- Case Report
- DiGeorge syndrome who developed lymphoproliferative mediastinal mass
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Kyu Yeun Kim, Ji Ae Hur, Ki Hwan Kim, Yoon Jin Cha, Mi Jung Lee, Dong Soo Kim
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Clin Exp Pediatr. 2015;58(3):108-111. Published online March 20, 2015
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DiGeorge syndrome is an immunodeficient disease associated with abnormal development of 3rd and 4th pharyngeal pouches. As a hemizygous deletion of chromosome 22q11.2 occurs, various clinical phenotypes are shown with a broad spectrum. Conotruncal cardiac anomalies, hypoplastic thymus, and hypocalcemia are the classic triad of DiGeorge syndrome. As this syndrome is characterized by hypoplastic or aplastic thymus, there are missing... |
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- Original Article
- Blood culture contamination in hospitalized pediatric patients: a single institution experience
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Hyewon Min, Cheong Soo Park, Dong Soo Kim, Ki Hwan Kim
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Clin Exp Pediatr. 2014;57(4):178-185. Published online April 30, 2014
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Purpose Blood culture is the most important tool for detecting bacteremia in children with fever. However, blood culture contamination rates range from 0.6% to 6.0% in adults; rates for young children have been considered higher than these, although data are limited, especially in Korea. This study determined the contamination rate and risk factors in pediatric patients visiting the emergency room (ER)... |
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- Enhanced detection and serotyping of Streptococcus pneumoniae using multiplex polymerase chain reaction
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Jong Gyun Ahn, Seong Yeol Choi, Dong Soo Kim, Ki Hwan Kim
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Clin Exp Pediatr. 2012;55(11):424-429. Published online November 23, 2012
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Purpose Methods for quick and reliable detection of Streptococcus pneumoniae are needed for the diagnosis of pneumococcal disease and vaccine studies. This study aimed to show that sequential multiplex polymerase chain reaction (PCR) is more efficient than conventional culture in achieving S. pneumoniae-positive results. MethodsNasopharyngeal (NP) secretions were obtained from 842 pediatric patients admitted with lower respiratory infections at Severance Children's Hospital... |
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- Case Report
- A case of postoperative nasopharyngeal reflux associated with retropharyngeal lymphangioma in newborn infant
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Ah Reum Kwon, Eun Jung Park, Ki Hwan Kim, Dong Soo Kim
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Clin Exp Pediatr. 2010;53(2):262-266. Published online February 15, 2010
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Tumor necrosis factor-α (TNF-α) is a major proinflammatory cytokine involved in the pathophysiology of juvenile rheumatoid arthritis. Etanercept is an effective inhibitor of TNF-α and has shown a beneficial effect in patients with JRA. However, the most important cause of concern related to etanercept administration is infection. We report a case of encephalitis in a JRA patient receiving long-term treatment... |
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- Review Article
- Juvenile idiopathic arthritis: Diagnosis and differential diagnosis
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Ki Hwan Kim, Dong Soo Kim
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Clin Exp Pediatr. 2010;53(11):931-935. Published online November 30, 2010
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Juvenile idiopathic arthritis (JIA) is comprised of a heterogeneous group of several disease subtypes that are characterized by the onset of arthritis before the age of 16 years and has symptoms lasting at least 6 weeks. The previous classification of JIA included seven different categories, whereas its current classification was compiled by the International League of the Association for Rheumatology,... |
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- Original Article
- Nationwide surveillance of acute interstitial pneumonia in Korea
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Byoung-Ju Kim, Han A Kim, Young-Hwa Song, Jinho Yu, Seonguk Kim, Seong Jong Park, Kyung Won Kim, Kyu-Earn Kim, Dong Soo Kim, June Dong Park, Kang Mo Ahn, Hyo-Bin Kim, Hyang-Min Jung, Chun Kang, Soo-Jong Hong
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Clin Exp Pediatr. 2009;52(3):324-329. Published online March 15, 2009
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Purpose : Acute interstitial pneumonia (AIP) is a rare disease, but its prognosis is fatal because of lack of efficient treatment modality. Recently, it has been reported that there was epidemic AIP in Korea. This study aims to investigate the past and current status of AIP in Korea.
