- Editorial
- Hematology
- Absolute versus functional iron deficiency
-
Hye Lim Jung
-
Clin Exp Pediatr. 2025;68(2):138-140. Published online November 13, 2024
-
|
|
· Iron deficiency (ID), the most common cause of anemia, can be classified into absolute and functional types. Absolute ID is a state of low total body iron, while functional ID is a state of imbalance between iron demand and iron availability due to inflammation and/or infection.
· ID is diagnosed by serum ferritin and transferrin saturation levels. |
-
-
- Review Article
- Oncology
- Update on infantile hemangioma
-
Hye Lim Jung
-
Clin Exp Pediatr. 2021;64(11):559-572. Published online May 26, 2021
-
|
· Infantile hemangiomas (IHs) are the most common benign vascular tumors, occurring in 5%–10% of infants.
· IHs are characteristically not present at birth but are usually diagnosed at 1–4 weeks of age, rapidly proliferate until 5 months of age, and then spontaneously involute.
· High-risk IHs (10%) require early treatment from 1 month of age.
· Oral propranolol, a nonselective beta-blocker, is the first-line treatment for IHs. |
-
-
- Original Article
- Pulmonology
- Increased procalcitonin level is a risk factor for prolonged fever in children with Mycoplasma pneumonia
-
Ji Eun Jeong, Ji Eun Soh, Ji Hee Kwak, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Moon Soo Park, Jung Yeon Shim
-
Clin Exp Pediatr. 2018;61(8):258-263. Published online August 15, 2018
-
|
Purpose: Macrolide-resistant Mycoplasma pneumoniae pneumonia (MPP) is characterized by prolonged fever and radiological progression despite macrolide treatment. Few studies have examined serum procalcitonin (PCT) level in children with MPP. We aimed to investigate the association of acute inflammation markers including PCT with clinical parameters in children with MPP. Methods: A total of 147 children were recruited. The diagnosis of MPP... |
-
-
- Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children
-
Bo Ram Cheon, Jeong Eun Shin, Yun Ji Kim, Jae Won Shim, Deok Soo Kim, Hye Lim Jung, Moon Soo Park, Jung Yeon Shim
-
Clin Exp Pediatr. 2015;58(3):96-101. Published online March 20, 2015
-
|
|
Purpose Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD. MethodsWe enrolled 91... |
-
-
- Case Report
- Klebsiella pneumoniae liver abscess in an immunocompetent child
-
Jang-Mi Kwon, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park
-
Clin Exp Pediatr. 2013;56(9):407-410. Published online September 30, 2013
-
|
|
Klebsiella pneumoniae has emerged as a leading pathogen that causes pyogenic liver abscesses (PLAs) in Korea. K. pneumoniae liver abscess (KLA) is potentially life threatening, and the diagnosis is difficult. In developed countries, PLA is rarely observed in children and is frequently associated with disorders of granulocyte function and previous abdominal infection. We observed a case of KLA in a... |
-
-
- Original Article
- Expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ in the lung tissue of obese mice and the effect of rosiglitazone on proinflammatory cytokine expressions in the lung tissue
-
Seung Lok Ryu, Jae Won Shim, Duk Soo Kim, Hye Lim Jung, Moon Soo Park, Soo-Hee Park, Jinmi Lee, Won-Young Lee, Jung Yeon Shim
-
Clin Exp Pediatr. 2013;56(4):151-158. Published online April 22, 2013
-
|
|
Purpose We investigated the mRNA levels of peroxisome proliferator-activated receptor (PPAR)-α, PPAR-γ, adipokines, and cytokines in the lung tissue of lean and obese mice with and without ovalbumin (OVA) challenge, and the effect of rosiglitazone, a PPAR-γ agonist. MethodsWe developed 6 mice models: OVA-challenged lean mice with and without rosiglitazone; obese mice with and without rosiglitazone; and OVA-challenged obese mice with and... |
-
-
- Successful and safe treatment of hemangioma with oral propranolol in a single institution
-
Sun Hee Chung, Dong Hyuk Park, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park, Hong Hoe Koo
-
Clin Exp Pediatr. 2012;55(5):164-170. Published online May 21, 2012
-
|
|
