- Original Article
- Diagnostic Significance of the Urine-Stick Test
in Middle and High School Children in Seoul
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Mi Jung Park, Yun Ju Kang, Jong Hee Kim, Duk Hi Kim
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Clin Exp Pediatr. 2000;43(3):411-416. Published online March 15, 2000
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Purpose : This study was performed to assess the diagnostic significance of the urine-stick test in detecting Diabetes Mellitus(DM) and to assess the clinical characteristics of adolescent diabetes.
Methods : A total of 926,208 middle and high school children participated. The urine-stick test was performed and those who showed glycosuria and, further studies such as evaluations of plasma glucose, triglyceride, cholesterol... |
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- The Clinical Types and Characteristics of Diabetes Mellitus in Korean Children
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Eun Gyong Yoo, Hye Jung Shin, Duk Hi Kim
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Clin Exp Pediatr. 2000;43(12):1591-1598. Published online December 15, 2000
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Purpose : Diabetic children should be classified into type 1 or 2 for adequate diabetic control. However, there is a shortage of information of the appropriate criteria in Korea. This study is desinged to discover the clinical types and characteristics of diabetes mellitus(DM) in Korean children.
Methods : We studied the clinical characteristics and laboratory findings of 177 diabetic children. Classification... |
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- Serial Changes of Blood Glucose Levelsin IDDM Patients Using Intermediate-acting Insulin only Therapy
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Ye Sik Kim, Mi Jung Park, Duk Hi Kim
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Clin Exp Pediatr. 1996;39(4):552-557. Published online April 15, 1996
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Purpose : We investigated the clinical characteristics of IDDM patients, treated with NPH only, and evaluated current problems by measurement of serial blood glucose, insulin, C-peptide for 12 hours after administration of intermediate-acting insulin.
Methods : We studied 19 IDDM patients who had been diagnosed and followed up on a
regular basis at Severance hospital. They were assigned into 2 groups, one(HbA1c... |
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- Clinical Observations of Transient Idiopathic Hypocalcemia
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Jeong Nyun Kim, Mi Jung Park, Duk Hi Kim, Ho Sung Kim
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Clin Exp Pediatr. 1995;38(9):1193-1200. Published online September 15, 1995
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Purpose : In concern of diagnosis and treatment of transient idiopathic hypocalcemia, a major cause of infantile, we studied the onset of age, clinical characteristics, laboratory findings, and duration of treatment and recovery of transient idiopathic hypocalcemia.
Methods : The author observed 19 infants with transient idiopathic hypocalcemia who had been admitted to Yonsei university hospital due to convulsion for 4... |
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- Characteristics of Childhood Diabetes
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Mi Jung Park, Wook Chang, Hyun Chul Lee, Duk Hi Kim, Ho Seoung Kim
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Clin Exp Pediatr. 1995;38(8):1116-1123. Published online August 15, 1995
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Purpose : Because of weternized life style, environmental air pollution and infection, the incidence of childhood diabetes is increasing daily. This study was attempted to evaluate charateristics of childhood diabetes.
Methods : We evaluated 117 patients diagnosed with Diabetes at Yonsei and Ewha University College of medicine from 1985 to 1994.
Results : 1) The majority of patients were diagnosed as IDDM(86%).... |
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- Sex Hormone Binding Globulin Levels in Children with Insulin Dependent Diabetes Mellitus
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Duk Hi Kim, Mi Jung Park, Ho Sung Kim
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Clin Exp Pediatr. 1995;38(7):963-969. Published online July 15, 1995
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Purpose : Sex hormone binding globulin(SHBG) is produced in liver and binds to testostero-ne and estradiol. Plasma SHBG levels are increased by estrogen and thyrotoxicosis and decreased by testostrone, insulin, growth hormone, prolactin, obesity and noninsulin dependent diabetes mellitus.
SHBG levels in patients with NIDDM is known to be higher than normal, but SHBG levels in children with IDDM is controversial.... |
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- Incidence and Complications of Obesity in Pubescent School Children
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Boo Hyun Han, Duk Hi Kim, Yoo Kyung Park, Jong Ho Lee, Ho Seong Kim
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Clin Exp Pediatr. 1995;38(4):520-528. Published online April 15, 1995
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Purpose : In recent years, obesity in children has become one of the major nutritional problems, and the trend is that number of obese children is increasing. The purpose of this research is to examine the incidence of obesity in pubescent school children in Seoul and Cheju, and to analyze body fat component, complications and eating habits of those obese... |
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- Clinical Differences by Karyotype in Patients with Turner Syndrome
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Mi Jung Park, Jin Sung Lee, Kir Young Kim, Duk Hi Kim, Ho Seoung Kim
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Clin Exp Pediatr. 1995;38(2):143-150. Published online February 15, 1995
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Purpose : The aim of this study was to evaluate clinical differences by karyotype in Turner Syndrome.
