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House Dust Mites Sensitivity in Korean Atopic children; Correlation between Skin Reaction and Relative Concentration of Specific IgE by ELISA

Journal of the Korean Pediatric Society 1994;37(12):1701-1708.
Published online December 15, 1994.
House Dust Mites Sensitivity in Korean Atopic children; Correlation between Skin Reaction and Relative Concentration of Specific IgE by ELISA
Ji Hong Kim, Soo Young Lee, Byeung Ju Jeung, Kye Earn Kim, Dong Soo Kim, Ki Young Lee
Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
알레르기 질환을 앓고 있는 환아에서 피부시험과 면역효소법을 이용한 집먼지 진드기 감작에 관한 연구
김지홍, 이수영, 정병주, 김규언, 김동수, 이기영
연세대학교 의과대학 소아과학교실
Abstract
House dust mites, Dermatophagoides farinae and Dermatophagoides pteronyssius, have been identified as the main sources of house dust allergen and are considersed the most important causative allergen in the etiology of allergic respiaratory disease and allergic rhinitis. To evaluate the incidence of positive skin reactivity to house dust mites and relationship between total serum IgE levels and specific IgE antibody to house dust mites, we performed allergic skin test (scratch) in 182 children with allergic respiatory disease and atopic dermatitis. We also checked serum total IgE by PRIST method and specific IgE antibody to D. farinae and K. pteronyssinus by ELISA. Our results showed that positive skin reaction was observed in 79% of patients in D. farinae, 71% in D. pternyssinus. There was a significant correlation between serum total IgE and IgE antibody specific to D. farinae(r=0.55, p<0.001). Serum total IgE and specific IgE antibody to D. petronyssinus had no significant correlation(r=0.39, p<0.001). D. farinae and D. pteronyssinus had close correlation in the skin test(r=0.82, p<0.0001) and relative concentration of specific IgE antibody (r=0.73, p<0.0001). The agreement between skin reaction and relative concentration of specific IgE to House dust mites was 68% in D. farinae and 63% in D. pteronyssinus.
Key Words: House dust mite, Allergic skin test, Specific IgE antibody, ELISA


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