| Changes of PPD-Specific Immunoglobulin in Pulmonary Tuberculosis After Treatment. |
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Ja Young Kim, Mun Hwan Lee, Pyoung Han Hwang, Chan Uhng Joo, Jung Soo Kim |
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Department of Pediatrics, College of Medicine, Chonbuk National University, Chonju, Korea |
| 폐결핵 치료에 따른 PPD 특이 항체의 변동 |
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김자영, 이문환, 황평한, 주찬웅, 김정수 |
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전북대학교 의과대학 소아과학교실 |
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Received: 18 June 1990 • Accepted: 18 September 1990 |
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| Abstract |
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The definite diagnosis and precise assessment of response to therapy is still a problem in childhood
tuberculosis because these patients rarely produce sputum and if obtained it may be negative. For this
reason, diagnosis rely largely on the clinical and X-ray examination, which have a low specificity and
high proportion of false positive results.
Recently immunologic diagnosis of tuberculosis using enzyme-linked immunosorbent assay (ELISA)
was emerged as a new diagnostic method This study was performed to evalvate the diagnostic and
prognostic efficacy of PPD-specific immunoglobulins on pulmonary tuberculosis. PPD-specific IgG,
IgA and IgM were measured using ELISA on the sera from 40 pulmonary tuberculosis patients and
19 healthy controls. The following results were obtained.
1) The values of PPD- specific IgG were significantly higher in pulmonary tuberculosis patients
than those in controls and correlated to the extent of the tuberculosis (P<0.01). The values of
PPD-specific IgA and IgM were higher only in far advanced pulmoary tuberculosis patients than
those in controls, but there no differences depending on the extent of tuberculosis.
2) The values of PPD-specific IgG were significantly decreased after 2~4 months of treatment in
all groups of pulmonary tuberculosis patients except far advanced pulmonary tuberculosis (P<0.01).
But there were no significant alterations of the values of PPD-specific IgA and IgM after treatment.
3) Among the moderate and far advanced pulmonary tuberculosis patients, the values of PPD-
specific IgG were significantly decreased in responders after 6 months of treatment, however PPD-
specific IgG in non-responder were rather increased (p<0.01).
The results indicate that detection of PPD-specific IgG using ELISA can be used for rapid diagnosis
of tuberculosis as well as evaluating the response of chemotherapy and prognosis. |
| Key Words:
PPD-specific immunoglobulins, Pulmonary tuberculosis |
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