Journal of the Korean Pediatric Society 1990;33(12):1705-1712.
Published online December 31, 1990.
HLA Typing, Islet Cell Antibody and C-Peptide of Insulin Dependent Diabetes Mellitus in Children.
Hyeong Rae Cho1, Sei Joong Ko1, Duk Hi Kim1, Hyun Chul Lee2, Kap Bum Huh2
1Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
2Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, Korea
인슐린 의존형 당뇨병 환아의 HLA Typing, Islet Cell Antibody 및 C-Peptide의 변화에 관한 연구
조형래1, 고세중1, 김덕희1, 이현철2, 허갑범2
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 내과학교실
Received: 13 August 1990   • Accepted: 10 September 1990
35 childhood insulin-dependent (Typel) diabetes mellitus were typed for HLA and examined for presence of islet cell antibody and level of C-peptide. The following results were obtained: 1) HLA types were present as follows; HLA A24 (9) in 58%, DR3 in 38% and DR4 in 62%. This was slightly higher than the Korean population of 38%, 7% and 48% but there was no significant difference. 2) When islet cell cytoplasmic antibody (ICA) and islet cell surface antibody (ICSA) were studied in 18 cases, ICA was positive in 22% and ICSA in 17%. All the ICSA positive cases were examined within 1 month after onset of the disease. 3) The C-peptide level in accordance with duration of the disease was similar to that of disease onset for a year after onset of the disease. However it was decreased after 2 years onset of the disease. These finding was independent of HLA types. And in groups receiving cyclosporin A it was noted that C-peptide level was significantly increased at 3 months after onset of the disease as compared to the group not receiving cyclosporin A but C-peptide level was decreased in both groups 2 years after onset of the disease.
Key Words: Childhood insulin-dependent (Typel) diabetes mellitus

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