- Original Article
- Serogroup and Antimicrobial Resistance of
Streptococcus pneumoniae Isolated from Oropharynx in
Children Attending Day Care Center
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Kyung Hyo Kim, Jong Eun Lee, Il Tae Whang, Kyung Ha Ryu, Young Mi Hong, Gyoung Hee Kim, Keun Lee, Eun-Suk Kang, Ki-Sook Hong
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Clin Exp Pediatr. 2002;45(3):346-353. Published online March 15, 2002
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Purpose : Penicillin- and multidrug-resistant S. pneumoniae poses a serious threat to clinicians because the rate of resistance of S. pneumoniae to penicillin in Korea has surged up to the world's highest level. This study was performed to assess the carriage rate, serogroups and antimicrobial susceptibility of S. pneumoniae isolated from oropharynx in children.
Methods : From March to July 1998,... |
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- Evaluation of Health Status and Growth and Developmental
Outcome of Intrauterine Growth-Retarded Infants
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Il Tae Hwang, Eun Ae Park, Ho Seong Kim, Gyoung Hee Kim
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Clin Exp Pediatr. 2001;44(6):635-641. Published online June 15, 2001
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Purpose : Although many children born with intrauterine growth retardation demonstrate significant catch-up growth in early childhood, substantial weight and height deficits remain in others. In addition, children with IUGR may demonstrate developmental deficits. The aims of this study are to evaluate the health status, growth and deveolpmental outcome of intrauterine growth retarded infants.
Methods : Sixty five intrauterine growth retarded... |
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- Inhibitory Effects of Dexamethasone on Production IL-1α and TNF-α in Peripheral Blood Mononuclear Cells
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Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
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Clin Exp Pediatr. 1999;42(7):921-927. Published online July 15, 1999
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Purpose : IL-1α and TNF-α have a seminal role in the intial events of inflammation. An area of intense interest is the assessment of new therapeutic modalities that regulate inflammatory response in acute bacterial infection. We conducted this study to compare the inhibitory effects of dexamethasone on the secretion of proinflammatory cytokines, such as IL-lα and TNF-α from cord... |
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- Effects of Thioredoxin on Apoptosis-Inducing Neuronal Cell Injury
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Hyunmi Kim, Gyoung Hee Kim, Yoon Song Lee
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Clin Exp Pediatr. 1999;42(6):825-832. Published online June 15, 1999
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Purpose : Thioredoxin is an endogenous antioxidant. It regulates the activities of transcriptional factors such as NF-kB(nuclear factor kappa B)and AP-1(activator protein-1) and it increases the synthesis of cytokines, preventing cellular proliferation and apoptosis. The aim of this study was to clarify the role of thioredoxin on apoptosis-inducing neuronal cell injury. We investigated the protective effects of thioredoxin against apoptosis-inducing... |
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- Effects of Thioredoxin on Oxidative Neuronal Cell Injury
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Hyunmi Kim, Gyoung Hee Kim, Yoon Song Lee
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Clin Exp Pediatr. 1999;42(5):686-696. Published online May 15, 1999
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Purpose : Thioredoxin is an endogenous antioxidant which directly scavenges reactive oxygen species(ROS) and regenerates oxidatively damaged protein by reducing potential at the redox active disulfide(-Cys-Gly-Pro-Cys-) site. Under oxidative stress, thiredoxin plays a protective and adaptative role by inducing expressions. The aim of this study was to clarify the role of thioredoxin on oxidative neuronal cell injury. We investigated the... |
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- Fcr Receptor and Mac-1 Expression and Functional Differentiation of HL-60 Cells by All-trans Retinoic Acid
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Hae Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh,
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Clin Exp Pediatr. 1999;42(4):462-471. Published online April 15, 1999
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Purpose : During differentiation of HL-60 cells by all-trans retinoic acid(ATRA), we analyzed the expression of Fcr receptors and Mac-1 by molecules of equivalent soluble fluorochromes(MESF) and functional studies.
