Korean Journal of Pediatrics 2005;48(3):298-305.
Published online March 15, 2005.
Evaluation of Serum Insulin-Like Growth Factor(IGF)-I, Insulin-Like Growth Factor Binding Protein(IGFBP)-2 and IGFBP-3 Levels in Healthy Korean Children
Gi Hoon Yang, Hye Lim Jung, Deok Soo Kim, Jae Won Shim, Jung Yeon Shim, Moon Soo Park
Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
정상 어린이에서 혈청 인슐린양 성장인자-I과 인슐린양 성장인자 결합단백-2 및 -3의 농도 분석
양기훈, 정혜림, 김덕수, 심재원, 심정연, 박문수
성균관대학교 의과대학 강북삼성병원 소아과
Hye Lim Jung, Email: jungped@samsung.co.kr
: We performed this study to evaluate the mean serum levels of insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 in healthy Korean children according to age and sex.
: Ninety two healthy children, consisting of 42 boys and 50 girls, were classified into five groups according to age : neonate; infancy; early childhood; late childhood; and adolescence. We measured serum levels of IGF-I, IGFBP-2 and IGFBP-3 by enzyme-linked immunosorbent assay(ELISA) and analysed the serum levels according to sex and age group.
: For boys, the mean serum levels of IGF-I(ng/mL) in neonate, infancy, early childhood, late childhood and adolescence were 41.1?.6, 70.9?3.7, 103.5?7.2, 89.8?6.5 and 51.4?7.8, respectively. Those of IGFBP-2(ng/mL) were 8.2?.4, 5.8?.4, 9.3?.0, 9.5?.1 and 7.0?.5, respectively. Those of IGFBP-3(ng/mL) were 559.2?15.2, 1,333.3?92.5, 2,254.6?,513.8, 2,447.1?,464.2, 1,533.6?07.4, respectively. For girls, the mean serum levels of IGF-I(ng/mL) according to five age groups were 53.3?.5, 99.3?5.8, 69.6?1.1, 106.2?7.0 and 145.1?27.8, respectively. Those of IGFBP-2 (ng/mL) were 9.1?.4, 5.3?.9, 6.9?.0, 10.5?.0 and 7.9?.3, respectively. Those of IGFBP-3(ng/ mL) were 858.2?33.4, 1,834.8?51.3, 1,404.3?70.2, 2,203.5?99.4 and 2,029.3?,316.7, respectively. There were significant positive correlations observed between IGF-I and IGFBP-3 levels(r=0.589, P= 0.000).
: IGF-I and IGFBP-3 levels increased as children get older. The peak level of IGFBP-3 was observed in late childhood for both boys and girls, suggesting a current trend of children reaching peak growth velocity before adolescence. The IGFBP-2 level was higher in neonates compare to infancy, suggesting that IGFBP-2 is an important substance for fetal growth.
Key Words: Insulin-like growth factor-1 , Insulin-like growth factor binding protein-2 , Insulin-like growth factor binding protein-3

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