Methods : We evaluated 66 patients with Turner syndrome diagnosed at Yonsei University College of medicine from Mar.1985 to Feb.1993. We divided subproups as pure 45,X groups, mosaisism groups and structural aberration groups. Clinical features, serum estrogen, LH, FSH, concentrations, gonadotropin release after GnRH... |
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- Physical Growth According to Sexual Maturation of Korean Adolescents
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Hwan Gyu Park, Chang Ho Hong, Duk Hi Kim
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Clin Exp Pediatr. 1994;37(9):1187-1195. Published online September 15, 1991
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Adolescence is the period in which physical, mental and social maturation occurs and it is an important transit stage, changing from childhood to adulthood. This is a period in which important changes occur physically such as rapid growth in height and weight gain but significant differences in growth may occur for the same age. Therfore, the degree of sexual maturation... |
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- Case Report
- One Case of Maffucco's Syndrome with Testicular Teratoma
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Seung Mo Park, Duk Hi Kim, Ho Seong Kim
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Clin Exp Pediatr. 1994;37(8):1162-1168. Published online August 15, 1994
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Maffucci's syndrome is a very rare, congenital and non-hereditary mesodermal dysplasia manifested by multiple enchondromas and soft tissue hemangiomas. Since Maffucci had reported this syndrome in 1881, there have been more than 100 cases reported, and also there has been reported that Maffuddi's syndrome has various interstitial tumor. However there hasn't been any report about Maffucci's syndrome with testicular teratoma.... |
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- Original Article
- Risk Factors for Hyperglycemia in Children with Leukemia Receiving L-asparaginase
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Min Joong Kwon, Ho Sung Kim, Kir Young Kim, Duk Hi Kim
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Clin Exp Pediatr. 1994;37(6):740-745. Published online June 15, 1994
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Hyperglycemia is a well-recognized side effect of L-asparaginase in remission induction therapy of acute lymphocytic leukemia. Since hyperglycemia has preceded fatal diabetic ketoacidosis or hyperosmotic nonketotic coma in some patients, early detection and treatment of this complication are important. We determined retrospectively the risk of hyperglycemia in 117 patients with leukemia who had received L-asparaginase (& prednisolone).
The results were as... |
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- Mechanism of Impaired Growth Hormone Response in Children with Simple Obesity
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Moon Sung Park, Mi Jung Park, Ho Seong Kim, Duk Hi Kim
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Clin Exp Pediatr. 1994;37(4):457-463. Published online April 15, 1994
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Obesity is associated with an impairment of the hormone secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown, To determine whether obesity is associated with a chronic state of tonic somatostatin, several tests with growth hormone stimuli such as GHRH (1㎍/kg), clonidine (150㎍/m2) and Resular insulin (0.1U/kg, subcutaneously), to obese subjects and... |
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- Body Composition of Children and Adolescents with Insulin-dependetn Diabetes Mellitus
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Hye Young Kang, Mi Jung Park, Duk Hi Kim, You Kyung Park, Jong Ho Lee, Ho Seong Kim
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Clin Exp Pediatr. 1994;37(12):1709-1716. Published online December 15, 1994
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Bodycomposition measurement is useful in the diagnosis of pathoogy, assessment of disease process and response to treatment in many endoclonologic and metabolic diseases. The Techniques used currently are mostly indirect, often expensive, difficult and time-consuming. A new method for estimation of body composition, infrared interactance, is rapid, safe, noninvasive, and may be useful in research ad clinical studies.
Body composition was... |
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- Case Report
- Three Cases of Acute Suppurative Thyroiditis in children
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Min Joong Kwon, Ho Seong Kim, Duk Hi Kim, Duk Hi Kim
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Clin Exp Pediatr. 1993;36(9):1320-1324. Published online September 15, 1993
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Acute suppurative thyroiditis is uncommon in children. The relative rarity of thyroid infection is thought to reflect its complete fibrous encapsulation, generous vascular and lymphatic supply and high local iodine level. the bacterial involvement include the normal oropharyngeal microflora, and broad spectrum antibiotic therapy including anaerobic coverage should be utilized initially.
We have experienced three cases of acute suppurative throiditis. All... |
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- Three Cases of Acute Suppurative Thyroiditis in children
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Min Joong Kwon, Ho Seong Kim, Duk Hi Kim, Duk Hi Kim
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Clin Exp Pediatr. 1993;36(9):1320-1324. Published online September 15, 1993
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Acute suppurative thyroiditis is uncommon in children. The relative rarity of thyroid infection is thought to reflect its complete fibrous encapsulation, generous vascular and lymphatic supply and high local iodine level. the bacterial involvement include the normal oropharyngeal microflora, and broad spectrum antibiotic therapy including anaerobic coverage should be utilized initially.
We have experienced three cases of acute suppurative throiditis. All... |
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- Pancreatic Islet-cell Adenoma
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Ji Hong Kim, Ho Seong Kim, Duk Hi Kim, Hyun Yee Im, Chan Il Park
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Clin Exp Pediatr. 1993;36(6):870-876. Published online June 15, 1993
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Pancreatic islet cell adenoma is a benign tumor of pancreatic β-cell and a rare cause of hyperinsulinemic hypoglycemia in chidren.
