- Original Article
- Neurology
- Instability of revised Korean Developmental Screening Test classification in first year of life
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Ji Eun Jeong, You Min Kim, Na Won Lee, Gyeong Nam Kim, Jisuk Bae, Jin Kyung Kim
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Clin Exp Pediatr. 2025;68(1):97-103. Published online November 11, 2024
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Question: How stable are the revised Korean Developmental Screening Test score classifications in early infancy?
Finding: A significant number of infants improved into the peer and high-level group (≥-1 standard deviations), especially in the gross motor area.
Meaning: The early detection of developmental delay requires a comprehensive medical history, physical and neurological examinations, and repeated developmental screenings. |
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- Developmental and Behavioral Medicine
- Development of the Korean Developmental Screening Test for Infants and Children (K-DST)
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Hee Jung Chung, Donghwa Yang, Gun-Ha Kim, Sung Koo Kim, Seoung Woo Kim, Young Key Kim, Young Ah Kim, Joon Sik Kim, Jin Kyung Kim, Cheongtag Kim, In-Kyung Sung, Son Moon Shin, Kyung Ja Oh, Hee-Jeong Yoo, Hee Joon Yu, Seoung-Joon Lim, Jeehun Lee, Hae-Ik Jeong, Jieun Choi, Jeong-Yi Kwon, Baik-Lin Eun
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Clin Exp Pediatr. 2020;63(11):438-446. Published online May 14, 2020
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Question: Can the Korean Developmental Screening Test for Infants and Children (K-DST) be a useful screening tool for infants and children in Korea?
Finding: The K-DST has high reliability (internal consistency of 0.73–0.93, test-retest reliability of 0.77–0.88) and a high discriminatory ability with a sensitivity of 0.833 and specificity of 0.979.
Meaning: The K-DST is an effective and reliable screening tool for infants and children with neurodevelopmental disorders in Korea. |
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- Original Article
- Developmental profiles of preschool children with delayed language development
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Jeong Ji Eun, Hyung Jik Lee, Jin Kyung Kim
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Clin Exp Pediatr. 2014;57(8):363-369. Published online August 25, 2014
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Purpose This study examines changes in developmental profiles of children with language delay over time and the clinical significance of assessment conducted at age 2-3 years. MethodsWe retrospectively reviewed the medical records of 70 children (62 male, 8 female), who had visited the hospital because of delayed language development at 2-3 years, and were reassessed at ages 5-6. Language and cognitive abilities... |
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- Case Report
- Atypical teratoid rhabdoid brain tumor in an infant with ring chromosome 22
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Eun Hae Cho, Jae Bok Park, Jin Kyung Kim
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Clin Exp Pediatr. 2014;57(7):333-336. Published online July 23, 2014
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Reports of constitutional ring chromosome 22, r(22) are rare. Individuals with r(22) present similar features as those with the 22q13 deletion syndrome. The instability in the ring chromosome contributes to the development of variable phenotypes. Central nervous system (CNS) atypical teratoid rhabdoid tumors (ATRTs) are rare, highly malignant tumors, primarily occurring in young children below 3 years of age. The... |
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- Original Article
- The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats
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Moon Sun Kim, Yoo Kyung Seo, Hye Jin Park, Kye Hyang Lee, Kyung Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Woo Taek Kim
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Clin Exp Pediatr. 2010;53(10):898-908. Published online October 31, 2010
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Purpose The neuroprotective effects of erythropoietin (EPO) have been recently shown in many animal models of brain injury, including hypoxic-ischemic (HI) encephalopathy, trauma, and excitotoxicity; however, limited data are available for such effects during the neonatal periods. Therefore, we investigated whether recombinant human EPO (rHuEPO) can protect against perinatal HI brain injury via an antiapoptotic mechanism. MethodsThe left carotid artery was ligated... |
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- Taurine exerts neuroprotective effects via anti-apoptosis in
hypoxic-ischemic brain injury in neonatal rats
