunosorbent assay (ELISA)
was... |
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- Changes of beta-lactoglobulin Specific Immunoglobulins According to the Age and the Onset of Cow's Milk Feeding.
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Jong San Lee, Soo Young Cho, Pyoung Han Hwang, Soo Cheol Cho, Jung Soo Kim
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Clin Exp Pediatr. 1990;33(12):1639-1646. Published online December 31, 1990
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It is not yet possible to explain in detail the pathogenesis of the diverse types of food allergy
encountered clinically. This generalization applies to milk allergy in spite of the large number of
studies reporting the immune responses to cow’s milk proteins, both in healthy subjects and in milk
sensitive patients.
This study was performed to define the changes of circulating immunoglobulins against milk
protein... |
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- Immunologic Diagnosis of Tuberculous Meningitis.
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Nak Wan Choi, Hong Ro Lee, Pyung Han Hwang, Dae Yeul Lee, Jung Soo Kim
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Clin Exp Pediatr. 1990;33(1):42-50. Published online January 31, 1990
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One of the inherent features of clinical microbiology is that substantial time is required for the
culture of infectious organisms. Especially acid fast bacilli require extensive time and labaratory
facilities for reliable recovery. This makes it difficult for clinicians to use the results in early
decisions concerning management of the patient. For these reasons, there has been increasing interest
in developing or refining methods... |
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- Percutaneous Balloon Valvuloplasty in Children with Pulmonary and Aortic Valvular Stenosis.
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Chan Uhng Joo, Jung Soo Kim, Ho Yunh Song
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Clin Exp Pediatr. 1989;32(9):1224-1231. Published online September 30, 1989
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Pulmonary and aortic valvular stenosis were relieved by percutaneous balloon valvuloplasty during
cardiac catheterization on 14 children aged 22 months to 18 years.
Before dilatation the transpulmonary systolic pressure gradients ranged from 43 mmHg (mean 87.
8 mmHg) in children with pulmonary valvular stenosis. There were significant reduction in the
transpulmonary systolic pressure gradient (mean 33.1 mmHg) immediately after balloon valvuloplas-
ty except one patient... |
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- Changes of Plasma Atrial Natriuretic Peptide and Antidiuretic Hormone in Congenital Heart Disease.
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Sun Jun Kim, Jong San Lee, Chan Uhng Joo, Dae Yeol Lee, Jung Soo Kim
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Clin Exp Pediatr. 1989;32(8):1106-1116. Published online August 31, 1989
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Human atrial myocytes secrete atrial natriuretic peptides (ANP) into the plasma, which causes
rapid and marked natriuresis, diuresis and vasorelaxation. The releases of renin, aldosterone, and
antidiuretic hormone are inhibited by ANP in vivo and in vitro experiments. Various atrial natriur-
etic peptides were isolated and synthesized. Plasma ANP concentrations usually elevated in conges-
tive heart failure, chronic renal failure, pulmonary arterial hypertension, tachyarrhythmia,... |
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- Changes of Specific Immunogloblins Against Dihperia Toxoid After DPT Vaccination.
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Byung Sook Park, Byung An Shim, Kyung Jin Shin, Soo Chul Cho, Jung Soo Kim
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Clin Exp Pediatr. 1988;31(9):1126-1132. Published online September 30, 1988
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The present study was performed to define the humoral immune responses after DPT vaccination
changes of diphteria specific IgG and IgM were evaluated suing ELISA method on 196 cases of 6
groups which were divided according to the frequency of DPT vaccination.
Alum-precipitated diphtheria toxoid was used as antigen for ELISA.
The results were as follows;
1) IgG was mainly involed in humoral immune responses against... |
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- Effect of Adriamycin on Lipid Metabolismin Rats.