The autors experienced a case of pancreatic islet cell adenoma(Insulinoam) in a 11 year and 8 month old male who had frequent loss of consciousness and seizuere. Enucleation was done after localiztion of tumor by selective celiac artery angiography and abdominal... |
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- Original Article
- Growth Outcome in Congenital Hypothyroidism
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Mi Jung Park, Ho Seong Kim, Duk Hi Kim
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Clin Exp Pediatr. 1993;36(5):713-720. Published online May 15, 1993
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Congenital hypothyroidism is one of the most common endocrine disease in childhood and it causes not only mental retardation but also growth retardation. There were many papers about evaluation of developmental outcome in congenital hypothyroidism, The aim of this study was to evaluate growth outcome in congenital hypothyroidism. We evaluated 65 patients with congenital hypothyroidism diagnosed at yonsei University College... |
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- Clinical Significance of Urinary Growth Hormone Measurement in patients with Growth Hormone Deficien
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Ho Seong Kim, Duk Hi Kim, Min-Seok Cheon
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Clin Exp Pediatr. 1993;36(4):478-484. Published online April 15, 1993
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Urinary growth hormone (GH) excretion was quantitated in 12-hr overniaght urine collections obtained from 13 children with complete growth hormone deficiency(CGHD), 6 children with partial growth hormone deficiency(PGHD), 5 children with short stature and normal GH provocation tests(NSC), and 5 normal control children (NC) to investigate whether the measurement of urinary GH can clearly separate the PGHD and CGHD groups... |
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- The Effect of Testosterone on the Response of Grow Hormone Secretion in Cultured Rat Pituitary Cells
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Ho Seong Kim, Duk Hi Kim, Deok Bae Park
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Clin Exp Pediatr. 1993;36(11):1578-1582. Published online November 15, 1993
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The effects of testosterone on the pituitary growth hormone(GH) response directly and to hypothalamic growth hormone-releasing hormone(GHRH) were evaluated in vitro using a male pituitary cell monolayer culture system. Wistar male rats were gonadectomized at 22 days of age, and 21 days later their anterior pituitaries were removed and trypsinized for cell dispersion. Testosterone 0.01, 1.0, 10.0nM was added to... |
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- Growth Pattern and Final Height in Congeital Adrenal Hyperplasia
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Ho Seong Kim, Duk Hi Kim
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Clin Exp Pediatr. 1993;36(10):1359-1365. Published online October 15, 1993
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Clinical characteristics and growth pattern were evaluated in 42 patients with classical congenital adrenal hyperplasia treated since diagnosis. And final height was evaluated in 16 patients who had reached final adult height with regard to clinical form, degree of hormonal control, and age of initial treatment.
The results were as follows;
1) Among 42 patients with classical congenital adrenal hyperplasia, the male... |
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- Case Report
- A Case of Primary Hyperparathyroidism in Infancy
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Mi Jung Park, Ho Seong Kim, Duk Hi Kim
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Clin Exp Pediatr. 1992;35(7):1008-1013. Published online July 15, 1992
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Primary hyperparathyroidism is very rare and often fatal disease in childhood. We experienced a case in which a 4 months old male patient complaning of lethargy, hypotonia, respiratory difficulty showed typical laboratory and radiological findings compatible to primary hyperparathyroidism.
He was successfully treated with total parathyroidectoimy with partial parathyroid autotrans-plantation. Thus the case of primary hyperparathyroidism in infancy is presented with... |
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- A Case of Congenital Hypopituitarism Presenting Ectopic Pituitary Gland and Pituitary Stalk Transection Identified by Magnetic Resonance Imaging
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Do Seong Kim, Kyung Eun Oh, Duk Hi Kim, Myung Joon Kim
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Clin Exp Pediatr. 1992;35(6):809-815. Published online June 15, 1992
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The syndrome of congenital hypopitutarism is a rare but well recognized entity. The typical clinical picture consists of presentation in infanncy with hypoglycemia, microgenitalia, and evidence of multiple anterior pituitary hormone deficiencies, but not diabetes inspidus. Recently, magnetic resonance imaging has disclosed a consistent abnormality in many patients with congenital hypopituitarism as well as idiopathic hypopituitarism characterized by an adenohypophysis... |
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- Original Article
- Quantification of Human Urinary Growth Hormone and Its Clinical Significance in the Diagnosis of Growth Hormone Deficiency
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Seung Ryul Lee, Ho Seong Kim, Duk Hi Kim, Chang Mi Kim
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Clin Exp Pediatr. 1992;35(5):595-601. Published online May 15, 1992
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Twelve-hour nocturnal urine was collecte in 5 patients diagnosed of having complete GH deficiency, 6 of having partial GH deficiency and 7 persons as normal control group. The GH levels in urine collections were evaluated, and the results are as follows.
1) The GH level of normal control group was 16.76¡¾1.91ng/12hr, 59.00¡¾6.92ng/gCr, 16.24¡¾2.52ng/m2, 0.58¡¾0.12ng/kg.
2) The GH level of complete GH deficiency... |
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- The Effects of Testosterone on the Pituitary Growth Hormone Secretion
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Ho Seong Kim, Duk Hi Kim, Kyung Za Ryu, Chang Mee Kim, Deok Bae Park
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Clin Exp Pediatr. 1992;35(2):174-181. Published online February 15, 1992
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The effects of testosterone on growth hormone secretion and somatic growth have been reported in several previous studies. In order to investigate the role of testosterone in growth hormone secretion, we have studied the effect of testosterone on somatic growth, basal growth hormone concentration, and growth hormone response to
growth hormone-releasing hormone (GHRH) in orchiectomized rats. In experiment 1, four groups... |
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- Erratum
- Measurement of Bone Mineral Density in Korean Newborns by Dual Photon Absorptiometry
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Kook In Park, Chul Lee, Ran Namgung, Duk Hi Kim, Dong Gwan Han
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Accepted January 1, 1970
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Bone mineral density (BMD), bone mineral content (BMC) and bone width (BW) of lumbar spine was measured in 37 term and 38 preterm appropriate-for-gestational-age (AGA) infants and 22 term small-for-gestational-age (SGA) infants who were delivered at Yonsei University Severance Hospital from January to September 1991 using dual photon absorptiometry (DPA). All of the infants were studied once within three days... |
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- Original Article
- Study on the antibody formation in patinets treated with recombinant human growth hormone(rhGH).