Methods : We performed a nationwide survey and a prospective study. From August... |
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- Comparison of a whole blood Interferon-γ assay and A tuberculin skin test for
detecting latent tuberculosis infection in children
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Jin-Kyong Chun, Jin-Kyong Chun, Chang Ki Kim, Chang Ki Kim, Hyun Sook Kim, Hyun Sook Kim, Ghee Young Jung, Ghee Young Jung, John A. Linton, John A. Linton, Ki Hwan Kim, Ki Hwan Kim, Taek Jin Lee, Taek Jin Lee, Ji Hyun Jeon, Ji Hyun Jeon, Dong Soo Kim, Dong Soo Kim
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Clin Exp Pediatr. 2008;51(9):971-976. Published online September 15, 2008
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Purpose : Surveillance for detecting and managing latent tuberculosis infection (LTBI) is a key component of tuberculosis control. The classic surveillance tool, the tuberculin skin test (TST), may have some limitations when used in the Bacillus Calmette-Guérin (BCG)-vaccinated population. The object was to perform a blood test QuantiFERON®-TB Gold In Tube (QFT-G IT) based on the detection of interferon-γ (IFN-γ)... |
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- Comparison of a whole blood Interferon-γ assay and A tuberculin skin test for
detecting latent tuberculosis infection in children
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Jin-Kyong Chun, Jin-Kyong Chun, Chang Ki Kim, Chang Ki Kim, Hyun Sook Kim, Hyun Sook Kim, Ghee Young Jung, Ghee Young Jung, John A. Linton, John A. Linton, Ki Hwan Kim, Ki Hwan Kim, Taek Jin Lee, Taek Jin Lee, Ji Hyun Jeon, Ji Hyun Jeon, Dong Soo Kim, Dong Soo Kim
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Clin Exp Pediatr. 2008;51(9):971-976. Published online September 15, 2008
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Purpose : Surveillance for detecting and managing latent tuberculosis infection (LTBI) is a key component of tuberculosis control. The classic surveillance tool, the tuberculin skin test (TST), may have some limitations when used in the Bacillus Calmette-Guérin (BCG)-vaccinated population. The object was to perform a blood test QuantiFERON®-TB Gold In Tube (QFT-G IT) based on the detection of interferon-γ (IFN-γ)... |
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- Clinical characteristics and prognostic factors for survival in
hemophagocytic lymphohistiocytosis
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Khi Joo Kim, Ki Hwan Kim, Taek Jin Lee, Jin-Kyong Chun, Chuhl Joo Lyu, Dong Soo Kim
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Clin Exp Pediatr. 2008;51(3):299-306. Published online March 15, 2008
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Purpose : Hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by fever, splenomegaly, pancytopenia, and hemophagocytosis in the bone marrow and other tissues. In this study, we investigated the clinical manifestations and prognostic factors in patients with HLH.
Methods : We retrospectively analyzed the data from 29 patients who were diagnosed whit HLH in the Severance Children's Hospital from... |
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- Review Article
- Fever
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Taek Jin Lee, Dong Soo Kim
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Clin Exp Pediatr. 2007;50(2):121-126. Published online February 15, 2007
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Fever has been recognized as a cardinal feature of disease since antiquity, but only recently has the pathophysiology of fever come to be understood. It became clear that the ultimate cause of fever is not a bacterial product (a so-called exogenous pyrogen) but a product of host inflammatory cells (i.e., an endogenous pyrogen). Many studies have demonstrated that mononuclear phagocytes... |
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- Juvenile rheumatoid arthritis
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Dong Soo Kim
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Clin Exp Pediatr. 2007;50(12):1173-1179. Published online December 15, 2007
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The diagnosis of juvenile rheumatoid arthritis (JRA) is based on patient's age at disease onset, symptom duration, gender, and clinical manifestations. JRA is of unknown origin, begins under the age of 16, and persists for a minimum of 6 weeks. JRA is categorized into three principal types, systemic, oligoarticular and polyarticular. Infection, other connective tissue diseases, malignancy, trauma, and immunodeficiency... |
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- Original Article
- A clinical study of systemic lupus erythematosus in children
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Ji Tae Kim, Young Mee Nam, Jae Seung Lee, Dong Soo Kim
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Clin Exp Pediatr. 2007;50(1):74-78. Published online January 15, 2007
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Purpose : Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease with complex clinical manifestations. It probably involves genetic, environmental and immunologic factors. In this study, we investigated the clinical manifestations, laboratory findings and prognosis of pediatric SLE to aid clinical care of pediatric SLE.
Methods : The data of 45 patients who were diagnosed as pediatric SLE in Severance... |
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- Epidemiology of central venous catheter related blood stream infections in pediatric patients
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Jung Hyun Kim, Ho Sun Eun, Kyung Min Choi, Dong Soo Kim, Dong Eun Young
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Clin Exp Pediatr. 2006;49(2):157-161. Published online February 15, 2006
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Purpose : The purpose of this study is to investigate the pathogens of central venous catheter-related blood stream infections and search for the association among the insertion site, the duration and the underlying conditions with the prevalence of central venous catheter-related blood stream infections under 15 years old.
Methods : A retrospective study was performed from Jan, 2003 to Dec, 2003... |
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- Statistical Analysis of 1,000 Cases of Kawasaki Disease Patients Diagnosed at a Single Institute
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Dae Hwan Hwang, Kyoung Mi Sin, Kyong Min Choi, Jae Young Choi, Jun Hee Sul, Dong Soo Kim
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Clin Exp Pediatr. 2005;48(4):416-424. Published online April 15, 2005
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Purpose : To find the risk factors associated with coronory artery lesions, non-responsiveness to intravenous immunoglobulin(IVIG) treatment, and recurrences in Kawasaki disease patients.
