Clinical and Experimental Pediatrics

Original articles

Neonatology (Perinatology)

Effectiveness of various nonpharmacological analgesic methods in newborns

Pancham Kumar, Rakesh Sharma, Sukhdev Rathour, Sunidhi Karol, Mohit Karol

Clin Exp Pediatr. 2020;63(1):25-29. Published online August 16, 2019

Question: Can nonpharmacological methods be used for neonatal pain management.
Finding: Nonpharmacological methods like Sucrose, breastfeeding etc have shown to significantly reduce the pain caused by intramuscular hepatitis B vaccination.
Meaning: Nonpharmacological methods are the safe and cheap potential modalities of analgesia which can be used during mild to moderate pain in newborns.

DOI: https://doi.org/10.3345/kjp.2017.05841

Original Articles

Critical Care Medicine

Comparative validity of microalbuminuria versus clinical mortality scores to predict pediatric intensive care unit outcomes

Shifa Nismath, Suchetha S. Rao, B.S. Baliga, Vaman Kulkarni, Gayatri M. Rao

Clin Exp Pediatr. 2020;63(1):20-24. Published online August 12, 2019

Question: Does microalbuminuria predict mortality in pediatric intensive care unit?
Finding: Positive correlation was found between albumin-creatinine ratio and pediatric intensive care unit stay, organ dysfunction and need of inotropes. Area under the receiver operating characteristic curve for albumin-creatinine ratio was comparable to mortality scores.
Meaning: Microalbuminuria is a good predictor of outcome in pediatric intensive care unit and is comparable with mortality scores.

DOI: https://doi.org/10.3345/kjp.2018.07220

Endocrinology

Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity

Bahar Özcabı, Salih Demirhan, Mesut Akyol, Hatice Öztürkmen Akay, Ayla Güven

Clin Exp Pediatr. 2019;62(12):450-455. Published online October 28, 2019

Background: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults. Purpose: Here we evaluated the ability of LAP to predict NAFLD in obese children. Methods: Eighty obese children (38 girls; age 6–18 years) were included. Anthropometric measurements and biochemical values were obtained from the patients’ medical records. LAP was calculated as [waist...

DOI: https://doi.org/10.3345/kjp.2019.00248

Neonatology (Perinatology)

Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia

Ga Won Jeon, R. Ann Sheldon, Donna M Ferriero

Clin Exp Pediatr. 2019;62(12):444-449. Published online October 18, 2019

Background: Sixty percent of infants with severe neonatal hypoxic-ischemic encephalopathy die, while most survivors have permanent disabilities. Treatment for neonatal hypoxic-ischemic encephalopathy is limited to therapeutic hypothermia, but it does not offer complete protection. Here, we investigated whether hypoxia-inducible factor (HIF) promotes cell survival and suggested neuroprotective strategies. Purpose: HIF-1α-deficient mice have increased brain injury after neonatal hypoxia-ischemia (HI), and the...

DOI: https://doi.org/10.3345/kjp.2019.00850

Nephrology (Genitourinary)

Clinical manifestations of BK virus infection in pediatric kidney transplant patients

Yiyoung Kwon, Jeong Yeon Kim, Yeonhee Lee, Heeyeon Cho

Clin Exp Pediatr. 2019;62(11):422-427. Published online September 5, 2019

Cited By 2

Background: Polyomavirus BK (BKV) infection is an important cause of graft loss in kidney transplant patients. Purpose: The purpose of this study was to evaluate clinical findings and risk factors for BKV in pediatric patients after kidney transplantation. Methods: This retrospective single-center study included 31 pediatric kidney transplant recipients from January 2002 to December 2017. Two patients received 2 transplantations during the...

DOI: https://doi.org/10.3345/kjp.2019.00388

Gastroenterology

Association between Body Mass Index and Hepatitis B antibody seropositivity in children

Yoowon Kwon, Su Jin Jeong

Clin Exp Pediatr. 2019;62(11):416-421. Published online August 12, 2019

Background: The seropositivity rate of hepatitis B surface antigen (anti-HBs) antibodies is known to be ≥95% after hepatitis B virus vaccination during infancy. However, a low level or absence of anti-HBs in healthy children is discovered in many cases. Recent studies in adults reported that a reduced anti-HBs production rate is related to obesity. Purpose: To investigate whether body mass index...

DOI: https://doi.org/10.3345/kjp.2019.00563

Influence of proton pump inhibitor therapy on intestinal inflammation assessed by fecal calprotectin in pediatric patients

Su Yeong Kim, Na Mi Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim, Eung Sang Choi, Dae Yong Yi

Clin Exp Pediatr. 2019;62(10):400-404. Published online July 3, 2019

Cited By 1

Background: An increase in the numbers of patients with gastrointestinal symptoms has recently been observed. Purpose: To investigate the effects of proton pump inhibitor (PPI) therapy on intestinal inflammation in children and adolescents as confirmed by clinical manifestations and objectively assessed by fecal calprotectin (FC) level measurement. Methods: Consecutive children (aged 3–18 years) who presented with gastrointestinal symptoms and were treated with...