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Hye Jung Joo, Duk Hi Kim, Dong Soo Kim
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Clin Exp Pediatr. 1991;34(9):1261-1268. Published online September 30, 1991
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Patients with short stature admitted to the Pediatrics Endocrinology Clinic, Yonsei University
College of Medicine during a six-year period from August, 1983 to August, 1989 were divided into
three groups.
The group 1 received rhGH, group 2 received Oxandrolone and group 3 did not receive any
treatment.
These patients were tested for presence of antibodies to rhGH with ELISA and effect of rhGH was
evaluated.
1) Among 53... |
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- Clinical effects of recombinant Korean growth hormone (LBD-003).
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Duk Hi Kim
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Clin Exp Pediatr. 1991;34(8):1110-1115. Published online August 31, 1991
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LBD-003, methionyl GH, has been produced recently in the yeast by the use of recombinant method.
The clinical efficacy and immunogenecity of LBD-003 were studied in 20 patients with naive GH
deficiency.
The subjects of this study were aged 5.1—13.9 years and received GH 1.5IU/kg thrice weekly for
1 year. During treatment, height, body weight & bone age were checked. Blood count, chemistry amd
thyroid... |
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- The effects of human growth hormone on short stature.
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Sang Mi Ha, Duk Hi Kim
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Clin Exp Pediatr. 1991;34(7):999-1008. Published online July 31, 1991
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Since Raben’s original report that human growth hormone promoted growth in a boy with pituitary
dwarfism, the hormone’s efficacy in children with growth hormone deficiency has been amply
confirmed. However the scarcity of growth hormone prepared human pituitaries has limited studies
of its usefulness in short stature. The availability of a biologically active human growth hormone
produced by recombinant-DNA technology has dramatically changed the... |
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- The mechanism of Arginine-stimulated growth hormone secretion.
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Wan Kyu Lee, Dong Goo Lee, Duk Hi Kim
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Clin Exp Pediatr. 1991;34(4):544-552. Published online April 30, 1991
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Although Arginine is widely used in the evaluation of growth hormone (GH) secretion in short
stature patient, the mechanism of action is unclear, yet. To elucidate how Arginine stimulate GH
secretion, we studied the interaction of Arginine with growth homrone releasing hormone (GHRH) on
GH secretion in GH deficient short stature patient and constitutional growth delay.
The results of the studies were as follows:
1) Peak... |
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- Effects of sex hormone on secretion of growth hormone.
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Bo Young Lee, Duk Hi Kim
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Clin Exp Pediatr. 1991;34(12):1621-1628. Published online December 31, 1991
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Sex honnone had been thought to influence in the serum level of growth honnone (GH) since 1944 year. After it became known that the exogenous administration of sex honnone to growth-retarded
children increase serum GH level, sex honnone-especially testosterone-was thought to induce GH release. Testosterone is thought to act on the hypothalamo-pituitary axis to stimulate GH secretion
and estradi이 is also thought... |
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- Study on Pubertal Changes in Adolescent Girls.
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Sang Mi Ha, Ki Soo Pai, Un Jun Hyoung, Duk Hi Kim
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Clin Exp Pediatr. 1990;33(7):989-998. Published online July 31, 1990
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Puberty is the period of transition from childhood to adulthood whereby rapid growth takes place
psychologically and physically, especially sexual maturation. Puberty usually starts at 10 to 12 years
and ends at 17 to 19 years. However due to recent improvement in general hygiene, nutrition and
standard of living, puberty comes at an earlier age.
Three thousand nine hundred and ninety seven girls from... |
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- Transsphenoidal Meningoencephalocele in Association with Hypopituitarism ans Congenital Dysplastic Optic Disc: A Case Report.
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Chang Gee Kang, Jung Wan You, Sung Chul Shin, Myung Goo Min, Duk Hi Kim, Jin Guk Kim, Oh Wong Kwon, Tae Sub Chung
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Clin Exp Pediatr. 1990;33(6):842-847. Published online June 30, 1990
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Transsphenoidal meningoencephalocele is congenital defects in the sphenoid bone through which
meninges and brain tissue have herniated; the defect, located in the midline of the base of the skull,
was first reported by Richter in 1813. The nine cases of transsphenoidal meningoencephalocele have
been reported.
Patients with transsphenoidal meningoencephalocele also may have other midline craniocerebral
and midfacial anomalies, including additional meningoencephalocele hypertelorism, cleft palate, and
abnormalities... |
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- A Case of Sexual Precocity with Congenital Hypothyroidism.
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Wan Kyu Lee, Eun Jun Hyung, Duk Hi Kim
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Clin Exp Pediatr. 1990;33(2):259-263. Published online February 28, 1990
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Sexual precocity in assocition with congenital hypothyroidism is a rare clinical entity. We experi-
enced a case of sexual precocity, such as vaginal bleeding, breast development in a patient with
congenital hypothyroidism'
We present with the brief review of related literature. |
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- HLA Typing, Islet Cell Antibody and C-Peptide of Insulin Dependent Diabetes Mellitus in Children.
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Hyeong Rae Cho, Sei Joong Ko, Duk Hi Kim, Hyun Chul Lee, Kap Bum Huh
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Clin Exp Pediatr. 1990;33(12):1705-1712. Published online December 31, 1990
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35 childhood insulin-dependent (Typel) diabetes mellitus were typed for HLA and examined for
presence of islet cell antibody and level of C-peptide. The following results were obtained:
1) HLA types were present as follows; HLA A24 (9) in 58%, DR3 in 38% and DR4 in 62%. This was
slightly higher than the Korean population of 38%, 7% and 48% but there was no significant
difference.