Methods : We retrospectively analyzed 1,000 Kawasaki disease patients who were admitted to Yonsei University Medical Center from September 1990 to December 2003. We compared between responder and non-responder groups to IVIG treatment as well as between relapsed... |
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- Expression of Toll-like Receptor-2 on the Peripheral Blood Monocytes in Kawasaki Disease Patients
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Dae Hwan Hwang, Jung Woo Han, Kyung Min Choi, Kyung Mi Shin, Dong Soo Kim
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Clin Exp Pediatr. 2005;48(3):315-320. Published online March 15, 2005
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Objective : Toll like receptor(TLR) is known to be involved in innate immunity. Many microbial antigens stimulate TLR, and as a result of intracellular signal transduction, they activate nuclear factor-kB which produces diverse inflammtory cytokines. Until now, many research topics in Kawasaki disease focused on cytokine increasement. In this study, we aim to reveal TLR increasement which might be associated... |
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- Case Report
- A Case of Multiple Giant Coronary Aneurysms with Large Mural Thrombus due to Kawasaki Disease in a Young Infant
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Eun Na Choi, Jeoung Tae Kim, Yuria Kim, Byung Won Yoo, Deok Young Choi, Jae Young Choi, Jun Hee Sul, Sung Kye Lee, Dong Soo Kim, Young Hwan Park
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Clin Exp Pediatr. 2005;48(3):321-326. Published online March 15, 2005
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Kawasaki disease is an acute systemic vasculitis of unknown origin. Giant coronary aneurysm is one of the most serious complications, although peripheral artery vasculitis can produce life-threatening events. Myocardial ischemia and infarction can be caused by coronary artery stenosis, aneurysm, and stagnation of blood flow in coronary arteries which triggers thromboembolism. Atypical presentation in young infants often interferes with prompt... |
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- Original Article
- Effect of Histone H1 on Collagen Induced Arthritis in Mice
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Jae Ho Yang, Kyung Mi Shin, Dong Soo Kim
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Clin Exp Pediatr. 2004;47(7):779-788. Published online July 15, 2004
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Objective : Besides the functions of histones in the nucleus of the cells, there is growing evidence that histones have many other extra-cellular or extra-nuclear functions, such as stabilizing axonemal microtubule of sea urchin sperm flagella. This microtule assembly function of the histone is similar to that of taxol, which has an effect of controlling joint inflammation. In this study,... |
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- Effect of a Flavon Extracted from Artemisia absinthium on Collagen Induced Arthritis in Mice
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Kyong Min Choi, Dae Hwan Hwang, Kyung Mi Shin, Do-Young Yoon, Dong Soo Kim
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Clin Exp Pediatr. 2004;47(6):677-684. Published online June 15, 2004
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Purpose : In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated.
Methods : DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies... |
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- Comparison of Serum Proteome Maps of Children with Kawasaki Disease
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Seoung Yon Baek, Young-Mock Lee, Kwang Hoon Lee, Dong Soo Kim
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Clin Exp Pediatr. 2004;47(1):81-89. Published online January 15, 2004
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Purpose : Kawasaki disease is a systemic vasculitis observed in children under five years of age and the leading cause of pediatric acquired heart disease, but its pathophysiology is still not completely understood. With proteomics, the study of quality and quantity of proteins, having been developed dramatically, we tried to find a way to evaluate the etiology and pathogenesis of... |
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- Characterization of B Cells of Lymph Nodes and Peripheral Blood in a Patient with Hyper IgM Syndrome
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Dong Soo Kim, Kyuong Mi Shin, Woo Ick Yang, Jeon-Soo Shin, Chang Hwa Song, Eun Kyeong Jo
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Clin Exp Pediatr. 2003;46(2):128-136. Published online February 15, 2003
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Purpose : Hyper IgM syndrome(HIGM) is characterized by severe recurrent bacterial infections with decreased serum levels of IgG, IgA, and IgE but elevated IgM levels. Recently, it has been classified into three groups; HIGM1, HIGM2 and a rare form of HIGM. HIGM1 is a X-linked form of HIGM and has now been identified as a T-cell deficiency in which mutations... |
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- A Clinical Study of the Acute Respiratory Distress Syndrome in Children
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Taek Jin, Dong Soo Kim, Dong Hwan Shin
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Clin Exp Pediatr. 2003;46(1):42-50. Published online January 15, 2003
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Purpose : The acute respiratory distress syndrome(ARDS), an acute form of severe alveolar-capillary injury evolving after a direct or indirect lung insult is thought to be a common cause of respiratory failure though not many clinical studies on the subject have been made yet.
Methods : Between January 1992 and December 2001, we conducted a retrospective study on 33 children who... |
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- Case Report
- A Case of Polyarteritis Nodosa in Childhood
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Jung Ho Seo, Dong Soo Kim, Myung Joon Kim
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Clin Exp Pediatr. 2001;44(4):456-459. Published online April 15, 2001
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Polyarteritis nodosa(PAN) is a multisystemic disease primarily involving the small and medium- sized vessels. Prognosis depends on the presence and severity of visceral involvement. Gastrointestinal involvement in PAN may result in vague abdominal pain, nausea and melena. Angiography can be used to establish a diagnosis of PAN. We report a case of polyarteritis nodosa presenting with recurrent abdominal pain, melena... |
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- Original Article
- Treatment Outcome of Penicillin-resistant S. Pneumoniae Infection
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Min Sook Choi, Young Won Kim, Dong Soo Kim, Kyung Won Lee
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Clin Exp Pediatr. 2001;44(2):149-153. Published online February 15, 2001
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Purpose : Streptococcus pneumoniae is a normal flora and common pathogen of the upper respiratory tract. S. pneumoniae infections are estimated to cause not only localized infection such as pneumonia, and otitis media, but also systemic infections, for example meningitis, sepsis, and so on. Recently, the resistance of S. pneumoniae to penicillin and multidrug has been rapidly increasing in many... |
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- Apoptosis of Peripheral Blood Mononuclear Cells in Different Ages of Normal Children
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Dong Soo Kim, Hyun Young Kim, John A Linton
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Clin Exp Pediatr. 2000;43(4):463-469. Published online April 15, 2000
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Purpose : To survive in an ecological environment, an individual must develop immunity to various antigens. Therefore, populations of peripheral blood mononuclear cells(PBMC) in humans change continuously with growth. The object of this study is to evaluate the apoptosis of peripheral blood mononuclear cells(PBMC) in normal children of different ages.
