Korean Journal of Pediatrics 2009;52(3):324-329.
Published online March 15, 2009.
Nationwide surveillance of acute interstitial pneumonia in Korea
Byoung-Ju Kim1, Han A Kim1, Young-Hwa Song1, Jinho Yu1, Seonguk Kim1, Seong Jong Park1, Kyung Won Kim2, Kyu-Earn Kim2, Dong Soo Kim2, June Dong Park3, Kang Mo Ahn4, Hyo-Bin Kim5, Hyang-Min Jung6, Chun Kang6, Soo-Jong Hong1
1Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
2Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
3Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
4Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
5Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea
6Korea Centers for Disease Control and Prevention, Seoul, Korea
급성 간질성 폐렴의 전국적 현황 조사
김병주1, 김한아1, 송영화1, 유진호1, 김성국1, 박성종1, 김경원2, 김규언2, 김동수2, 박준동3, 안강모4, 김효빈5, 정향민6, 강춘6, 홍수종1
1울산대학교 의과대학 소아과학교실
2연세대학교 의과대학 소아과학교실
3서울대학교 의과대학 소아과학교실
4성균관대학교 의과대학 소아과학교실
5인제대학교 의과대학 소아과학교실
6질병관리본부 국립보건연구원
Correspondence: 
Soo-Jong Hong, Email: sjhong@amc.seoul.kr
Abstract
Purpose
: Acute interstitial pneumonia (AIP) is a rare disease, but its prognosis is fatal because of lack of efficient treatment modality. Recently, it has been reported that there was epidemic AIP in Korea. This study aims to investigate the past and current status of AIP in Korea.
Methods
: We performed a nationwide survey and a prospective study. From August 6 to 15, 2008, a questionnaire survey was conducted to identify the prevalence, local distribution, and response to current treatments. The questionnaire was answered by pediatrician working in 23 referral centers in Korea. In addition, 5 referral centers in Seoul performed a preliminary prospective observational study by obtaining clinical data and specimens from appropriate patients. The Korea Centers for Disease Control and Prevention analyzed the samples for possible pathogens.
Results
: The survey showed 78 AIP cases had occurred and 36 patients had died. Lung biopsy was performed only on 20 patients. In 2008, 9 AIP cases developed. In a prospective study, 9 (M:F=5:4) patients developed AIP in spring and 7 (78%) died, with the mean rate of death occurring 46 days after diagnosis. Human corona virus 229E, cytomegalovirus, influenza A virus, influenza B virus, and parainfluenza virus were isolated from the respiratory specimens.
Conclusion
: This study showed nationwide prevalence of AIP in Korea. In addition, because of the high mortality rate and rapid progress, pediatricians need to be aware of the disease. Further studies and a nationwide network are required for reducing the morbidity and mortality rates related to AIP.
Key Words: Acute interstitial pneumonia, Child, Prevalence, Virus


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