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Chang Beom Shin, Sun Jun Kim, Chan Unng Joo, Dae Yeol Lee, Jung Soo Kim
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Clin Exp Pediatr. 1988;31(9):1133-1138. Published online September 30, 1988
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This experiment was carried out to investigate the disturbance of lipid metabolism after long-term
administration of adriamycin in rats (2.5 mg/kg/week for 5 weeks, S.C.).
Changes of Serum lipids, GOT, GPT, LDH, albumin, BUN, and creatinine were investigated after
administration of adriamycin.
Clinical findings of congestive heart failure and changes of body weight were also observed during
experiment.
The results were as follows;
1) Serum triglyceride, total cholesterol,... |
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- Specific Immunoglobulin Responses Against Tetanus Toxoid after DPT Vaccination.
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Kyung Jin Shin, Sng Nam Chun, Heon Seob Song, Dae Yeal Lee, Jung Soo Kim
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Clin Exp Pediatr. 1987;30(6):625-632. Published online June 30, 1987
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DPT vaccination has successfully been applied to the prevention of tetanus infection. Edsall (1949)
reported the presence of serum tetanus antitoxin after tetanus toxoid immunization. Gill et al (1983)
also demonstrated that the values of tetanus specific IgM were increased on neonates after maternal
tetanus toxiod immunization.
The present study was performed to define the humoral immune responses after DPT vaccination.
Changes of tetanus specific... |
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- A Study of Radionuclide Angiocardiography in Congenital Heart Disease.
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Beyong Sang Choi, Kyung Jin Shin, Beyong Sook Park, In Soo Choi, Chan Uhng Joo, Jung Soo Kim
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Clin Exp Pediatr. 1986;29(9):964-968. Published online September 30, 1986
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In 101 heart disease patients, the radionuclide angiocardiography(RNA) were performed.
Quantitation of left to right shunts were obtained by RNA and oximetry method in 41 patients simultaneously.
A comparison of the values for Qp/Qs ratio obtained by RNA & oximetry in those patients revealed a good correlation coefficient of 0.87(P
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- Endogenous Digoxin-like Substance in Neonatal Serum, Pregnant Women and Placental Extracts.
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Heon Seob Song, In Soo Choi, Dae Yeol Lee, Jung Soo Kim, Chang Beom Shin, Yong Bae Shin
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Clin Exp Pediatr. 1986;29(9):940-947. Published online September 30, 1986
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To digoxin-like substance, the authers tried to confirm the presence of this substance in cord blood,
sera from premature and full-term infants, third trimester pregnant women not receiving digoxin,
and placental extracts, and to investigate the origin and potential physiologic role of DLS, endogenous
Na+, K+-ATPase inhibitor in relation to renin activity. The results were as follows;
1) Cord sera DLS... |
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- Influence of Isoproterenol on the Plasma Renin Activity in Rats.
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Woong Kyou Park, Yong Bae Shin, In soo Choi, Hyeon Suk Lee, Jung Soo Kim, Kyung Woo Cho
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Clin Exp Pediatr. 1985;28(9):899-905. Published online September 30, 1985
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It has been suggested that the effect of catecholamine administered into the renal artery on the plasma renin activity may be controlled by extrarenal beta-receptor. Still the exact mechanism responsible for the increase of the plasma renin activity by catecholamines is obscure. In this experiment I have intended to clarify the involvement of extrarenal beta-receptor concerning renin release in the... |
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- Experimental Study of Influence of Some Barbiturate Derivatives on the Renal Function.
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Jong Duck Kim, Byeung Sang Choi, In Soo Choi, Heon Sook Lee, Jung Soo Kim
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Clin Exp Pediatr. 1985;28(8):773-782. Published online August 31, 1985
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One of the most frequently used anesthetics in the laboratory or clinical practice is barbiturate derivatives. There have been many reports on the renal effects of barbiturate anesthesia, but they still controversial. It has been reported that the central administration of very small dose of thiopental sodium influence the renal function directly. To compare possible different renal effects of the... |
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- Case Report
- Two Cases of Hand-Schuller-Christian Disease in Monozygotic Twin.
