- Perspective
- Other
- The long journey toward improving children’s health: from ‘Korean Journal of Pediatrics’ to ‘Clinical and Experimental Pediatrics’
- Man Yong Han, Yeong Ho Rha, Chong-Woo Bae, Baik-Lin Eun; Clinical and Experimental Pediatrics Editorial Team
- Clin Exp Pediatr. 2020;63(1):1-2. Published online January 15, 2020
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- Original Article
- Endocrinology
- Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity
- Bahar Özcabı, Salih Demirhan, Mesut Akyol, Hatice Öztürkmen Akay, Ayla Güven
- Clin Exp Pediatr. 2019;62(12):450-455. Published online October 28, 2019
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Background: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults.
Purpose: Here we evaluated the ability of LAP to predict NAFLD in obese children. Methods: Eighty obese children (38 girls; age 6–18 years) were included. Anthropometric measurements and biochemical values were obtained from the patients’ medical records. LAP was calculated as [waist...
- Neonatology (Perinatology)
- Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia
- Ga Won Jeon, R. Ann Sheldon, Donna M Ferriero
- Clin Exp Pediatr. 2019;62(12):444-449. Published online October 18, 2019
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Background: Sixty percent of infants with severe neonatal hypoxic-ischemic encephalopathy die, while most survivors have permanent disabilities. Treatment for neonatal hypoxic-ischemic encephalopathy is limited to therapeutic hypothermia, but it does not offer complete protection. Here, we investigated whether hypoxia-inducible factor (HIF) promotes cell survival and suggested neuroprotective strategies.
Purpose: HIF-1α-deficient mice have increased brain injury after neonatal hypoxia-ischemia (HI), and the...
- Editorial
- Nephrology (Genitourinary)
- Is there a simple and less invasive way to accurately diagnose acute pyelonephritis?
- Seong Heon Kim
- Clin Exp Pediatr. 2019;62(12):442-443. Published online November 19, 2019
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- Neonatology (Perinatology)
- Practical considerations when administering surfactants to preterm infants with respiratory distress syndrome
- Heui Seung Jo
- Clin Exp Pediatr. 2019;62(12):440-441. Published online August 16, 2019
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- Eosinophil count and neutrophil-to-lymphocyte count ratio as biomarkers for predicting early-onset neonatal sepsis
- Jang Hoon Lee
- Clin Exp Pediatr. 2019;62(12):438-439. Published online July 9, 2019
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- Review Article
- Nephrology (Genitourinary)
- Reconsideration of urine culture for the diagnosis of acute pyelonephritis in children: a new challenging method for diagnosing acute pyelonephritis
- Jun Ho Lee, Seonkyeong Rhie
- Clin Exp Pediatr. 2019;62(12):433-437. Published online October 18, 2019
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Acute pyelonephritis (APN) should be detected and treated as soon as possible to reduce the risk of the development of acquired renal scarring. However, in the medical field, urine culture results are not available or considered when the prompt discrimination of APN is necessary and empirical treatment is started. Furthermore, urine culture cannot discriminate APN among children with febrile urinary...
- Perspective
- Allergy
- Food allergy and food-induced anaphylaxis in children: an increasing critical public health issue
- Sooyoung Lee
- Clin Exp Pediatr. 2019;62(12):431-432. Published online November 12, 2019
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- Clinical note
- Neonatology (Perinatology)
- Gray-brown skin discoloration following phototherapy for hyperbilirubinemia due to anti-E alloimmunization
- Da Jeong Lee, Woo Sun Song, Seung Yeon Kim
- Clin Exp Pediatr. 2019;62(11):428-430. Published online September 18, 2019
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- Original Article
- Nephrology (Genitourinary)
- Clinical manifestations of BK virus infection in pediatric kidney transplant patients
- Yiyoung Kwon, Jeong Yeon Kim, Yeonhee Lee, Heeyeon Cho
- Clin Exp Pediatr. 2019;62(11):422-427. Published online September 5, 2019
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Background: Polyomavirus BK (BKV) infection is an important cause of graft loss in kidney transplant patients.
Purpose: The purpose of this study was to evaluate clinical findings and risk factors for BKV in pediatric patients after kidney transplantation. Methods: This retrospective single-center study included 31 pediatric kidney transplant recipients from January 2002 to December 2017. Two patients received 2 transplantations during the...
- Gastroenterology
- Association between Body Mass Index and Hepatitis B antibody seropositivity in children
- Yoowon Kwon, Su Jin Jeong
- Clin Exp Pediatr. 2019;62(11):416-421. Published online August 12, 2019
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Background: The seropositivity rate of hepatitis B surface antigen (anti-HBs) antibodies is known to be ≥95% after hepatitis B virus vaccination during infancy. However, a low level or absence of anti-HBs in healthy children is discovered in many cases. Recent studies in adults reported that a reduced anti-HBs production rate is related to obesity.
