| Effects of sex hormone on secretion of growth hormone. |
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Bo Young Lee, Duk Hi Kim |
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Departmemt of Pediatrics, Yonsei University, College of Medidne, Seoul, Korea |
| 성호르몬이 혈중 성장호르몬 분비에 미치는 영향 |
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이보영, 김덕희 |
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연세대학교 의과대학 소아과학교실 |
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Received: 10 April 1991 • Accepted: 18 July 1991 |
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| Abstract |
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Sex honnone had been thought to influence in the serum level of growth honnone (GH) since 1944 year. After it became known that the exogenous administration of sex honnone to growth-retarded
children increase serum GH level, sex honnone-especially testosterone-was thought to induce GH release. Testosterone is thought to act on the hypothalamo-pituitary axis to stimulate GH secretion
and estradi이 is also thought to have an effect on GH release, although the exact mechanism is not known.
We compared serum sex honnone and GH levels of 103 growth retarded patients, 17 hypogonadic patients and 4 sexually precocious patients who were admitted to Department of Pediatrics, Yonsei
University College of Medicine. We measured testosterone levels as sex honnone in males and estradi이 in females. As serum GH ìevels, we measured the peak GH levels during provocative tests
and post-sleep 60 minutes GH levels.
The results were as follows:
1) In males, when testosterone levels were above 0.2 ng/ml, there were good correlation between serum testosterone and peak GH levels during provocative tests
2) In females, there were no significant correlation between serum estradiol and GH levels. In this study, testosterone influenced the release of GH but estradi이 did not have an effect on GH
release.
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| Key Words:
Testosterone, Estradiol, Growth Hormone |
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