Methods : PBMC were isolated from the study groups. Ten... |
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- Apoptosis of Cord Blood Mononuclear Cells Infected with Enterovirus
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Dong Soo Kim
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Clin Exp Pediatr. 2000;43(3):372-379. Published online March 15, 2000
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Purpose : To evaluate apoptosis of cord blood mononuclear cells(CBMC) infected with enterovirus.
Methods : Cord blood was obtained from 20 neonates which were delivered vaginally without any complications. Cord blood mononuclear cells(CBMC) were isolated, and after 24h and 48h incubation, cells were stained with Annexin V and Propidium Iodide and were analyzed with FACScan flowcytometer. CBMCs were also incubated with... |
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- Prevalence and Identification of Rotaviruses in Stool Specimens of Patients with Acute Diarrhea from Several Regions of Korea
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Dong Soo Kim, Beom Soo Park, Dong Hyuk Jung, Jae Moon Ahn, Chul Joong Kim, Shien Young Kang
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Clin Exp Pediatr. 1999;42(4):501-509. Published online April 15, 1999
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Purposes : Rotaviruses are the main cause of infantile diarrheal diseases worldwide. The purpose of this study is to obtain epidemiologic data of rotavirus infections in Korea.
Methods : Stool specimens were collected from 150 patients with acute diarrheal symptoms, who were admitted to Yonsei Medical Center and Chungbuk National University Hospital. After isolating the virus from the specimens, the viruses... |
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- The Effect of Acanthopanax koreanum Extract on the Induction of Collagen Induced Arthritis for DBA/1J Mice
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Dong Soo Kim, Chang Ho Song, Soo Kon Lee
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Clin Exp Pediatr. 1998;41(2):247-254. Published online February 15, 1998
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Purpose : It is well known that the Acanthopanax koreanum extract has an anti-inflammatory action without any adverse effects reported. We conducted this study to see whether the Acanthopanax koreanum extract has a preventive effect on the development of collagen induced arthritis in DBA/1J mice.
Methods : Three groups of BDA/1J mice were immunized by intradermal injection of 2mg/kg bovine type... |
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- Case Report
- A Case of Kawasaki Disease of Five Recurrences During 4 Years
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Jeong Woo Ryu, Dong Soo Kim, Jong Kyun Lee, Jun Hee Sul, Sung Kyu Lee
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Clin Exp Pediatr. 1997;40(9):1293-1296. Published online September 15, 1997
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Kawasaki disease is an acute illness of early childhood, especially less than 5 years of age,
characterized by prolonged fever(> 5 days), changes of lips and oral cavity, changes of peripheral
extremities, polymorphous skin rash, bilateral conjunctival congestion and acute nonpurulent cervical
lymphadenopathy. Usually, the recurrence of Kawasaki disease is not frequent.
It is thought that the factors in recurrence of Kawasaki disease was... |
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- Original Article
- Clinical Investigation of Neck Masses in Children
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Sung Chul Byun, Dong Soo Kim
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Clin Exp Pediatr. 1996;39(10):1429-1442. Published online October 15, 1996
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Purpose : Neck masses are frequently encountered in pediatric practice, and have various
underlying diseases. If the underlying diseases of the neck mass are not confirmed by its clinical
characteristics, it can be done by neck mass biopsy. To define the necessity and the appropriate
time of neck mass biopsy is very difficult and also important. Therefore the authers have
conducted this study to... |
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- Changes of Interleukin-6 Level in Serum and CSF in Aseptic Meningitis
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Moon Kyu Kim, Dong Soo Kim
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Clin Exp Pediatr. 1995;38(5):625-632. Published online May 15, 1995
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Purpose : Aseptic meningitis is an infection of CNS caused by virus and there are remarka-ble changes in endogenous cytokine level. Interleukin-6 is a pleiotropic and multi-functional cyt-okine and plays a central role in host defense mechanisms. We studied the IL--6 level in serum and CSF with the patients of aseptic meningitis and investigated the relationship of IL-6 with C... |
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- House Dust Mites Sensitivity in Korean Atopic children; Correlation between Skin Reaction and Relative Concentration of Specific IgE by ELISA
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Ji Hong Kim, Soo Young Lee, Byeung Ju Jeung, Kye Earn Kim, Dong Soo Kim, Ki Young Lee
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Clin Exp Pediatr. 1994;37(12):1701-1708. Published online December 15, 1994
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House dust mites, Dermatophagoides farinae and Dermatophagoides pteronyssius, have been identified as the main sources of house dust allergen and are considersed the most important causative allergen in the etiology of allergic respiaratory disease and allergic rhinitis.