Purpose Dramatic improvement of hemangioma to propranolol has been recently reported; however, details on dose and duration of treatment, potential risks, and monitoring have not been determined. The objective of this study is to describe and analyze the use of propranolol as a first-line treatment or as a single therapy in management of complicated hemangioma. MethodsA retrospective chart review of eight patients... |
-
-
- Transforming growth factor-β promoted vascular endothelial growth factor release by human lung fibroblasts
-
Sang Uk Park, Joo Hwa Shin, Jae Won Shim, Deok Soo Kim, Hye Lim Jung, Moon Soo Park, Jung Yeon Shim
-
Clin Exp Pediatr. 2008;51(8):879-885. Published online August 15, 2008
-
|
|
Purpose : The human lung fibroblast may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, which are important in airway remodeling. Vascular endothelial growth factor (VEGF) induces mucosal edema and angiogenesis. Thymus and activation regulated chemokine (TARC) induces selective migration of T helper 2 cells. We investigated whether human lung fibroblasts produced VEGF and TARC, and the... |
-
-
- Clinical features of congenital muscular torticollis
-
Ji Eun Jun, Hye Kyeong Ryu, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-Soo Kim
-
Clin Exp Pediatr. 2007;50(3):241-247. Published online March 15, 2007
-
|
|
Purpose : Congenital muscular torticollis (CMT) is a common and benign congenital disorder of the musculoskeletal system in neonates and infants. The pathophysiology is that the sternocleidomastoid muscle (SCM) is shortened on the involved side by fibrosis, leading to ipsilateral tilt and contralateral rotation of the face and chin. In this study, we investigated the clinical features of CMT, the... |
-
-
- Relationship of serum IL-13 and eotaxin level with airway hyperresponsiveness in children with asthma
-
Eun Young Park, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
-
Clin Exp Pediatr. 2006;49(8):889-894. Published online August 15, 2006
-
|
|
Purpose : Asthma is characterized by the presence of airway hyperresponsiveness(AHR) and inflammation. The extensive eosinophil infiltration into the lung is the hallmark of asthma and contributes to the damage of respiratory epithelium during late phase airway responses. Eotaxin is the major eosinophil chemoattractant found in bronchoalveolar lavage(BAL) fluid of allergic inflammation. IL-13 has been known to induce the... |
-
-
- A study of neuropeptides related to headaches in children with meningeal irritation signs
-
Bo Gil Seo, Myung Hwan Yoo, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-Soo Kim
-
Clin Exp Pediatr. 2006;49(5):533-538. Published online May 15, 2006
-
|
|
Purpose : The headache, one of the symptoms of meningitis, is related to abrupt elevation of intracranial pressure(ICP) or stimulation of intracranial nociceptive structure. However, in cases of mild elevation of ICP or normal findings of cerebrospinal fluid(CSF) analysis, patients sometimes complain of headaches. Therefore, other pathways may contribute to the occurrence of headaches in aseptic meningitis or meningismus. We... |
-
-
- The significance of vascular endothelial growth factor(VEGF) in children with asthma and pneumonia
-
Seong Hwan Choi, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
-
Clin Exp Pediatr. 2006;49(2):192-197. Published online February 15, 2006
-
|
|
Purpose : Vascular endothelial growth factor(VEGF) is a key cytokine for controlling vascular permeability and angiogenesis, which is one of the major findings in airway remodeling. However, it is not well known if it is associated with acute lower respiratory tract disease such as lobar pneumonia. The aim of this study is to compare serum VEGF levels in patients with... |
-
-
- A clinical study of migraines without aura in children : based on revised international headache society criteria
-
Bo Gil Seo, Myung Hwan Yoo, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-soo Kim
-
Clin Exp Pediatr. 2006;49(1):71-75. Published online January 15, 2006
-
|
|
Purpose : Because migraine in children has different characteristics from that in adults, it is inappropriate to apply migraine criteria for adults to children. Recently, the International Headache Society(IHS) revised criteria regarding children's characteristics. Therefore, we reviewed the characteristics of childhood migraines without auras based on the revised criteria and compared the data with the findings of childhood migraine by... |
