| The Study of Transplacental Transfer of Immunoglobulin G in Premature Infants |
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Sung Soo Moon, Yoon Ki Kang, Soo Chul Cho, Jung Soo Kim |
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Department of Pediatrics, College of Medicine, Chonbuk National University Hospital, Chonju, Korea |
| 미숙아에서 면역글로블린 G의 정상치 및 태반통과에 관한 연구 |
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문성수, 강윤기, 조수철, 김정수 |
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전북대학교 의과대학 소아과학교실 |
Correspondence:
Sung Soo Moon, Email: 1
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| Abstract |
Purpose
: Premature infants have low serum immunoglobulin G(IgG) levels because IgG is transplacentally
acquired, primarily after 32-34 weeks of gestational age. We studied the transplacental
transfer of serum IgG in preterm infants.
Methods
: The IgG levels in the sera were measured by radial immunodiffusion method(Behring
nephelometer, Germany).
Results
: There was a significant difference between IgG concentration and gestational age; the
IgG concentration increased from 462.2¡¾105.5mg/dL at less than 26 weeks of gestation to
1009.0¡¾242.6mg/dL at 35 and 36 weeks of gestation with increasing gestational age(P < 0.01). The
linear relation between IgG concentration and birthweight; the IgG concentration in the sera of
premature infants were increased from 588.3¡¾136.4mg/dL at birthweight less than 1250g to
1149.3¡¾287.8mg/dL at birthweight more than 2251g with increasing birth weight(P < 0.05).
Conclusion
: The effects of gestational age and birthweight on the concentration of IgG at birth
were highly interdependent and significant. These results suggest that IVIG administration is
needed for nearly all premature infants with birthweight less than 1200g and gestational age less
than 32 weeks. |
| Key Words:
Immunoglobulin G, Premature infants, Gestational age, Birth weight, Intravenous immunoglobulin |
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