2) When... |
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- Diagnostic Significance in Case with Growth Hormone Deficient Dwarfs.
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Duk Hi Kim, Mi Jung Park, Yan Kyu Lee
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Clin Exp Pediatr. 1990;33(12):1699-1704. Published online December 31, 1990
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As the scope for treatment with GH widens, it is of interest to evaluate those criteria that are used
conventionally for diagnosis of GH deficiency.
11 patients with hypotha lamic-pituitay lesions and 11 patients with idiopathic GH deficiency
underwent retesting GH secretion with insulin or arginine stimulation test. All 11 parients with
organic GH deficiency remained GH deficient. Of the 11 retested patients with... |
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- Effect of Oxandrolone Therapy in Short Stature.
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Yil Sub Lee, Soo Young Lee, Duk Hi Kim
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Clin Exp Pediatr. 1989;32(9):1273-1281. Published online September 30, 1989
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Fifty six boys and 28 girls aged 4 to 15.8 years were treated with oxandrolone during the 4 to 25
months. Measurement of height and bone age were made at the beginning and at 6 months intervals.
The daily dose were 0.08 mg to 0.28 mg per kilogram. Predictions for adult height at the beginning of
the study were compared with those at... |
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- Clinical Study of Hypophosphatemic Rickets.
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Seok Min Choi, Duk Hi Kim, Chin Suck Suh
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Clin Exp Pediatr. 1989;32(8):1057-1063. Published online August 31, 1989
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Hypophosphatemic rickets is a disorder characterized by a normal or slightly reduced serum
calcium level, a moderately reduced serum phosphorus level and elevated alkaline phosphatase
activity. The usual mode of inheritance is X-linked dominant and postulated mechanism is a selective
disorder of tubular reabsorption of phosphate, defective conversion of 21-hydroxyvitamin D3 to
calcitriol and increased catabolism of calcitriol.
In children with renal hypophosphatemic rickets, growth... |
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- Effects of long-term anticonvulsant therapy of thyroid function.
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Sei Joong Ko, Duk Hi Kim, Chang Jun Coe
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Clin Exp Pediatr. 1989;32(11):1533-1539. Published online November 30, 1989
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Serum concentrations of total triiodothyronine (T3) and thyroxine (T4) as well as serum thyroid-
stimulating hormone (TSH) were measured in 108 patients with childhood epilepsy taking anticonvul-
sants and in 54 normal healthy children as control group. Of these 108 patients, 23 were treated with
carbamazepine alone, 17 were phenytoin alone and the rest 68 were treated with combination of two
or more drugs... |
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- Study on Antithyroid Antibody and Thyroid Functional Status in Patients with Turner Syndrome.
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Bo Young Lee, Duk Hi Kim, Kir Young Kim
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Clin Exp Pediatr. 1989;32(10):1397-1401. Published online October 31, 1989
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This study is a systematic cytogenetic and clinico-hormonal analysis of 26 cases who were
diagnosed as Turner syndrome at the Yonsei Medical Center from Jan. 1978 to Jan. 1988. Antithyroid
antibody and thyroid function tests were performed in Turner syndrome(3 groups according to
karyotypes) and control group.
The results were as follows:
1) The incidence of positive antithyroid antibody in the 26 cases was 42.3% and... |
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- Goiter in Children.
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Young Wan Kim, Duk Hi Kim, Byeung Ju Jeoung
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Clin Exp Pediatr. 1988;31(8):1028-1036. Published online August 31, 1988
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We studied 197 cases of patients with goiter who visited Department of Pediatrics, Yonsei University
College of Medicine from January 1980 to June 1987. For each patient, serum T4, free T4, T3, TSH,
antithyroid antibody, and antimicrosomal antibody were analyzed, thyroid scan was performed,
and radioiodine uptake was measured.
Following results were obtained:
1) Male to female ratio of 197 cases of goiter was 1:7.5, predominent... |
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- The Effect of Pertussive Vaccine & Cyclosporin on Streptozotocin Induced Diabetic Rats.
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Duk Hi Kim
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Clin Exp Pediatr. 1988;31(7):914-923. Published online July 31, 1988
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The injection of streptozotocin (STZ) at higher dose (60 mg/kg) to young male rats produce direct
beta cell destruction and lead to insulin dependent diabetes (IDD). In contrast, the injection of multiple
smaller dose of STZ (40 mg/kg/d for 5 days) produce IDD, which resembles type 1 diabetes in man.
The protective effect of pertussis vaccine (PV) & cyclosporin (CA) against the develoment... |
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- Neurologic Outcome in Congenital Hypothyroidism.
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Byeung Ju Jeoung, Duk Hi Kim, Chang Jun Coe, Hang Cho Kang
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Clin Exp Pediatr. 1988;31(7):901-913. Published online July 31, 1988
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Congenital hypothyroidism is one of the most common endocrine disease in childhood and is a
major cause of mental retardation. It is clear that the earlier treatment is started, the better intellec-
tual potential and the likely absence of neurological sequellae.
The present study was carried out to try to define the incidence and the nature of the neurologic
disorders and to examine the... |
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- Clinical Study on Growth Hormone Deficient Dwarfs.
