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Case Report
Reninoma: a rare cause of curable hypertension
Ji Hye Kim, Ji Hyun Kim, Myung Hyun Cho, Eujin Park, Hye Sun Hyun, Yo Han Ahn, Hee Gyung Kang, Kyung Chul Moon, Il-Soo Ha, Hae Il Cheong
Clin Exp Pediatr. 2019;62(4):144-147.   Published online October 29, 2018
The most common type of refractory hypertension found in children is secondary hypertension, which is a potentially curable disease. Reninoma, a renin-secreting juxtaglomerular cell tumor, is a rare cause of severe hypertension that is usually diagnosed in adolescents and young adults. Surgical resection of the tumor completely cures the hypertension of patients with reninoma. The typical clinical presentation of reninoma...
Original Article
Effect of renin inhibition on an experimental glomerulonephritis - a preliminary report
Ju Hyung Kang, Jae Kyung Huh, Young Sook Lee, Ji Young Han, Il Soo Ha
Clin Exp Pediatr. 2009;52(8):938-943.   Published online August 15, 2009

Purpose:We performed this study in order to investigate the effect of direct renin inhibition on an experimental animal model with nephrotoxic serum nephritis and tried to give useful information for clinical research and renin inhibitor treatment. Methods:Thirty BALB/c 6-week-old male mice were divided into 4 groups: control group (CO, n=5), control-treatment group with aliskiren (CT, n=5), disease group (DO, n=10), and disease treatment...
Case Report
Wilms' tumor with polydipsia, polyuria, hyponatremic hypertension and congestive heart failure : a case report
Chul Hee Woo, Ji Min Jang, Chan Wook Woo, Ki Hyung Lee, Kwang Chul Lee
Clin Exp Pediatr. 2006;49(1):99-102.   Published online January 15, 2006
A 3-year-old girl presented with polydipsia, polyuria, hyponatremia, hypertension and congestive heart failure. Her polyuria was unresponsive to water restriction and vasopressin challenge tests, and her blood pressure was not effectively controlled by antihypertensive drugs. Radiologic examinations revealed a Wilms' tumor in the right kidney. Her plasma renin activity and aldosterone concentration were greatly increased. After surgical removal of the...
Angiotensin Converting Enzyme Inhibition Modulates Mitogen Activated Protein Kinase Family Expressions in the Neonatal Rat Kidney
Byung Min Choi, Mee-Hye Oh, Kee Hwan Yoo
Clin Exp Pediatr. 2004;47(3):325-331.   Published online March 15, 2004
Purpose : In a developing kidney, the renin-angiotensin system(RAS) is markedly activated and is thought to play an important role in postnatal renal growth and maturation. We previously demonstrated that angiotensin converting enzyme(ACE) inhibition in a developing rat kidney increases apoptosis and decreases its related gene expressions, which may account for renal growth impairment. Among the mitogen-activated protein kinases(MAPK) family...
Original Article
A Study on the Change of Plasma Renin Activity(PRA) and Aldosterone Concentration(PAC) before and after Heart Operation in Children with Congenital Heart Disease.
Jae Hong You, Jae Ho Lee
Clin Exp Pediatr. 1989;32(9):1232-1239.   Published online September 30, 1989
Thes is a study on changes of plasma renin activity (PRA) and aldosterone concentration (PAC) which was obtained before and after heart operation in 26 normotensive children with congenital heart diseases without renal disease admitted in Chungnam National University Hospital for cardiac catheterization with angiogram and heart operation from Apr. 1988 to Aug. 1988 to confirm any differences of PRA and PAC between groups...
Plasma Renin Activity (PRA) in Peripheral Vein and Renal Veins in Normotensive Children with Cyanotic Congenital Heart Disease.
Sang Kyu Park, Hae Il Cheong, Chung Il Noh, Yong Soo Yun, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1988;31(8):1021-1027.   Published online August 31, 1988
PRA’s in peripheral vein, both renal veins, and inferior vena cava (IVC) were measured in 25 normotensive children without renal disease undergoing cardiac catheterization for their underlying cyanotic congenital heart disease. And we presented the results as reference values/ranges of PRA in children. 1) There was no significant difference in PRA between both side renal veins at any absolute PRA levels with a mean ratio (RT/LT)...
Periperal Plasma Renin Activity in Children with Normotensive Reflux Nephropathy.
