| The Effects of RU 41.740, a Glycoprotein Extract from Klebsiella pneumoniae, on Peripheral Blood Mononuclear Cells |
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Moon Kyu Kim1, Dong Soo Kim1, Hyun Ok Kim2 |
1Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
2Department of Clinical Pathology, Yonsei University, College of Medicine, Seoul, Korea |
| Klebsiella Pneumoniae에서 추출한 당단백질(RU 41.740)의 성상과 세포성 면역에 미치는 영향 |
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김문규1, 김동수1, 김현욱2 |
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 임상병리학교실 |
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| Abstract |
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RU 41.740 is extract of Klebsiella pneumoniae K2O1 stain with immunomodulatory properties. It was composed of two glycoproteins, each being 31 KD and 33 KD in their molecular weight, on SDS-PAGE analysis. RU 41.740 was observed to augment cell mediated immunity of human peripheral blood mononulear cells measured by tritiated thymidine uptake method. Maximal augmentation was observed after 72 hours of incubation. This effect on cellular immunity was suppressed by the antibodies which was producted by injecting RU 41.740 intradermally to the rabbit. Treatment of peripheral blood mononuclear cells with RU 41.740 did not change NK cell activity using K 562 cell as a target cell. |
| Key Words:
RU 41.740, Cell mediated immunity |
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