| The Effect of Thyroid Hormone Deficiensy on Growth Hormone Levels. |
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Duk Hi Kim1, Chan Il Park2 |
1Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
2Department of Pathology, Yonsei University, College of Medicine, Seoul, Korea |
| 갑상선 기능저하상태에서 성장호르몬 분비에 관한 연구 |
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김덕희1, 박찬일2 |
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 병리학교실 |
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Received: 23 July 1987 |
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| Abstract |
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Growth hormone and thyroid hormone are known to affect growth and development.
The present experiment was undertaken to assess GH levels in the serum and pituitary gland of
prophylthiouracil (PTU) treated rats.
The serum concentration of T4 were decreased during PTU treatment. Serum GH concentration
and pituitary GH content were decresed with severity of hypothyroid status. After withdrawl of PTU,
their levels were recovered gradually.
Acidophil granulation and populations dropped during PTU treatment, whereas subsequent
withdrawal of PTU allowed pituitary histologic changes to return to normal.
The results suggested that thyroid hormone, acts directly on synthesis of GH by the pituitary gland.
Thus, much of the failure of growth in hypothyroidism may be related to decreased synthesis and
secretion of GH. |
| Key Words:
Hypothyroidism, Growth hormone, Dwarfism |
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