DOI: https://doi.org/10.3345/kjp.2019.00115

Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures

Yasser K. Rashed, Mohamed El-Guindi

Clin Exp Pediatr. 2019;62(10):395-399. Published online June 24, 2019

Background: The esophagus is the most common part of gastrointestinal (GI) tract at the risk of stricture. Benign disorders are the leading causes of narrowing. Caustic ingestion is the most common cause of esophageal stricture in children, especially in developing countries. Clinical responses to the topical application of Mitomycin C in various medical procedures have been reported. Purpose: The study aimed...

DOI: https://doi.org/10.3345/kjp.2018.07157

Neonatology (Perinatology)

Clinical impact of admission hypothermia in very low birth weight infants: results from Korean Neonatal Network

Na Hyun Lee, Soo Kyung Nam, Juyoung Lee, Yong Hoon Jun

Clin Exp Pediatr. 2019;62(10):386-394. Published online May 22, 2019

Background: Preterm infants have difficulty maintaining body temperature after birth. However, clinical guidelines advocate that neonatal body temperature should be maintained at 36.5°C–37.5°C. Purpose: We aimed to investigate the incidence of admission hypothermia in very low birth weight (VLBW) infants and to determine the association of admission temperature with in-hospital mortality and morbidities. Methods: A cohort study using prospectively collected data involving...

DOI: https://doi.org/10.3345/kjp.2019.00206

Developmental and Behavioral Medicine

Effect of omega-3 plus methylphenidate as an alternative therapy to reduce attention deficit-hyperactivity disorder in children

Soleiman Mohammadzadeh, Narmin Baghi, Fayegh Yousefi, Bahar Yousefzamani

Clin Exp Pediatr. 2019;62(9):360-366. Published online May 20, 2019

Background: Attention deficit-hyperactivity disorder (ADHD) is one of the most common chronic behavioral disorders in school-aged children. Purpose: This study aimed to evaluate the effect of omega-3 supplementation as an alternative therapy for ADHD, which can be caused by vitamin and mineral deficiencies. Methods: This was a double-blinded clinical trial study. Sixty-six children with ADHD (aged 6–12 years) referred to our child...

DOI: https://doi.org/10.3345/kjp.2018.06982

Allergy

Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis

Yeonu Choi, Haeun Jeon, Eun Ae Yang, Jong-Seo Yoon, Hyun Hee Kim

Clin Exp Pediatr. 2019;62(9):353-359. Published online April 24, 2019

Cited By 1

Background: Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. However, its use as a marker of eosinophilic inflammation in nasal secretions is limited because the diagnostic cutoff values of EPO for use as a one-time test for allergic diseases such as allergic rhinitis have not been established. Purpose: To identify the correlation...

DOI: https://doi.org/10.3345/kjp.2019.00318

Nutrition

The effect of high fat dietary modification and nutritional status on the outcome of critically ill ventilated children: single-center study

Nehal Mohamed El Koofy, Hanaa Ibrahim Rady, Shrouk Moataz Abdallah, Hafez Mahmoud Bazaraa, Walaa Ahmed Rabie, Ahmed Ali El-Ayadi

Clin Exp Pediatr. 2019;62(9):344-352. Published online April 2, 2019

Background: Ventilator dependency constitutes a major problem in the intensive care setting. Malnutrition is considered a major determinant of extubation failure, however, attention has been attracted to modulating carbon dioxide production through decreasing carbohydrate loading and increasing the percent of fat in enteral feeds. The detected interrelation between substrate oxidation and ventilation outcome became the base of several research to...

DOI: https://doi.org/10.3345/kjp.2018.06835

General Pediatrics

Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016–2017 Korea National Health and Nutrition Examination Survey

Jung Hyun Lee

Clin Exp Pediatr. 2019;62(8):317-323. Published online June 24, 2019

Purpose: Investigating the prevalence of hyperuricemia and its association with metabolic syndrome (MetS) and cardiometabolic risk factors (CMRFs) in Korean children and adolescents. Methods: This cross-sectional survey used data from the 7th Korea National Health and Nutrition Examination Survey (2016–2017); 1,256 males and females aged 10–18 years were included. Hyperuricemia was defined as serum uric acid levels were >6.6 mg/dL at...

DOI: https://doi.org/10.3345/kjp.2019.00444

Neurology

Evaluation of hematologic profile may be needed for patients treated with oxcarbazepine

Gu Hyun Jung, Su Jeong You

Clin Exp Pediatr. 2019;62(8):312-316. Published online April 11, 2019

Cited By 2

Purpose: The major side effects of treatment with oxcarbazepine (OXC) are skin rash and hyponatremia. Hematologic side effects are reported rarely. The aim of this study was to investigate the rate and types of the hematologic side effects of OXC. Methods: The medical records of 184 patients diagnosed with epilepsy or movement disorder and on OXC monotherapy, at the Department of...

DOI: https://doi.org/10.3345/kjp.2019.00017

Neonatology (Perinatology)

The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates

Heba Mostafa Ahmed, Nsreen Mostafa Kamel

Clin Exp Pediatr. 2019;62(8):307-311. Published online March 15, 2019

Purpose: Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport. The aim of this study was to assess the role of epidermal growth factor in the...

DOI: https://doi.org/10.3345/kjp.2018.07108

Cited By 35	The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects
Cited By 7	Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment
Cited By 4	A long-term subacute sclerosing panencephalitis survivor treated with intraventricular interferon-alpha for 13 years
Cited By 4	Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis
Cited By 3	Epilepsy syndromes during the first year of life and the usefulness of an epilepsy gene panel

Original article