-
-
- Case Report
- Two Cases of Lead Poisoning due to Herb Medicinal Pills
-
Seong Hwan Choi, Eun Young Park, Jung Yeon Shim, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
-
Clin Exp Pediatr. 2005;48(9):1009-1015. Published online September 15, 2005
-
|
|
We encountered two children with lead poisoning who were administered herb medicinal pills recommended by their clergyman. These patients presented anemia and severe coliky abdominal pain, but no neurologic symptoms. For this reason, they were initially misdiagnosed with gastrointestinal hemorrhagic disease. However, we got a clue that they took herb medicinal pills. Finally, based on the assay of blood lead... |
-
-
- Original Article
- Clinical Significance of Immature Reticulocyte Fraction and Reticulocyte Cellular Indices in Pediatric Anemia Patients
-
Young Seo, Hye Lim Jung, Jae Won Shim, Deok Su Kim, Jeong Yeon Shim, Moon Soo Park
-
Clin Exp Pediatr. 2005;48(3):284-291. Published online March 15, 2005
-
|
|
Purpose : Flow cytometric automated reticulocyte analysis is a superior method to manual reticulocyte counting, with respect to precision and sensitivity. Furthermore, flow cytometric analysis is able to measure immature reticulocyte fraction(IRF) and reticulocyte cellular indices(RCI : cell hemoglobin content : CHr, mean cell volume : MCVr, cell hemoglobin concentration mean : CHCMr, distribytion width : RDWr, HDWr, CHDWr). In... |
-
-
- Evaluation of Serum Insulin-Like Growth Factor(IGF)-I, Insulin-Like Growth Factor Binding Protein(IGFBP)-2 and
IGFBP-3 Levels in Healthy Korean Children
-
Gi Hoon Yang, Hye Lim Jung, Deok Soo Kim, Jae Won Shim, Jung Yeon Shim, Moon Soo Park
-
Clin Exp Pediatr. 2005;48(3):298-305. Published online March 15, 2005
-
|
|
Purpose : We performed this study to evaluate the mean serum levels of insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 in healthy Korean children according to age and sex.
Methods : Ninety two healthy children, consisting of 42 boys and 50 girls, were classified into five groups according to age : neonate; infancy; early childhood; late childhood;... |
-
-
- Serum and Cerebrospinal Fluid(CSF) Nitric Oxide, Macrophage Inflammatory Protein-1α and Lactoferrin Levels in Aseptic Meningitis
-
Young Seo, Jung Yeon Shim, Jae Won Shim, Deok Su Kim, Hye Lim Jung, Moon Soo Park
-
Clin Exp Pediatr. 2005;48(1):48-54. Published online January 15, 2005
-
|
|
Purpose : The pathologic mechanisms of central nervous system(CNS) injuries in human meningitis are not yet completely understood. Recent studies indicate that the host inflammatory responses are as important in brain damage as the infecting organisms and toxins. There have been some reports on the relationship of nitric oxide(NO), macrophage inflammatory protein-1α(MIP-1α), and lactoferrin in bacterial meningitis, but few reports... |
-
-
- Serum Vascular Endothelial Growth Factor as a Predictive Risk Factor for the Occurrence of
Coronary Artery Lesions in Kawasaki Disease
-
Min Hyuk Park, Hye Lim Jung, Ju Hee Yang, Jung-Yeon Shim, Deok Soo Kim, Jae Won Shim, Moon Soo Park
-
Clin Exp Pediatr. 2003;46(8):811-816. Published online August 15, 2003
-
|
|
Purpose : Kawasaki disease is an acute systemic vasculitis of unknown etiology with a predilection for the coronary arteries. Vascular endothelial growth factor(VEGF) is a cytokine which promotes vascular permeability and angiogenesis. We investigated serum VEGF(sVEGF) levels in Kawasaki disease to determine whether sVEGF level can be used as a risk factor to predict the occurrence of coronary artery lesions(CAL)... |
-
-
- Increased Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Levels in the Cerebrospinal Fluid from Children with Aseptic Meningitis
-
Ju Hee Yang, Min Hyuk Park, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuck Keum
-
Clin Exp Pediatr. 2003;46(6):548-553. Published online June 15, 2003
-
|
|