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Duk Hi Kim
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Clin Exp Pediatr. 1988;31(5):597-606. Published online May 31, 1988
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34 patients with growth hormone (GH) deficiency were studied. The affected males outnumber
females in a proportion of 1.8 to 1. The chronological ages on diagnosis was average 9.4 years old
and bone age was delayed with average 6.6 years old.
The major cause of GH deficiency was idiopathic and organic causes such as craniopharyngioma,
germinoma & Tb. meningitis were relatively uncommon.
Cerebral anoxia seemed... |
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- The Effect of Thyroid Hormone Deficiensy on Growth Hormone Levels.
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Duk Hi Kim, Chan Il Park
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Clin Exp Pediatr. 1988;31(1):64-71. Published online January 31, 1988
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Growth hormone and thyroid hormone are known to affect growth and development.
The present experiment was undertaken to assess GH levels in the serum and pituitary gland of
prophylthiouracil (PTU) treated rats.
The serum concentration of T4 were decreased during PTU treatment. Serum GH concentration
and pituitary GH content were decresed with severity of hypothyroid status. After withdrawl of PTU,
their levels were recovered gradually.
Acidophil... |
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- Clinical Study of Diabetes Insipidus.
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Jung Bae Lee, Duk Hi Kim
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Clin Exp Pediatr. 1987;30(8):882-890. Published online August 31, 1987
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From Aug. 1979 to June 1986 we reviewed 27 patients with diabetes insipidus to observe the clinical
features, laboratory findings and treatment of diabetes insipidus.
The results were as follows:
1) Central diabetes insipidus were 22 cases (81.5%) and nephrogenic diabetes insipidus were 5 cases
(18.5%). Etiologic factors in the central diabetes insipidus included idiopathic (54.6%), craniopharyn-
gioma (18.2%), germinoma (13.6%), post-encephalitis (9.1%) and Histiocytosis X... |
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- Case Report
- A Case of Renal Candidiasis Associated with Type I Diabetes Mellitus.
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Shin Heh Kang, Jae Seung Lee, Duk Hi Kim
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Clin Exp Pediatr. 1987;30(6):677-683. Published online June 30, 1987
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We have experienced a case of renal candidiasis in type I DM (IDDM). The patient was a 15-year old girl
who suffered from type I DM since 3 years earlier with development of retinopathy,
cataract & renal failure. Ultrasonic examination revealed multiple fungus balls in renal pelvis & urinary bladder. Candida tropicalis was cultured from fungus balls passed during urination.
A brief... |
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- Original Article
- A Study on Serum Growth Hormone in DM of Childhood.
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Duk Hi Kim
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Clin Exp Pediatr. 1987;30(2):175-180. Published online February 28, 1987
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The human growth hormone (hGH) levels were evaluated in 13 diabetes mellitus, 11 patients were
insulin dependent diabetes (ages 2 yr 10 mo to 13 yr 14 mo), 2 patients were noninsulin dependent
diabetes (age 12 yr & 12 yr 5 mo).
No difference in hGH level was observed in relation to duration of diabetes. The hGH responses to
glucagon 1 mg injection in... |
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- A Clinical Studies in Patients with Turner's Syndrome.
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Chang Hyun Yang, Duk Hi Kim, Kir Young KIm, Young Ho Yang
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Clin Exp Pediatr. 1987;30(10):1143-1151. Published online October 31, 1987
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This study is systematical cytogenetic and clinico-hormonal analysis of 42 cases who were
diagnosed as Turner’s syndrome at the Yonsei Medical Center from Jan. 1971 to Dec. 1985. The
careful history taking, physical examination, cytogenetic studies, radiologic and hormonal evalua-
tion, and GnRH stimulation test were performed.
The results were as follows.
1) The patients ranged in age from 14 months to 30 years at the... |
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- Juvenile Chronic Lymphocytic Thyroiditis.
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Duk Hi Kim
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Clin Exp Pediatr. 1987;30(1):71-79. Published online January 31, 1987
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A diagnosis of chronic lymphocytic thyroiditis(CLT) was made in 90 children & adolescents according to Fisher’s criteria. The age of the group ranged between 4 years & 16 years.
On the basis of serum T4, T3 & TSH, three groups of patients were distinguished at the time of
diagnosis.: euthyroid group (n=49), hyperthyroid group (n=7), hypothyroid group (n=34), where three
subgroups were classified;... |
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- A Study on Hormonal Change of Lh, FSH, and Testosterone and Testicular Volumes in Pubertal Mal Children.
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Heung Dong Kim, Duk Hi Kim, Ki Keun Oh
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Clin Exp Pediatr. 1986;29(9):979-987. Published online September 30, 1986
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The mechanism involved in pubertal changes has not been clearly demonstrated, but evidence has been accumulated that hormonal changes are responsible for this pubertal changes.
We studied the height, weight, testicular volume, bone age, LH, FSH, and testosterone, "by Tanner stage of
pubic hair development in 134 pubertal male children with no previous endocrine disease, who admitted at Yonsei University Medical... |
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- Clinical Studies on Sexual Precocity.
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Ki Seok Ahn, Duk Hi Kim
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Clin Exp Pediatr. 1986;29(3):255-264. Published online March 31, 1986
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The majority of cases of sexual precocity is idiopathic, but it can be caused by the intracranial lesions,
gonadal or adrenal disorders. Clinical studies on the 33 cases of precocious puberty who visited the Dept, of Pediatrics of Yonsei Medical Center from Aug. 1978:to July 1984 were subjected in this study. The careful history taking, physical examination, radiologic and hormonal... |
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- Case Report
- A Case of Hutchinson-Gilford Progeria Syndrome.