Methods : HL-60 cells were induced to differentiate by adding 1μM ATRA. On the 4th and 7th day after stimulation as well as before stimulation, the cells were analyzed for phenotypic and... |
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- Functional Differentiation of HL-60 Cells by Dimethylsulfoxide and Phorbol 12-myristate 13-acetate
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Hae Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh
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Clin Exp Pediatr. 1999;42(3):355-363. Published online March 15, 1999
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Purpose : During hematopoietic differentiation of HL-60 cells by DMSO and PMA, we demonstrated functional changes of HL-60 cells-phagocytic activity, respiratory burst, antibody-dependent cell-mediated cytotoxicity(ADCC) and opsonophagocytic activity.
Methods : HL-60 cells(ATCC CCL-240), cultured in RPMI 1640 and supplemented with 10% FBS, were induced to differentiate by adding 1.0% DMSO or 16nM PMA. On the 4th and 7th day after... |
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- Effects of Two Different Surfactants on RBC Membrane and Type Ⅱ Alveolar Epithelial Cell in Vitro
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Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1999;42(1):32-39. Published online January 15, 1999
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Purpose : Respiratory distress syndrome(RDS) is a major cause of death in premature babies. For the treatment of RDS, various artificial pulmonary surfactants have been used. The incidence of pulmonary hemorrhage is increased in association with surfactant therapy in extremely low birth weight infants. But the pathogenesis of this increased incidence is not clear. So we conducted this study... |
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- Study of Seroprevalence of Antimycoplasma Antibody in Healthy Children and its Diagnostic Value
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Soo Kyung Choi, Ji Ah Jung, Kyung Hyo Kim, Gyoung Hee Kim
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Clin Exp Pediatr. 1998;41(4):489-497. Published online April 15, 1998
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Purpose : To evaluate the diagnostic reliability of the single serum titers of the specific serum
antibody determiantion method, we compared antimycoplasma antibody titers of 177 healthy children
with 353 children who had respiratory symptoms indicative of Mycoplasma pneumoniae infection.
Methods : We used Serodia-Myco II particle agglutination test and the titers of ≥1:40 were
regarded as positive.
Results : Age distribution of 177 healthy... |
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- Normal Predicted Values of Pulmonary Function Test in Healthy Korean Children
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Seung Yeon Nam, Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1998;41(3):338-345. Published online March 15, 1998
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Purpose : We performed a pulmonary function test with simple, computerized spirometry composed
of pneumotachometry and evaluated the predicted normal values of air flow rates and lung volumes
in healthy Korean children. We calculated each of the simple and complex linear and logarithmic
regression equations setting the predicted values.
Methods : Four hundred and fifty-two healthy children were enrolled from December, 1994 to
August, 1995.... |
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- Diagnostic Sensitivity in Predicting Hyperlipidemia by Bioelectrical Impedance Analysis in Obese Children
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Ji Ah Jung, Hyun Mi Kim,, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1998;41(11):1583-1589. Published online November 15, 1998
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Purpose : Childhood obesity is currently on the rise. The complications of childhood obesity are depression, adult obesity, hypertension, diabetes, hyperlipidemia, coronary artery disease and fatty liver. Therefore, accurate diagnosis of obesity is important. The purpose of this study was to assess diagnostic sensitivity to predict hypelipidemia by bioelectrical impedance analysis(BI) in obese children.