Purpose : Matrix metalloproteinase(MMP)-9 is known to breakdown the blood-brain barrier by degrading the extracellular matrix of the subendothelial basement membrane in meningitis. Tissue inhibitor of metalloproteinase(TIMP)-1, a known inhibitor of MMP-9, has been postulated to inhibit the proteolytic activity of MMP-9 by bindng to MMP-9, but their interaction has not been fully understood yet. So far, there have been... |
-
-
- Case Report
- Two Cases of Gitelman's Syndrome Diagnosed by
Renal Clearance Study
-
Tae Hwa Kim, Seung Jun Kim, Yu Kyung Seo, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuk Kum
-
Clin Exp Pediatr. 2002;45(3):413-417. Published online March 15, 2002
-
|
|
Gitelman's syndrome is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria that has recently been reported to be linked to thiazide-sensitive Na-Cl cotransporter gene mutation. In this study, we performed renal clearance studies to differentiate Gitelman's from Bartter's syndrome and to confirm the diagnosis in two patients clinically diagnosed with Gitelman's syndrome. Each patient was hydrated... |
-
-
- Two Cases of Thymic Carcinoma in Childhood
-
Young Ah Lee, Jin Young Park, Hye Lim Jung, Moon Soo Par, Hyoung Soo Choi, Eun Sun Yoo, Hyo Seop Ah
-
Clin Exp Pediatr. 1999;42(3):424-429. Published online March 15, 1999
-
|
|
Thymic carcinoma is a malignant neoplasm arising from the thymic epithelium, and is known to be extremely uncommon in the pediatric population. The tumor is clinically highly aggressive with frequent local intrathoracic spread and extrathoracic metastases detected in the majority of patients at initial diagnosis and often shows minimal or no response to conventional chemotherapy. We experienced two pediatric patients... |
-
-
- Original Article
- A Seroepidemiologic Study on Hepatitis A in Seoul, Korea
-
Dong Woon Yang, Young Ah Lee, Jung Yeon Shim, Jin Young Park, Hye Lim Jung, Moon Soo Park, Dong Hyeuk Keum
-
Clin Exp Pediatr. 1999;42(2):180-185. Published online February 15, 1999
-
|
|
Purpose : The prevalence of hepatitis A(HAV) in a certain community reflects that community’s living standard and hygienic condition. And the pattern of HAV infection differs over time and geography, with varying widely from country to country and even within the same city. Recently a shift in prevalence has been observed in cases from childhood to adulthood. We studied HAV... |
-
-
- Diagnostic Significance of DMSA Renal Scan and C-Reactive Protein in Urinary Tract Infection of Childhood
-
Sung Ho Hong, Hyang Mi Kwon, Hye Lim Jung, Dong Hyuck Kuem
-
Clin Exp Pediatr. 1996;39(11):1565-1575. Published online November 15, 1996
-
|
|
Purpose : Renal scar or reflux nephropathy, known as a major cause of end-stage renal
failure and hypertension in children and young adults, is frequently detected in pediatric urinary
tract infection(UTI) patients at their first infections. So early and accurate diagnosis, and follow
up of renal scar are very important. We performed this study to recognize the importance of
radiologic examinations for detection of... |
-
-
- Case Report
- A Case of Disseminated Pagetoid Reticulodsis
-
Hyang Mi Kwon, Sun Seong Park, Hye Lim Jung, Dong Hyuck Keum, Kye Yong Song
-
Clin Exp Pediatr. 1995;38(7):988-992. Published online July 15, 1995
-
|
|
Pagetoid reficulosis is a rare skin disorder consisting of localized(WoringerKolopp type) or disseminated (Ketron-Goodman type), asymptomatic hyperkeratotic, cutaneous plaque. The disseminated form has clinical similarities with mycosis fungoides and histologically characteri-sed by prominent infiltration of cytologically atypical mononuclear cells within a hyperplastic epidermis. It is suggested that the infiltrating cells orginate from T-lymphocytes. A 6yr old male patient visited with... |
-
-
- Original Article
- A Clinical Study of Childhood Soft Tissue Sarcoma
-
Hye Lim Jung, Hong Heo Koo, Hee Young Shin, Hyo Seop Ahn
-
Clin Exp Pediatr. 1993;36(9):1258-1270. Published online September 15, 1993
-
|
|
Medicine, Seoul, Korea Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
To study the clinical characteristics and treatment results of childhood soft tissue sarcoma, the retrospective study was performed on 67 patients with soft tissue sarcoma, experienced at the Department of Pediatrics, Seoul National University Hospital from January, 1982 to July, 1990.