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Ji Eun Jeong, Tae Yeol Kim, Hye Jin Park, Kye Hyang Lee, Kyung Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Eok Su Seo, Woo Taek Kim
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Clin Exp Pediatr. 2009;52(12):1337-1347. Published online December 15, 2009
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Purpose : Taurine (2-aminoethanesulfonic acid) is a simple sulfur-containing amino acid. It is abundantly present in tissues such as brain, retina, heart, and skeletal muscles. Current studies have demonstrated the neuroprotective effects of taurine, but limited data are available for such effects during neonatal period. The aim of this study was to determine whether taurine could reduce hypoxic-ischemic (HI) cerebral... |
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- Case Report
- A case of two sisters births from mother with phenylketonuria lacking mental retardation
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Chang-Seok Ki, Jin Kyung Kim
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Clin Exp Pediatr. 2008;51(5):546-550. Published online May 15, 2008
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In this untreated classic phenylketonuria (PKU) case, mental retardation is severe; however, there have been individualslike the mother of this casewho have escaped mental retardation and all the other potential sequelae of phenylketonuria, despite having high blood phenylalanine levels, and very poor dietary control. It appears that they have nearly normal brain phenylalanine levels despite high blood phenylalanine (Phe) levels.... |
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- A case of lethal kwashiorkor caused by
feeding only with cereal grain
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Hyun Ju Lee, Kyung Hye Km, Hye Jin Park, Kye Hyang Lee, Gyeong Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Woo Taek Kim
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Clin Exp Pediatr. 2008;51(3):329-334. Published online March 15, 2008
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Kwashiorkor is a syndrome of severe protein malnutrition, which manifests itself in hypoalbuminemia, diarrhea, dermatitis, and edema. It can be life-threatening due to associated immune deficiency and an increased susceptibility to infections. Kwashiorkor should be treated early with nutritional support and the control of infection. Dilated cardiomyopathy may develop during the treatment and in such cases a poor prognosis is... |
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- Original Article
- Neuroprotective effects of geneticin (G418) via apoptosis
in perinatal hypoxic-ischemic brain injury
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Mi Ju, Hyun Ju Lee, Sun Ju Lee, Eo Su Seo, Hye Jin Park, Kye Yang Lee, Gyeong Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Jong Won Lee, Hai Lee Chung, Woo Taek Kim
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Clin Exp Pediatr. 2008;51(2):170-180. Published online February 15, 2008
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Purpose : Some antibiotics were known to exert neuroprotective effects in the animal model of hypoxic-ischemic (H-I) brain injury, but the mechanism is still unclear. A recent study reported that geneticin (G418), an aminoglycoside antibiotic, increased survival of human breast cancer cells by suppressing apoptosis. We investigated the neuroprotective effects of systemically administrated geneticin via anti-apoptosis following the H-I brain... |
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- Neuroprotective effects of resveratrol via anti-apoptosis on
hypoxic-ischemic brain injury in neonatal rats
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Jin Young Shin, Min Ae Seo, Eun Jin Choi, Jin Kyung Kim, Eok Su Seo, Jun Hwa Lee, Hai Lee Chung, Woo Taek Kim
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Clin Exp Pediatr. 2008;51(10):1102-1111. Published online October 15, 2008
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Purpose : Resveratrol, extracted from red wine and grapes, has an anti-cancer effect, an antiinflammatory effect, and an antioxidative effect mainly in heart disease and also has neuroprotective effects in the adult animal model. No studies for neuroprotective effects during the neonatal periods have been reported. Therefore, we studied the neuroprotective effect of resveratrol on hypoxic-ischemic brain damage in neonatal... |
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- The neuroprotective effect of mycophenolic acid via anti-apoptosis in perinatal hypoxic-ischemic brain injury
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Ji Young Kim, Seung Ho Yang, Sun Hwa Cha, Ji Yeun Kim, Young Chae Jang, Kwan Kyu Park, Jin Kyung Kim, Hai Lee Chung, Eok Su Seo, Woo Taek Kim
