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"Most downloaded" Articles are from the articles published in 2023 during the last six months.
- Review Article
- Nephrology (Genitourinary)
- Kidney complications associated with COVID-19 infection and vaccination in children and adolescents: a brief review
(11 times)
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Hee Sun Baek, Min Hyun Cho
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Clin Exp Pediatr. 2023;66(10):424-431. Published online June 28, 2023
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Several observational studies have shown that acute kidney injury affects up to 46% of children and adolescents who develop severe postinflammatory responses, such as multisystem inflammatory syndrome in childhood, due to coronavirus disease 2019 (COVID-19). Although causality has not been established, some cases of glomerulopathy or nephrotic syndrome occurring after COVID-19 infection or vaccination have been reported. Therefore, kidney complications associated with these conditions in children and adolescents warrant attention. |
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- Other
- Children’s health affected by parent’s behavioral characteristics: a review
(11 times)
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Sung Eun Kim, Jongin Lee
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Clin Exp Pediatr. 2024;67(5):232-239. Published online August 21, 2023
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· Parents’ occupational hazards, long working hours, and smoking behaviors should be modified adequately to minimize adverse health effects on their children.
· As of 2023, several diseases from fetal exposure to occupational hazards can be compensated with Industrial Accident Compensation Insurance in South Korea.
· A directed acyclic graph is recommended for medical research to control the effects of parents’ behaviors on children’s health. |
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- Original Article
- Developmental and Behavioral Medicine
- Attention-deficit/hyperactive-impulsive disorder symptoms among grade 1 students with reading disorder in Thailand
(11 times)
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Patcharapun Sarisuta, Issarapa Chunsuwan, Tippawan Hansakunachai, Paskorn Sritipsukho
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Clin Exp Pediatr. 2023;66(11):485-492. Published online October 24, 2023
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Question: Would students with reading disorder have a significantly higher prevalence of attention-deficit/hyperactiveimpulsive disorder (ADHD) symptoms than neurotypical students?
Finding: Students at risk of reading disorder exhibited significant ADHD symptoms compared with those not at risk of reading disorder according to all presentations of teacher assessments versus only for predominantly inattentive presentations of the parental assessments.
Meaning: Students with reading disorder have a significantly higher prevalence of ADHD symptoms than neurotypical students. Sex, parental education level, average family income, and children’s school affiliation significantly influenced reading disorder prevalence. |
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- Review Article
- Allergy
- Recent advances in food allergen immunotherapy
(11 times)
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You Hoon Jeon, Edwin H. Kim
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Clin Exp Pediatr. 2024;67(8):386-394. Published online December 7, 2023
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· To enhance the safety of food allergen immunotherapy, alternative approaches such as sublingual immunotherapy, epicutaneous immunotherapy, low-dose oral immunotherapy (OIT), and omalizumab with OIT are being explored.
· Factors such as causative allergen type, natural outgrowth, symptom severity, and patient age should be considered.
· Individualized food allergen immunotherapy plans should be established to determine the most beneficial treatment for each patient. |
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- Editorial
- Neurobehavior
- Importance of pediatrician’s role in preventing positional plagiocephaly
(11 times)
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Hee-Jeong Kang
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Clin Exp Pediatr. 2024;67(6):294-295. Published online May 21, 2024
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· Plagiocephaly is characterized by the asymmetrical shape of a baby’s head.
· Since positional plagiocephaly is associated with developmental delay and further musculoskeletal problems, early detection allows for timely intervention and prevents worsening of the condition.
· Pediatricians can educate parents about proper head positioning and encourage supervised tummy time during awake hours. |
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- Review Article
- Cardiology
- Environmental changes surrounding congenital heart disease
(10 times)
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Eun-Young Choi
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Clin Exp Pediatr. 2023;66(8):332-338. Published online January 2, 2023
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· As the number of patients with congenital heart disease increases, the medical burden increases.
· Various fusion imaging techniques using percutaneous procedures have been introduced.
· With advances in technology, convenient ambulatory devices have been introduced.
· A well-organized team approach is required to resolve advanced heart failure in patients with congenital heart disease. |
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- Original Article
- Gastroenterology
- Assessing indicators and clinical differences between functional and organic childhood constipation: a retrospective study in pediatric gastroenterology clinics
(10 times)
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Hasan M. Isa, Fatema A. Alkharsi, Fatema A. Salman, Maryam S. Ali, Zahra K. Abdulnabibi, Afaf M. Mohamed
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Clin Exp Pediatr. 2023;66(7):296-306. Published online June 14, 2023
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Question: What causes childhood constipation, and what can predict organic constipation?
Finding: Constipation represents 14.7% of gastroenterology visits. Functional constipation is more common among constipation types, while organic constipation is more common in young children and those with a low body weight, stunted growth, mucus in the stool, and associated diseases.