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Pyoun Han Hwang, Ju Hyung Kim, In Soo Choi, Jung Soo Kim
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Clin Exp Pediatr. 1985;28(1):85-89. Published online January 31, 1985
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Authors experienced two cases of Hand-Schuller-Christian disease developed simultaneously in 35 month old male monozygotic twin. So we report with literature review briefly as follow. The elder had the complaints of polyuria, exophthalmos, skin lesion. The younger had the complaints of mild exophthalmos and skin lesion. They were confirmed by clinical and pathological features and radiological examination. But patients died... |
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- Two cases of Aplastic Anemia Following Hepatitis.
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Chang Yeol Jeon, Beyung Sang Choi, Hyeon Sook Lee, Jung Soo Kim
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Clin Exp Pediatr. 1985;28(1):73-77. Published online January 31, 1985
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Recently, we experienced two cases of aplastic anemia following hepatitis in 6 and 12year old boys. A 6 year old boy was admitted to Jeonbug National University Hospital in Dec. ’82, because of frequent expistaxis and petechiae on entire body. He had a history of hepatitis 2 months ago. On admission liver function was normal and pancytopenia was revealed. Bone... |
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- Original Article
- Changes of Plasma Inactive Renin in Newborn Infant and Children.
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Pyoung Han Hwang, Woong Kyou Park, Heon Sook Lee, Jung Soo Kim, Kyung Woo Cho
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Clin Exp Pediatr. 1984;27(9):872-876. Published online September 30, 1984
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There have been some suggestion that inactive renin may be a kind of precursor renin. There have not yet been however, founded direct evidence for that suggestion. To understand more about the physiological role of the plasma inactive renin, experiments have been done. The results obtained as follows. 1)In the newborn infants plasma renin activity showed highest level up to... |
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- Change of Renal Excretion of Ascorbic Acid in Children.
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Chang Yeal Jeon, Jong Duck Kim, Heon Sook Lee, Jung Soo Kim, Kyung Woo Cho
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Clin Exp Pediatr. 1984;27(6):548-553. Published online June 30, 1984
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In order to investigate the development of renal function, especially of the capacity of reabsorption of ascorbic acid in proximal tubule, in function of aging, experiments have been done. 1)Urinary flow, creatinine and electrolytes excretion in children (age :1~13yrs, weight: 10~39 kg) increased by aging and reached near the adult value at 11~13 years old. 2) Urinary concentration ability was matured... |
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- Histological Study of Ductus Arteriosus Affected by Indomethacin in the Fetal Rates.
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Young Sook Jang, Chang Yeoul Jeon, Heon Sook Lee, Jung Soo Kim, Moo Sam Lee
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Clin Exp Pediatr. 1983;26(8):770-777. Published online August 31, 1983
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This work was perforrred for the observation of morphological changes and beginning portion of obliteration in ductus arteriosus. And also histological findings in ductus arteriosus affected by indomethacin (4ug/kg/day)
were studied. The following results were obtained. In the process of obliteration, intimal pillow became irregular
with the narrowing of the lumen and loose connective tissue was frequently filled into the... |
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- A Study on the Renal Function in Neonates and Children.
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In Soo Choi, Young Sook Kim, Soo Chul Cho, Jung Soo Kim, Kyung Woo Cho
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Clin Exp Pediatr. 1983;26(8):744-750. Published online August 31, 1983
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A study on the renal function and its changes by aging in neonates and children has been
done, and the result obtained were as follow.
1) Urinary output, creatinine and electrolyte excretion in neonates (age: 12 〜 24 hrs) were
significantly lower than children over 1 〜2 yrs, and urine concentrating ability may not yet t>e matured.
2) Urinary output, creatinine and electrolyte excretion in children... |
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- Bone Changes in Childhood Leukemia.
