| The Effects of Cyclosporin in Treatment of Insulin Dependent Diabetes Mellitus. |
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Duk Hi Kim |
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Dept, of Pediatrics, Yonsei Univ. College of Med. |
| 인슈린의존형 당뇨병 환아에 대한 Cyclosporin투여 효과 |
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김덕희 |
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연세의대 소아과 |
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| Abstract |
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A 2 year 10 month old girl with 6 weeks duration and 13 year 4 month old boy with 8 weeks duration were given cyclosporin for 68 days. Therapy was initiated orally at the dosage of 10 mg per kg of body per day.
Blood glucose, C-peptide, cyclosporin, creatinin, BUN and transaminase were checked regularly. Cyclosporin treatment allowed two patients to reduce their insulin dosage by 80% or more and fasting C-peptide level had increased from 0.52 to 1.32 ng/ml and 0.87 to 1.8 ng/ml respectively. At 68 days After cyclosporin treatment, glucagon tests were done and C-peptide levels increased with glucose levels. They didn’t have any hepatotoxicity or nephrotoxicity but have minor side reaction including mild loss of hair in scalp and hirsutism around eyebrows.
I suggest that cyclosporin seems to be apparent benificial effect in type I diabetes mellitus and those results call for further study in a controlled clinical trials.
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| Key Words:
Cyclosporin, C-peptide, Insulin dependent diabetes mellitus |
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