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Clin Exp Pediatr. 2007;50(7):686-693. Published online July 15, 2007
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Purpose : Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is a potent inhibitor of inosine-monophosphate dehydrogenase (IMPDH), a new immunosuppressive drug used. It was reported that MPA protected neurons after excitotoxic injury, induced apoptosis in microglial cells. However, the effects of MPA on hypoxic-ischemic (HI) brain injury has not been yet evaluated. Therefore, we examined whether MPA... |
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- Case Report
- Identification of a de novo mutation (H435Y) in the THRB gene in a Korean patient with resistance to thyroid hormone
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Jin Young Shin, Chang-Seok Ki, Jin Kyung Kim
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Clin Exp Pediatr. 2007;50(6):576-579. Published online June 15, 2007
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The syndrome of resistance to thyroid hormone (RTH) is characterized by reduced tissue sensitivity to thyroid hormone (TH). In the majority of subjects, RTH is caused by mutations in the thyroid hormone receptor beta (TRβ) gene, located on the chromosome locus 3p24.3. RTH is inherited in an autosomal dominant manner. The clinical presentation of RTH is variable, but common features... |
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- Original Article
- The Effectiveness of Intravenous Immunoglobulin for Clinically Suspected Neonatal Sepsis
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Hyun Jung Na, Ji Young Kim, Gyeong Hoon Lee, Jun Hwa Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Woo Taek Kim
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Clin Exp Pediatr. 2005;48(11):1187-1192. Published online November 15, 2005
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Purpose : The purpose of this study is to determine the effectiveness of intravenous immunoglobuin (IVIG) administration in fullterm neonates having clinically suspected neonatal sepsis.
Methods : Forty full-term neonates admitted to the neonatal intensive care unit with clinically suspected neonatal sepsis, who had at least two positive diagnostic criteria were enrolled. Twenty neonates were enrolled into the IVIG arm and... |
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- Case Report
- A Case of Biliary Atresia with Ileal Atresia
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So Yeon Kim, Hyun Jung Na, Woo Taek Kim, Woo Hyun Park, Jin Kyung Kim
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Clin Exp Pediatr. 2004;47(8):908-911. Published online August 15, 2004
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Biliary atresia is a progressive obliterative cholangiopathy. However, the actual causes remain unknown, although a number of factors such as developmental malformation, viral infection, toxicity of bile constituents, and anatomic abnormality in the hepatobiliary system have been considered. Recently, several studies have been done to find out specific gene expression. Some cases of biliary atresia are associated with anomalies of... |
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- A Case of Asymptomatic 3-methylcrotonylglycinuria Detected by Tandem Mass Spectrometry in Newborn Screening
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Jin Kyung Kim
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Clin Exp Pediatr. 2004;47(8):912-916. Published online August 15, 2004
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3-Methylcrotonylglycinuria is an autosomal recessive inborn error of leucine catabolism that results from the deficiency of 3-methylcrotonyl-CoA carboxylase(3-MCC). In 3-MCC deficiency 3-methylcrotonyl-CoA, may form glycine and carnitine conjugates. The primary metabolites are 3-hydroxyisovaleric acid(3-HIVA), 3-hydroxyisovaleryl carnitine(3-HIVC) and 3-methylcrotonylglycine(3-MCG). 3-hydroxyisovaleric acid(3-HIVA) and 3-methylcrotonylglycine(3-MCG) are increased in urine, and 3-hydroxyisovaleryl carnitine(3-HIVC) is found in blood and urine. 3-MCC is one of the... |
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- Original Article
- The Relationship between Developmental Quotient in Children with Delayed Language Development and Later Intellectual Quotient
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So Yeon Kim, Yeon Kyung Jung, Hai Lee Jung, Woo Taek Kim, Im Hee Shin, Jung Han Park, Heng Mi Kim, Jin Kyung Kim
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Clin Exp Pediatr. 2004;47(5):496-504. Published online May 15, 2004
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Purpose : The objective of this study was to test the predictive validity of developmental test for later intellectual development in young children with delayed language development.