Methods : One hundred fifteen healthy... |
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- Immunologic Changes of HL-60 Cells by Differentiation Inducing Agents I : Phenotypic Differentiation of FcγR and Mac-1
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Hye Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh
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Clin Exp Pediatr. 1998;41(10):1342-1350. Published online October 15, 1998
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Purpose : Fc receptors and Mac-1 play an important role in the protective response of granulocytes and monocytes against microbial infection. FcγRⅠ, FcγRⅡ, FcγRⅢ as well as CD11b/ CD18 have never been measured in a quantitative way during hemopoiesis. Thus we quantified the expression of FcγRⅠ, FcγRⅡ, FcγRⅢ, and CD11b/CD18 during hematopoietic differentiation using HL-60 cells, which was induced to... |
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- Urinary Interleukin-1β Levels in Children with Urinary Tract Infection
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Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1997;40(7):981-990. Published online July 15, 1997
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Purpose : IL-1β and TNF-α are important mediators of the inflammatory response in serious
bacterial infections. The mucosal and systemic IL-1β and TNF-α responses to urinary tract
infection are analyzed in children with acute urinary tract infection.
Methods : We studied the levels of these two cytokines in the urine and sera of 21 children at
diagnosis and after treatment with sandwich ELISA method.
Results... |
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- The Expression of Fcγ Receptors in Cord and Adult Blood Granulocytes
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Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh, Hae-Kyung Park
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Clin Exp Pediatr. 1997;40(6):794-800. Published online June 15, 1997
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Purpose : The immature neonatal immune system is thought to result in increased risk of infection.
Receptors for the Fc moiety of IgG(FcγR) are important in antibody-mediated clearance of
microbes by granulocytes and monocytes/macrophages. As an approach to understand their role in
neonatal life, we compared the constitutive expression of the three Fc receptors-FcγRI(CD64), Fcγ
RII(CD32) and FcγRIII(CD16)-of neonatal granulocytes with those of adult... |
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- Production of Interleukin-1α and Tumor Necrosis Factor-α by Human Cord and Adult Blood Mononuclear Cells Stimulated by TSST-1 and LPS
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Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
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Clin Exp Pediatr. 1997;40(5):690-700. Published online May 15, 1997
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Purpose : Immature immunological defens mechanism in the neonate may contribute to the high susceptibility to overwhelming sepsis. S. aureus TSST-1 and E. coli LPS known as one of the important pathogens of septic shock or toxic shock induce massive release of various cytokines, such as tumor necrosis factor-alpha(TNF-α) and interleukin-1α(IL-1α) produced from peripheral blood mononuclear cells(PBMC). In contrast, limited... |
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- Plasma Fibronectin Concentration in the Premature,Fullterm Neonates and Infants
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Hyun Joo Lee, Kyung Hyo Kim, Gyoung Hee Kim
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Clin Exp Pediatr. 1997;40(4):473-479. Published online April 15, 1997
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Purpose : Plasma fibronectin has important role in the inflammatory response as non-specific opsonin and host defense. Plasma fibronectin concentration is different according to age and presence of infection. We performed this study to evalulate plasma fibronectin concentration in the healthy preterm, term neonates and infants and how that correlate with gestational age and birth weight and increased CRP concentration.... |
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- The Usefulness of Clinical Scoring System as Prognostic Predictor in Neonatal Seizure
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Hyunmi Kim, Gyoung Hee Kim
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Clin Exp Pediatr. 1996;39(6):829-838. Published online June 15, 1996
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Purpose : Neonatal seizure is usually the presentation of underlying neurologic
dysfunction rather than a disease and have high mortality and morbidity as sequalae.
Therefore, the parameter predicting the neurologic prognosis is necessary. This study
was performed to identify the usefulness of clinical scoring as predictor in neonatal
seizure by analyzing outcomes.