To evaluate the incidence of positive skin reactivity to house dust mites and relationship between total serum IgE levels and specific IgE antibody to... |
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- Production, Characterization, and Clinical Application of Perchloric Acid Soluble M. tuberculosis Antigen (TB-I)
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Kyung Hyo Kim, John Linton, Yunsop Chong, Dong Soo Kim
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Clin Exp Pediatr. 1993;36(8):1107-1115. Published online August 15, 1993
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The immune response to M. tuberculosis engages T-cell medicated reactions which determine the degree of resistance and also the clinical pattern of disease. Although antibodies produced by the infected host have yet no proven protection, they are appilicable for alternative diagnostic tests in tuberculosis. Preparation of purified antigens from Mycobacteria with specific antigenic determinants would improve serological diagnosis in tuberculosis.
The... |
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- Production and Characterization of Monoclonal Antibodies to Perchloric Acid Soluble Antigen of M. tuberculosis(TB-II)
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Kyung Hyo Kim, Dong Soo Kim
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Clin Exp Pediatr. 1993;36(8):1116-1123. Published online August 15, 1993
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Mycobacteria cause diseases which occur the world over and whoich carry a considerable burden in morbidity, mortality and social problems. A battery of monoclonal antibodies specific for mycobacterial antigens would provide a useful tool for rapid diagnosis of mycobacterial diseases. Fourtenn monoclonal antibodies to perchloric acid soluble antigne of M. tuberculosis were produced. Immunoglobulin isotypes of monoclonal antibodies were ten... |
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- Inteleukin-6 Level in Systemic Lupus Erythematosus
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Young Nae Yim, Dong Soo Kim
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Clin Exp Pediatr. 1993;36(3):386-393. Published online March 15, 1993
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Systemic lupus erythematousus(SLE) is a disease affecting blood vessels and connective tissue, which are damaged by deposition of pathogenic autoantibodies and immune complexes.Although a complex disease, SLE provides a number of insights into autoimmune pathogenesis. Autoimmune disease, in general, is characterized by B cell hyperactivity which results in hypergammaglobulinemia and production of a variety of autoantibodies reactive to organ-nonspecific antigens... |
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- Production and Characterization of Monoclonal Antibodies to Perchloric Acid Extract Antigen of M. bovis BCG(BCG Ⅱ)
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Kyung Hyo Kim, Dong Soo Kim, Jeon Soo Shin
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Clin Exp Pediatr. 1992;35(9):1183-1192. Published online September 15, 1992
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Mycobacteria causes disease which occur over the world. The development of reliable serological teset for the diagnosis of tuberculosis in humans has been complicated by the large degree of cross reactivitiy between antigens of Mycobacteria species can be used as a tool for serodiagnosis of tuberculosis. Fourteen monoclonal antibodies to perchloric acid extract antigen of M. bovis BCG were produced.... |
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- Clinical Features of Twelve Coxiellemia Pediatric Patients in Korea
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Chuhl-Joo Lyu, Dong Soo Kim, Young Mo Sohn, Ki Sup Chung, Kir-Young Kim, Won Young Lee
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Clin Exp Pediatr. 1992;35(9):1220-1225. Published online September 15, 1992
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Coxiella burnetii is a rickettsial organism and extremely infectious for humans animals. The infection caused by this organism is endemic throughout the world. Although it has not been reported in Korea because of the nonspecific clinical manifestations, the difficulties in diagnosis, and the underestimate of this disease. Update this infection has been misdiagnosed as other disease.
We experienced twelve cases of... |
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- Case Report
- Acquired Persistent Cytomegalovirus Infection : An Association with Common Variable Immunodeficiency
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Min Hyea Kim, Young Mi Hong, Sung Joo Lee, Je Geun Chi, Dong Soo Kim
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Clin Exp Pediatr. 1992;35(9):1272-1279. Published online September 15, 1992
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Acquired persistent cytomegalovirus infection was diagnosed by anti CMV antibody and lymph node biopsy and persisted in a 3-year-old boy with recurrent episode of high fever, lymphadenopathy hepatosplenomegaly and pneumonia.
Initial immunologic abnormalities including low serum IgG, high IgM decreased T4 and T4/T8 ratio finally progressed to immunologic paralysis which was compatible to common variable immunodeficiency.