Purpose: To investigate whether body mass index...
- Editorial
- Nephrology (Genitourinary)
- Monitoring BK virus infection in pediatric kidney transplant recipients
- Min Hyun Cho
- Clin Exp Pediatr. 2019;62(11):414-415. Published online October 18, 2019
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- Endocrinology
- Correlation between genetic heterogeneity and variability for response to growth hormone in Noonan syndrome
- Young-Lim Shin
- Clin Exp Pediatr. 2019;62(11):412-413. Published online July 9, 2019
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- Neonatology (Perinatology)
- Controversy in the diagnosis and treatment of hemodynamically significant patent ductus arteriosus in preterm infants
- Se In Sung
- Clin Exp Pediatr. 2019;62(11):410-411. Published online June 21, 2019
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- Systematic review and meta-analysis
- Neurobehavior
- Evaluation of drug interventions for the treatment of sleep disorders in children with autism spectrum disorders: a systematic review
- Ensiyeh Jenabi, Sara Ataei, Saeid Bashirian
- Clin Exp Pediatr. 2019;62(11):405-409. Published online October 2, 2019
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A structured review study of drug interventions on sleep disorders in patients with autism spectrum disorders (ASD) has not been published to date. This systematic review aimed to investigate drug interventions for the treatment of sleep disorders in children with ASD. The Web of Science, PubMed, and Scopus databases were searched until March 2019. Study quality was assessed using the...
- Original Article
- Gastroenterology
- Influence of proton pump inhibitor therapy on intestinal inflammation assessed by fecal calprotectin in pediatric patients
- Su Yeong Kim, Na Mi Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim, Eung Sang Choi, Dae Yong Yi
- Clin Exp Pediatr. 2019;62(10):400-404. Published online July 3, 2019
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Background: An increase in the numbers of patients with gastrointestinal symptoms has recently been observed.
Purpose: To investigate the effects of proton pump inhibitor (PPI) therapy on intestinal inflammation in children and adolescents as confirmed by clinical manifestations and objectively assessed by fecal calprotectin (FC) level measurement. Methods: Consecutive children (aged 3–18 years) who presented with gastrointestinal symptoms and were treated with...
- Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures
- Yasser K. Rashed, Mohamed El-Guindi
- Clin Exp Pediatr. 2019;62(10):395-399. Published online June 24, 2019
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Background: The esophagus is the most common part of gastrointestinal (GI) tract at the risk of stricture. Benign disorders are the leading causes of narrowing. Caustic ingestion is the most common cause of esophageal stricture in children, especially in developing countries. Clinical responses to the topical application of Mitomycin C in various medical procedures have been reported.
Purpose: The study aimed...
- Neonatology (Perinatology)
- Clinical impact of admission hypothermia in very low birth weight infants: results from Korean Neonatal Network
- Na Hyun Lee, Soo Kyung Nam, Juyoung Lee, Yong Hoon Jun
- Clin Exp Pediatr. 2019;62(10):386-394. Published online May 22, 2019
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Background: Preterm infants have difficulty maintaining body temperature after birth. However, clinical guidelines advocate that neonatal body temperature should be maintained at 36.5°C–37.5°C.
Purpose: We aimed to investigate the incidence of admission hypothermia in very low birth weight (VLBW) infants and to determine the association of admission temperature with in-hospital mortality and morbidities. Methods: A cohort study using prospectively collected data involving...
- Editorial
- Gastroenterology
- Can proton pump inhibitors cause intestinal inflammation in children?
- Ben Kang
- Clin Exp Pediatr. 2019;62(10):384-385. Published online October 2, 2019
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- Neonatology (Perinatology)
- Central line-associated bloodstream infections in the neonatal intensive care unit
- Woo Ryoung Lee
- Clin Exp Pediatr. 2019;62(10):382-383. Published online July 17, 2019
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- Strategies to improve outcomes of bronchopulmonary dysplasia
- Young Hwa Jung, Chang Won Choi, Beyong Il Kim
- Clin Exp Pediatr. 2019;62(10):380-381. Published online September 11, 2019
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- Systematic review and meta-analysis
- General Pediatrics
- The maternal prepregnancy body mass index and the risk of attention deficit hyperactivity disorder among children and adolescents: a systematic review and meta-analysis
- Ensiyeh Jenabi, Saied Bashirian, Salman Khazaei, Zohreh Basiri
- Clin Exp Pediatr. 2019;62(10):374-379. Published online June 14, 2019
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Background: Attention deficit hyperactivity disorder (ADHD) symptoms have a major impact on individuals, families, and society. Therefore identification risk factors of ADHD are a public health priority.