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In Soo Choi, Jong Soo Kim, Jung Soo Kim, Kyu Cha Kim, Yea Seong Youn
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Clin Exp Pediatr. 1983;26(2):143-150. Published online February 28, 1983
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Leukemia, the most common malignant disease in pediatric field, is one of the most interesting targets of modern medical research. So we reviewed the bone changes in 51 patients of leukemia admitted
to the Dept, of Pediatrics Jeonbug National University Hospital for 5 years from Jan. 1st 1977 to Dec. 31st 1981.
The results were as follow. The male patient was... |
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- Case Report
- A Cases of Heredotary Anhidrotic Ectodermal Dyslasia.
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Jong Soo Kim, Pyoung Han Hwang, Hyeon Sook Lee, Jung Soo Kim
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Clin Exp Pediatr. 1983;26(10):1018-1023. Published online October 31, 1983
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Hereditary anhidrotic ectodermal dysplasia is a rare hereditary condition in which certain
structures derived from the ectoderm are undeveloped or underdeveloped, although,
on a rarity, mesodermal or endodermal derivatives may be associated.
Recently, we have experienced a case of anhidrotic ectodermal dysplasia in 4 years old male.
He had abscence of sweating, hypotrichosis and anodontia, which was characteristic features of this disorder.
We established... |
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- Original Article
- The effect of vincristine and adriamycin on the phagocytic function of reticuloendothelial system of rats.
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Hyun Suk Lee, Jong Soo Kim, Jung Soo Kim, Kyu Cha Kim, Ho Yeul Choi
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Clin Exp Pediatr. 1982;25(9):880-887. Published online September 30, 1982
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This experiment was carried out to investigate the effects of anticancer drugs on the
phagocytic function of reticuloendothelial system. The phagocytic activity was assessed by-
means of carbon clearance method, after intravenous injection of vincristine(5 pg or 25 y^g/lOO
gm of body weight) and adriamycin (70 pg or 350 ^g/100 gm of body weight) through one，
two, and three times at the interval of... |
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- Two Cases of Teratoma on Sacrococcygeal Region in Newborn.
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Chan Uhng Joo, Young Suk Jang, Jung Soo Kim, Kyu Cha Kim
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Clin Exp Pediatr. 1982;25(8):859-863. Published online August 31, 1982
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Two cases of teratoma on sacrococcygeal region in newborn are reported with pathological findings, and a brief review of related literature is included in this report. |
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- Developmental Changes of Membrane Proteins from Human Erythrocytes.
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Chan Uhng Joo, Hyun Suk Lee, Jung Soo Kim, Kyu Cha Kim, Hyung Rho Kim
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Clin Exp Pediatr. 1982;25(6):541-546. Published online June 30, 1982
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To investigate the developmental changes of human erythrocytes, adult and fetal erythrocyte membranes prepared from adult and cord blood were analyzed in regard to their proteins, glycoproteins, enzyme activities and glucose transport systems. 1. Adult and fetal erythrocyte membranes appeared to have the same major proteins and gl-ycoproteins in the electrophoretic pattern. 2. ATPase activity in adult erythrocyte membranes was... |
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- Clinical Considerations of Convulsive Diseases in Children.
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In Soo Choi, Jung Soo Kim
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Clin Exp Pediatr. 1982;25(3):250-257. Published online March 31, 1982
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The authors reviewed 312 pediatric convulsive patients admitted to the Department of Pediatrics Jeonbug national University Hospital during the last 3 years period from Sep. 1st, 1978 to Aug. 31st. 1981. The clinical and statistical results were obtained as follows. 1) Of the total 312 pediatric convulsive patients, the patients over 6 years of age and preschool children between 2... |
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- Effects of Arginine Vasopressin on Renal Function in the Rabbit.