Chong Guk Lee, Kwang Mann Ko
Clin Exp Pediatr. 1988;31(6):731-737.   Published online June 30, 1988
Peripheral renin activity was measured in 11 children with normotensive reflux nephropathy and 20 normal children to disclose the abnormality of the renin-angiotensin system in the patient group. 9 children among the patient group were allocated to single-dose captopril test for the assessment of the response to the test in patients with normotensive reflux nephropathy. 1. Contrary to the significant negative correlation between PRA and...
Plasma Renin Acivity in Children with Acute Glomerulonephritis and Nephrotic Syndrome.
Oh Kyun Kwon, Young Hun Chung
Clin Exp Pediatr. 1987;30(11):1213-1220.   Published online November 30, 1987
This is a study on plasma renin acitivity (PRA) which was obtanined from the patients with acute glomerulonephritis or nephrotic syndrome and normotensive control group admitted in Chungnam National University Hospital from Oct. 1985 to Aug. 1986 to confirm any differences of PRA between groups and to establish their influencing factors. The results were as follows; 1) PRA of noimal children in preschool age (3.49 ±0.98...
Studies on the Changes of Serum Osmolality Electrolytes, Digoxin-like Substance and Plasma Renin Activity Following Angiocardiography using Hypertonic Contrast Media.
Heon Seob Song, Hyeong Won Shin, Chan Uhung Joo, Dae Yeol Lee, Jin Gon Jun
Clin Exp Pediatr. 1987;30(4):398-405.   Published online April 30, 1987
Angiocardiography and cineangiocardiography have been employed with increasing frequency for the diagnosis of cardiovascular diseases. These commonplace technics of cardiovascular radiology depend upon the rapid injection of hypertonic contrast media into the heart or central circulation. In order to study the effects of concentrated radiopaque materials(Conray®, 1382 mOsm/L, 1-2 ml/ kg) on hemodynamic consequences, the changes of serum osmolality, sodium, potassium, chloride, digoxin-like substance and...
Influence of Isoproterenol on the Plasma Renin Activity in Rats.
Woong Kyou Park, Yong Bae Shin, In soo Choi, Hyeon Suk Lee, Jung Soo Kim, Kyung Woo Cho
Clin Exp Pediatr. 1985;28(9):899-905.   Published online September 30, 1985
It has been suggested that the effect of catecholamine administered into the renal artery on the plasma renin activity may be controlled by extrarenal beta-receptor. Still the exact mechanism responsible for the increase of the plasma renin activity by catecholamines is obscure. In this experiment I have intended to clarify the involvement of extrarenal beta-receptor concerning renin release in the...
Plasma Renin Activity (PRA) in Peripheral Vein and Renal Veins in Normotensive Children.
Chong Ku Yun, Hae Il Cheong, Chung Il Noh, Jung Yun Choi, Yong Choi, Kwang Wook Ko, Kyung Mo Yeon
Clin Exp Pediatr. 1985;28(6):555-563.   Published online June 30, 1985
PRA in peripheral vein, both renal veins and both inferior vena cava (JVC) both proximal and distal to the drainage of the both renal veins was measured in 80 normotensive children with no renal disease undergoing routine cardiac catheterization due to congenital heart disease which did not cause significant hemodynamic changes in most of them. And we presented the results...
Changes of Plasma Inactive Renin in Newborn Infant and Children.
Pyoung Han Hwang, Woong Kyou Park, Heon Sook Lee, Jung Soo Kim, Kyung Woo Cho
Clin Exp Pediatr. 1984;27(9):872-876.   Published online September 30, 1984
There have been some suggestion that inactive renin may be a kind of precursor renin. There have not yet been however, founded direct evidence for that suggestion. To understand more about the physiological role of the plasma inactive renin, experiments have been done. The results obtained as follows. 1)In the newborn infants plasma renin activity showed highest level up to...
Plasma Renin Activities in Patients with Acute Poststreptococcal Glomerulonephritis.
S Y Chang, B H Oh, W G Lee, C M Park
Clin Exp Pediatr. 1982;25(4):329-333.   Published online April 30, 1982
Acute poststreptococcal glomeruonephritis is the most common non-pyogenic renal disease in childhood. The main clinical manifestations are edema, hematuria and hypertension. During the course of the disease, acute renal failure and hypertension are most common complications. Hypertension may give rise to encephalopasthy in small percentage of patients. Yet, the precise mechanism of its pathogenesis has remained uncertain. Increased cardiac output...
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