Methods : From 1982 to 1994, 101 neonates were admitted to Neonatal Intensive... |
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- Serum Secretory CD4 and CD8 Levelsin Kawasaki Disease
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Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1996;39(4):543-551. Published online April 15, 1996
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Purpose : Kawasaki disease (KD) is an acute febrile illness of infancy and early childhood characterized by diffuse vasculitis. Although the disease is generally self-limited, up to 25% of untreated patients with KD may develop coronary artery abnormalities. The acute phase of KD is characterized by marked activation of the immune system leading to increased cytokine production by immune effector... |
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- Pulmonary Function Test in Korean Neonates by Expiratory Flow-Volume Curve
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So Young Park, Kyung Hyo Kim, Gyoung Hee Kim
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Clin Exp Pediatr. 1996;39(1):53-62. Published online January 15, 1996
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Purpose : Neonatal pulmonary function test(PFT) adds a new dimension to the understanding and care of the infant at risk for lung dysfunction. PFT can be identified the risk for pulmonary problems and safely and effectively diagnosed, quantified, and qualified the dysfunction. So it is possible to early institution of prophylatic respiratory therapy in such neonates and it can improved... |
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- Case Report
- A Case of Meckel-Gruber Syndrome
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Hye Jin Lee, Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1995;38(9):1299-1303. Published online September 15, 1995
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We report a case of male neonate that showed multiple congenital anomalies that could be designated as Meckel-Gruber syndrome.
The principle signs of Meckel-Gruber syndrome are encephaolcelem, polydactly, and polycystic kidneys with normal karyotype. Due to rarity of the Meckel-Gruber syndrome, the cause was still unknown. At present, autosomal recessive is thought to be as one of the causes. This malformation... |
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- Laryngotracheoesophageal Cleft Type III A Report of 1 Case
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Myung Su Lee, Young Eun Lee, Eun Ae Park, Gyoung Hee Kim, Eun Chul Chung, Hac Soo Gyu
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Clin Exp Pediatr. 1995;38(5):719-724. Published online May 15, 1995
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Laryngotracheoesophageal cleft is rare congenital anomaly due to failure of fusion of the e sophagus and the larynx.
We experienced 1 case of larygotracheoesophageal cleft type III in neonate which was confirmed by autopsy.
One day of age male newborn infant with grunting, retraction, and copious secretion canofirm diagnosis as laryngotracheoesophageal cleft type Ill by several radiographic studies and sutopsy.
Brief review and... |
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- Original Article
- Evaluation of Pulmonary Venous, Mitral and Aortic Flow Pattern by Doppler Echocardiography in Neonates
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Hye Soon Kim, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1994;37(5):596-605. Published online May 15, 1994
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Pulmonary vein velocities have recently been estimated in conjunction with mitral flow velocities to increase our understanding of ventricular filling. The advent of transesophageal echocardiography with pulsed doppler imaging capability has provided a method by which both the mitral valve and pulmonary vein velocities can be easily recorded because of the posterior approach providing unimpeded interrogation of cardiac structures.
The purpose... |
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- Comparative Study on the Allergy Skin Test and RAST in Allergic Patients
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Il Tae Whang, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1994;37(12):1693-1700. Published online December 15, 1994
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The allegic skin test and RAST are used commonly to demonstrate the presence of skin sensitizing IgE antibody in the diagnosis of allergic disease.
To evaluate the agreement rate and correlation between results of skin test and RAST (radioallergosorbent test) in allergic subject, 83 allergic childgood with positive skin test (bronchial asthma: 26, allergic rhinitis: 27, atopic dermatitis and urticaria: 6... |
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- The Changes of Fetal Hemoglobin in Preterm and Small for Gestational Age Newborn Infants
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Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1993;36(7):919-927. Published online July 15, 1993
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The fetal hemoglobin, which is structurally different from adult hemoglobin, has higher affinity for oxygen and higher resistance to denaturation with alkali than adult hemoglobin. Intrauterine growth retarded neonates have highter mortality and morbidity than normal neonates.