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Dae Yeol Lee, Sun Taik Rhim, Jung Soo Kim, Kyu Cha Kim, Kyung Woo Cho
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Clin Exp Pediatr. 1981;24(7):638-644. Published online July 15, 1981
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It has long been known that Vasopressin could increase the urinary sodium and chloride excretion. The exact mechanism and site of action, however, have not yet been explained. Experiments were performed whether the renal effects were the same in both cortical and juxtamedullary nephron in decorticated kiddney model. Heat-decortication was car ried out in the left kidney immersed in water... |
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- Case Report
- Hepatorenal Syndrome.
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Kyo Sun Kim, Young Mo Sohn, Jung Soo Kim, Jae Seung Lee, Pyung Kil Kim, Tae Jung Kwon, In Jun Choi
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Clin Exp Pediatr. 1981;24(3):257-270. Published online March 15, 1981
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Hepatorenal syndrome is generally urged, at least until specific interrelationships between the two organs are confirmed by experimental and clinical data. Case I was a 11 year old boy, who had been suffered from acute fulminant viral hepatitis, which had developed acute hepatic necrosis associated with acute renal failure.
Cass H was a 10 year old girl, who was performed corrective... |
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- Nursing Bottle Caries.
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Dae Yeol Lee, Soo Chul Cho, Jung Soo Kim, Kyu Cha Kim
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Clin Exp Pediatr. 1980;23(7):582-585. Published online July 15, 1980
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Feeding habits and sugar contents contents affect dental health and ultimately the total health of young chidren. Nursing bottle caries, nursing botte syndreme, bottle-propping caries are synonymous term for a devastaing condition that may render young children dental cripples. Typically, the primary maxillary incisors are affected most severely and mandibular incisors are seldom involved. We report 4 cases of nursing... |
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- Original Article
- Congenital Hypothyroidism.
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Duk Hi Kim, Chang Ho Hong, Baek Keum Lim, Jung Sang Oh, Jung Soo Kim
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Clin Exp Pediatr. 1980;23(7):550-556. Published online July 15, 1980
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We made a clinical observation of 17 cases of congenital Hypothyroidism at the Pediatric department of Yonsei University hospital in Seoul, Korea during the period from January, 1969 to August, 1979. The results were as followings : 1) Male to female sex was about 1 : 1.1, and 6 cases (35%) of congenital hypothyroid-sm were diagnosed under 1 year old.... |
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- Case Report
- A Case of Ask-Upmark Kidney.
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Jun Hee Sul, Jung Soo Kim, Pyung Kil Kim, Duk Jin Yun, Dong Chan Shin, In Joon Choi
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Clin Exp Pediatr. 1980;23(10):855-858. Published online October 15, 1980
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Severe segmental renal atrophy with loss of parenchymal elements in small kidney is commonly known as segmental hypoplasia. Since the original description in 1929 by Ask-Upmark, the association of hypertension with congenital renal hypoplasis has been well established and there have been several reports. But there was no reported case in Korea. The diseases commonly recognized after the age of... |
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- Original Article
- A Study on School Health Service in Elementary Schools in Seoul.
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Jung Soo Kim
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Clin Exp Pediatr. 1979;22(7):491-498. Published online July 15, 1979
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Considering the importance of school health regular vaccintions of children primary schools is strongly recommended, as well as a comprehensive school health program, however, neither has been satisfactorily carried out in Seoul. Without exception, all schools in Korea are facing many problems ; shortage of school health personnel, lack of adequate facilities, poor school environmental sanitation, etc., but the health... |
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- Case Report
- A Case of Fibrous Dysplasia.
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Jung Soo Kim, Young Mo Sohn, Jae Song Kim, Duk Hi Kim, Kyoung Ja Cho
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Clin Exp Pediatr. 1979;22(3):234-238. Published online March 15, 1979
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Fibrous dysplasia of bone is a relatively rare condition characterized by fibrous tissue replacement of skeleton, usually not disabling, of slow progress, and showing a tendency to become arrested. It may be monostotic (confined to one bone) or Polyostotic (situated in many bones). The etiology of fibrous dysplasia is unkown but it is now believed to be a developmental error... |
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