The... |
-
-
- The Significance of Nucleated Red Blood Cell Counts in Low Birth Weight Neonates
-
In Ho Song, Weon Kee Lee, Hye Lim Jung, Dong Hyuck Keum
-
Clin Exp Pediatr. 1993;36(11):1526-1533. Published online November 15, 1993
-
|
|
We studied to assess the relationship between intrauterine growth retardation and the increased nucleated red blood cell counts (NRBC) in small for gestational age (SGA) and appropriate for gestational age (AGA) neonates with low birth weight. We also evaluated the nucleated red blood cell counts in low birth weight neonates who had either perinatal asphyxia or hyaline membrane disease (HMD)... |
-
-
- The Relationship Between Neonatal Hypoglycemia and Newborn Iron Status in Hypoglycemic Large-for-Gestational Age Infants
-
Myung Ja Yun, In Ho Song, Hye Lim Jung, Dong Hyuck Kum
-
Clin Exp Pediatr. 1992;35(12):1667-1673. Published online December 15, 1992
-
|
|
We assessed the relationship between neonatal hypoglycemia and newborn iron status in hypoglycemic large-for-gestational age, euglycemic large for gestational age and euglycemic appropriate for gestational age infants that were admitted to the department of Pediatrics, Koryo General Hospital from July 1989 to June 1990. The results are as follows;
1) The incidence of large for gestational age infants was 3.3% (32... |
-
-
- Carcinomas in Childhood -A 10-Year Experience in Seoul National University Hospital-
-
Hong Hoe Koo, Kyung Duk Park, Hye Lim Jung, Sang Kyu Park, Hee Young Shin, Hyo Seop Ahn
-
Clin Exp Pediatr. 1992;35(10):1369-1376. Published online October 15, 1992
-
|
|
Carcinomas in childhood differ from those in adults in their frequency, histologic type, and distribution of primary sites. In children, carcinomas are rare and few series have been published containing sufficient mumbers of cases to permit a reliable account of the incidence and survival of children with carcinoma. During a 10-year period, 1982-1991, we observed 40 patients less than 16... |
-
-
- Clinical Considerations of the Mediastinal Tumors in Children
-
Eun Joo Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
-
Clin Exp Pediatr. 1992;35(1):98-107. Published online January 15, 1992
-
|
|
Mediastinal tumors of children constitute a heterogeneous group of malignant and benign neoplasms because they originated from a variety of structures. But they show some characteristics in type of tumor according to location, relative frequency of masses, clinical manifestations. Management and long-term reusult. We observed 82 patients less than 16 years of age who were evaluated and treated for a... |
-
-
- A case of bone marrow necrosis in acute lymphoblastic leukemia.
-
Mee Ran Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
-
Clin Exp Pediatr. 1991;34(8):1163-1168. Published online August 31, 1991
-
|
|
Bone marrow necrosis is a rare complication most commonly encountered in patients with leuke-
mia, metastatic tumor in marrow, sickle cell disease, DIC and severe infections.
Recently it is regarded as a more common finding frequently overlooked and carrying not so poor
prognosis. We reported here a boy with ALL who showed marrow necrosis on biopsy at the time of
diagnosis and achieved complete... |
-
-
- Clinical considerations of acute leukemia or transient myeloprolifo- rative disorder in Down syndrome.
-
Eun Sil Dong, Sung Hee Jang, Hong Hoe Koo, Hye Lim Jung, Hee Young Shin, Hyo Seop Ahn
-
Clin Exp Pediatr. 1991;34(1):74-82. Published online January 31, 1991
-
|
|
Children with Down syndrome have an increased incidence of acute leukemia. Infants with Down
syndrome are also at risk of developing a transient myeloproliferative disorder indistinguishable from
acute nonlymphocytic leukemia (ANLL) except by its eventual clinical recovery. We observed 11
patients with acute leukemia or transient myeloproliferative disorder in Down syndrome who had
admitted to the Departmetn of Pediatrics, Seoul National University Children’s Hospital,... |
-
-
- Asymptomatic human rotavirus infections during infancy and preschool period.
-
Hye Lim Jung, Byoung Hoon Yoo, Tae Sub Shim
-
Clin Exp Pediatr. 1989;32(11):1482-1488. Published online November 30, 1989
-
|
|
Asymptomatic human rotavirus (HRV) infection rate was studied by comparing the rate of HRV
excretion in diarrhea cases with that in nondiarhea group of children under preschool age. HRV
antigen in stool was detected by enzyme-linked immunosorbent assay (ELISA) from children under 6
years of age who were admitted to Pediatric Department of Chung-Ang University Medical Center
from November 1988 to mid-April 1989.
1) HRV antigen... |
-
-
|