This is the first case which... |
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- Original Article
- Production, Characterization, and Clinical Application of Perchloric Acid Extract of M. bovis BCG (BCG I)
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Kyung Hyo Kim, Dong Soo Kim
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Clin Exp Pediatr. 1992;35(8):1059-1065. Published online August 15, 1992
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Tuberculosis has been an important world-wide infectious disease. The prevalence of radiologically active tuberculosis was 1.8% of population in Korea. Probably the most important aspect of the pathogenesis of tuberculosis is the nature and specificity of the response of the immune system to the antigens of tubercle bacilli. Preparation of purified antigens from Mycobacteria with specific antigenic deterninants would improve... |
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- The Effects of RU 41.740, a Glycoprotein Extract from Klebsiella pneumoniae, on Peripheral Blood Mononuclear Cells
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Moon Kyu Kim, Dong Soo Kim, Hyun Ok Kim
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Clin Exp Pediatr. 1992;35(8):1066-1072. Published online August 15, 1992
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RU 41.740 is extract of Klebsiella pneumoniae K2O1 stain with immunomodulatory properties. It was composed of two glycoproteins, each being 31 KD and 33 KD in their molecular weight, on SDS-PAGE analysis. RU 41.740 was observed to augment cell mediated immunity of human peripheral blood mononulear cells measured by tritiated thymidine uptake method. Maximal augmentation was observed after 72 hours... |
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- In Vitro Immunization-IV: Antibody Response of Mouse Splenocytes Grown in a Mixture of Conditioned Media, Thymocytes, and Bone Marrow Cells
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Dong Soo Kim, Geun Woong Noh
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Clin Exp Pediatr. 1992;35(7):902-908. Published online July 15, 1992
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We have previously reported several methods of in vitro immunization using different conditioned media, and the highest antibody titer was observed when a mixture of three conditioned media[PHA-stimulated adherent splenocytes conditioned medium (ASM-P), ASM-p-stimulated non-adherent splenocyte conditioned medium (NASM-A), ASM-P-stimulated thymocyte conditioned medium (TM-A)] was used.
In this experiment, thymocytes and/or bone marrow cells was added instead of above conditioned media... |
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- The Interleukin-6 Level in Kawasak Disease
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Moon Kyu Kim, Dong Soo Kim
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Clin Exp Pediatr. 1992;35(4):515-526. Published online April 15, 1992
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Kawasaki disease is an acute multisystemic disease affecting infants and children with prominent vasculitic features. Although there has been considerable progress in understanding the pathogenesis of this disease, the inciting cause remains unclear. It has been noticed that there were many immunologic abnormalities during the acute stage of Kawasaki disease. In the pres-ent study, we studied serum interleukin-6(IL-6), C-reactive protein(CRP),... |
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- The Soluble Interleukin 2 Receptor Levels in Kawasaki Disease
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Keum Chun Kim, Dong Soo Kim
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Clin Exp Pediatr. 1992;35(12):1657-1666. Published online December 15, 1992
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Kawasaki disease has been known as an acute febrile mucocutaneous lymph node syndrome since 1967. But its definite pathophysiology still remains unclear. In order to study the immunologic basis for immunologic abnormalities in this disease, we studied the level of soluble interleukin-2 receptor (sIL-2R), interleukin-6 (IL-6) and C-reactive protein (CRP) at the acute and convalescent phases of the disease, comparing... |
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- Case Report
- Effect of Cultured Thymic Epithelium Transplantation in a Patients with Severe Combined Immunodeficiency
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Soo Kyung Yun, Byoung Ho Cha, Woo Seung Jeoun, Dong Soo Kim
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Clin Exp Pediatr. 1992;35(10):1443-1448. Published online October 15, 1992
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Severe combined immunodeficiency disease is caused by a group of genetic disease characterized by abnormal function of T and B lymphocytes.
The treatment of choice for severe combined immunodeficiency disease is a HLA mached bone marrow transplant, but transplantation of cultured thymus epithelium was used to treat severe combined immunodeficiency disease in case of that mached, related bone... |
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- Original Article
- A case of neonatal herpes simplex virus encephalitis.
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Kook In Park, Young Mo Sohn, Dong Soo Kim, Ran Namgung, Chul Lee, Dong Gwan Han, Won Young Lee, Ki Keun Oh, Myung Joon Kim
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Clin Exp Pediatr. 1991;34(9):1276-1285. Published online September 30, 1991
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Neonatal herpes simplex virus infection still remains a life-threatening infection for the newborn.
With an increasing incidence of genital herpes and an increase in the incidence of neonatal herpes
simplex virus infections, it is important that pediatricians and neonatologists continue to maintain a
high index of suspicion in infants whose symptoms may be compatible with herpes simplex virus
infections so that early identification leads... |
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- Study on the antibody formation in patinets treated with recombinant human growth hormone(rhGH).
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Hye Jung Joo, Duk Hi Kim, Dong Soo Kim
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Clin Exp Pediatr. 1991;34(9):1261-1268. Published online September 30, 1991
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Patients with short stature admitted to the Pediatrics Endocrinology Clinic, Yonsei University
College of Medicine during a six-year period from August, 1983 to August, 1989 were divided into
three groups.
The group 1 received rhGH, group 2 received Oxandrolone and group 3 did not receive any
treatment.
These patients were tested for presence of antibodies to rhGH with ELISA and effect of rhGH was
evaluated.
1) Among 53... |
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- The effect of dietary fats of immune response in sublethally irradiated rats.
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Soon Hwan Oh, Dong Soo Kim, Hae Won Nam, Juhn Kyu Loh
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Clin Exp Pediatr. 1991;34(11):1494-1504. Published online November 30, 1991
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To investigate the effect of dietary fats on cellular immune response in the immunosuppressed rats,
different compositions in the quality and quantity of dietary fats were fed to sublethally irradiated
male rats.
The results are as follows;
1) After 2 weeks of irradiation, the mean body weight of the fat free dietary group was significant-
ly lower than the com oil group. The organ weight, especially... |
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- Effect of dietary fats on immune response in rats.
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Soon Hwan Oh, Dong Soo Kim, Hae Won Nam
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Clin Exp Pediatr. 1991;34(10):1334-1345. Published online October 31, 1991
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To investigate the effect of dietary fats on the humoral and cellular immune response, different
compositions in the quality and quantity of dietary fats were fed to male rats.