Meaning: Younger children and those with lower growth or mucus in the stool should be assessed for underlying organic causes of constipation. |
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- Neonatology (Perinatology)
- Association between maternal coronavirus disease 2019 and transient tachypnea of the newborn: a single-center study
(10 times)
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Sung Hee Lee, Ju Hyun Jin, Jong Ha Yoo, Shin Won Yoon
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Clin Exp Pediatr. 2023;66(11):493-500. Published online October 24, 2023
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Question: What are the adverse clinical outcomes of neonates of coronavirus disease 2019 (COVID-19)–infected mothers?
Finding: Infants of mothers with COVID-19 were at significantly increased risk of transient tachypnea of the newborn (TTN), use of noninvasive ventilation, and need for supplemental oxygen (P<0.05).
Meaning: Neonates of mothers with COVID-19 are at risk of TTN and require respiratory support. Close monitoring is essential to ensuring timely intervention if required. |
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- Editorial
- Gastroenterology
- Noninvasive and simple, but accurate? Meta-analysis of evidence-based point-of-care ultrasound for assessing dehydration in children
(9 times)
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Jin-Hee Oh
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Clin Exp Pediatr. 2023;66(11):475-476. Published online July 11, 2023
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· Point-of-care ultrasound imaging, including measurement of the inferior vena cava/aorta ratio, is powerful for evaluating the hemodynamic status of pediatric patients.
· Owing to the limited feasibility of randomized clinical trials and insufficient data in children, imaging tools require validation.
· Objective validity meta-analyses of imaging studies can affect clinical decision-making and serve as a cornerstone for evidence-based practice in pediatrics. |
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- Review Article
- Gastroenterology
- High-resolution esophageal manometry in children
(9 times)
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Yogesh Waikar
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Clin Exp Pediatr. 2023;66(4):155-160. Published online October 17, 2022
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High-resolution esophageal manometry can be safely performed in children where recurrent vomiting and persistent dysphagia is the working diagnosis after excluding nonluminal and structural obstructive pathologies using pediatric upper gastrointestinal endoscopy. Normal manometry values are available. Clinical picture, biochemical tests, radiological interpretation, and endoscopic findings with manometry completes the analysis of patients with recurrent vomiting and dysphagia. |
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- Original Article
- Neonatology (Perinatology)
- Protective effect of recombinant interleukin-10 on newborn rat lungs exposed to short-term sublethal hyperoxia
(9 times)
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Hyeon-Soo Lee, Young-Joon Ryu, Min-Jae Lee
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Clin Exp Pediatr. 2024;67(10):540-549. Published online September 27, 2024
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Lung injury is generated from the early stage of hyperoxia through the biologic effects of cell death and inflammatory response, which eventually leads to evolution of bronchopul-monary dysplasia. Therefore, a protective measure against hyperoxia-induced lung injury is needed. The present study observed that anti-inflammatory cytokine, interleukin-10 had protective effects on newborn rat lungs from injury induced at the early stage of hyperoxia, by preventing cell death and down-regulating inflammatory response. |
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- Editorial
- Nephrology (Genitourinary)
- Clinical considerations and practical issues of kidney complications in children after COVID-19 infection or vaccination
(8 times)
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Jiwon Jung, Joo Hoon Lee
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Clin Exp Pediatr. 2024;67(1):35-36. Published online November 17, 2023
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· The proper monitoring for and treatment of coronavirus disease 2019 (COVID-19)-induced acute kidney injury, which is common in critically ill children, are recommended.
· Glomerulopathy associated with COVID-19 or its vaccination has been reported, and the overall clinical course is similar to that of non-COVID-19-associated diseases.
· Additional COVID-19 vaccinations are recommended; however, careful and individualized decisions should be made in patients with COVID-19- or vaccination-associated glomerulopathy. |
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- Infection
- COVID-19 infection and vaccination among children
(8 times)
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Amnuay Kleebayoon, Viroj Wiwanitkit
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Clin Exp Pediatr. 2023;66(12):531-532. Published online August 30, 2023
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· Coronavirus disease 2019 (OVID-19) infection and immunization have been linked with kidney problems; however, causality has not been proven.
· Concern about confounders is usually needed.
· Correspondence about a published article on the COVID-19 vaccine |
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- Letter to the Editor
- Neonatology (Perinatology)
- Association between feeding intolerance and intestinal dysbiosis in very premature infants
(8 times)
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Putri Maharani Tristanita Marsubrin, Agus Firmansyah, Rinawati Rohsiswatmo, Zakiudin Munasir, Saptawati Bardosono, Safarina G. Malik, Yuditiya Purwosunu, Ina S. Timan, Tetty Yuniati, Maya Yulindhini
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Clin Exp Pediatr. 2023;66(11):501-503. Published online October 24, 2023
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- Original Article
- Infection
- Predicting COVID-19 transmission in a student population in Seoul, South Korea, 2020–2021
(7 times)
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Young Hwa Lee, Han Ho Kim, Young June Choe
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Clin Exp Pediatr. 2023;66(4):173-178. Published online December 22, 2022
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Question: What is the spatial distribution and determinants of coronavirus disease 2019 (COVID-19) infection among students in Korea?