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Byeung Ju Jeoung, Duk Hi Kim
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Clin Exp Pediatr. 1986;29(10):1138-1142. Published online October 31, 1986
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Recently, the authers experienced a case of Hutchinson-Gilford Progeria sydrome which
is characterized by stunded growth, premature aging and normal intelligence. They die
prematurely as a results of myocardial infarction with on average age of 13. Berief review
of the literatures was made.
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- Original Article
- The Effects of Cyclosporin in Treatment of Insulin Dependent Diabetes Mellitus.
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Duk Hi Kim
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Clin Exp Pediatr. 1985;28(6):564-569. Published online June 30, 1985
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A 2 year 10 month old girl with 6 weeks duration and 13 year 4 month old boy with 8 weeks duration were given cyclosporin for 68 days. Therapy was initiated orally at the dosage of 10 mg per kg of body per day.
Blood glucose, C-peptide, cyclosporin, creatinin, BUN and transaminase were checked regularly. Cyclosporin treatment allowed two patients to... |
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- The Study on Residual Beta-cell Function in Children with Dibetes Mellitus.
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Duk Hi Kim
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Clin Exp Pediatr. 1985;28(5):492-498. Published online May 31, 1985
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C-peptide can be used as a measure of endogenous insulin secretion in insulin treated diabetes mellitus.
Pancreatic p cell secretory activity was measured in 11 patients with insulin dependent and 2 patients with non insulin-dependent diabetes mellitus by means of serum C-peptide response to 1 mg of glucagon subcutaneously.
Serum C-peptide was increased to near normal range in the remission phase and... |
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- Case Report
- A Case of Thyroid Papillary Adenocarcinoma.
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Duk Hi Kim, Chul Lee, Pyung Kil Kim, Byung Soo Kim, Yi Ho Hwang, Kyung Sik Lee, Woo Hee Chung
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Clin Exp Pediatr. 1984;27(3):288-292. Published online March 31, 1984
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We report a case of thyroid papillary adenocarcinoma in a 5 year 1 month old boy. His major problem was palpable thyroid nodule & cervical lymph nodes. Extensive bilateral pulmonary metastasis was noticed. The metastatic thyroid carcinoma was regressed after therapeutic doses of radioiodine without total thyroidectomy.
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- Cushing'S Syndrome In Childhood.
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Duk Hi Kim, Nan Ae Kim, Do Kwang Yun, Duk Jin Yun, Eui Ho Hwang
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Clin Exp Pediatr. 1983;26(6):593-597. Published online June 30, 1983
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There are little reports on Cushing’s syndrome in children. We have seen a case of
Cushing’s syndrome due to left adrenal adenoma from 5 year 6 months old girl.
She has been complained from obesity with, buffalo hump, hirsutism and vaginal spotting.
Her blood cortisol levels were high and no diurnal variation. No suppression was occurred
following dexamethasone 1 mg overnight or 4 mg... |
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- Original Article
- True Hermaphroditism, Report of Eight Cases.
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Duk Hi Kim, Chul Young Lee
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Clin Exp Pediatr. 1983;26(5):435-439. Published online May 31, 1983
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True hermaphroditism is the most uncommon variant of intersexuality in the human beings
A case of truehermaphroditism contains both ovarian and testicular tissue.
Author’s eight cases of true hermaphroditism are described with 373 cases reviewed in the literature.
Three cases show lateral ovary and testis, one bilateral ovotestes, one ovotestis-testis, one ovotestis, ovary and two undetermined. 46 XX chromosomal complement is the most... |
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- Case Report
- A Study of Intersex.
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Chul Young Lee, Duk Hi Kim, Moo Sang Lee, Seung Kang Choi
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Clin Exp Pediatr. 1982;25(6):607-615. Published online June 30, 1982
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Intersex is the state of having ambiguous or inappropriate genitalia due to abnormalities of normal mechanisms for sexual development. Three broad subcategories of intersex have been defined according to the histology of the gonad: Female & male pseudohermaphroditism and true hermaphroditism. Twenty two cases of intersex are described. Among them, true hermaphroditism was 7 cas-es, female pseudohermaphroditism 10 cases and... |
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- Original Article
- Hashimoto's Thyroiditis in childhood.
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Hee Jung Chung, Back Keun Lim, Duk Hi Kim, Duk Jin Yun, Chan Il Park
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Clin Exp Pediatr. 1981;24(8):752-759. Published online August 15, 1981
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Serum levels of T3, T4, TSH, 24-h RAIU and Thyroid antibodies were examined in 13 cases of chronic lymphocytic thyroiditis who were diagnosed at the pediatric department of Yonsei University hospital during the period from 1978 to 1980. The results were as follows: 1. The age distribution was dispersed between 8 and 15 years of age and all the cases... |
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- A Clinical and Pathological Study on the Treatment and Course of Purpura Nephritis in Chidren.
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Jae Seung Lee, Sang Hak Park, Duk Hi Kim, Pyung Kil Kim, Duk Jin Yun, In Joon Choi
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Clin Exp Pediatr. 1981;24(5):466-476. Published online May 15, 1981
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Purpura nephritis, one of the commonly known complications of allergic purpura has variable symptoms ranging from mild transient hematuria to severe nephrotic syndrome leading to renal failure and death. This paper reports on the treatment and course of purpura nephritis with special reference to serum immunoglobulins and immunopathology. These cases were selected among pediatric patients with purpura nephritis admitted to... |
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- Clinical Analysis of Short Stature.
