| Effects of long-term anticonvulsant therapy of thyroid function. |
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Sei Joong Ko, Duk Hi Kim, Chang Jun Coe |
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Department of Pediatrics, Yonsei University Medical College, Seoul, Korea |
| 항경련제의 장기투여가 갑상선 기능에 마치는 영향 |
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고세중, 김덕희, 고창준 |
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연세대학교 의과대학 소아과학교실 |
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Received: 13 July 1989 • Accepted: 13 July 1989 |
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| Abstract |
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Serum concentrations of total triiodothyronine (T3) and thyroxine (T4) as well as serum thyroid-
stimulating hormone (TSH) were measured in 108 patients with childhood epilepsy taking anticonvul-
sants and in 54 normal healthy children as control group. Of these 108 patients, 23 were treated with
carbamazepine alone, 17 were phenytoin alone and the rest 68 were treated with combination of two
or more drugs involving carbamazepine and phenytoin.
The T4 and the TSH concentrations were depressed in anticonvulsant treated group, and the degree
of the decrease was more severe in a group who had combination therapy with carbamazepine and
phenytoin. And as for the treatment duration, the degrees of the decrease of the T4 and the TSH were
most markedly observed in more than 5 year treatment group. There was no significant decrease in
serum T3 concentration in any treatment group. The possible mechanisms of the influence of
anticonvulsants on thyroid function were discussed.
It is thought that thyroid function test would be needed during long-term anticonvulsant therapy. |
| Key Words:
Anticonvulsant drug, Thyroid function |
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