Finding: The community population was closely associated with the risk of COVID-19, and the number of students per school class were inversely associated with COVID-19 rates in students.
Meaning: Our finding suggests that controlling the community-level burden of COVID-19 can help prevent sudden acute respiratory syndrome coronavirus 2 infection in school-aged children. |
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- Editorial
- Other
- Advancing pediatric health: the multifaceted scope of Clinical and Experimental Pediatrics
(7 times)
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Jin Hee Oh, Man Yong Han
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Clin Exp Pediatr. 2023;66(4):171-172. Published online March 29, 2023
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Clinical and Experimental Pediatrics (CEP) is a journal that specializes in pediatric research topics. It covers a wide range of research areas, including basic research, translational research, and research related to improving pediatric health and diseases. CEP also focuses on the coordination of societal structures and processes that orchestrate pediatric health and disease throughout society, and the parallel relationship between regional characteristics and globalization. The journal intends to continue promoting pediatric health through relentless efforts and the discovery of new research areas. |
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- Perspective
- Other
- New public-centered child protection system in Korea
(7 times)
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We Sun Shim
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Clin Exp Pediatr. 2023;66(5):179-181. Published online April 18, 2023
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Korea’s child abuse response system was transformed under policy change in April 2020, from what was previously operated on a private-centered basis to a focus on the public sector with expanded role of local governments. Promising outcomes are expected with new system as greater governmental intervention will effectively protect at-risk children with acceleration in institutional collaboration and expertise in information management and administration. |
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- Review Article
- Infection
- COVID-19 in immunocompromised children and adolescents
(7 times)
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Byung Ok Kwak, Byung Wook Eun
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Clin Exp Pediatr. 2023;66(5):182-189. Published online April 18, 2023
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Most immunocompromised children and adolescents are not at increased risk of developing severe coronavirus disease 2019 (COVID-19). COVID-19 outcomes for low- or medium-risk immunocompromised children are favorable, while more serious illness reportedly occurs in high-risk immunocompromised children by underlying disease, its treatments, and other factors. Therefore, the early detection and timely management of severe COVID-19 and treatment of underlying disease are important. Hospitalization and COVID-19 vaccination should be carefully considered. |
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- Editorial
- Critical Care Medicine
- Is it possible to provide palliative care to pediatric patients with neurological diseases?
(7 times)
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Young-Hoon Kim
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Clin Exp Pediatr. 2024;67(8):403-404. Published online February 15, 2024
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· Patients with neurological diseases often require external mechanical support to maintain mechanical ventilation or supply.
· Little has been done to help the families of affected children make difficult decisions that carry significant physical and psychological consequences.
· The establishment of a department that provides pediatric palliative care for neurological patients should be considered. |
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- Editorial
- Neonatology (Perinatology)
- Does cord blood cortisol have a mediating effect on maternal prepregnancy body mass index and birth weight?
(6 times)
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Gyu Hong Shim
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Clin Exp Pediatr. 2023;66(1):24-25. Published online November 30, 2022
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· A high prepregnancy body mass index (pre-BMI) is associated with large for gestational age (LGA) and macrosomia, whereas a low pre-BMI is associated with small for gestational age (SGA) and low birth weight (LBW).
· The identification of the role of the hypothalamus-pituitary-adrenal axis in the effect of pre-BMI and maternal gestational weight gain on birth weight could reduce the frequency of LGA, macrosomia, SGA, or LBW through maternal diet optimization. |
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- Neurology
- Lumbar puncture or not: when does febrile seizure require a neurodiagnostic evaluation?
(6 times)
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Seung Soo Kim
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Clin Exp Pediatr. 2023;66(2):68-69. Published online December 9, 2022
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· A neurodiagnostic evaluation (lumbar puncture, blood tests, electroencephalography, and neuroimaging) is not indicated in most patients with simple febrile seizures.
· A lumbar puncture is indicated when a central nervous system infection is suspected in any patient with febrile seizures.
· Blood tests (glucose, electrolytes, and complete blood count) are indicated in patients with persistent seizure after benzodiazepine treatment, prolonged loss of consciousness, poor general condition, or signs of dehydration. |
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- Neonatology (Perinatology)
- Impacts of maternal COVID-19 during pregnancy on neonatal health and epidemiology
(6 times)
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Jae Woo Lim
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Clin Exp Pediatr. 2024;67(3):149-151. Published online December 28, 2023
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Newborns born to mothers infected with coronavirus disease 2019 (COVID-19) should be closely monitored for respiratory disorders, such as transient tachypnea of the newborn, regardless of their COVID-19 test results. Further research is required of the development of infants born to mothers with COVID-19. The trends in Korea's birth rate and infant mortality rates have not been significantly affected by COVID-19. |
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