Methods : The study subjects were 66 children who had presented delayed language development and had an initial developmental test and a follow-up intelligence test. The mean age at initial test was 34.2 months(17-48... |
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- Cytokines in Neonatal Sepsis
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Hye Jin Park, So Yeon Kim, Jun Hwa Lee, Eun Jin Choi, Jin Kyung Kim, Sang Gyung Kim, Hai Lee Chung, Woo Taek Kim
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Clin Exp Pediatr. 2004;47(5):515-520. Published online May 15, 2004
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Purpose : Maternal premature rupture of membrane(PROM) over 24 hours is a risk factor in neonatal sepsis and a main cause of administration to neonatal intensive care unit. Levels of proinflammatory cytokines were studied to diagnose and treat early in newborn infants with sepsis and with a history of maternal PROM.
Methods : Interleukin-1β(IL-1β), Interleukin-6(IL-6), Interleukin-8(IL-8), and tumor necrosis factor-α(TNF-α) were... |
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- Neuroprotective Effects of Minocycline in
Rat Brain Cortical Cell Culture Induced by Hypoxia
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Kyung A Ha, Bum Seok Yang, Jin Kyung Kim, Hong Tae Kim, Sung Jin Ha, Jong Won Lee, Hai Lee Chung, Woo Taek Kim
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Clin Exp Pediatr. 2003;46(11):1101-1106. Published online November 15, 2003
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Purpose : In vivo, minocycline appears to be neuroprotective. Thus, the neuroprotective effects of minocycline were studied in a rat brain cortical cell culture induced by hypoxia.
Methods : Cultured cells from the brains of Sprague-Dawley rats were divided into two sets of groups : normoxia groups treated with 5% CO2 and hypoxia groups treated with 1% CO2. After several... |
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- Case Report
- A Case of Klinefelter Syndrome associated with
Unilateral Multicystic Dysplastic Kidney in a Newborn Infant
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Kyung A Ha, Sun Mi Chung, Eun Jin Choi, Jin Kyung Kim, Un Seok Nho, Jae Shin Park, Woo Taek Kim, Young Dae Kwon
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Clin Exp Pediatr. 2002;45(9):1141-1145. Published online September 15, 2002
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Klinefelter syndrome is the most common chromosomal abnormality, with a 47, XXY karyotype and typical clinical findings of infertility, hypogonadism, reduced body hair, gynecomastia, tall stature, and incresed gonadotropins and decreased testosterone levels. In addition to this classic description, several other diseases have been discribed in Klinefelter syndrome such as unilateral renal aplasia, autoimmune disease, diabetes mellitus, sexual precoxity, renal... |
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- Original Article
- A Clinical Characteristics of Systemic Candidiasis in Neonatal
Intensive Care Unit : Comparison with Systemic Bacterial Infection
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Jung Hwa Lim, Kyung Pil Park, Jin Kyung Kim, Heng Mi Kim
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Clin Exp Pediatr. 2002;45(7):847-854. Published online July 15, 2002
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Purpose : Long term hospitalized infants in neonatal intensive care units(NICUs) are prone to systemic infection. It is important to differentiate systemic candidiasis from systemic bacterial infection early in the course. Thus, in this study, we have compared clinical characteristics of systemic candidiasis and systemic bacterial infection, in premature low birth weight infants.