The results are as follows;
1) The mean body weights of the rats which were fed the various dietary fats were not significant
during the experimental period. The weights of the organs measured were the spleen,... |
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- Lipoid Pneumonia.
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Chang Gee Kang, Ho Seong Kim, Jung Tak Kim, Dong Soo Kim, Eun Kyung Han, Kwang Gil Lee, In Joon Choi
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Clin Exp Pediatr. 1990;33(3):393-397. Published online March 31, 1990
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Lipoid pneumonia is a chronic, interstitial, proliferative inflammation resulting from aspiration of
lipoid material; it occurs principally in debilitated infants.
Animal oils, owing to their high fatty acid content, are the most damaging.
There are no characteristic signs or symptoms; cough is most common and in severe cases there
may be dyspnea.
We have experenced one case of lipoid pneumonia cause by an aspiration of... |
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- Prolonged Fever in Korean Children: Review of 120 Cases.
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Ho Seong Kim, Dong Goo Lee, Dong Soo Kim
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Clin Exp Pediatr. 1990;33(11):1516-1525. Published online November 30, 1990
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The authors reviewed the 120 patients with prolonged fever whose temperature was over 38.5°C and
of undetermined etiology, who were admitted in Y야isei Medical Center from March 1982 to March
1989. The results were as follows;
1) The children admitted with prolonged fever were 0.3% of total in-patients at the same time.
2) 20 cases were less than 1 year of age on admission and 39... |
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- A Case of Patient with Common Variable Immunodeficiency.
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Keun Cheon Kim, Chang Gee Kang, Chang Hyun Yang, Dong Soo Kim, Kir Young Kim
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Clin Exp Pediatr. 1989;32(8):1123-1127. Published online August 31, 1989
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Common variable immunodeficiency, as defined by World Health Organization classification of
primary immunodeficiency, is a heterogenous group of disorders with hypogammaglobulinemia,
decreased ability to produced antibody following antigenic challenge, and increased incidence of
infections. The disorder was often familial, but no mode of inheritance has been discerned. Clinical
fingings are recurrent bacterial infections, particularly respiratory infection.
Laboratory evaluations in common variable immunodeficiency demonstrate decrease in... |
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- Truncus Arteriosus Associated with Interrupted Aortic Arch.
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Chang Hyun Yang, Jae Seung Yang, Jun Hee Sul, Dong Soo Kim, Sung Kyu Lee, Dong Shik Chin
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Clin Exp Pediatr. 1988;31(6):779-783. Published online June 30, 1988
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We experienced a case of truncus arteriousus associated with interrupted aortic arch, ventricular
septal defect and patent ductus arteriosus. A 5 month old boy had complained of rapid respiration and
feeding difficulty since birth.
There was no visible cyanosis or clubbing toes and nails. There was a grade 2 〜3 ejection systolic
murmur with maximum intensity at the left lower sternal border. Diagnosis was... |
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- Case Report
- Coarctation of the Aorta : Unusual Type.
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Jung Bae Lee, Dong Soo Kim, Chuhl Joo Ryu, Kwang Sin Cho, Jun Hee Sul, Sung Kyu Lee, Dong Shik Chin, Kyu Ok Choe, Bum Koo Cho
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Clin Exp Pediatr. 1986;29(7):773-778. Published online July 31, 1986
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We experienced a case of coarctation of the aorta with aneurysmal dilatation which was
located in aortic arch, who was a 13 year old male.On physical examination on admission,
pulses were weak in right radial artery and in both femoral artery. Blood pressure measured 100/70 mmHg
in right arm, 100/70 mmHg in left arm, 130/110 mmHg in right leg and 130/110... |
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- A case of Unilateral Absence of Pulmonary Artery.
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Kwang Sin Joh, Dong Soo Kim, Chul Joo Ryu, Shin Heh Kang, Sung Kyu Lee, Ki Young Lee, Dong Shik Chin
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Clin Exp Pediatr. 1986;29(5):559-563. Published online May 31, 1986
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Unilateral Absence of Pulmonary Artery(UAPA) is a rare disease. It is characterized by no specfiic cardiopulmonary symptoms in general. We experienced a case of UAPA in a 9 year-old female patient with the chief complaint of abnormal chest Xray finding. Lung perfusion scan, cardiac catheterization with pulmonary and aortic angiography confirmed the diagnosis of right side UAPA.
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- Original Article
- A Measurement of Measles Antibodies among the Age Between 6 to 15 Months
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Ki Young Lee, Sang Woo Kim, Kyoung Tae Hwang, Kyu Chong Choi, Jong Soo Kim, Chang Ju Cho, Baek Keun Lim, Hyun Sook Kim, Dong Soo Kim
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Clin Exp Pediatr. 1986;29(4):375-380. Published online April 30, 1986
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To determine the proper age of the measles vaccination, we must know the time when the passively transferred measles antibody from mother disappeared. Because it can be a major factor for vaccine failure to take the measles vaccine to the children who still have the passive immunity. We measured the degree of immunity of 50 children with the age between... |
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- Case Report
- Two cases of Vascular Ring.