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Kwang Ho Kim, Hak Yong Kim, Duk Hi Kim, Duk jin Yun
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Clin Exp Pediatr. 1980;23(9):702-709. Published online September 15, 1980
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Adequate growth is the most importment and principal factor in the fields of pediatrics and also it is great concern to all parents. There are many causes of short stature, secondary to a variety of causes. Clinical evaluation of short stature requires a wide variety of clinical, radiographic, pathologic, and biochemical tools. The most important thing is early and accurate... |
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- Case Report
- 3 Cases of Congenital Adrenal Hyperplasia.
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Kyo Sun Kim, Dong Soo Kim, Seoung Ku Kim, Kwang Ho Kim, Duk Hi Kim, Duk Jin Yun
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Clin Exp Pediatr. 1980;23(8):662-669. Published online August 15, 1980
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We present 3 cases of congenital hyperplasia. Case lis a 5 year and 9 month old who is suffered from excessive salt craving and symptoms of precocious puberty. Case llis a 2 month old boy who has failure to thrive and frequent episode of dehydration. Case lll is a 5 year and 3 month old girl who has enlarged clitoris... |
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- Original Article
- Thyroid Disease in Childhood.
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Duk Hi Kim, Chang Ho Hong, Kyung Suk Han, Dong Sik Jin
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Clin Exp Pediatr. 1980;23(8):653-661. Published online August 15, 1980
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Diseases of the thyroid gland are manifested by either increase in gland size, alterations in hormonal secretion, or both. Changes in gland size and weight are associated with toxic or nontoxic goiter, adenomas, thyroiditis, or malignancies. Many reports can be found to study thyroid disease, but there is no report of thyroid disease in childhood. So the present studies have... |
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- Congenital Hypothyroidism.
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Duk Hi Kim, Chang Ho Hong, Baek Keum Lim, Jung Sang Oh, Jung Soo Kim
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Clin Exp Pediatr. 1980;23(7):550-556. Published online July 15, 1980
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We made a clinical observation of 17 cases of congenital Hypothyroidism at the Pediatric department of Yonsei University hospital in Seoul, Korea during the period from January, 1969 to August, 1979. The results were as followings : 1) Male to female sex was about 1 : 1.1, and 6 cases (35%) of congenital hypothyroid-sm were diagnosed under 1 year old.... |
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- Case Report
- IntuInfantile Acute Febrile Mucocutaneous Lymph Node Syndrome Report of 4 cases.
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Hae Kwang Lee, Jin Sook Lee, Du Yong Lee, Duk Hi Kim
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Clin Exp Pediatr. 1980;23(10):815-821. Published online October 15, 1980
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Mucocutaneous Lymph Node Syndrome(MLNS), a recently recognized entity was first reported by Dr. T. Kawasaki in Japan in 1967 and then about 12,000 cases have been reported since 1967; it is now being found in the United States, but it's etiology is still unknown. The characteristic symptoms is high fever, hypermia of conjunctivae and sclera, reddening of lips and oral... |
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- A Case of Fibrous Dysplasia.
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Jung Soo Kim, Young Mo Sohn, Jae Song Kim, Duk Hi Kim, Kyoung Ja Cho
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Clin Exp Pediatr. 1979;22(3):234-238. Published online March 15, 1979
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Fibrous dysplasia of bone is a relatively rare condition characterized by fibrous tissue replacement of skeleton, usually not disabling, of slow progress, and showing a tendency to become arrested. It may be monostotic (confined to one bone) or Polyostotic (situated in many bones). The etiology of fibrous dysplasia is unkown but it is now believed to be a developmental error... |
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- Original Article
- The Effect of Prednisolone on Tuberculin Reaction in Guinea Pigs
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Duk Hi Kim
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Clin Exp Pediatr. 1973;16(1):1-11. Published online January 31, 1973
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Stoerk (1950) reported that the administration of cortisone or ACTH to guinea pigs, vaccinated with BCG, will attenuate or block the tuberculin reaction. Derbes et al (1950) and Cummings et al (1952) confirmed this.
Tuberculin skin reaction is the prototype of delayed hypersensitivity and contact dermatitis, homograft rejection phenomena and autoimmune disease are kind of delayed type of hypersensitivity. The present... |
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- Case Report
- A case of renal carbuncle
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Duk Hi Kim, Moon Hee Yang, Dong Shik Chin
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Clin Exp Pediatr. 1971;14(3):181-184. Published online March 31, 1971
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We have reported a case o£ 10 year old boy having a renal carbuncle which is very rare disease and reviewed literatures. Diagnosis has been established by clinical symptoms and signs, including irregular high fever
and tender, egg-sized mass on the left costovertebral area, IVP and renal scanning. The patient was completely cured after drainage following incision and antibiotic therapy for... |
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- Methemoglobinemia associated with salmonellosis (A case report and Review of the literature)
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Duk Hi Kim, Hyung- Sun Yoon, Pyung Kil Kim
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Clin Exp Pediatr. 1970;13(11):645-650. Published online November 30, 1970
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We experienced a patient of acquired methemoglobinemia arising from a 13 years old girl. The patient was suffered from high fever for seven days and generalized cyanosis for one day. This cyanosis proved to be due to abnormal high level of methemoglobin (3. 83 gm%) which was measured by Evelyn Malloy’s technique. The cause of high fever was salmonellosis, which... |
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