Methods : Retrospective chart review of the medical... |
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- Case Report
- A Case of Hypernatremic Dehydration in an Exclusively
Breast-Fed Newborn Infant
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Kyung Pil Park, Jin Kyung Kim, Heng Mi Kim
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Clin Exp Pediatr. 2002;45(6):790-795. Published online June 15, 2002
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Sporadic reports of hypernatremic dehydration in breastfed newborn infants have appeared in medical literature for at least 3 decades. We report the first case of hypernatremic dehydration resulting from inadequate breast-feeding in Korea. A 14-day old baby, born to a mentally retarded mother, was transferred to our hospital with a body weight loss of 460 g since birth(17%) and a... |
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- A Case of Rett Syndrome with MECP2 Gene Mutation
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Jin Kyung Kim, Chang Seok Ki, Jong Won Kim
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Clin Exp Pediatr. 2002;45(4):540-544. Published online April 15, 2002
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Rett syndrome is an X-linked dominant, progressive neurodevelopmental disorder, with a prevalence estimated to be one in 10,000-15,000 girls, which is thought to be the second most common genetic causes of mental retardation in females after Down syndrome. Patients with classic Rett syndrome show an apparently normal neonatal period, followed by developmental regression and deceleration of head growth, accompanied by... |
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- A Case of Scoliosis Due to a Foreign Body(Pencil) in the Colon
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Jeong Sik Seo, Sun Mi Chung, Eun Jin Choi, Jin Kyung Kim, Un Seok Nho, Hai Lee Chung, Dae Hyun Joo, Woo Taek Kim
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Clin Exp Pediatr. 2002;45(11):1417-1421. Published online November 15, 2002
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Scoliosis describes a lateral curvature of the spine and is often associated with cosmetic and functional impairments due to severe deformity of the spine. The incidence of adolescent scoliosis is 2-4% of children between 10 and 16 years of age. Eighty five percent of them are idiopathic, in which the most common type of scoliosis is right side-bending. In addition,... |
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- Original Article
- Clinical Significance of Auditory Brainstem Response(ABR) in Speech/Language Disorders
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Ki Won Oh, Woo Saeng Park, Soon Hak Kwon, Jin Kyung Kim, Jun Hwa Lee
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Clin Exp Pediatr. 2002;45(10):1199-1203. Published online October 15, 2002
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Purpose : The study aimed to evaluate the efficacy of auditory brainstem response(ABR) as a
screening tool in children with speech and language disorders.
Methods : Between January 1, 1999 and December 31, 2001, 139 patients with chief complaints of
speech and language delay were recruited from the pediatric neurology clinic, Kyungpook National
University Hospital, Daegu, Korea. They had ABR on entry and the... |
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- Serial M-mode Echocardiographic Assessment of Left Ventricular Function in Kawasaki Disease
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Byung Ho Choi, Jin Kyung Kim, Myung Chul Hyun, Sang Bum Lee
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Clin Exp Pediatr. 1994;37(6):759-766. Published online June 15, 1994
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To investigate the effect of kawasaki disease on left ventricular function, we studied 92 patients with Kawasaki disease at initial visit, after 3 months (78 patients) and after 1 year (9 patients).
Using serial M-mode echocardiogram, we obtained LVD(d) (left ventricular internal dimension at end diastole), LVD(s)(left ventricular internal dimension at end systole), FS(fractional shortening), ET(ejection time), VmCF(mean velocity of circumferential... |
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- A Comparison of Reagent Test Strip-photometer and Laboratory Plasma Glucose Values in Newborns
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Jin Kyung Kim, Myung Chul Hyun, Sang Bum Lee, Heng Mi Kim
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Clin Exp Pediatr. 1992;35(8):1501-1058. Published online August 15, 1992
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Although reagent test strip-photometer method is frequently used to estimate plasma glucose values in nurseries, the accuracy in newborns have not been evaluated previously.
In this study values of 44 samples of laboratory glucose were compared with values simultaneously obtained by reagent test strip-photometer.
Laboratory values were determined by glucose oxidase method using veous plasma. Reagent test strip-photometer values were determined... |
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