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Jun Chul Choi, Dong Soo Kim, Jun Hee Sul, SUng Kyu Lee, Dong Shik Chin
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Clin Exp Pediatr. 1986;29(3):312-317. Published online March 31, 1986
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This study is a report of two cases of vascular ring that were experienced at Yonsei University in 1983 and 1985.
The first case was a one-month-old female patient with a double aortic arch and PDA.
The main pulmonary artery was connected to the anterior arch by PDA. The anterior arch was larger in diameter than the posterior arch and the descending... |
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- A Case of Gastroenteritis Complicated with Empyema of Gall Bladder Caused by Salmonella Serogroup B.
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Dong Soo Kim, Ki Sup Chung, Dong Shik Chin, Seung Hoon Choi, Eui Ho Hwang
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Clin Exp Pediatr. 1986;29(2):221-224. Published online February 28, 1986
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There are four main groups of clinical manifestations in salmonellosis, gastroenteritis。
enteric fever, localized infection, and chronic carrier state, that may occur individually, simultaneously or consecutively in the course of an infection. The authors experienced a case of salmonella gastroenteritis complicated with empyema of gall bladder in a 12-year-old male patient. The clinical diagnosis was confirmed on the operating table and... |
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- Original Article
- Changing Pattern of Parasitic Infection by Year in Pediatric Age Group.
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Dong Soo Kim, Ki Young Lee, Duk Jin Yun, Chin Thak Soh
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Clin Exp Pediatr. 1981;24(6):567-576. Published online June 15, 1981
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To contract the parasitic infection, the environmental factor is more important although the host defense mechanism must be considered. Though it is important to consider the physical conditions, social and economic conditions are most important factors. Now it has been reported that the parasitic infection rate has been on the decrease along with improvement of social and economic conditions. Parasitologic... |
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- Clinical Study on Foreign body Aspiration and Aspiration Pneumonia.
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Dong Soo Kim, Ki Choon Kim, Ki Young Lee, Duck Jin Yun
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Clin Exp Pediatr. 1981;24(4):343-351. Published online April 15, 1981
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A clinical study was done on 177 cases of inpatients, who had been admitted under the diagnosis of aspiration pneumonia and foreign body aspiration at the Department of Pedia-trics, Yonsei University College of Medicine from Jan. 1965 to Dec. 1977. The results were obtained as follows:
1)Children below 5 years old(59.3%) are prone to aspirate and it is more common in... |
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- A Case of Congenital Hypoplastic Anemia.
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Dong Soo Kim, Chul Lee, Hong Kyu Lee, Kir Young Kim, Duk Jin Yun
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Clin Exp Pediatr. 1980;23(9):771-775. Published online September 15, 1980
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Authours have observed a case of congenital hypoplastic anemia in 21 months old Korean male patient who was diagnosed through aspirations of bone marrow. His hematologic improvement was followed by administrations of prednisolone. A brief review of related literature was made. |
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- Case Report
- 3 Cases of Congenital Adrenal Hyperplasia.
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Kyo Sun Kim, Dong Soo Kim, Seoung Ku Kim, Kwang Ho Kim, Duk Hi Kim, Duk Jin Yun
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Clin Exp Pediatr. 1980;23(8):662-669. Published online August 15, 1980
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We present 3 cases of congenital hyperplasia. Case lis a 5 year and 9 month old who is suffered from excessive salt craving and symptoms of precocious puberty. Case llis a 2 month old boy who has failure to thrive and frequent episode of dehydration. Case lll is a 5 year and 3 month old girl who has enlarged clitoris... |
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- Original Article
- Computerized Transverse Axial Tomography in Seizure Disorders.
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Dong Soo Kim, Chul Lee, Chang Jun Coe, Duk Jin Yun, Jung Ho Suh
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Clin Exp Pediatr. 1980;23(8):646-652. Published online August 15, 1980
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Seizure is the frequent disorder in childhood and detection of organic lesions is very important for both the determination of a therapeutic plan and the prognosis of the patient. Computerized transverse axial tomographic examination of 106 patients with seizure in Severance Hospital, Yonsei University from Dec. '77 to Dec. '79 was reviewed and analysed the following results were obtained. 1.... |
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- Case Report
- Emergencies in Hemophilia.
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Dong Soo Kim, Kwan Sub Chung, Kir Young Kim, Duk Jin Yun
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Clin Exp Pediatr. 1980;23(10):809-814. Published online October 15, 1980
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9 classic hemophilacs in Severance Hospital, Yonsei University from Dec. '77 to Aug. '79 were reviewed and analysed and the following results were obtained. 1. Intracranial hemorrhage is required the most immediate emergent therapy in hemophiliacs and computerized transverse axial tomogarhy may be essential for the accurate and noninvasive diagnosis and for the effective emergency treatment. 2. To conserve supplies... |
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- A Case of Benign Recurrent Hematuria.
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Dong Soo Kim, Soo Hyung Kim, Duk Jin Yun, In Jun Choi
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Clin Exp Pediatr. 1979;22(7):532-537. Published online July 15, 1979
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We experienced a case with benign recurrent hematuria in a 13-year-old boy. He had 5 times of gross hematuria during past four years. There was no abnormal findings on physical examination. He had normal renal function. However the renal biopsy specimen revealed IgA deposits in mesangium under immunofluorescent stain. A brief review of related literatures is also presented. |
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