Purpose: This is meta-analysis evaluated the association between maternal prepregnancy body mass index and the risk of ADHD among the resulting offspring. Methods: The search identified studies published through December 2018 in the PubMed, Web...
- Review Article
- Neonatology (Perinatology)
- Bronchopulmonary dysplasia: how can we improve its outcomes?
- Tae-Jung Sung
- Clin Exp Pediatr. 2019;62(10):367-373. Published online May 17, 2019
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Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants with multiple factors affected from prenatal to postnatal periods. Despite significant advances in neonatal care over almost 50 years, BPD rates have not decreased; in fact, they may have even increased. Since more preterm infants, even at periviable gestational age, survive today, different stages of lung development affect the...
- Original Article
- Developmental and Behavioral Medicine
- Effect of omega-3 plus methylphenidate as an alternative therapy to reduce attention deficit-hyperactivity disorder in children
- Soleiman Mohammadzadeh, Narmin Baghi, Fayegh Yousefi, Bahar Yousefzamani
- Clin Exp Pediatr. 2019;62(9):360-366. Published online May 20, 2019
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Background: Attention deficit-hyperactivity disorder (ADHD) is one of the most common chronic behavioral disorders in school-aged children.
Purpose: This study aimed to evaluate the effect of omega-3 supplementation as an alternative therapy for ADHD, which can be caused by vitamin and mineral deficiencies. Methods: This was a double-blinded clinical trial study. Sixty-six children with ADHD (aged 6–12 years) referred to our child...
- Allergy
- Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis
- Yeonu Choi, Haeun Jeon, Eun Ae Yang, Jong-Seo Yoon, Hyun Hee Kim
- Clin Exp Pediatr. 2019;62(9):353-359. Published online April 24, 2019
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Background: Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. However, its use as a marker of eosinophilic inflammation in nasal secretions is limited because the diagnostic cutoff values of EPO for use as a one-time test for allergic diseases such as allergic rhinitis have not been established.
Purpose: To identify the correlation...
- Nutrition
- The effect of high fat dietary modification and nutritional status on the outcome of critically ill ventilated children: single-center study
- Nehal Mohamed El Koofy, Hanaa Ibrahim Rady, Shrouk Moataz Abdallah, Hafez Mahmoud Bazaraa, Walaa Ahmed Rabie, Ahmed Ali El-Ayadi
- Clin Exp Pediatr. 2019;62(9):344-352. Published online April 2, 2019
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Background: Ventilator dependency constitutes a major problem in the intensive care setting. Malnutrition is considered a major determinant of extubation failure, however, attention has been attracted to modulating carbon dioxide production through decreasing carbohydrate loading and increasing the percent of fat in enteral feeds. The detected interrelation between substrate oxidation and ventilation outcome became the base of several research to...
- Editorial
- Allergy
- Is determining nasal eosinophil count and nasal eosinophil peroxidase concentration clinically useful in children with rhinits?
- Bong Seok Choi
- Clin Exp Pediatr. 2019;62(9):342-343. Published online July 9, 2019
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- Should partially hydrolyzed infant formula be given to the general infant population for the primary prevention of allergic disease?
- Tae Won Song
- Clin Exp Pediatr. 2019;62(9):340-341. Published online May 17, 2019
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- Review Article
- Cardiology
- Understanding the importance of cerebrovascular involvement in Kawasaki disease
- Jung Sook Yeom, Jae Young Cho, Hyang-Ok Woo
- Clin Exp Pediatr. 2019;62(9):334-339. Published online May 16, 2019
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Kawasaki disease (KD) is a systemic vasculitis in infants and young children. However, its natural history has not been fully elucidated because the first case was reported in the late 1960s and patients who have recovered are just now entering middle age. Nevertheless, much evidence has raised concerns regarding the subclinical vascular changes that occur in post-KD patients. KD research...
- Allergy
- Phenotypes of allergic diseases in children and their application in clinical situations
- Eun Lee, Soo-Jong Hong
- Clin Exp Pediatr. 2019;62(9):325-333. Published online April 23, 2019
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Allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, are common heterogeneous diseases that encompass diverse phenotypes and different pathogeneses. Phenotype studies of allergic diseases can facilitate the identification of risk factors and their underlying pathophysiology, resulting in the application of more effective treatment, selection of better treatment responses, and prediction of prognosis for each phenotype. In the early phase...