In this article, to determine the changes of fetal hemoglobin by gestational age in infants appropriate in wieght for gestational age (AGA) and to... |
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- Dermatophagoides Farinae Specific IgG-Subclass Antibody in Allergic Children
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Young Mi Hong, Kyung Hyo Kim, Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1993;36(10):1651-1358. Published online October 15, 1993
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For determining the distribution of specific IgE and IgG-subclass antibodies and their role in allergic disorders, we measured the serum levels of specific IgG-subclass and IgE antibodies to Dermatophagoides farinae(Df) on 60 atopic children, aged between 8 to 12. All of them had positive skin test to Df, and was grouped into three: children with asthma only (group 1), with... |
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- Evaluation of the Serum Erythropoietin Levels in Neonates
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Soo Young Kweon, Gyoung Hee Kim
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Clin Exp Pediatr. 1993;36(1):67-72. Published online January 15, 1993
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Erythropoietin is the major hormonal regulator of erythropoiesis. It is controlled by many factors induct=ing hypoxia in tissue. The serum erythropoietin levels of neonates have shown gradual decrease untill 1 month of age. Which they are reactivated in the period of pysiologic anemia. This change is exaggerated if the neonates are born prematurely, and the levels of erythropoietin respond to... |
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- A case of neonatal systemic candidiasis.
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Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1991;34(9):1286-1293. Published online September 30, 1991
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Systemic infection with Candida albicans in very premature infants is frequently fatal or associated
with significant morbidity in survivors. Several common practices in newborn intensive care units,
such as insertion of indwelling catheters, provision of parenteral nutrition, and prolonged administra-
tion of broad-spectrum antibiotics or aminophylline, are associated with an increased risk of systemic
disease.
We have experienced a case of systemic candidiasis in 1/365... |
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- The relationship between diuresis and pulmonary function in respira- tory distress syndrome of the newborn.
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Eun Ae Park, Yung Sook Ko, Gyoung Hee Kim
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Clin Exp Pediatr. 1991;34(8):1086-1092. Published online August 31, 1991
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The purpose of this study was to determine the relationship between improvement of pulmonary,
function and diuresis in respiratory distress syndrome. This study was based on 24 cases of RDS
infants admitted in NICU of Ewha Womans University from January 1988 to December 1990.
The results were as follows.
1) Mean birth weight of study cases was 2.11 kg with gestational age between 29〜39 weeks.
2) Maximum... |
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- A case of posterior urethral valve of the newborn.
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Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1991;34(10):1439-1445. Published online October 31, 1991
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Posterior urethral valve is the most common obstructive abnormality in male children affecting
both kidneys and likely arise from maldevelopment of the mesonephric duct.
We have experienced a case of posterior urethral valve with urinary ascites in 10/365 year old male
neonate. Abdominal distension, oligouria, and azotemia were improved by urinary catheterization.
Pelvo-ureterostomy operation was done, and this case had excellent results with much... |
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- The Present Status of Infants Feeding in Korea.
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Gyoung Hee Kim, Keun Lee, Choong Hee Kim, Keun Soo Lee, Sang Man Shin, Dong Gawn Han, Soo Jee Moon
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Clin Exp Pediatr. 1985;28(10):960-966. Published online October 31, 1985
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A Survey on the present status of infants feeding in Korea was carried out during the period form July to September of 1984.
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- Clinical Studies on the Hyaline Membrane Disease.
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Jung Hee Lee, Gyoung Hee Kim, Keun Lee
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Clin Exp Pediatr. 1984;27(9):859-864. Published online September 30, 1984
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The medical records Of 99 cases of hyaline membrane disease who were admitted to the nursery of Ewha Womans University Hospital from Jan. 1980 to June 1983 were analysed and compared with the results obtained in the period of 1967 to 1975. 1)The incidence of hyaline membrane disease among the total live birth was 1.09%, that of full ttertn baby,... |
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- Statistical Analysis of Prognostic Factors in Hyaline Membrane Disease.
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Gyoung Hee Kim
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Clin Exp Pediatr. 1984;27(1):19-24. Published online January 31, 1984
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Medical records of 53 newborns, who were admitted with H.M.D. to the nursery of Dept, of Pediatrics, Ewha Womans Univ. Hosp, from Jan. 1980 through June 1983, were analyzed. The relationship between the mortality rate and laboratory data, including arterial blood gas analysis obtained within 12 hours after birth were studied in these H.M.D. patients. Significant correlation was found between... |
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